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11. 发明授权

US06501052B2 Aerosol generator having multiple heating zones and methods of use thereof 有权
标题翻译：具有多个加热区域的气溶胶发生器及其使用方法
公开(公告)号：US06501052B2
公开(公告)日：2002-12-31
申请号：US09742322
申请日：2000-12-22
申请人： Kenneth A. Cox , Walter A. Nichols , F. Murphy Sprinkel, Jr. , Douglas D. McRae , William R. Sweeney
发明人： Kenneth A. Cox , Walter A. Nichols , F. Murphy Sprinkel, Jr. , Douglas D. McRae , William R. Sweeney
IPC分类号： H05B102
CPC分类号： A61M11/041 , A61M11/007 , A61M11/042 , A61M15/025 , A61M2205/3372
摘要： A temperature and flow rate controlled capillary aerosol generator includes two heating zones optionally separated by a region in which a pressure drop is induced. Power is metered or applied to the downstream, second zone to achieve a target resistance, and therefore a target temperature, while power is metered or applied to the upstream, first zone to achieve a target mass flow rate exiting the second zone. A target temperature is achieved in the second zone to generate an aerosol from the liquid flowing through the generator at the desired mass flow rate.
摘要翻译：温度和流速控制的毛细管气溶胶发生器包括两个加热区，任选地由诱导压降的区域分开。将功率计量或施加到下游的第二区域以实现目标电阻，并因此实现目标温度，同时计量或施加功率到上游第一区域以实现离开第二区域的目标质量流量。在第二区域中实现目标温度，以期望的质量流率从流过发生器的液体产生气溶胶。

12. 发明授权

US07367334B2 Fluid vaporizing device having controlled temperature profile heater/capillary tube 有权
标题翻译：具有受控温度曲线加热器/毛细管的流体蒸发装置
公开(公告)号：US07367334B2
公开(公告)日：2008-05-06
申请号：US10648282
申请日：2003-08-27
申请人： Gene G. Faison, Jr. , Rajiv Gupta , Douglas D. McRae , Walter A. Nichols
发明人： Gene G. Faison, Jr. , Rajiv Gupta , Douglas D. McRae , Walter A. Nichols
IPC分类号： A61M11/00
CPC分类号： A61M11/041 , A61M11/007 , A61M11/042 , A61M15/025
摘要： A fluid vaporizing device useful for vaporizing fluid into an aerosol includes a capillary tube made from an electrically conductive material, an upstream electrode connected to the capillary tube, and a downstream electrode connected to the tube and provided with an electrical resistivity sufficient to cause heating of the downstream electrode during operation. According to various manufacturing techniques (a) the downstream electrode can be made of a material having a resistivity that is approximately constant over a desired temperature range, (b) the ratio of the resistance of the downstream electrode to the resistance of the capillary tube can be selected as a function of a preset liquid flow rate through the capillary tube, (c) the tuning range over which a desired quality aerosol can be produced can be selected to compensate for dimensional tolerances during mass production, and (d) the total hot resistance of the downstream electrode and capillary tube can be adjusted to control the location of a meniscus of a liquid vaporized in the capillary tube to produce a desired quality aerosol.
摘要翻译：用于将流体蒸发成气溶胶的流体蒸发装置包括由导电材料制成的毛细管，连接到毛细管的上游电极和连接到管的下游电极，并且具有足以引起操作期间的下游电极。根据各种制造技术（a），下游电极可以由在所需温度范围内电阻率近似恒定的材料制成，（b）下游电极的电阻与毛细管的电阻的比率可以作为通过毛细管的预设液体流速的函数来选择，（c）可以选择可以产生期望质量气溶胶的调谐范围以补偿大量生产期间的尺寸公差，以及（d）总热量可以调节下游电极和毛细管的电阻以控制在毛细管中蒸发的液体的弯液面的位置以产生期望的质量气溶胶。

13. 发明授权

US10188823B2 Continuous high pressure delivery system 有权
公开(公告)号：US10188823B2
公开(公告)日：2019-01-29
申请号：US13555810
申请日：2012-07-23
申请人： Sudarsan Srinivasan , David Ammann , Donald Brookman , Niranjan Maharajh , Gary Grollimund , F. Murphy Sprinkel, Jr. , Douglas D. McRae
发明人： Sudarsan Srinivasan , David Ammann , Donald Brookman , Niranjan Maharajh , Gary Grollimund , F. Murphy Sprinkel, Jr. , Douglas D. McRae
IPC分类号： A61M11/04 , A61M16/14 , A61M15/00 , A61M16/10 , A61M11/00 , A61M15/02 , A61M16/00 , A61M16/08
摘要： A drug delivery system, which includes an aerosol generator unit, a pumping unit, a flow tube, at least one condensate collector and an aerosol transition adapter. The aerosol generator forms an aerosol from a liquid formulation, which is partially volatilized. The pumping unit supplies the liquid formulation to the aerosol generator unit and a flow tube having an inlet end in fluid communication with an outlet of the aerosol generator unit and an outlet adapted for connection to a patient interface, which supplies ventilation gas to a patient's lungs. The system also includes at least one condensate collector adapted to collect condensed liquid or liquid produced by the aerosol generator unit, and a transition adapter arranged to mix aerosol produced by the aerosol generator unit with heated air or ventilation gas and direct the mixed aerosol into the inlet end of the flow passage.

