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11. 发明授权

US08333764B2 Device and method for determining tissue thickness and creating cardiac ablation lesions 失效
标题翻译：用于确定组织厚度并产生心脏消融病变的装置和方法
公开(公告)号：US08333764B2
公开(公告)日：2012-12-18
申请号：US10844213
申请日：2004-05-12
申请人： David E. Francischelli , Eduardo N. Warman , Rahul Mehra
发明人： David E. Francischelli , Eduardo N. Warman , Rahul Mehra
IPC分类号： A61B18/14
CPC分类号： A61B18/1442 , A61B2018/00666 , A61B2018/1861 , A61B2090/061 , A61B2090/064
摘要： A tissue ablation device has a handle and an ablation head coupled to the handle. The ablation head has a first jaw, a second jaw, and an ablative element coupled to at least one of the first and second jaws. A thickness measurement device may be coupled to the ablation device to indicate the distance separating the first and second jaws. Further, a force measurement device may be coupled to the ablation device to measure the force being applied by the first and second jaws to a piece of tissue. Further, a strain measurement device may be coupled to the ablation device to indicate the strain resulting in a piece of tissue disposed between the first and second jaws when a stress is applied to the tissue.
摘要翻译：组织消融装置具有手柄和联接到手柄的消融头。消融头具有联接到第一和第二钳口中的至少一个的第一钳口，第二钳口和消融元件。厚度测量装置可以联接到消融装置以指示分离第一和第二钳口的距离。此外，力测量装置可以联接到消融装置以测量由第一和第二钳口施加到一片组织上的力。此外，当应力施加到组织时，应变测量装置可以联接到消融装置以指示当应力施加到组织上时产生设置在第一和第二钳口之间的一片组织的应变。

12. 发明授权

US07336994B2 Control of atrial defibrillation therapy based on hemodynamic sensor feedback 有权
标题翻译：基于血流动力学传感器反馈控制心房除颤治疗
公开(公告)号：US07336994B2
公开(公告)日：2008-02-26
申请号：US10760155
申请日：2004-01-16
申请人： Douglas A. Hettrick , David E. Euler , Eduardo N. Warman , Michael R. Ujhelyi , Rahul Mehra , Paul D. Ziegler , Shailesh Kumar V. Musley , Charles E. Distad , David E. Ritscher
发明人： Douglas A. Hettrick , David E. Euler , Eduardo N. Warman , Michael R. Ujhelyi , Rahul Mehra , Paul D. Ziegler , Shailesh Kumar V. Musley , Charles E. Distad , David E. Ritscher
IPC分类号： A61N1/39
CPC分类号： A61N1/3702 , A61N1/3621 , A61N1/365 , A61N1/36564 , A61N1/395 , A61N1/3962
摘要： Control of defibrillation therapy delivered by implantable medical devices (IMDs) using hemodynamic sensor feedback is disclosed. The hemodynamic sensor feedback allows for increased control over application of atrial defibrillation therapy. Specifically, the therapy is delivered when a fibrillation episode results in a discrete loss of hemodynamic function. Defibrillation therapy is thus withheld for hemodynamically benign arrhythmias.
摘要翻译：公开了使用血液动力学传感器反馈控制由可植入医疗装置（IMD）递送的除颤疗法。血液动力学传感器反馈允许增加对心房除颤治疗的应用的控制。具体来说，当纤维性颤动发作导致血液动力学功能的离散损失时，进行治疗。因此，对于血液动力学良性心律失常，禁止使用除颤疗法。

