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    • 14. 发明授权
      US4902699A Oxime of 1, 2, 5, 6-tetrahydropyridine compounds their use as medicaments and the compositions containing them 失效
    • Oxime of 1, 2, 5, 6-tetrahydropyridine compounds their use as medicaments and the compositions containing them
    • 1,2,5,6-四氢吡啶的肟化合物用作药物和含有它们的组合物
    • US4902699A
    • 1990-02-20
    • US234627
    • 1988-08-22
    • Emilio Toja , Carla Bonetti , Fernando Barzaghi , Giulio Galliani
    • Emilio Toja , Carla Bonetti , Fernando Barzaghi , Giulio Galliani
    • A61K31/445 , A61P25/28 , C07D211/94
    • C07D211/94
    • Compounds useful in the treatment of patients suffering from senile dementia, Alzheimer's disease or memory defects, of the formula ##STR1## in which R represents hydrogen or a linear, branched or cyclic alkyl, alkenyl, or alkynyl, containing up to 8 carbon atoms, or the radical ##STR2## in which R.sub.1 represents a linear or branched, alkyl, alkenyl or alkynyl, containing up to 8 carbon atoms, a linear or branched, saturated or unsaturated, alkoxy containing up to 8 carbon atoms, or aryl containing up to 14 carbon atoms, or the radical ##STR3## in which R.sub.2 represents a linear or branched alkyl, alkenyl or alkynyl, containing up to 8 carbon atoms, aryl containing up to 14 carbon atoms, possibly substituted, or aralkyl containing up to 18 carbon atoms, possibly substituted, and R' represents a linear, branched or cyclic alkyl, alkenyl or alkynyl, containing up to 8 carbon atoms, as well as their addition salts with organic or mineral acids.
    • 用于治疗患有老年性痴呆，阿尔茨海默氏病或​​记忆缺陷的患者，其中R表示氢或含有至多8个碳原子的直链，支链或环状的烷基，烯基或炔基， 或其中R 1表示含有至多8个碳原子的直链或支链的烷基，烯基或炔基，含有至多8个碳原子的直链或支链，饱和或不饱和的烷氧基，或含有至多 14个碳原子，或者其中R 2表示含有至多8个碳原子的直链或支链烷基，烯基或炔基，含有至多14个碳原子的芳基，可能被取代的基团，或含有至多18个碳原子的芳烷基 ，可能被取代，R'代表含有至多8个碳原子的直链，支链或环状的烷基，烯基或炔基，以及它们与有机或无机酸的加成盐。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
    • 18. 发明授权
      US5053416A Derivatives of 1,2,5,6-tetrahydropyridine substituted by a thiazolyl or oxazolyl radical, their use as medicaments and compositions containing them 失效
    • Derivatives of 1,2,5,6-tetrahydropyridine substituted by a thiazolyl or oxazolyl radical, their use as medicaments and compositions containing them
    • 作为药物和组合物使用的由噻唑啉或氧杂唑基衍生物取代的1,2,5,6-四氢吡啶的衍生物
    • US5053416A
    • 1991-10-01
    • US457566
    • 1989-12-27
    • Emilio Toja , Carla Bonetti , Fernando Barzaghi , Giulio Galliani
    • Emilio Toja , Carla Bonetti , Fernando Barzaghi , Giulio Galliani
    • A61K31/425 , A61K31/435 , A61P25/00 , C07D413/04 , C07D417/04
    • C07D413/04 , C07D417/04
    • Compounds of formula (I) ##STR1## in which X represents oxygen or sulphur, R.sub.1 represents hydrogen, a linear, branched or cyclic alkyl containing up to 8 carbon atoms, an alkenyl or alkynyl containing up to 6 carbon atoms, hydroxyl, an OCOalk.sub.1 radical in which alk.sub.1 represents alkyl containing up to 6 carbon atoms, an OCONHalk.sub.2 radical in which alk.sub.2 represents alkyl containing up to 6 carbon atoms, a CO.sub.2 alk.sub.3 radical in which alk.sub.3 represents alkyl or alkenyl containing up to 6 carbon atoms, an Oalk.sub.4 radical in which alk.sub.4 represents alkyl containing up to 6 carbon atoms, an OCOAr.sub.1, OCONHAr.sub.2 or CO.sub.2 Ar.sub.3 radical in which Ar.sub.1, Ar.sub.2 or Ar.sub.3 represents aryl containing up to 14 carbon atoms, R.sub.2 represents hydrogen, a linear, branched or cyclic alkyl containing up to 6 carbon atoms, alkenyl or alkynyl containing up to 6 carbon atoms, an alkoxyalkyl alk'.sub.1 Oalk'.sub.2 radical in which alk'.sub.1 and alk'.sub.2 represent alkyl containing up to 6 carabon atoms, hydroxyalkyl in which the alkyl contains up to 6 carbon atoms or aryl containing up to 14 carbon atoms, as well as their addition salts with organic or mineral acids, which compounds are useful in the treatment of patients suffering from Alzheimer's disease, senile dementia or memory disorders of the aged; also, compositions containing the same, method of use, method of preparation, and intermediates therefor.