14. 发明授权

US08251055B2 Continuous high pressure delivery system 有权
标题翻译：连续高压输送系统
公开(公告)号：US08251055B2
公开(公告)日：2012-08-28
申请号：US11866283
申请日：2007-10-02
申请人： Sudarsan Srinivasan , David Ammann , Donald Brookman , Niranjan Maharajh , Gary Grollimund , F. Murphy Sprinkel, Jr. , Douglas D. McRae
发明人： Sudarsan Srinivasan , David Ammann , Donald Brookman , Niranjan Maharajh , Gary Grollimund , F. Murphy Sprinkel, Jr. , Douglas D. McRae
IPC分类号： A61M11/04
CPC分类号： A61M16/14 , A61M11/001 , A61M11/007 , A61M11/041 , A61M11/042 , A61M15/00 , A61M15/025 , A61M16/024 , A61M16/0808 , A61M16/1065 , A61M16/1075 , A61M2205/128 , A61M2205/3368 , A61M2205/505
摘要： A drug delivery system, which includes an aerosol generator unit, a pumping unit, a flow tube, at least one condensate collector and an aerosol transition adapter. The aerosol generator forms an aerosol from a liquid formulation, which is partially volatilized. The pumping unit supplies the liquid formulation to the aerosol generator unit and a flow tube having an inlet end in fluid communication with an outlet of the aerosol generator unit and an outlet adapted for connection to a patient interface, which supplies ventilation gas to a patient's lungs. The system also includes at least one condensate collector adapted to collect condensed liquid or liquid produced by the aerosol generator unit, and a transition adapter arranged to mix aerosol produced by the aerosol generator unit with heated air or ventilation gas and direct the mixed aerosol into the inlet end of the flow passage.
摘要翻译：药物递送系统，其包括气溶胶发生器单元，泵送单元，流动管，至少一个冷凝物收集器和气溶胶转换适配器。气溶胶发生器从液体制剂形成气溶胶，其被部分挥发。泵送单元将液体制剂供应到气溶胶发生器单元和具有与气溶胶发生器单元的出口流体连通的入口端的流管和适于连接到患者接口的出口，该患者接口向患者的肺部提供通气气体。该系统还包括至少一个冷凝收集器，适于收集由气溶胶发生器单元产生的冷凝液体或液体;以及转换适配器，其被布置成将由气溶胶发生器单元产生的气溶胶与加热的空气或通风气体混合并将混合的气溶胶引导到流道的入口端。

15. 发明申请

US20130068224A1 CONTINUOUS HIGH PRESSURE DELIVERY SYSTEM 审中-公开
标题翻译：连续高压输送系统
公开(公告)号：US20130068224A1
公开(公告)日：2013-03-21
申请号：US13555810
申请日：2012-07-23
申请人： Sudarsan Srinivasan , David Ammann , Donald Brookman , Niranjan Maharajh , Gary Grollimund , F. Murphy Sprinkel, JR. , Douglas D. McRae
发明人： Sudarsan Srinivasan , David Ammann , Donald Brookman , Niranjan Maharajh , Gary Grollimund , F. Murphy Sprinkel, JR. , Douglas D. McRae
IPC分类号： A61M16/14 , A61M16/10
CPC分类号： A61M16/14 , A61M11/001 , A61M11/007 , A61M11/041 , A61M11/042 , A61M15/00 , A61M15/025 , A61M16/024 , A61M16/0808 , A61M16/1065 , A61M16/1075 , A61M2205/128 , A61M2205/3368 , A61M2205/505
摘要： A drug delivery system, which includes an aerosol generator unit, a pumping unit, a flow tube, at least one condensate collector and an aerosol transition adapter. The aerosol generator forms an aerosol from a liquid formulation, which is partially vaporized. The pumping unit supplies the liquid formulation to the aerosol generator unit and a flow tube having an inlet end in fluid communication with an outlet of the aerosol generator unit and an outlet adapted for connection to a patient interface, which supplies ventilation to a patient's lungs. The system also includes at least one condensate collector adapted to collect condensed liquid or liquid produced by the aerosol generator unit, and a transition adapter arranged to mix aerosol produced by the aerosol generator unit with heated air and directs the mixed aerosol into the inlet end of the flow passage.
摘要翻译：药物递送系统，其包括气溶胶发生器单元，泵送单元，流动管，至少一个冷凝物收集器和气溶胶转换适配器。气溶胶发生器从液体制剂形成气溶胶，其被部分汽化。泵送单元将液体制剂供应到气溶胶发生器单元和具有与气溶胶发生器单元的出口流体连通的入口端的流管和适于连接到患者接口的出口，该患者接口向患者的肺提供通气。该系统还包括至少一个冷凝收集器，适于收集由气溶胶发生器单元产生的冷凝液体或液体;以及转换适配器，其被布置成将由气溶胶发生器单元产生的气溶胶与加热空气混合，并将混合气溶胶引导到流路。