13. 发明授权

US07029470B2 Ablation system and method of use 有权
标题翻译：消融系统和使用方法
公开(公告)号：US07029470B2
公开(公告)日：2006-04-18
申请号：US10685236
申请日：2003-10-14
申请人： David E. Francischelli , Eduardo N. Warman , Rahul Mehra , Mark T. Stewart , James R. Skarda , Harry Puryear , David Schwartzman
发明人： David E. Francischelli , Eduardo N. Warman , Rahul Mehra , Mark T. Stewart , James R. Skarda , Harry Puryear , David Schwartzman
IPC分类号： A61B18/18 , A61B5/02 , A61N1/00
CPC分类号： A61B18/1445 , A61B5/04 , A61B18/12 , A61B2018/00065 , A61B2018/00363 , A61B2018/00577 , A61B2018/00654 , A61B2018/00702 , A61B2018/00755 , A61B2018/00779 , A61B2018/00791 , A61B2018/00839 , A61B2018/00875 , A61B2018/1226 , A61B2018/1253 , A61B2018/126 , A61B2018/1467 , A61B2018/1472 , A61B2218/002 , A61N1/403
摘要： A system and method for creating lesions and assessing their completeness or transmurality. Assessment of transmurality of a lesion is accomplished by monitoring the depolarization signal in a local electrogram taken using electrodes located adjacent the tissue to be ablated. Following onset of application of ablation energy to heart tissue, the local electrogram is measured with electrodes located adjacent tissue to be ablated so that the ablation energy to ablation elements can be selectively reduced or terminated when transmurality is detected.
摘要翻译：用于创建病变并评估其完整性或透视性的系统和方法。病变透壁度的评估是通过使用邻近待消融组织的电极拍摄的局部电描记图来监测去极化信号来实现的。在开始将消融能量施加到心脏组织之后，用邻近待组织的组织的电极测量局部电描记图，以便当检测到透视时，消融元件的消融能量可被选择性地减少或终止。

14. 发明授权

US07561913B2 Automatic adjusting R-wave synchronization algorithm for atrial cardioversion and defibrillation 有权
标题翻译：自动调整心律转复和除颤的R波同步算法
公开(公告)号：US07561913B2
公开(公告)日：2009-07-14
申请号：US10426284
申请日：2003-04-30
申请人： Luc R. Mongeon , Rahul Mehra
发明人： Luc R. Mongeon , Rahul Mehra
IPC分类号： A61N1/39
CPC分类号： A61N1/3956 , A61N1/3987
摘要： An implantable medical device system and method are provided for synchronizing atrial cardioversion shocks to the ventricular rhythm using an adjustable atrial cardioversion/defibrillation ventricular refractory period. Upon determining a need for an atrial shock therapy, the method determines if the ventricular rate meets synchronization criteria based on an upper ventricular refractory period limit. If synchronization criteria are not met, the refractory period is automatically adjusted in stepwise decrements until the synchronization criteria are met, or until a lower refractory period limit is exceeded. If synchronization criteria are met, an atrial shock is synchronized to the next ventricular depolarization occurring outside the current refractory period. If the lower refractory period limit is exceeded, the atrial therapy is aborted.
摘要翻译：提供了一种植入式医疗装置系统和方法，用于使用可调节心房复律/除颤心室不应期使心房心律转复冲击与心室节律同步。在确定需要心房休克治疗后，该方法确定心室率是否满足基于上心室不应期限的同步标准。如果不符合同步标准，则可以逐步递减地自动调整不应期，直到达到同步标准，或直到超过较低的不应期限为止。如果符合同步标准，心房休克与当前不应期以外发生的下一次心室去极化同步。如果超过较低的不应期限，则中止心房治疗。

15. 发明授权

US5690686A Atrial defibrillation method 失效
标题翻译：心房除颤方法
公开(公告)号：US5690686A
公开(公告)日：1997-11-25
申请号：US640380
申请日：1996-04-30
申请人： Xiaoyi Min , Luc R. Mongeon , Rahul Mehra , Kenneth M. Anderson
发明人： Xiaoyi Min , Luc R. Mongeon , Rahul Mehra , Kenneth M. Anderson
IPC分类号： A61N1/39
CPC分类号： A61N1/3962 , A61N1/3918 , A61N1/395
摘要： A method and apparatus for treating atrial tachyarrhythmias, particularly atrial fibrillation. High energy pulses are delivered between electrodes located in the right atrium/SVC, the left pectoral region and the coronary sinus/great vein, with the left pectoral and coronary sinus/great vein electrodes connected in common. Optionally a ventricular electrode may also be employed in conjunction with one or more of the other listed electrodes to accomplish ventricular cardioversion or defibrillation.
摘要翻译：一种治疗房性快速性心律失常的方法和装置，特别是房颤。在位于右心房/ SVC，左胸部区域和冠状窦/大静脉的电极之间传递高能量脉冲，左胸部和冠状窦/大静脉电极共同连接。任选地，心室电极还可以与一个或多个其它列出的电极结合使用以完成心室复律或除颤。

