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11. 发明申请

US20050240304A1 Method and apparatus for automatic health monitoring 审中-公开
标题翻译：自动健康监测方法和装置
公开(公告)号：US20050240304A1
公开(公告)日：2005-10-27
申请号：US10828491
申请日：2004-04-21
申请人： Matthew York , Thomas Largi , Paul Kuwik , Dennis Crump , David Livingston , James Squire
发明人： Matthew York , Thomas Largi , Paul Kuwik , Dennis Crump , David Livingston , James Squire
IPC分类号： A61B5/11 , G06F17/00 , G06F19/00 , G07C3/00
CPC分类号： G07C3/00 , A61B5/11 , G06F19/3418
摘要： Embodiments of the present invention are directed to a method and apparatus for automatic health monitoring. In one embodiment, a regularly accessed device is equipped with an access detection unit. In one embodiment, a regularly accessed device is a temperature controlled compartment. In one embodiment, a timer is started when the access detection unit detects an access to the temperature controlled compartment. In one embodiment, a determination unit determines whether a second access is made within a time interval of a first access. In one embodiment, the time interval is determined using the patient's recommended medication regimen. In one embodiment, when a determination unit determines that a second access is not made within a time interval of a first access, a signal generator generates a signal. In one embodiment, the signal is transmitted to a healthcare provider. In one embodiment, the signal is transmitted via a computer network.
摘要翻译：本发明的实施例涉及一种用于自动健康监测的方法和装置。在一个实施例中，定期访问的设备配备有访问检测单元。在一个实施例中，定期访问的设备是温度控制的隔间。在一个实施例中，当访问检测单元检测到对温度控制室的访问时，启动定时器。在一个实施例中，确定单元确定在第一访问的时间间隔内是否进行第二访问。在一个实施例中，使用患者推荐的药物治疗方案确定时间间隔。在一个实施例中，当确定单元确定在第一次访问的时间间隔内不进行第二次访问时，信号发生器产生信号。在一个实施例中，信号被传送到医疗保健提供者。在一个实施例中，信号经由计算机网络传输。

12. 发明授权

US5491068A Assay method for detecting the presence of bacteria 失效
标题翻译：用于检测细菌存在的测定方法
公开(公告)号：US5491068A
公开(公告)日：1996-02-13
申请号：US999363
申请日：1992-12-31
申请人： Thomas L. Benjamin , Joan Chen-Wu , Thomsen Hansen , Barbara Jackson , David Livingston , Steven Tannenbaum , Gerald Wogan
发明人： Thomas L. Benjamin , Joan Chen-Wu , Thomsen Hansen , Barbara Jackson , David Livingston , Steven Tannenbaum , Gerald Wogan
IPC分类号： C12Q1/04 , C12Q1/06 , C12Q1/24 , C12Q1/26 , C12Q1/34 , C12Q1/68 , C12R1/01 , C12R1/645 , G01N33/00 , G01N33/53 , G01N33/543 , G01N33/569 , G01N33/02 , G01N33/538 , G01N33/547
CPC分类号： C12Q1/689 , C12Q1/04 , C12Q1/24 , C12Q1/6804 , G01N33/54313 , G01N33/54326 , G01N33/569 , G01N33/56911
摘要： An assay method is provided to easily and quickly detect the presence of organisms capable of being cultured, such as bacteria, characterized by antibody capture of the organism of interest by use of specialized magnetic beads, incubation of the captured cells to form colonies; removal of material from the colonies with a colony lift membrane; and detection of the colony material on the membrane sheet by use of labeled antibodies, PCR or nucleic acid probes.
摘要翻译：提供测定方法以容易且快速地检测能够培养的生物体的存在，例如细菌，其特征在于通过使用专门的磁珠抗体捕获感兴趣的生物体，孵育所捕获的细胞以形成菌落; 用菌落提取膜从菌落中去除物质; 以及通过使用标记抗体，PCR或核酸探针检测膜片上的菌落物质。

13. 发明授权

US09061346B2 Die locking system and method 有权
标题翻译：模具锁定系统和方法
公开(公告)号：US09061346B2
公开(公告)日：2015-06-23
申请号：US13451101
申请日：2012-04-19
申请人： David Hebert , Matthew John Villani , David Livingston
发明人： David Hebert , Matthew John Villani , David Livingston
IPC分类号： B21D37/14 , B21D37/02 , B21J13/03 , B21J5/00
CPC分类号： B21J13/03 , B21D37/02 , B21D37/14 , B21J5/00
摘要： A die locking device including a press having a top end, a bottom end and a plurality of channels disposed around a perimeter of the press. The device also includes a plurality of actuators, each of the plurality of actuators affixed to a first end of one of a plurality of locking arms that are each at least partially disposed in one of the plurality of channels. The device also includes a plurality of locking clips, each affixed to a second end of each of the plurality of locking arms and each affixed to one of a plurality of hinges. The plurality of hinges is configured to receive and secure a die stack to the top end of the press.
摘要翻译：一种模具锁定装置，包括具有顶端，底端以及设置在压机周边周围的多个通道的压力机。所述装置还包括多个致动器，所述多个致动器中的每一个致动器固定到多个锁定臂中的一个的至少部分地设置在所述多个通道中的一个中的多个锁定臂中的一个的第一端。该装置还包括多个锁定夹，每个锁定夹固定到多个锁定臂中的每一个的第二端，并且每个固定到多个铰链中的一个。多个铰链被配置成接收并固定模具堆叠到压机的顶端。

