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11. 发明授权

US06391921B1 Treatment of inflammation with 2,4,6-trihydroxy-&agr;-para-methoxyphenylacetophenone, or its pharmaceutically acceptable derivatives 有权
公开(公告)号：US06391921B1
公开(公告)日：2002-05-21
申请号：US09884245
申请日：2001-06-19
申请人： Fatih M. Uckun , Ravi Malaviya
发明人： Fatih M. Uckun , Ravi Malaviya
IPC分类号： A61K3112
摘要： 2,4,6-trihydroxy-&agr;-p-methoxyphenylacetophenone (also identified herein as “D-58”), or its pharmaceutically acceptable derivatives such as salt and ester forms, is administered for inhibiting inflammatory reactions. The treatment can be remedial or prophylactic. Examples of the conditions that can be treated include acute inflammatory reactions and allergic inflammatory reactions, and specific examples include allergy, asthma, arthritis, psoriasis, skin sunburn, inflammatory pelvic disease, inflammatory bowel disease, urethritis, uvitis, senusitis, pneumonitis, encephalitis, meningitis, myocarditis, nephritis, osteomyelitis, myositis, hepatitis, gastritis, enteritis, dermatitis, gingivitis, appendicitis, pancreatitis, cholocystitis and cholangitis. The 2,4,6-trihydroxy-&agr;-p-methoxyphenylacetophenone can be administered by various routes as needed.

12. 发明授权

US06326373B1 JAK-3 inhibitors for treating allergic disorders 失效
公开(公告)号：US06326373B1
公开(公告)日：2001-12-04
申请号：US09688755
申请日：2000-10-16
申请人： Fatih M. Uckun , Ravi Malavia , Elise A. Sudbeck
发明人： Fatih M. Uckun , Ravi Malavia , Elise A. Sudbeck
IPC分类号： A61K31505
CPC分类号： A61K31/517
摘要： Inhibitors of JAK3 kinase for the treatment of allergy inhibit mast cell degranulation an dmediator release.

13. 发明授权

US06306897B1 Calanolides for inhibiting BTK 失效
标题翻译：氯化胆碱抑制BTK
公开(公告)号：US06306897B1
公开(公告)日：2001-10-23
申请号：US09354550
申请日：1999-07-15
申请人： Fatih M. Uckun , Elise Sudbeck
发明人： Fatih M. Uckun , Elise Sudbeck
IPC分类号： A61K3135
CPC分类号： C07D493/04 , A61K31/352 , A61K31/37 , C07D493/14
摘要： The invention provides calanolide compounds used as Tec family/BTK inhibitors, methods for their identification and use, and pharmaceutical compositions comprising calanolide Tec family/BTK inhibitors.
摘要翻译：本发明提供用作Tec家族/ BTK抑制剂的calanolide化合物，其鉴定和使用方法，以及包含calanolide Tec家族/ BTK抑制剂的药物组合物。

14. 发明授权

US06245808B1 Oxy-vanadium (IV) complexes having spermicidal activity 失效
标题翻译：具有杀精活性的氧 - 钒（IV）络合物
公开(公告)号：US06245808B1
公开(公告)日：2001-06-12
申请号：US09187115
申请日：1998-11-05
申请人： Fatih M. Uckun , Osmond D'Cruz , Wanhong Dong
发明人： Fatih M. Uckun , Osmond D'Cruz , Wanhong Dong
IPC分类号： A61K3128
CPC分类号： C07F9/005
摘要： Organometallic oxovanadium (IV) complexes having potent spermicidal activity, particularly those having at least one bidentate ligand. Preferred compounds are stable oxovanadium (IV) complexes having, as ancillary ligands linked via nitrogen or oxygen-metal bonds, bis and/or mono-1,10-phenanthroline; 2,2′-bipyridyl; or 2-hydroxyacetophenone.
摘要翻译：有机金属氧化钒（IV）配合物具有有效的杀精活性，特别是具有至少一个二齿配体的那些。优选的化合物是稳定的氧化钒（IV）络合物，其具有作为通过氮或氧 - 金属键连接的辅助配体，双和/或单-1,10-菲咯啉; 2,2'-联吡啶基或2-羟基苯乙酮。

15. 发明授权

US06221900B1 BTK inhibitors and methods for their identification and use 失效
公开(公告)号：US06221900B1
公开(公告)日：2001-04-24
申请号：US09411759
申请日：1999-10-04
申请人： Fatih M. Uckun , Yaguo Zheng , Sutapa Ghosh
发明人： Fatih M. Uckun , Yaguo Zheng , Sutapa Ghosh
IPC分类号： A61K3147
CPC分类号： A61K31/225 , A61K31/275 , A61K31/277 , A61K31/40 , A61K31/445 , A61K31/525
摘要： The invention provides BTK inhibitors, methods for their identification and use, and pharmaceutical compositions comprising BTK inhibitors.

