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11. 发明申请

US20080262601A1 Stent Device with Multiple Helix Construction 审中-公开
标题翻译：具有多个螺旋结构的支架装置
公开(公告)号：US20080262601A1
公开(公告)日：2008-10-23
申请号：US12146656
申请日：2008-06-26
申请人： Edward H. Cully , Michael J. Vonesh
发明人： Edward H. Cully , Michael J. Vonesh
IPC分类号： A61F2/88
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/91516 , A61F2002/91525 , A61F2002/91533 , A61F2002/9155 , A61F2002/91558 , A61F2220/0033 , A61F2220/005 , A61F2230/0013 , A61F2230/0054
摘要： An improved stent design is disclosed that employs a series of helically oriented expansion elements encircling the stent. Each of the expansion elements includes a stepped pattern employing two distinct pitch angles. The expansion elements are oriented to cooperate with each other to form a series of virtual radially expandable rings that provide suitable outward force for proper stent function, but which are not connected together to form a continuous coherent ring if separated from the stent as a whole. In this manner, a distinctive stent design is provided that has numerous functional benefits over stents described in the prior art.
摘要翻译：公开了一种改进的支架设计，其采用环绕支架的一系列螺旋定向的膨胀元件。每个膨胀元件包括采用两个不同倾斜角的阶梯形图案。膨胀元件被定向成彼此配合以形成一系列虚拟的可径向扩张的环，其提供用于适当的支架功能的合适的向外的力，但如果与整个支架分离，则它们不连接在一起以形成连续的相干环。以这种方式，提供了与现有技术中描述的支架相比具有许多功能益处的独特的支架设计。

12. 发明授权

US06899727B2 Deployment system for intraluminal devices 有权
标题翻译：管腔内装置的部署系统
公开(公告)号：US06899727B2
公开(公告)日：2005-05-31
申请号：US09767314
申请日：2001-01-22
申请人： Joseph P. Armstrong , Edward H. Cully , Edward E. Shaw , Mark J. Ulm , Michael J. Vonesh
发明人： Joseph P. Armstrong , Edward H. Cully , Edward E. Shaw , Mark J. Ulm , Michael J. Vonesh
IPC分类号： A61F2/86 , A61F2/06
CPC分类号： A61F2/97 , A61F2/86 , A61F2/95 , A61F2/958 , A61F2002/9511 , A61F2002/9522 , A61F2002/9583 , A61F2250/0071
摘要： A constraining sheath for use around an endoprosthesis (e.g., a stent device, with or without a graft covering), which may be a balloon expandable endoprosthesis but more preferably is a self-expanding prosthesis. The endoprosthesis is coaxially enclosed within the constraining sheath, which is an outer, disruptable, preferably implantable tubular sheath, preferably made of ePTFE. The constraining sheath and endoprosthesis are preferably mounted together as an assembly on an angioplasty balloon for delivery. Deployment of the endoprosthesis entails inflating the angioplasty balloon to a pressure sufficient to disrupt or break the constraining sheath in a prescribed fashion, thereby allowing a self-expanding endoprosthesis to spontaneously deploy. The constraining sheath of ePTFE may be attached to the endoprosthesis and implanted along with the device, or alternatively attached to the balloon catheter shaft and removed with the balloon catheter.
摘要翻译：用于内置假体周围使用的约束护套（例如，具有或不具有移植物覆盖物的支架装置），其可以是球囊可膨胀内置假体，但更优选是自膨胀假体。内置假体同轴地封闭在约束护套内，约束鞘是外部的，可破坏的，优选可植入的管状护套，优选地由ePTFE制成。约束鞘和内假体优选地作为组件安装在血管成形术气囊上用于递送。内窥镜假体的部署需要将血管成形术气囊膨胀至足以以规定的方式破坏或打破约束鞘的压力，从而允许自膨胀内置假体自发部署。 ePTFE的约束鞘可以连接到内置假体并与装置一起植入，或者替代地附接到球囊导管轴并且用球囊导管去除。