16. 发明授权

US06195584B1 Method and apparatus for determining atrial lead dislocation 有权
标题翻译：用于确定心房铅脱位的方法和装置
公开(公告)号：US06195584B1
公开(公告)日：2001-02-27
申请号：US09303279
申请日：1999-04-30
申请人： Michael R. S. Hill , Rahul Mehra , Michael F. Hess , Raylene Pitschneider
发明人： Michael R. S. Hill , Rahul Mehra , Michael F. Hess , Raylene Pitschneider
IPC分类号： A61N137
CPC分类号： A61N1/371 , A61N2001/083
摘要： A method and apparatus for determining the occurrence of a mis-location of an atrial electrode in a cardiac stimulation device having an atrial pulse generator coupled with the atrial electrode and a ventricular sense amplifier coupled to a ventricular electrode. The device paces the atrium in a first pacing mode employing atrial pacing pulses at a first energy level and in a test mode employs higher energy atrial pacing pulses. In the test mode the device measures PR intervals between atrial pacing pulses following sensed ventricular depolarizations and determines that the atrial electrode is mis-located responsive to occurrence of a threshold number of short PR intervals or that the atrial electrode is appropriately located responsive to occurrence of a threshold number of long PR intervals. Operation of the device in the test mode may be pre-conditioned on an absence of atrial tachyarrhythmia.
摘要翻译：一种用于确定在具有与心房电极耦合的心房脉冲发生器和耦合到心室电极的心室感应放大器的心脏刺激装置中心房电极错位的发生的方法和装置。该装置以第一起搏模式采用心房起搏脉冲在第一能级进行起搏，并且在测试模式中采用更高能量的心房起搏脉冲。在测试模式中，该装置测量感测到的心室去极化之后的心房起搏脉冲之间的PR间隔，并且确定心房电极响应于出现阈值数量的短PR间期而错位，或者心房电极适当地位于响应于长PR间隔的阈值数。在测试模式下的装置的操作可以在没有心房快速性心律失常的情况下进行预处理。

17. 发明授权

US5411531A Method and apparatus for control of A-V interval 失效
标题翻译：用于控制A-V间隔的方法和装置
公开(公告)号：US5411531A
公开(公告)日：1995-05-02
申请号：US125579
申请日：1993-09-23
申请人： Michael R. S. Hill , Rahul Mehra
发明人： Michael R. S. Hill , Rahul Mehra
IPC分类号： A61N1/362 , A61N1/368
CPC分类号： A61N1/3622 , A61N1/3627
摘要： A device for controlling the duration of A-V conduction intervals in a patient's heart. Stimulation of the AV nodal fat pad is employed to maintain the durations of the A-V conduction intervals within a desired interval range, which may vary as a function of sensed heart rate or other physiologic parameter. AV nodal fat pad stimulation may also be triggered in response to defined heart rhythms such as a rapid rate or the occurrence of PVC's, to terminate or prevent induction of arrhythmias.
摘要翻译：用于控制患者心脏中A-V导通间隔的持续时间的装置。使用AV节点脂肪垫的刺激来将A-V传导间期的持续时间保持在期望的间隔范围内，其可以根据感测的心率或其他生理参数而变化。 AV节点脂肪垫刺激也可以响应定义的心律（例如快速率或PVC的发生）触发，以终止或阻止心律不齐的诱导。

