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11. 发明授权

US06254852B1 Porous inorganic targeted ultrasound contrast agents 失效
标题翻译：多孔无机靶向超声造影剂
公开(公告)号：US06254852B1
公开(公告)日：2001-07-03
申请号：US09356178
申请日：1999-07-16
申请人： Joseph L Glajch , Alan P. Carpenter, Jr. , Edward H. Cheesman
发明人： Joseph L Glajch , Alan P. Carpenter, Jr. , Edward H. Cheesman
IPC分类号： A61B800
CPC分类号： A61K49/225
摘要： Targeted ultrasound contrast agents are described. The contrast agents are porous particles of an inorganic material containing an entrapped gas or liquid and having an average particle diameter of about 0.05 to 500 microns. The outer surfaces of the particles incorporate a targeting ligand to target delivery of the contrast agent.
摘要翻译：描述了靶向超声造影剂。造影剂是含有截留气体或液体并且平均粒径为约0.05至500微米的无机材料的多孔颗粒。颗粒的外表面包含靶向配体以靶向造影剂的递送。

12. 发明授权

US4894445A Metal-isonitrile adducts for preparing radionuclide complexes 失效
标题翻译：用于制备放射性核素配合物的金属 - 腈腈加合物
公开(公告)号：US4894445A
公开(公告)日：1990-01-16
申请号：US880349
申请日：1986-06-25
申请人： Alan P. Carpenter, Jr. , Leo J. Maheu , Michael A. Patz , Thomas H. Tulip , Karen E. Linder , Vinayakam Subramanyam , Jeffery S. Thompson
发明人： Alan P. Carpenter, Jr. , Leo J. Maheu , Michael A. Patz , Thomas H. Tulip , Karen E. Linder , Vinayakam Subramanyam , Jeffery S. Thompson
IPC分类号： A61K51/04 , C07F1/00 , C07F11/00 , C07F15/00 , C07F15/04 , C07F15/06
CPC分类号： C07F15/065 , A61K51/0476 , C07F1/005 , C07F11/005 , C07F15/0066 , C07F15/008 , C07F15/045 , A61K2123/00
摘要： A method for preparing a coordination complex of an isonitrile ligand and a radioisotope of Tc, Ru, Co, Pt, Re, Os, Ir, W, Re, Cr, Mo, Mn, Ni, Rh, Nb and Ta from a non-radioactive metal adduct of the isonitrile.
摘要翻译：一种从非极性配位体制备异氰酸酯配体和Tc，Ru，Co，Pt，Re，Os，Ir，W，Re，Cr，Mo，Mn，Ni，Rh，Nb和Ta的放射性同位素的配位络合物的方法，异腈的放射性金属加成物。

13. 发明授权

US07412279B2 Systems and methods for targeted magnetic resonance imaging of the vascular system 失效
标题翻译：用于血管系统靶向磁共振成像的系统和方法
公开(公告)号：US07412279B2
公开(公告)日：2008-08-12
申请号：US10209416
申请日：2002-07-30
申请人： Robert M. Weisskoff , Peter D. Caravan , Sonia Witte , Randall B. Lauffer , Alan P. Carpenter, Jr.
发明人： Robert M. Weisskoff , Peter D. Caravan , Sonia Witte , Randall B. Lauffer , Alan P. Carpenter, Jr.
IPC分类号： A61B5/05
CPC分类号： A61B5/416 , A61B5/055
摘要： This invention relates to MRI-based methods and systems useful for diagnosing and clinically assessing the presence, location, and size of cardiovascular disease-associated stationary targets, e.g., thrombi and atherosclerotic lesions, within the vascular system. Methods and systems of the invention allow for improved anatomical information to be obtained from MRI images and allow the clinician to develop more effective treatment plans. In one aspect, the invention provides a method of determining the presence or absence of a stationary target within the vascular system of a mammal wherein two MRI data sets representing images of the vascular system and the stationary target are acquired after administration of a targeted MRI contrast agent. In another embodiment, both a targeted MRI contrast agent and a vascular MRI contrast agent are administered to a mammal, and both a vascular MRI and a targeted MRI data set are acquired.
摘要翻译：本发明涉及基于MRI的方法和系统，其可用于诊断和临床评估血管系统内心血管疾病相关的静止目标（例如血栓和动脉粥样硬化病变）的存在，位置和大小。本发明的方法和系统允许从MRI图像获得改进的解剖信息，并允许临床医生开发更有效的治疗计划。一方面，本发明提供一种确定哺乳动物血管系统中静止靶的存在或不存在的方法，其中在施用靶向MRI对比后获取表示血管系统和静止靶的图像的两个MRI数据集代理商在另一个实施方案中，向哺乳动物施用靶向MRI造影剂和血管MRI造影剂，并且获取血管MRI和靶向MRI数据组。

14. 发明授权

US07138104B2 Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent 失效
公开(公告)号：US07138104B2
公开(公告)日：2006-11-21
申请号：US10213713
申请日：2002-08-07
申请人： Alan P. Carpenter, Jr.
发明人： Alan P. Carpenter, Jr.
IPC分类号： A61B5/055
CPC分类号： A61K49/04 , A61K49/0002 , A61K49/085 , A61K49/10 , A61K49/223 , A61K51/0455 , A61K51/0459 , A61K51/0497
摘要： The present invention describes a method of concurrent imaging in a mammal comprising: a) administering to said mammal a vitronectin receptor targeted imaging agent and a perfusion imaging agent; and b) concurrently detecting the vitronectin receptor targeted imaging agent bound at the vitronectin receptor and the perfusion imaging agent; and c) forming an image from the detection of said vitronectin targeted imaging agent and said perfusion imaging agent.

