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11. 发明申请

US20130229940A1 METHODS AND DEVICES FOR PROVIDING MEASUREMENT REPORTS 有权
标题翻译：提供测量报告的方法和设备
公开(公告)号：US20130229940A1
公开(公告)日：2013-09-05
申请号：US13884324
申请日：2010-11-09
申请人： Matthew Baker , Teck Hu , Christian Gerlach , Qi Jiang
发明人： Matthew Baker , Teck Hu , Christian Gerlach , Qi Jiang
IPC分类号： H04W24/02
CPC分类号： H04W24/02 , H04W24/10 , H04W28/04 , H04W48/16
摘要： The invention proposes method of providing measurement reports. The eNodeB sends (S10, S11) a user equipment information about a plurality of subframe patterns used by a plurality of wireless networks respectively, and notifies (S12, S13) the user equipment associations between the measurement reports and said plurality of subframe patterns. The user equipment measures (S14) channel information in at least one subframe patterns, generates measurement reports for said at least one sub-frame frame patterns according to said association, and sends (S15, S16) said measurement reports to said eNodeB. The eNodeB relates (S17) each of the received measurement reports with the corresponding subframe pattern according to said association.
摘要翻译：本发明提出了提供测量报告的方法。 eNodeB分别发送（S10，S11）关于多个无线网络使用的多个子帧模式的用户设备信息，并通知（S12，S13）测量报告与所述多个子帧模式之间的用户设备关联。用户设备在至少一个子帧模式中测量（S14）信道信息，根据所述关联产生所述至少一个子帧帧模式的测量报告，并向所述eNodeB发送（S15，S16）所述测量报告。 eNodeB根据所述关联（S17）将每个接收的测量报告与相应的子帧模式相关联。

12. 发明申请

US20100254964A1 Modified Bouganin Proteins, Cytotoxins and Methods and Uses Thereof 有权
标题翻译：改良的Bouganin蛋白，细胞毒素及其用途
公开(公告)号：US20100254964A1
公开(公告)日：2010-10-07
申请号：US12784820
申请日：2010-05-21
申请人： Matthew Baker , Francis J. Carr , Koen Hellendoorn , Jeannick Cizeau , Glen Christopher MacDonald , Joycelyn Entwistle , Denis Georges Bosc , Nicholas Ronald Glover
发明人： Matthew Baker , Francis J. Carr , Koen Hellendoorn , Jeannick Cizeau , Glen Christopher MacDonald , Joycelyn Entwistle , Denis Georges Bosc , Nicholas Ronald Glover
IPC分类号： A61K38/47 , A61P35/00
CPC分类号： C07K16/30 , A61K38/00 , A61K47/6825 , A61K2039/505 , C07K14/415 , C07K2317/34 , C07K2317/55 , C07K2317/622 , C07K2319/00 , C07K2319/30 , C07K2319/33 , C07K2319/55
摘要： The invention provides modified forms of bouganin protein having biological activity and a reduced propensity to activate human T cells as compared to the non-modified bouganin protein. The invention also provides T-cell epitope peptides of bouganin, and modified T-cell epitope peptides of bouganin which have a reduced propensity to activate human T cells as compared to the non-modified T-cell epitope peptide. The invention also provides cytotoxins having the having a ligand that binds to a cancer cells attached to the modified bouganin proteins. Also provided are methods of inhibiting or destroying mammalian cancer cells using the cytotoxins of the invention and pharmaceutical compositions for treating human cancer.
摘要翻译：本发明提供具有生物活性的bouganin蛋白质的修饰形式，与非修饰的bouganin蛋白质相比，活化人类T细胞的倾向降低。本发明还提供了与非修饰的T细胞表位肽相比，bouganin的T细胞表位肽和bouganin的修饰的T细胞表位肽，其具有降低的活化人T细胞的倾向。本发明还提供了具有与附着于改良的bouganin蛋白的癌细胞结合的配体的细胞毒素。还提供了使用本发明的细胞毒素和用于治疗人类癌症的药物组合物来抑制或破坏哺乳动物癌细胞的方法。

