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11. 发明授权

US4364937A Monoclonal antibody to a human T cell antigen and methods of preparing same 失效
标题翻译：人T细胞抗原的单克隆抗体及其制备方法
公开(公告)号：US4364937A
公开(公告)日：1982-12-21
申请号：US110510
申请日：1980-01-08
申请人： Patrick C. Kung , Gideon Goldstein
发明人： Patrick C. Kung , Gideon Goldstein
IPC分类号： A61K39/395 , A61K38/00 , A61P37/00 , C07K14/005 , C07K14/195 , C07K16/00 , C07K16/28 , C12N5/00 , C12N5/10 , C12N15/02 , C12P21/00 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/577 , C12N5/02 , C12N15/00 , C12Q1/00 , G01N33/48 , G01N33/68 , G01N33/96
CPC分类号： C07K16/2806 , A61K38/00 , Y10S435/948 , Y10S530/806 , Y10S530/808 , Y10S530/809 , Y10S530/868
摘要： Hybrid cell line for production of monoclonal antibody to an antigen found on essentially all normal human T cells and on approximately 95% of normal human thymocytes. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
摘要翻译：用于在基本上所有正常人T细胞和大约95％正常人胸腺细胞上发现的抗原的单克隆抗体的杂交细胞系。通过将来自免疫的CAF1小鼠的脾细胞与P3X63Ag8U1骨髓瘤细胞融合来形成杂交体。还公开了单克隆抗体的诊断和治疗用途。

12. 发明授权

US4364936A Monoclonal antibody to a human monocyte antigen and methods of preparing same 失效
标题翻译：人单核细胞抗原的单克隆抗体及其制备方法
公开(公告)号：US4364936A
公开(公告)日：1982-12-21
申请号：US110509
申请日：1980-01-08
申请人： Patrick C. Kung , Gideon Goldstein
发明人： Patrick C. Kung , Gideon Goldstein
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , A61P37/00 , C07K14/005 , C07K14/195 , C07K14/705 , C07K16/00 , C07K16/28 , C12N5/00 , C12N5/10 , C12N15/02 , C12P21/00 , C12P21/08 , C12R1/91 , G01N33/577 , C12N5/02 , C12N15/00 , C12Q1/00 , G01N33/48 , G01N33/68 , G01N33/96
CPC分类号： C07K16/28 , A61K38/00 , Y10S530/808
摘要： Hybrid cell line for production of monoclonal antibody to an antigen found on normal human monocytes and granulocytes. The hybrid is formed by fusing splenocytes from immunized BALB/cJ mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
摘要翻译：用于在正常人单核细胞和粒细胞上发现的抗原的单克隆抗体的杂交细胞系。通过将来自免疫的BALB / cJ小鼠的脾细胞与P3X63Ag8U1骨髓瘤细胞融合来形成杂交体。还公开了单克隆抗体的诊断和治疗用途。

13. 发明授权

US4077949A Polypeptide hormones of the thymus 失效
标题翻译：多肽激素的胸腺
公开(公告)号：US4077949A
公开(公告)日：1978-03-07
申请号：US606843
申请日：1975-08-22
申请人： Gideon Goldstein
发明人： Gideon Goldstein
IPC分类号： A61K38/00 , C07K14/66 , C07C103/52 , A61K37/00
CPC分类号： C07K14/66 , A61K38/00 , Y10S530/854 , Y10S930/18
摘要： There are disclosed closely related new polypeptides isolated from bovine thymus, which are distinct polypeptides denoted as Thymin I and Thymin II or Thymopoietin I and Thymopoietin II, respectively. Thymin I may be characterized as having a relative mobility (Rf) on 7% polyacrylamide gel disc electrophoresis of 0.63 with respect to methyl green at a pH of 4.3, and having the following structural sequence:H.sub.2 n-gly-gln-phe-leu-glu-asp-pro-ser-val-leu-thr-lys-glu-lys-leu-lys-ser-glu-leu-val-ala-asn-asn-val-thr-leu-pro-ala-gly-glu-gln-arg-lys-asp-val-tyr-val-gln-leu-tyr-leu-gln-his-leu-thr-ala-val-lys-arg-cooh.Thymin II may be characterized as having a relative mobility (Rf) on 7% polyacrylamide gel disc electrophoresis of 0.57 with respect to methyl green at a pH of 4.3, and having the following structural sequence:H.sub.2 n-ser-gln-phe-leu-glu-asp-pro-ser-val-leu-thr-lys-glu-lys-leu-lys-ser-glu-leu-val-ala-asn-val-thr-leu-pro-ala-gly-glu-gln-arg-lys-asp-val-tyr-val-gln-leu-tyr-leu-gln-thr-leu-thr-ala-val-lys-arg-cooh.Both polypeptides are highly purified and in powder form and are isolated from bovine thymus by multiple purification methods involving molecular sieving and chromatography. Both products cause delayed impairment of neuromuscular transmission in vivo and induce bone marrow cells to develop the characteristics of thymus-derived lymphocytes and thus are useful in therapeutic areas involving thymic or immunity deficiencies or imbalances, and neuromuscular hyperactivity.
摘要翻译：公开了分离自牛胸腺的密切相关的新多肽，其分别是分别称为Thymin I和Thymin II或Thymopoietin I和Thymopoietin II的不同多肽。可以将Thymin I的特征在于在4.3的pH下，相对于甲基绿在7％聚丙烯酰胺凝胶盘电泳上具有0.63的相对迁移率（Rf），并且具有以下结构序列：