    • 式（I）化合物其中X表示氧或硫，R1表示氢，含有至多8个碳原子的直链，支链或环状烷基，含有至多6个碳原子的烯基或炔基，羟基 ，其中alk1表示含有至多6个碳原子的烷基的OCOalk1基团，其中alk2表示含有至多6个碳原子的烷基的OCONHalk2基团，其中alk3表示含有至多6个碳原子的烷基或烯基的CO 2alk 3基团，Oalk4 其中alk4表示含有至多6个碳原子的烷基，OCOAr1，OCONHAr2或CO2Ar3基团，其中Ar1，Ar2或Ar3表示含有至多14个碳原子的芳基，R2表示氢，直链，支链或环状烷基， 6个碳原子，含有至多6个碳原子的烯基或炔基，烷基alk'1Oalk'2基团，其中alk'1和alk'2代表含有多达6个carabon原子的烷基，其中烷基含有多达6个碳原子的羟烷基 含有至多14个碳原子的原子或芳基，以及它们与有机或无机酸的加成盐，该化合物可用于治疗患有阿尔茨海默病，老年痴呆或老年记忆障碍的患者; 也可以使用含有该组合物的组合物，使用方法，制备方法及其中间体。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
    • 19. 发明授权
      US5041436A 1-arylsulphonyl-2-piperidinone derivatives, process and intermediates for the preparation thereof, their application as antispasmodics and compositions containing them 失效
    • 1-arylsulphonyl-2-piperidinone derivatives, process and intermediates for the preparation thereof, their application as antispasmodics and compositions containing them
    • 1-芳基磺酰基-2-哌啶酮衍生物，其制备方法和中间体，其作为解痉药的应用和含有它们的组合物
    • US5041436A
    • 1991-08-20
    • US482806
    • 1990-02-21
    • Emilio Toja , Fernando Barzaghi , Giulio Galliani
    • Emilio Toja , Fernando Barzaghi , Giulio Galliani
    • C07D211/76 , A61K31/445 , A61K31/55 , A61P25/02 , C07D211/32 , C07D211/96
    • C07D211/96
    • The invention relates to the products of formula ##STR1## in which R represents the radical ##STR2## in which R.sub.1 at any position on the benzene ring represents linear, branched or cyclic alkyl, alkenyl or alkynyl containing up to 8 carbon atoms, or the radical ##STR3## in which R.sub.2 and R.sub.3, which may be identical or different, represents hydrogen or linear alkyl, alkenyl or alkynyl containing up to 8 carbon atoms or form, together with the nitrogen atom to which they are attached, a carbonaceous heterocyclic radical optionally containing another hetero atom, or the radical OR', R' representing hydrogen, a linear, branched or cyclic alkyl containing up to 8 carbon atoms or aryl containing up to 14 carbon atoms, or the radical SR.sub.4 or S(O)R.sub.5, R.sub.4 and R.sub.5 representing linear, branched or cyclic alkyl, alkenyl, or alkynyl containing up to 8 carbon atoms, or R represents naphthyl optionally substituted with the radical R'.sub.1, R'.sub.1 being as defined above for R.sub.1, to a process and intermediates for the preparation thereof, to their application as medicinal products and to compositions containing them.
    • 本发明涉及式（I）的产物，其中R表示基团，其中苯环上任何位置的R 1表示直链，支链或环烷基，含有至多8个碳原子的烷基，烯基或炔基 或者其中可以相同或不同的R 2和R 3表示氢或含有至多8个碳原子的直链烷基，烯基或炔基或与它们所连接的氮原子一起形成的基团 或任选含有另一个杂原子的碳质杂环基，或代表氢的基团OR'，R'，含有至多8个碳原子的直链，支链或环状烷基或含有至多14个碳原子的芳基，或基团SR4或S（O ）R 5，R 4和R 5表示直链，支链或环状的含有至多8个碳原子的烷基，烯基或炔基，或R表示任选被R 1'，R''如上面对R 1所定义的基团取代的萘基， 过程和中间体 他的准备，作为药用产品和含有它们的组合物的应用。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
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