13. 发明申请

US20090006200A1 SYSTEM AND METHODS FOR MANAGING THE UTILIZATION OF A COMMUNICATIONS DEVICE 有权
标题翻译：用于管理通信设备的使用的系统和方法
公开(公告)号：US20090006200A1
公开(公告)日：2009-01-01
申请号：US12027240
申请日：2008-02-06
申请人： Matthew Baker , Steven Geller , Douglas Kesser , Daniel Neal , Carol Politi , Ben Weintraub
发明人： Matthew Baker , Steven Geller , Douglas Kesser , Daniel Neal , Carol Politi , Ben Weintraub
IPC分类号： G06Q30/00
CPC分类号： H04W4/24 , G06Q10/103 , G06Q20/105 , G06Q20/32 , G06Q20/322 , G06Q20/3224 , G06Q20/405 , G06Q30/0273 , H04M3/42 , H04M15/61 , H04W8/186 , H04W48/14 , H04W88/02
摘要： A system and method for the real-time management of a device, and more particularly to the allocation of electronic wallets that are associated with one or more devices and various controls that enable at least two entities to manage how the device is utilized for various activities and to pay for goods and services. Each device is associated with at least two electronic wallets, a user wallet and an administrator wallet. The administrator can establish rules that designate how and when the device can be used and which wallet will be used to pay for goods and services desired by the user, but in the event the user wallet is depleted or low on funds, the administrator wallet can serve as a backup funding source for specified types of goods and/or services. Additional wallets can also be associated with the device to authorize and pay for goods and services, under the control of the administrator wallet, such as a promotional wallet that could be designated for use with the device before a primary or administrative wallet was used, or a dynamic wallet that could be associated for use with multiple different devices as well as other wallets, but acts in conjunction with the user and administrator wallets. Additional rules can be established to perform many other functions, such as manage the movement of value between wallets and from other sources to the wallets.
摘要翻译：一种用于实时管理设备的系统和方法，更具体地涉及与一个或多个设备和各种控制相关联的电子钱包的分配，其使至少两个实体能够管理如何将该设备用于各种活动并支付货物和服务费用。每个设备与至少两个电子钱包，用户钱包和管理员钱包相关联。管理员可以建立指定如何以及何时可以使用设备的规则，以及将使用哪个钱包来支付用户期望的商品和服务，但是如果用户钱包耗尽或资金不足，则管理员钱包可以作为指定类型商品和/或服务的备用资金来源。额外的钱包还可以与管理员钱包控制下的授权和支付商品和服务的设备相关联，例如在使用主要或管理钱包之前可以指定与设备一起使用的促销钱包，或可以与多个不同设备以及其他钱包相关联的动态钱包，但与用户和管理员钱包配合使用。可以建立额外的规则来执行许多其他功能，例如管理钱包之间的价值和从其他来源到钱包的价值的移动。

14. 发明申请

US20080090243A1 PSEUDO-TISSUES AND USES THEREOF 审中-公开
标题翻译： PSEUDO-TISSUES及其用途
公开(公告)号：US20080090243A1
公开(公告)日：2008-04-17
申请号：US11873313
申请日：2007-10-16
申请人： Matthew Baker
发明人： Matthew Baker
IPC分类号： C12N5/00 , C12Q1/68 , G01N1/28
CPC分类号： G01N1/30 , G01N33/5082
摘要： The invention provides compositions and methods useful in the analysis of tissues and cells. More specifically, the invention provides compositions, referred to as “pseudo-tissue samples,” which comprise aggregated fixed cells embedded in an embedding medium. The invention also provides histological specimens comprising pseudo-tissues, as well as histological specimen-substrate compositions, such as microscope slides upon which pseudo-tissues and histological specimens prepared therefrom are placed. The histological specimen-substrate compositions may comprise arrays (or microarrays) of pseudo-tissues and/or histological specimens. The invention also provides methods for preparing pseudo-tissues, histological specimens, and histological specimen-substrate compositions containing the same. Also provided is a method for analyzing a tissue sample by comparing the subcellular features of a reference histological specimen to those found in a candidate histological specimen, such that one or more subcellular features shared by both the candidate and reference histological specimens may be identified. The subcellular features that may be identified include, e.g., DNA, RNA, proteins, enzymes and carbohydrates.
摘要翻译：本发明提供了可用于组织和细胞分析的组合物和方法。更具体地，本发明提供称为“假组织样品”的组合物，其包含嵌入嵌入介质中的聚集的固定细胞。本发明还提供了包含假组织的组织学标本，以及组织学样本 - 底物组合物，例如放置了由其制备假组织和组织学标本的显微镜载玻片。组织学样本 - 底物组合物可以包括伪组织和/或组织学标本的阵列（或微阵列）。本发明还提供了制备假组织，组织学标本和含有该组织学标本的组织学标本 - 底物组合物的方法。还提供了通过将参考组织学标本的亚细胞特征与候选组织学标本中发现的亚细胞特征进行比较来分析组织样品的方法，使得可以鉴定候选参考组织学标本共有的一个或多个亚细胞特征。可以鉴定的亚细胞特征包括例如DNA，RNA，蛋白质，酶和碳水化合物。