16. 发明申请

US20080110458A1 CONTINUOUS HIGH PRESSURE DELIVERY SYSTEM 有权
标题翻译：连续高压输送系统
公开(公告)号：US20080110458A1
公开(公告)日：2008-05-15
申请号：US11866283
申请日：2007-10-02
申请人： Sudarsan Srinivasan , David Ammann , Donald Brookman , Niranjan Maharajh , Gary Grollimund , F. Murphy Sprinkel , Douglas D. McRae
发明人： Sudarsan Srinivasan , David Ammann , Donald Brookman , Niranjan Maharajh , Gary Grollimund , F. Murphy Sprinkel , Douglas D. McRae
IPC分类号： A61M16/00 , A61M11/06 , A61B19/00
CPC分类号： A61M16/14 , A61M11/001 , A61M11/007 , A61M11/041 , A61M11/042 , A61M15/00 , A61M15/025 , A61M16/024 , A61M16/0808 , A61M16/1065 , A61M16/1075 , A61M2205/128 , A61M2205/3368 , A61M2205/505
摘要： A drug delivery system, which includes an aerosol generator unit, a pumping unit, a flow tube, at least one condensate collector and an aerosol transition adapter. The aerosol generator forms an aerosol from a liquid formulation, which is partially vaporized. The pumping unit supplies the liquid formulation to the aerosol generator unit and a flow tube having an inlet end in fluid communication with an outlet of the aerosol generator unit and an outlet adapted for connection to a patient interface, which supplies ventilation to a patient's lungs. The system also includes at least one condensate collector adapted to collect condensed liquid or liquid produced by the aerosol generator unit, and a transition adapter arranged to mix aerosol produced by the aerosol generator unit with heated air and directs the mixed aerosol into the inlet end of the flow passage.
摘要翻译：药物递送系统，其包括气溶胶发生器单元，泵送单元，流动管，至少一个冷凝物收集器和气溶胶转换适配器。气溶胶发生器从液体制剂形成气溶胶，其被部分汽化。泵送单元将液体制剂供应到气溶胶发生器单元和具有与气溶胶发生器单元的出口流体连通的入口端的流管和适于连接到患者接口的出口，该患者接口向患者的肺提供通气。该系统还包括至少一个冷凝收集器，适于收集由气溶胶发生器单元产生的冷凝液体或液体;以及转换适配器，其被布置成将由气溶胶发生器单元产生的气溶胶与加热空气混合，并将混合气溶胶引导到流路。

17. 发明授权

US4980571A Methods and apparatus for measuring sidestream smoke 失效
标题翻译：测量侧流烟雾的方法和装置
公开(公告)号：US4980571A
公开(公告)日：1990-12-25
申请号：US410933
申请日：1989-09-22
申请人： Douglas D. McRae , Bobby W. Francis , Leonard E. Brown, Jr. , Roger A. Comes , Randall K. Greene
发明人： Douglas D. McRae , Bobby W. Francis , Leonard E. Brown, Jr. , Roger A. Comes , Randall K. Greene
IPC分类号： G01N21/59 , A24C5/34 , G01N21/53
CPC分类号： A24C5/3406 , G01N21/534
摘要： Methods and apparatus for continuously and instantaneously measuring sidestream smoke are provided. A hood assembly is provided to fit over the ports of a conventional smoking machine. Sidestream smoke produced by test cigarettes is continuously drawn through the hood by an exhaust system. A laser beam is passed through the smoke one or more times before the beam is sensed by a photodiode detector. An electrical signal from the detector, representing the light transmission, is received by a strip recorder or computer system. The transmission measurements are used to calculate the extinction coefficient of the smoke for comparison purposes.
摘要翻译：提供连续和瞬时测量侧流烟雾的方法和设备。提供罩组件以装配在常规吸烟机的端口上。由测试香烟产生的侧流烟气通过排气系统连续地通过发动机罩。在光束被光电二极管检测器检测到之前，激光束通过烟雾一次或多次。表示光传输的来自检测器的电信号由条带记录器或计算机系统接收。传输测量用于计算烟雾的消光系数用于比较目的。

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