14. 发明授权

US07950401B2 Adjustable hair holding device 有权
标题翻译：可调头发夹持装置
公开(公告)号：US07950401B2
公开(公告)日：2011-05-31
申请号：US10764237
申请日：2004-01-23
申请人： Bruce A. Rogers , David Livingston
发明人： Bruce A. Rogers , David Livingston
IPC分类号： A45D8/20 , A45D8/00
CPC分类号： A45D8/22
摘要： A hair holding device including hingedly connected first and second body members each including hair gripping portions adapted to be squeezed by a user whereby the hair gripping portions come into contact with gathered strands of a user's hair. The device further includes a friction-type adjustment mechanism coaxially arranged with respect to the hinge for causing the hair gripping portions to remain at a point at which the hair gripping portions are squeezed together by a user. Optionally, the device may include squeezable release handles or other release mechanism, as well as a torsion spring for biasing the hair gripping portions into either an open or a closed position.
摘要翻译：一种头发保持装置，包括铰接地连接的第一和第二主体部件，每个主体部件包括适于被使用者挤压的头发夹持部分，由此毛发夹持部分与用户头发的聚集的股线接触。该装置还包括相对于铰链同轴布置的摩擦式调节机构，用于使头发夹持部分保持在使用者将头发夹持部分挤压在一起的点处。可选地，该装置可以包括可挤压释放手柄或其它释放机构，以及用于将头发夹持部分偏压到打开或关闭位置的扭转弹簧。

15. 发明授权

US07460960B2 Proteome epitope tags and methods of use thereof in protein modification analysis 失效
标题翻译：蛋白质组表位标签及其在蛋白质修饰分析中的应用方法
公开(公告)号：US07460960B2
公开(公告)日：2008-12-02
申请号：US10712425
申请日：2003-11-13
申请人： Frank D. Lee , Xun Meng , David Livingston
发明人： Frank D. Lee , Xun Meng , David Livingston
IPC分类号： G01F19/00 , G01N33/53
CPC分类号： B82Y5/00 , B82Y10/00 , C12Q1/26 , C12Q1/34 , C12Q1/48 , C12Q1/485 , G01N33/6803 , G01N33/6842
摘要： Disclosed are methods for reliably detecting the presence of proteins, especially proteins with various post-translational modifications (phosphorylation, glycosylation, methylation, acetylation, etc.) in a sample by the use of one or more capture agents that recognize and interact with recognition sequences uniquely characteristic of a set of proteins (Proteome Epitope Tags, or PETs) in the sample. Arrays comprising these capture agents or PETs are also provided.
摘要翻译：公开了通过使用一种或多种识别并与识别序列相互作用的捕获剂来可靠地检测样品中存在蛋白质，特别是具有各种翻译后修饰（磷酸化，糖基化，甲基化，乙酰化等）的蛋白质的方法的方法样品中一组蛋白质（Proteome Epitope Tags，或PET）的独特特征。还提供了包含这些捕获剂或PET的阵列。

16. 发明申请

US20080070953A1 Inhibitors of interleukin-1 beta converting enzyme 失效
标题翻译：白细胞介素-1β转换酶抑制剂
公开(公告)号：US20080070953A1
公开(公告)日：2008-03-20
申请号：US11901843
申请日：2007-09-18
申请人： Guy Bemis , Julian Golec , David Lauffer , Michael Mullican , Mark Murcko , David Livingston
发明人： Guy Bemis , Julian Golec , David Lauffer , Michael Mullican , Mark Murcko , David Livingston
IPC分类号： A61K31/44 , A61K31/27 , C07C259/00 , C07D211/08 , C07D207/00 , A61K31/4025
CPC分类号： C07D243/08 , A61K38/00 , C07D243/12 , C07D263/56 , C07D413/04 , C07D487/04 , C07K5/0202 , C07K5/06052 , C07K5/0812
摘要： The present invention relates to novel classes of compounds which are inhibitors of interleukin-1β converting enzyme. The ICE inhibitors of this invention are characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting ICE activity and consequently, may be advantageously used as agents against interleukin-1 mediated diseases, including inflammatory diseases, autoimmune diseases and neurodegenerative diseases. This invention also relates to methods for inhibiting ICE activity and methods for treating interleukin-1 mediated diseases using the compounds and compositions of this invention.
摘要翻译：本发明涉及作为白细胞介素-1β转换酶抑制剂的新型化合物。本发明的ICE抑制剂的特征在于具体的结构和物理化学特征。本发明还涉及包含这些化合物的药物组合物。本发明的化合物和药物组合物特别适用于抑制ICE活性，因此可有利地用作抗白介素-1介导的疾病（包括炎性疾病，自身免疫性疾病和神经变性疾病）的药物。本发明还涉及使用本发明的化合物和组合物来抑制ICE活性的方法和用于治疗白细胞介素-1介导的疾病的方法。