13. 发明申请

US20130116655A1 BALLOON ASSEMBLIES HAVING CONTROLLABLY VARIABLE TOPOGRAPHIES 有权
标题翻译：具有控制性可变地形的气球组件
公开(公告)号：US20130116655A1
公开(公告)日：2013-05-09
申请号：US13645414
申请日：2012-10-04
申请人： John E. Bacino , Carey V. Campbell , Edward H. Cully , Jeffrey B. Duncan , Douglas S. Paget , John M. Squeri , Benjamin M. Trapp , Michael J. Vonesh , Edward E. Shaw
发明人： John E. Bacino , Carey V. Campbell , Edward H. Cully , Jeffrey B. Duncan , Douglas S. Paget , John M. Squeri , Benjamin M. Trapp , Michael J. Vonesh , Edward E. Shaw
IPC分类号： A61M25/10 , A61B17/3207
CPC分类号： A61B17/320725 , A61M25/1002 , A61M25/10184 , A61M25/1027 , A61M25/1029 , A61M25/104 , A61M2025/1031 , A61M2025/105 , A61M2025/1059 , A61M2025/1084 , A61M2025/1086 , Y10T29/49826 , Y10T29/49888
摘要： Various embodiments provide a device comprising a balloon disposed at least partially along a template, the template including an aperture, wherein the template has a substantially cylindrical portion that resists deformation in a radial direction, wherein the balloon expands radially during inflation, wherein a portion of the balloon at least partially protrudes about the aperture. Other embodiments are directed toward balloons having textured surfaces.
摘要翻译：各种实施例提供了一种装置，其包括至少部分地沿着模板设置的气囊，模板包括孔，其中模板具有抵抗径向变形的大致圆柱形部分，其中气囊在充气期间径向膨胀，其中一部分气球至少部分地围绕孔突出。其他实施例针对具有纹理表面的气球。

14. 发明申请

US20120143306A1 Removable Stent-Graft 有权
标题翻译：可移植支架移植
公开(公告)号：US20120143306A1
公开(公告)日：2012-06-07
申请号：US13324187
申请日：2011-12-13
申请人： Edward H. Cully , Erin B. Hutchinson , Michael J. Vonesh , Woodrow W. Watson
发明人： Edward H. Cully , Erin B. Hutchinson , Michael J. Vonesh , Woodrow W. Watson
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61B2017/22035 , A61F2/848 , A61F2/88 , A61F2/89 , A61F2002/072 , A61F2002/075 , A61F2002/9528 , A61F2220/005 , A61F2250/0071
摘要： A stent-graft including a helically-wound stent component provided with a covering of graft material. It is removable from the site of implantation by gripping an end of the helically-wound stent component with a retrieval device and applying tension to the stent component. The use of such a retrieval device allows the stent-graft to be removed remotely, such as via a catheter inserted into the body at a different location from the implantation site. The design of the stent-graft is such that the stent component is extended axially while the adjacent portion of the graft separates between windings of the stent component. The axial extension of the stent component, with portions of the graft still joined to the stent component, allows the device to be unravelled and removed through a catheter of diameter adequately small to be inserted into the body cavity that contained the stent-graft.
摘要翻译：一种支架移植物，其包括设置有移植材料覆盖物的螺旋缠绕的支架部件。通过用拾取装置夹持螺旋缠绕的支架部件的一端并将张力施加到支架部件，其可从植入部位移除。使用这种检索装置允许远程地移除支架移植物，例如通过在与植入部位不同的位置插入体内的导管。支架移植物的设计使得支架部件沿轴向延伸，而移植物的相邻部分在支架部件的绕组之间分离。支架部件的轴向延伸，其中移植物的一部分仍然连接到支架部件，允许装置通过足够小的直径的导管被拆开并移除，以插入到容纳支架移植物的体腔中。

15. 发明申请

US20120065721A1 THERMOPLASTIC FLUOROPOLYMER-COATED MEDICAL DEVICES 有权
标题翻译：热塑性氟聚合物涂层医疗器械
公开(公告)号：US20120065721A1
公开(公告)日：2012-03-15
申请号：US13282892
申请日：2011-10-27
申请人： James W. Chang , Robert L. Cleek , Edward H. Cully , Michael J. Vonesh
发明人： James W. Chang , Robert L. Cleek , Edward H. Cully , Michael J. Vonesh
IPC分类号： A61F2/82
CPC分类号： A61L31/10 , A61L27/34 , C08L101/04
摘要： A medical device provided with at least a partial surface coating of a thermoplastic copolymer of tetrafluoroethylene and perfluoroalkylvinylether that is free of cross-linking monomers and curing agents. The fluoropolymer coating is preferably an amorphous thermoplastic, is highly inert and biocompatible, has elastomeric characteristics that provide desirable mechanical properties such as good flexibility and durability. These characteristics allow the coating to be considered “functionally transparent” because it withstands mechanical deformations required for the assembly, deployment, expansion, and placement of medical devices, without any adverse effect on the mechanical and biological functionality of the coated device. Further, its inertness, derived from the perfluorocarbon structure, contributes to its functionally transparent nature. The coating can be provided with various liquid or solid additives, can be loaded with large quantities of additives including a wide range of therapeutic agents, and has excellent drug elution characteristics when elutable additives are used.
摘要翻译：一种医疗装置，其具有不含交联单体和固化剂的四氟乙烯和全氟烷基乙烯基醚的热塑性共聚物的至少部分表面涂层。含氟聚合物涂层优选为无定形热塑性塑料，具有高度惰性和生物相容性，具有提供所需机械性能（例如良好的柔韧性和耐久性）的弹性体特性。这些特性使得涂层被认为是“功能上透明的”，因为它可以承受医疗装置的组装，展开，膨胀和放置所需的机械变形，而不会对涂覆装置的机械和生物功能产生任何不利影响。此外，其衍生自全氟化碳结构的惰性有助于其功能上的透明性。该涂层可以提供各种液体或固体添加剂，可以加载大量的添加剂，包括广泛的治疗剂，并且当使用可洗脱添加剂时具有优异的药物洗脱特性。