15. 发明授权

US07339031B2 Modified bouganin proteins, cytotoxins and methods and uses thereof 有权
标题翻译：改良的bouganin蛋白，细胞毒素及其方法和用途
公开(公告)号：US07339031B2
公开(公告)日：2008-03-04
申请号：US11084080
申请日：2005-03-18
申请人： Matthew Baker , Francis J. Carr , Koen Hellendoorn , Jeannick Cizeau , Glen Christopher MacDonald , Joycelyn Entwistle , Denis Georges Bosc , Nicholas Ronald Glover
发明人： Matthew Baker , Francis J. Carr , Koen Hellendoorn , Jeannick Cizeau , Glen Christopher MacDonald , Joycelyn Entwistle , Denis Georges Bosc , Nicholas Ronald Glover
IPC分类号： C07K14/00 , C07K16/40 , C12P21/04
CPC分类号： C07K16/30 , A61K38/00 , A61K47/6825 , A61K2039/505 , C07K14/415 , C07K2317/34 , C07K2317/55 , C07K2317/622 , C07K2319/00 , C07K2319/30 , C07K2319/33 , C07K2319/55
摘要： The invention provides modified forms of bouganin protein having biological activity and a reduced propensity to activate human T cells as compared to the non-modified bouganin protein. The invention also provides T-cell epitope peptides of bouganin, and modified T-cell epitope peptides of bouganin which have a reduced propensity to activate human T cells as compared to the non-modified T-cell epitope peptide. The invention also provides cytotoxins having the having a ligand that binds to a cancer cells attached to the modified bouganin proteins. Also provided are methods of inhibiting or destroying mammalian cancer cells using the cytotoxins of the invention and pharmaceutical compositions for treating human cancer.
摘要翻译：本发明提供具有生物活性的bouganin蛋白质的修饰形式，与非修饰的bouganin蛋白质相比，活化人类T细胞的倾向降低。本发明还提供了与非修饰的T细胞表位肽相比，bouganin的T细胞表位肽和bouganin的修饰的T细胞表位肽，其具有降低的活化人T细胞的倾向。本发明还提供了具有与附着于改良的bouganin蛋白的癌细胞结合的配体的细胞毒素。还提供了使用本发明的细胞毒素和用于治疗人类癌症的药物组合物来抑制或破坏哺乳动物癌细胞的方法。

16. 发明申请

US20080031168A1 Method, System And Station For Communicating Data Packets Using Arq 有权
标题翻译：方法，系统和站用于使用Arq通信数据包
公开(公告)号：US20080031168A1
公开(公告)日：2008-02-07
申请号：US11579778
申请日：2005-05-05
申请人： Paul Bucknell , Matthew Baker , Timothy Moulsley
发明人： Paul Bucknell , Matthew Baker , Timothy Moulsley
IPC分类号： H04B7/00
CPC分类号： H04L1/1867 , H04L2001/0093
摘要： A system (50) for communicating data packets from a first station (100) to a destination (400) via at least one of a plurality of second stations (200) which are coupled to the destination (400), in which the second stations (200) acknowledge receipt of the data packets. The first station (100) decides whether to retransmit a data packet or to proceed with transmitting the next data packet, the decision being dependent on receiving a plurality of positive acknowledgements or a plurality of negative acknowledgements.
摘要翻译：一种用于经由耦合到目的地（400）的多个第二站（200）中的至少一个将数据分组从第一站（100）传送到目的地（400）的系统（50），其中第二站（200）确认数据包的接收。第一站（100）决定是重传数据分组还是继续发送下一个数据分组，该决定取决于接收多个肯定确认或多个否定确认。

17. 发明申请

US20070297435A1 Method for Priority Based Queuing and Assembling of Packets 有权
标题翻译：基于优先级排队和分组的方法
公开(公告)号：US20070297435A1
公开(公告)日：2007-12-27
申请号：US11718720
申请日：2005-11-04
申请人： Paul Bucknell , Matthew Baker , Timothy Moulsley
发明人： Paul Bucknell , Matthew Baker , Timothy Moulsley
IPC分类号： H04L12/56
CPC分类号： H04L47/14 , H04L47/50 , H04L47/56 , H04L47/6215 , H04L47/6255 , H04W28/14 , H04W72/1242
摘要： Data packets having different assigned priorities are multiplexed by operating a queue for each different priority of data packet and assembling groups (80) of the data packets for transmission. Each group has two portions. A first portion (90) of the group is populated with data packets selected from one or more of the queues according to a first rule and a second portion (95) of the group is populated with data packets selected from one or more of the queues according to a second rule. Preferably the first portion contains data packets having the highest priority, and the second portion contains a selection of the data packets having a lower a priority. Selection of data packets for the second portion may depend on criteria such as delay experienced and queue length. The size of the first and second portions may be adapted according to delay experienced and queue length.
摘要翻译：具有不同分配优先级的数据分组通过为数据分组和数据分组的组合组（80）的每个不同优先级操作队列进行复用以进行传输。每组有两部分。该组的第一部分（90）根据第一规则填充从一个或多个队列中选择的数据分组，并且该组的第二部分（95）填充有从一个或多个队列中选择的数据分组根据第二条规则。优选地，第一部分包含具有最高优先级的数据分组，并且第二部分包含具有较低优先级的数据分组的选择。对第二部分的数据分组的选择可以取决于诸如延迟经验和队列长度等标准。第一和第二部分的大小可以根据所经历的延迟和队列长度进行调整。