15. 发明授权

US06838074B2 Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent 失效
标题翻译：同时成像心脏灌注和玻连蛋白受体靶向成像剂
公开(公告)号：US06838074B2
公开(公告)日：2005-01-04
申请号：US10214429
申请日：2002-08-07
申请人： Alan P. Carpenter, Jr.
发明人： Alan P. Carpenter, Jr.
IPC分类号： A61K49/00
CPC分类号： A61K49/0002
摘要： The present invention describes a method of concurrent imaging in a mammal comprising: a) administering to said mammal a vitronectin receptor targeted imaging agent and a perfusion imaging agent; and b) concurrently detecting the vitronectin receptor targeted imaging agent bound at the vitronectin receptor and the perfusion imaging agent; and c) forming an image from the detection of said vitronectin targeted imaging agent and said perfusion imaging agent.
摘要翻译：本发明描述了哺乳动物同时成像的方法，包括：a）向所述哺乳动物施用玻连蛋白受体靶向成像剂和灌注成像剂; 和b）同时检测在玻连蛋白受体和灌注成像剂结合的玻连蛋白受体靶向成像剂; 和c）从所述玻连蛋白靶向成像剂和所述灌注成像剂的检测形成图像。

16. 发明授权

US07179446B2 Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent 失效
标题翻译：同时成像心脏灌注和玻连蛋白受体靶向成像剂
公开(公告)号：US07179446B2
公开(公告)日：2007-02-20
申请号：US09995388
申请日：2001-11-27
申请人： Alan P. Carpenter, Jr.
发明人： Alan P. Carpenter, Jr.
IPC分类号： A61K49/00
CPC分类号： A61K49/14 , A61K38/00 , A61K49/0004 , A61K49/085 , A61K49/223 , A61K51/0476 , A61K51/082 , A61K51/088 , C07D259/00 , C07K7/52
摘要： The present invention describes a method of concurrent imaging in a mammal comprising: a) administering to said mammal a vitronectin receptor targeted imaging agent and a perfusion imaging agent; and b) concurrently detecting the vitronectin target imaging agent bound at the vitronectin receptor and the perfusion imaging agent; and c) forming an image from the detection of said vitronectin receptor targeted imaging agent and said perfusion imaging agent.
摘要翻译：本发明描述了哺乳动物同时成像的方法，包括：a）向所述哺乳动物施用玻连蛋白受体靶向成像剂和灌注成像剂; 和b）同时检测在玻连蛋白受体和灌注显像剂结合的玻连蛋白目标显像剂; 和c）从所述玻连蛋白受体靶向成像剂和所述灌注成像剂的检测中形成图像。

17. 发明授权

US08557222B2 Radiopharmaceutical imaging of neurodegenerative diseases 失效
标题翻译：神经退行性疾病的放射性药物成像
公开(公告)号：US08557222B2
公开(公告)日：2013-10-15
申请号：US12418177
申请日：2009-04-03
申请人： Franz F. Hefti , Daniel M. Skovronsky , Alan P. Carpenter, Jr.
发明人： Franz F. Hefti , Daniel M. Skovronsky , Alan P. Carpenter, Jr.
IPC分类号： A61M36/04
CPC分类号： A61K51/0491 , A61B6/037 , A61B6/508 , A61K51/0455
摘要： Methods for simultaneously detecting dementia or cognitive impairment, such as Alzheimer's Disease (AD), Parkinson's Disease (PD), Lewy Body Dementia (LBD) and Vascular Dementia (VaD) in a patient using dual or multiple radiopharmaceutical probes are provided herein.
摘要翻译：本文提供了在使用双重或多个放射性药物探针的患者中同时检测痴呆或认知障碍的方法，例如阿尔茨海默病（AD），帕金森病（PD），路易体痴呆（LBD）和血管性痴呆（VaD）。

18. 发明授权

US06770259B2 Simultaneous dual isotope imaging of cardiac perfusion and cardiac inflammation 失效
标题翻译：心脏灌注和心脏炎症的同时双重同位素成像
公开(公告)号：US06770259B2
公开(公告)日：2004-08-03
申请号：US10002359
申请日：2001-11-02
申请人： Alan P. Carpenter, Jr.
发明人： Alan P. Carpenter, Jr.
IPC分类号： A61K4900
CPC分类号： A61K51/12 , A61K51/0497
摘要： The present invention provides novel diagnostic compositions comprising a radiolabeled LTB4 binding agent and a radiolabeled perfusion imaging agent, diagnostic kits comprising such compositions, and methods of concurrent imaging in a mammal comprising administering a radiolabeled LTB4 binding agent and a radiolabeled perfusion imaging agent, and concurrently detecting the radiolabeled LTB4 binding agent bound at the LTB4 receptor and the radiolabeled perfusion imaging agent.
摘要翻译：本发明提供了包含放射性标记的LTB4结合剂和放射性标记的灌注成像剂的新型诊断组合物，包含这种组合物的诊断试剂盒，以及在哺乳动物中同时成像的方法，包括施用放射性标记的LTB4结合剂和放射性标记的灌注成像剂，检测在LTB4受体和放射性标记的灌注成像剂上结合的放射性标记的LTB4结合剂。

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