16. 发明授权

US08048440B2 Thermoplastic fluoropolymer-coated medical devices 有权
标题翻译：热塑性含氟聚合物涂层医疗器械
公开(公告)号：US08048440B2
公开(公告)日：2011-11-01
申请号：US11378401
申请日：2006-03-16
申请人： James W. Chang , Robert L. Cleek , Edward H. Cully , Michael J. Vonesh
发明人： James W. Chang , Robert L. Cleek , Edward H. Cully , Michael J. Vonesh
IPC分类号： A61F2/82
CPC分类号： A61L31/10 , A61L27/34 , C08L101/04
摘要： A medical device provided with at least a partial surface coating of a thermoplastic copolymer of tetrafluoroethylene and perfluoroalkylvinylether that is free of cross-linking monomers and curing agents. The fluoropolymer coating is preferably an amorphous thermoplastic, is highly inert and biocompatible, has elastomeric characteristics that provide desirable mechanical properties such as good flexibility and durability. These characteristics allow the coating to be considered “functionally transparent” because it withstands mechanical deformations required for the assembly, deployment, expansion, and placement of medical devices, without any adverse effect on the mechanical and biological functionality of the coated device. Further, its inertness, derived from the perfluorocarbon structure, contributes to its functionally transparent nature. The coating can be provided with various liquid or solid additives, can be loaded with large quantities of additives including a wide range of therapeutic agents, and has excellent drug elution characteristics when elutable additives are used. The desirable mechanical characteristics are surprising given the absence of cross-linking monomers and curing agents that would otherwise render such materials inadequately biocompatible. The perfluoroalkylvinylether may be perfluoromethylvinylether, perfluoroethylvinylether or perfluoropropylvinylether.
摘要翻译：一种医疗装置，其具有不含交联单体和固化剂的四氟乙烯和全氟烷基乙烯基醚的热塑性共聚物的至少部分表面涂层。含氟聚合物涂层优选为无定形热塑性塑料，具有高度惰性和生物相容性，具有提供所需机械性能（例如良好的柔韧性和耐久性）的弹性体特性。这些特性使得涂层被认为是“功能上透明的”，因为它可以承受医疗装置的组装，展开，膨胀和放置所需的机械变形，而不会对涂覆装置的机械和生物功能产生任何不利影响。此外，其衍生自全氟化碳结构的惰性有助于其功能上的透明性。该涂层可以提供各种液体或固体添加剂，可以加载大量的添加剂，包括广泛的治疗剂，并且当使用可洗脱添加剂时具有优异的药物洗脱特性。鉴于不存在交联单体和固化剂，否则将使得这些材料生物相容性不足，理想的机械特性令人惊奇。全氟烷基乙烯基醚可以是全氟甲基乙烯基醚，全氟乙基乙烯基醚或全氟丙基乙烯基醚。

17. 发明申请

US20100228262A1 ATRAUMATIC LEAD REMOVAL SHEATH 有权
公开(公告)号：US20100228262A1
公开(公告)日：2010-09-09
申请号：US12397886
申请日：2009-03-04
申请人： Edward H. Cully , Jeffrey B. Duncan , Aaron J. Hopkinson , Michael J. Vonesh
发明人： Edward H. Cully , Jeffrey B. Duncan , Aaron J. Hopkinson , Michael J. Vonesh
IPC分类号： A61N1/05 , B23P11/00
CPC分类号： A61N1/05 , A61N1/0587 , A61N2001/0578
摘要： The present invention is an implantable device for the atraumatic removal of chronically implanted medical devices.
摘要翻译：本发明是一种用于无损伤去除长期植入的医疗装置的可植入装置。