14. 发明授权

US07563437B2 Methods and compositions for impairing multiplication of HIV-1 失效
标题翻译：减少HIV-1增殖的方法和组合物
公开(公告)号：US07563437B2
公开(公告)日：2009-07-21
申请号：US11353293
申请日：2006-02-13
申请人： Roland Carlsson , Elisabeth Sonesson , Yvonne Stenberg , Leif Strandberg , Gideon Goldstein
发明人： Roland Carlsson , Elisabeth Sonesson , Yvonne Stenberg , Leif Strandberg , Gideon Goldstein
IPC分类号： A61K39/395
CPC分类号： C07K16/1072 , C07K2317/92
摘要： A single isolated antibody or antibody fragment thereof binds to multiple variant sequences within an epitope of HIV-1 Tat protein displayed in multiple strains and subtypes of HIV-1. This “pan-epitope” antibody is useful in therapeutic and prophylactic compositions and treatments of HIV-1 infection, regardless of strain. This pan-epitope antibody is useful in assays for the detection of levels of HIV-1 based on a measurement of the amount of Tat protein in a biological sample.
摘要翻译：单个分离的抗体或其抗体片段结合HIV-1多重菌株和亚型中显示的HIV-1 Tat蛋白的表位内的多个变体序列。这种“泛表位”抗体可用于HIV-1感染的治疗和预防组合物和治疗，不管应变如何。该泛表位抗体可用于基于生物样品中Tat蛋白量的测量来检测HIV-1水平的测定中。

15. 发明申请

US20090123488A1 Compositions and methods for the treatment and prophylaxis of Alzheimer's disease 审中-公开
标题翻译：用于治疗和预防阿尔茨海默病的组合物和方法
公开(公告)号：US20090123488A1
公开(公告)日：2009-05-14
申请号：US11891880
申请日：2007-08-14
申请人： Gideon Goldstein
发明人： Gideon Goldstein
IPC分类号： A61K39/385 , A61P37/04
CPC分类号： A61K45/06 , A61K31/714 , A61K2300/00
摘要： A self-adjuvanting immunogenic composition comprising an immunogen comprising a lipopeptide cap (R2), a universal T helper sequence (R1) and an immunodominant Aβ B cell epitope. The immunogen also comprises one or more linker sequences and/or polar charged amino acid sequences. The B cell epitope of each immunogen has an amino acid sequence located within the first 17 amino acids of SEQ ID NO: 1. The lipopeptide is a dipalmitoyl-S-glyceryl-cysteine or a tripalmitoyl-S-glyceryl cysteine or N-acetyl (dipalmitoyl-S-glyceryl cysteine), each with an optional neutral amino acid linker. Optional polar sequences of at least four charged polar amino acids enhance solubility of the immunogen and are located at the carboxy terminal end of R2, optionally flanked by neutral linker amino acids, or elsewhere in the immunogen. Such compositions, at surprisingly low dosages of less than 10 mg per subject, can induce anti-Aβ peptide antibodies with GMTs of 50,000 or greater than 1,000,000 when employed to immunize a mammalian subject, without any extrinsic adjuvant.
摘要翻译：一种自佐剂免疫原性组合物，其包含包含脂肽帽（R2），通用T辅助序列（R1）和免疫优势Abeta B细胞表位的免疫原。免疫原还包含一个或多个接头序列和/或极性带电荷的氨基酸序列。每个免疫原的B细胞表位具有位于SEQ ID NO：1的前17个氨基酸内的氨基酸序列。脂肽是二棕榈酰基-S-甘油基半胱氨酸或三棕榈酰基-S-甘油基半胱氨酸或N-乙酰基（二棕榈酰基-S-甘油基半胱氨酸），每个具有任选的中性氨基酸接头。至少四个带电极性氨基酸的任选的极性序列增强了免疫原的溶解度，并且位于R2的羧基末端，任选地侧接于中性接头氨基酸或免疫原中的其他位置。当以惊人的低剂量小于10mg每个受试者时，这些组合物可以诱导具有50,000或大于1,000,000的GMT的抗Aβ肽抗体，当用于免疫哺乳动物受试者时，没有任何外源性佐剂。