16. 发明授权

US6051603A Vanadium (IV) metallocene complexes having sperm motility inhibiting activity 失效
标题翻译：具有精子活力抑制活性的钒（Ⅳ）茂金属络合物
公开(公告)号：US6051603A
公开(公告)日：2000-04-18
申请号：US8898
申请日：1998-01-20
申请人： Osmond D'Cruz , Phalguni Ghosh , Fatih M. Uckun
发明人： Osmond D'Cruz , Phalguni Ghosh , Fatih M. Uckun
IPC分类号： A61P15/16 , A61K31/28 , A61K31/555 , A61P35/00 , C07F17/00
CPC分类号： A61K31/555 , A61K31/28
摘要： Novel spermicidal compounds which are organometallic cyclopentadienyl metal complexes, particularly vanadium IV complexes, are described including corresponding contraceptive and therapeutic compositions and method for providing contraception and selective killing of testicular germ cells. Included among the vanadium complexes are vanadocene dichloride, vanadocene dibromide, bis (methyl cyclopentadienyl) vanadium dichloride, vanadocene diiodide, vanadocene di-pseudohalides, and others. Most active found was vanadocene diselenocyanate.
摘要翻译：描述了作为有机金属环戊二烯基金属络合物，特别是钒IV络合物的新型杀精细胞化合物，包括相应的避孕和治疗组合物以及用于提供避孕和选择性杀死睾丸生殖细胞的方法。在钒络合物中包括二茂酰二茂，二溴二茂二，二（甲基环戊二烯基）二氯化钒，二氢二钒，二卤代二卤化物等。最活跃的是二茂铁二硒化物。

17. 发明授权

US5911995A EGF-genistein conjugates for the treatment of cancer 失效
标题翻译： EGF-染料木黄酮缀合物用于治疗癌症
公开(公告)号：US5911995A
公开(公告)日：1999-06-15
申请号：US602186
申请日：1996-02-16
申请人： Fatih M. Uckun
发明人： Fatih M. Uckun
IPC分类号： A61K38/00 , A61K47/48 , A61P35/00 , C07K16/28 , A61K39/385 , A01N61/00 , A61K39/00 , C07K16/00
CPC分类号： A61K47/48384 , A61K47/48269 , A61K47/48561 , C07K16/28 , A61K38/00
摘要： A conjugate formed of epidermal growth factor covalently linked to a tyrosine kinase inhibitor, such as genistein, and a method for killing cancer cells, in vivo and in vitro, by administering a cytotoxic dose of an epidermal growth factor tyrosine kinase inhibitor conjugate.
摘要翻译：通过施用细胞毒性剂量的表皮生长因子酪氨酸激酶抑制剂缀合物，在体内和体外通过与酪氨酸激酶抑制剂如染料木黄酮共价连接的表皮生长因子形成的缀合物和杀死癌细胞的方法。

18. 发明授权

US5690935A Biotherapy of cancer by targeting TP-3/P80 失效
标题翻译：通过靶向TP-3 / P80进行癌症生物治疗
公开(公告)号：US5690935A
公开(公告)日：1997-11-25
申请号：US372608
申请日：1995-01-13
申请人： Fatih M. Uckun , Peter M. Anderson
发明人： Fatih M. Uckun , Peter M. Anderson
IPC分类号： A61K47/48 , A61P35/00 , A61K39/44 , C07K14/415 , C07K16/28 , C12N15/13
CPC分类号： A61K47/48469 , Y10S530/866
摘要： Cytotoxic biotherapeutic agents effective for treating certain types of cancer in humans are provided which comprise the TP-3 murine monoclonal antibody chemically conjugated to pokeweed antiviral protein (PAP). The invention further provides a method which utilizes the disclosed cytotoxic biotherapeutic agents to systemically treat cancer patients. With slight modifications the method of the present invention should be generally applicable to preparation and use of other cytotoxic biotherapeutic agents using chemical or recombinant derivatives of the TP-3 or TP-1 antibodies or PAP toxin. The invention is applicable to cancer patients who express the p80 antigen recognized by the TP-1/TP-3 antibodies either on the surface of their tumor cells or on the tumor blood vessels.
摘要翻译：提供了有效治疗人类某些类型癌症的细胞毒性生物治疗剂，其包含与pokeweed抗病毒蛋白（PAP）化学偶联的TP-3鼠单克隆抗体。本发明进一步提供利用所公开的细胞毒性生物治疗剂系统地治疗癌症患者的方法。通过轻微修改，本发明的方法应通常适用于使用TP-3或TP-1抗体或PAP毒素的化学或重组衍生物制备和使用其它细胞毒性生物治疗剂。本发明适用于在肿瘤细胞表面或肿瘤血管上表达由TP-1 / TP-3抗体识别的p80抗原的癌症患者。

19. 发明授权

US4831117A Monoclonal antibody specific for human B-cells 失效
标题翻译：对人B细胞特异性的单克隆抗体
公开(公告)号：US4831117A
公开(公告)日：1989-05-16
申请号：US816141
申请日：1986-01-03
申请人： Fatih M. Uckun
发明人： Fatih M. Uckun
IPC分类号： A61K47/48 , C07K16/30
CPC分类号： A61K47/48469 , A61K47/4863 , C07K16/3061 , Y10S530/808
摘要： A hybrid cell line yields a monoclonal antibody which is highly restricted to B-lineage lymphoblastic leukemia cells and their progenitors.
摘要翻译：杂交细胞系产生高度限于B系血淋巴细胞白血病细胞及其祖细胞的单克隆抗体。

20. 发明授权

US07144874B2 Aryl phosphate derivatives of d4T having activity against resistant HIV strains 失效
标题翻译： d4T的芳基磷酸酯衍生物具有抗HIV病毒株的活性
公开(公告)号：US07144874B2
公开(公告)日：2006-12-05
申请号：US10281333
申请日：2002-10-25
申请人： Fatih M. Uckun
发明人： Fatih M. Uckun
IPC分类号： A61K31/70
CPC分类号： A61K31/675 , Y10S514/885
摘要： Methods of inhibiting virus replication of in a cell infected with a resistant strain of HIV that includes administering to the infected cell a virus replication inhibiting amount of an aryl phosphate derivative of d4T.
摘要翻译：抑制HIV感染的细胞中的病毒复制的方法，其包括向感染的细胞施用病毒复制抑制量的d4T的芳基磷酸酯衍生物。

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