18. 发明申请

US20090088790A1 RETRIEVAL CATHETER 有权
标题翻译：检索针
公开(公告)号：US20090088790A1
公开(公告)日：2009-04-02
申请号：US11864354
申请日：2007-09-28
申请人： Juan C. Parodi , John Cheer , Edward H. Cully , Michael J. Vonesh , Jeremy P. Young
发明人： Juan C. Parodi , John Cheer , Edward H. Cully , Michael J. Vonesh , Jeremy P. Young
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61B2017/22039 , A61F2/958 , A61F2002/011 , A61F2002/9528 , A61F2002/9534 , A61F2230/0006 , A61M2025/018 , A61M2025/0183
摘要： A retrieval catheter operable by a single clinician that will neither displace a deployed stent nor cause undue trauma to the vascular lumen or lesion. The retrieval catheter may be sized to accommodate both a guidewire and a balloon wire. The retrieval catheter is easy to navigate through tortuous passageways and will cross a previously deployed stent or stent-graft easily with minimal risk of snagging on the deployed stent or stent graft. The sheath and dilator are adapted to allow a guidewire or balloon wire to pass through the walls of both and to allow the sheath and dilator to move axially with respect to each other.
摘要翻译：可由单个临床医生操作的取出导管既不会移位部署的支架，也不会对血管腔或病变造成不适当的创伤。取回导管的尺寸可以适应导丝和气球线。检索导管容易通过曲折的通道导航，并且将容易地穿过先前部署的支架或支架移植物，同时在展开的支架或支架移植物上具有最小的阻塞风险。护套和扩张器适于允许导线或气球线穿过两者的壁并允许护套和扩张器相对于彼此轴向移动。

19. 发明授权

US07056336B2 Covered endoprosthesis and delivery system 有权
公开(公告)号：US07056336B2
公开(公告)日：2006-06-06
申请号：US10176929
申请日：2002-06-21
申请人： Joseph R. Armstrong , Edward H. Cully , Margaret L. Gallegos , Michael J. Vonesh
发明人： Joseph R. Armstrong , Edward H. Cully , Margaret L. Gallegos , Michael J. Vonesh
IPC分类号： A61F2/06
CPC分类号： A61F2/88 , A61F2/07 , A61F2/844 , A61F2/89 , A61F2/90 , A61F2002/072 , A61F2002/075 , A61F2230/0054
摘要： The present invention is an improved endovascular device particularly useful for use in transjugular intrahepatic portosystemic shunt (TIPS) procedures. The device employs a two-part stent-graft construction that provides a low permeability membrane to line the shunt and an uncovered stent portion designed to reside in the portal vein. The device provides numerous benefits over previous stents and stent-grafts used in TIPS procedures, including being more compact to deliver, being easier to accurately deploy, a controlled compacted surface with tucked apices, an improved stent winding pattern, and being more flexible in delivery and use.

20. 发明授权

US06336937B1 Multi-stage expandable stent-graft 有权
标题翻译：多级可扩张支架移植
公开(公告)号：US06336937B1
公开(公告)日：2002-01-08
申请号：US09207944
申请日：1998-12-09
申请人： Michael J. Vonesh , Edward H. Cully , Gerald R. Martin , Steven R. Bruun , Dennis L. Salzmann
发明人： Michael J. Vonesh , Edward H. Cully , Gerald R. Martin , Steven R. Bruun , Dennis L. Salzmann
IPC分类号： A61F206
CPC分类号： A61F2/07 , A61F2/89 , A61F2/958 , A61F2002/072 , A61F2002/075 , A61F2230/005 , A61F2230/0054 , A61F2230/0078 , A61F2230/008 , A61F2250/0039
摘要： An improved device for use in a conduit, such as a blood vessel, is provided. The device uniquely combines desirable properties from two distinct previous devices. The device of the present invention assumes and is constrained to a first diametrical dimension for insertion into the conduit. Once inserted and properly positioned in the conduit the device expands to a second diametrical dimension within the conduit when the constraint is removed. The device can then be dilated to one or more enlarged third diametrical dimensions by using a balloon catheter or similar device. The result is a device that provides desirable properties of both self-expanding stents and balloon-expandable endoprostheses. The device can be employed in a variety of applications.
摘要翻译：提供了用于诸如血管的导管中的改进的装置。该设备独特地结合了来自两个不同的先前设备的所需属性。本发明的装置假设并被约束到用于插入导管中的第一直径尺寸。一旦插入并且正确地定位在导管中，当约束被去除时，该装置在导管内膨胀成第二直径尺寸。然后可以通过使用球囊导管或类似装置将该装置扩张至一个或多个扩大的第三直径尺寸。结果是提供自扩张支架和气囊可扩展内假体的理想特性的装置。该器件可用于各种应用。

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