18. 发明申请

US20070148739A1 Fusion proteins of interferon alpha muteins with improved properties 失效
标题翻译：具有改善性质的干扰素α突变蛋白的融合蛋白
公开(公告)号：US20070148739A1
公开(公告)日：2007-06-28
申请号：US10546112
申请日：2004-02-18
申请人： Tim Jones , Matthew Baker , Marian Hanlon , Francis Carr
发明人： Tim Jones , Matthew Baker , Marian Hanlon , Francis Carr
IPC分类号： A61K38/21 , C07H21/04 , C12P21/04 , C07K14/56
CPC分类号： A61K38/212 , C07K14/56 , C07K2319/30
摘要： The invention concerns human interferon alpha and in particular modified forms of interferon alpha 2 with improved properties. The improved proteins contain amino acid substitutions at specific positions that confer increased relative activity in biological assays. The invention provides also modified interferon alpha with improved biological activity concomitant with reduced immunogenic potential in the protein. The improved proteins are intended for therapeutic use in the treatment of diseases in humans.
摘要翻译：本发明涉及人类干扰素α，特别涉及具有改进性质的干扰素α2的修饰形式。改进的蛋白质在特定位置含有氨基酸取代，其在生物测定中赋予增加的相对活性。本发明还提供修饰的干扰素α，其具有改善的生物活性，伴随蛋白质中的免疫原性潜力降低。改进的蛋白质用于治疗人类疾病的治疗用途。

19. 发明申请

US20070080167A1 Bulk transfer dispensing device and method 有权
标题翻译：批量转运分配装置及方法
公开(公告)号：US20070080167A1
公开(公告)日：2007-04-12
申请号：US11505634
申请日：2006-08-17
申请人： Matthew Baker , Charles Schnorr , Ward Powell , W. Urmson
发明人： Matthew Baker , Charles Schnorr , Ward Powell , W. Urmson
IPC分类号： B65D35/28
CPC分类号： B65B69/0091 , B60P3/224
摘要： A dispensing device and method for dispensing fluids from a flexible container is disclosed. The dispensing device includes a support and a linkage pivotally attached to the support. The dispensing device may also include a roller mechanism coupled to the linkage, wherein the roller mechanism has at least two squeeze members configured to engage a flexible container that coact with a drive roller to force the roller mechanism in a first direction to dispense fluids from a flexible container.
摘要翻译：公开了一种用于从柔性容器分配流体的分配装置和方法。分配装置包括支撑件和枢转地附接到支撑件的连杆。分配装置还可以包括联接到联动装置的滚子机构，其中滚子机构具有至少两个挤压构件，其构造成接合与驱动辊共同作用的柔性容器，以将辊机构沿第一方向从第一方向分配流体柔性容器。

20. 发明申请

US20060263780A1 Tagged polyfunctional reagents capble of reversibly binding target substances in a ph-dependent manner 审中-公开
标题翻译：标记的多官能试剂以ph依赖的方式可逆地结合靶物质
公开(公告)号：US20060263780A1
公开(公告)日：2006-11-23
申请号：US10547644
申请日：2003-12-16
申请人： Matthew Baker , Matthew Taylor , Shilpa Uppal , Simon Douglas , Elliot Lawrence
发明人： Matthew Baker , Matthew Taylor , Shilpa Uppal , Simon Douglas , Elliot Lawrence
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： G01N33/532 , C12N15/101 , G01N33/58 , Y10T436/13 , Y10T436/145555
摘要： Polyfunctional reagents are disclosed that are capable of reversibly binding to target substances, for example nucleic acid, proteins, polypeptides, cells, cell components, microorganisms or viruses, for use in purifying or otherwise manipulating them. The reagents comprise a tagging group for manipulating and/or detecting the target substance when bound to the polyfunctional reagent. The polyfunctional reagents work by binding the target substance at a first pH and then releasing it at a second pH, usually higher than the first. Examples of tagging groups include tagging group members of a specific binding pair which is capable of binding to a specific binding partner and/or a label.
摘要翻译：公开了能够可逆地结合目标物质（例如核酸，蛋白质，多肽，细胞，细胞成分，微生物或病毒）以用于纯化或以其他方式操作的多官能试剂。试剂包含用于在与多官能试剂结合时操纵和/或检测目标物质的标记基团。多官能试剂通过在第一pH下结合目标物质然后在通常高于第一pH的第二pH释放它来起作用。标记组的实例包括能够结合特异性结合配偶体和/或标签的特异性结合对的标记组成员。

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