18. 发明授权

US5507784A Method and apparatus for control of A-V interval 失效
标题翻译：用于控制A-V间隔的方法和装置
公开(公告)号：US5507784A
公开(公告)日：1996-04-16
申请号：US419068
申请日：1995-04-06
申请人： Michael R. S. Hill , Rahul Mehra
发明人： Michael R. S. Hill , Rahul Mehra
IPC分类号： A61N1/362
CPC分类号： A61N1/3622 , A61N1/3627
摘要： A device for controlling the duration of A-V conduction intervals ia a patient's heart. Stimulation of the AV nodal fat pad is employed to maintain the durations of the A-V conduction intervals within a desired interval range, which may vary as a function of sensed heart rate or other physiologic parameter. AV nodal fat pad stimulation may also be triggered in response to defined heart rhythms such as a rapid rate or the occurrence of PVC's, to terminate or prevent induction of arrhythmias.
摘要翻译：用于控制患者心脏的A-V传导间隔的持续时间的装置。使用AV节点脂肪垫的刺激来将A-V传导间期的持续时间保持在期望的间隔范围内，其可以根据感测的心率或其他生理参数而变化。 AV节点脂肪垫刺激也可以响应定义的心律（例如快速率或PVC的发生）触发，以终止或阻止心律不齐的诱导。

19. 发明授权

US08512337B2 Method and system for treatment of atrial tachyarrhythmias 有权
标题翻译：治疗房性快速性心律失常的方法和系统
公开(公告)号：US08512337B2
公开(公告)日：2013-08-20
申请号：US10923073
申请日：2004-08-20
申请人： David E. Francischelli , Rahul Mehra
发明人： David E. Francischelli , Rahul Mehra
IPC分类号： A61B18/12
CPC分类号： A61B18/1445 , A61B18/1402 , A61B2017/2945 , A61B2018/00994 , A61B2018/126 , A61B2018/1432 , A61B2018/1472
摘要： A method of and a system for treatment of atrial tachyarrhythmias. The system includes a set of hemostats having elongated opposing jaws carrying mechanisms for applying ablation energy along the jaws. The jaws having straight and curved configurations selected to allow arrangement of the jaws of along opposite sides of walls of a patient's atrium. Treatment is accomplished by applying of ablation energy to the walls of a patient's artria to create lines of lesion corresponding generally to incisions employed in a Maze type procedure.
摘要翻译：一种治疗房性快速性心律失常的方法和系统。该系统包括一组具有延长的相对的夹爪的止血器，该钳口携带用于沿钳口施加消融能量的机构。钳口具有直的和弯曲的构造，其被选择为允许沿着病人心房的壁的相对侧布置钳口。通过将消融能量施加到患者的肌肉的壁上来实现治疗，以产生通常对于迷宫类型手术中使用的切口相应的损伤线。

20. 发明授权

US07435250B2 Method and apparatus for tissue ablation 有权
标题翻译：组织消融的方法和装置
公开(公告)号：US07435250B2
公开(公告)日：2008-10-14
申请号：US11061425
申请日：2005-02-18
申请人： David E. Francischelli , Richard H. Comben , Michael F. Hoey , Rahul Mehra , Jon M. Ocel , Robert Pearson , Paul V. Trescony , Scott E. Jahns
发明人： David E. Francischelli , Richard H. Comben , Michael F. Hoey , Rahul Mehra , Jon M. Ocel , Robert Pearson , Paul V. Trescony , Scott E. Jahns
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B18/1445 , A61B2018/00065 , A61B2018/00351 , A61B2018/00577 , A61B2018/1435 , A61B2018/1472 , A61B2218/002
摘要： A device for ablating tissue is provided. The device comprises a conductive element with a channel for irrigating fluid formed therein, which is in contact with a non-conductive microporous interface. All or a portion of the interface may be removable. When the interface is removed, a portion of the conductive element is exposed for use in ablating tissue. Methods of using the device and of removing the interface are also provided.
摘要翻译：提供了用于消融组织的装置。该装置包括导电元件，其具有用于在其中形成的冲洗流体的通道，其与非导电微孔界面接触。界面的全部或部分可以是可移动的。当界面被去除时，导电元件的一部分被暴露以用于消融组织。还提供了使用设备和移除界面的方法。

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