16. 发明授权

US5639729A Tripeptides useful in immune and CNS therapy 失效
标题翻译：用于免疫和CNS治疗的三肽
公开(公告)号：US5639729A
公开(公告)日：1997-06-17
申请号：US112413
申请日：1993-08-26
申请人： Gideon Goldstein , Ponniah Shenbagamurthi , James I. Koenig
发明人： Gideon Goldstein , Ponniah Shenbagamurthi , James I. Koenig
IPC分类号： G01N33/50 , A61K38/00 , A61P25/24 , A61P25/26 , A61P37/00 , C07K5/072 , C07K5/09 , C07K5/097 , A61K38/02 , C07K5/00 , C07K7/00
CPC分类号： C07K5/0823 , C07K5/06095 , A61K38/00
摘要： Tripeptides capable of regulating the function of cells of the mammalian immune and/or central nervous system, pharmaceutical compositions containing the peptides and methods of use thereof are provided.
摘要翻译：提供能够调节哺乳动物免疫和/或中枢神经系统细胞功能的三肽，含有该肽的药物组合物及其使用方法。

17. 发明授权

US5593842A Method of measuring thymopoietin proteins in plasma and serum including acidification of the plasma and serum 失效
标题翻译：血浆和血清中胸腺生成素蛋白测定方法，包括血浆和血清的酸化
公开(公告)号：US5593842A
公开(公告)日：1997-01-14
申请号：US309419
申请日：1994-09-20
申请人： Gideon Goldstein , Michael D. Culler
发明人： Gideon Goldstein , Michael D. Culler
IPC分类号： C07K14/66 , G01N33/74 , G01N33/53 , G01N1/00 , G01N1/18
CPC分类号： C07K14/66 , G01N33/74 , Y10S435/962 , Y10S435/967 , Y10S435/975 , Y10T436/25 , Y10T436/25125 , Y10T436/25375 , Y10T436/255
摘要： Method for accurately measuring thymopoietin (TP) in human serum or plasma by dissociating TP from protein complexes, releasing bound TP in a unbound form, extracting TP, preparing it for assay, and measuring TP levels in a suitable assay.
摘要翻译：通过将TP从蛋白质复合物中解离出来，准确测定人血清或血浆中的胸腺生成素（TP）的方法，以未结合的形式释放结合的TP，提取TP，制备其用于测定，以及在合适的测定中测量TP水平。

18. 发明授权

US5140010A Stabilized aqueous formulations of thymopentin 失效
标题翻译：胸腺五肽的稳定水性制剂
公开(公告)号：US5140010A
公开(公告)日：1992-08-18
申请号：US665532
申请日：1991-03-06
申请人： Gideon Goldstein , Tapan Audhya
发明人： Gideon Goldstein , Tapan Audhya
IPC分类号： A61K38/04 , A61K38/16 , A61K47/12 , A61K47/18
CPC分类号： A61K9/0019 , A61K38/04 , A61K38/16 , A61K47/12 , A61K47/183
摘要： The present invention provides a method for preparing aqueous formulations of thymopentin, which method permits the peptide to retain its biological activity during storage at room temperature.
摘要翻译：本发明提供一种制备胸腺五肽的水性制剂的方法，该方法允许肽在室温储存期间保持其生物学活性。

19. 发明授权

US4912045A Hybrid cell line for producing monoclonal antibody to a human monocyte, antigen, antibody and methods 失效
标题翻译：用于产生人单核细胞单克隆抗体的杂交细胞系，抗原，抗体和方法
公开(公告)号：US4912045A
公开(公告)日：1990-03-27
申请号：US763330
申请日：1985-08-08
申请人： Patrick C. Kung , Gideon Goldstein
发明人： Patrick C. Kung , Gideon Goldstein
IPC分类号： A61K38/00 , C07K16/28 , G01N33/569
CPC分类号： G01N33/56972 , C07K16/28 , A61K38/00
摘要： Hybrid cell line for production of monoclonal antibody to an antigen found on normal human monocytes and granulocytes. The hybrid is formed by fusing splenocytes from immunized BALB/cJ mice with P3X63Ag8Ul myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
摘要翻译：用于在正常人单核细胞和粒细胞上发现的抗原的单克隆抗体的杂交细胞系。通过将来自免疫的BALB / cJ小鼠的脾细胞与P3X63Ag8U1骨髓瘤细胞融合来形成杂交体。还公开了单克隆抗体的诊断和治疗用途。

20. 发明授权

US4749690A Treatment of allergy with thymopentin 失效
标题翻译：用胸腺肽治疗过敏
公开(公告)号：US4749690A
公开(公告)日：1988-06-07
申请号：US822704
申请日：1986-01-27
申请人： Gideon Goldstein
发明人： Gideon Goldstein
IPC分类号： A61K38/32 , A61K37/02
CPC分类号： A61K38/32 , Y10S514/885 , Y10S930/18
摘要： A method for treating allergy by administration of the peptide thymopentin.
摘要翻译：通过施用肽胸腺五肽来治疗过敏的方法。

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