17. 发明授权

US6153373A Method for sex determination of mammalian offspring 有权
公开(公告)号：US6153373A
公开(公告)日：2000-11-28
申请号：US299181
申请日：1999-04-23
申请人： Thomas L. Benjamin , Barbara Kohn , Christopher J. Basker , Susan George , David Livingston
发明人： Thomas L. Benjamin , Barbara Kohn , Christopher J. Basker , Susan George , David Livingston
IPC分类号： C12N5/00 , C12N5/071 , G01N33/543 , G01N33/569 , A01N1/02 , C07K16/28 , C12N5/06 , G01N33/538
CPC分类号： C12N5/0612 , G01N33/54326 , G01N33/56966 , Y10S530/852
摘要： A method for increasing the percentage of mammalian offspring of either sex which comprises contacting a semen sample with an antibody specific for the spermatozoa determinative of one sex and separating said spermatozoa from spermatozoa determinative of the other sex, said antibody being bound to a non-porous magnetic bead support having a diameter of 0.1 to 2 microns.

18. 发明申请

US20170291956A1 HER3 Inhibition in Low-grade Serous Ovarian Cancers 审中-公开
公开(公告)号：US20170291956A1
公开(公告)日：2017-10-12
申请号：US15325336
申请日：2015-07-15
申请人： David Livingston , Joyce Liu , Ronny Drapkin
发明人： David Livingston , Joyce Liu , Ronny Drapkin
IPC分类号： C07K16/32 , A61K39/395 , C12N15/113 , A61K45/06
CPC分类号： C07K16/32 , A61K39/3955 , A61K45/06 , A61K2039/55 , C07K2317/34 , C07K2317/56 , C07K2317/73 , C07K2317/76 , C12N15/111 , C12N15/1135 , C12N15/1138 , C12N2310/14 , C12N2320/31
摘要： Methods of treatment of cancer are provided. In particular, methods of treatment of low-grade serous ovarian cancers by inhibiting signaling of an EGFR family member are provided.

19. 发明申请

US20080047477A1 BOAT HULL AND BAIT TANK DESIGN 审中-公开
标题翻译：船和船舱设计
公开(公告)号：US20080047477A1
公开(公告)日：2008-02-28
申请号：US11676119
申请日：2007-02-16
申请人： Lawrence Graf , David Pugh , David Livingston
发明人： Lawrence Graf , David Pugh , David Livingston
IPC分类号： B63B1/10 , A01K97/05 , B63B17/00 , A47B96/00
CPC分类号： A01K97/06 , A01K97/05 , B63B1/12 , B63B1/20 , B63B35/14
摘要： A boat hull is described that includes a plurality of features to improve stability and tracking. Any one or more of the features can be provided in a watercraft having displacement and planing characteristics. The hull features improve tracking and stability of the hull when in displacement mode and planing mode.
摘要翻译：描述了一种船体，其包括多个特征以改善稳定性和跟踪。可以在具有位移和刨削特性的船只中提供任何一个或多个特征。船体特征提高了在位移模式和刨床模式下船体的跟踪和稳定性。

20. 发明授权

US07086122B2 Ratchet-type buckle and snowboard binding 失效
标题翻译：棘轮式扣环和滑雪板绑定
公开(公告)号：US07086122B2
公开(公告)日：2006-08-08
申请号：US10851052
申请日：2004-05-21
申请人： David Livingston
发明人： David Livingston
IPC分类号： A44C11/14
CPC分类号： A63C10/06 , A43C11/1406 , A43C11/146 , A44B11/125 , A44B11/14 , Y10S24/909 , Y10T24/21 , Y10T24/2106 , Y10T24/216 , Y10T24/2183 , Y10T24/3703
摘要： A ratchet-type buckle (100) is disclosed for use with a ladder strap (80), wherein the buckle includes a toothed, barrel-shaped strap engagement member (140) that is rotatably mounted between oppositely disposed sidewalls (130) that are pivotally coupled to a base (110). The engagement member is positioned to drivably engage and hold the strap. A holding pawl (160) allows forward rotation and hinders backward rotation of the engagement member. A driving pawl (180) is incorporated into a lever assembly (170), which is pivotally coupled to the sidewalls, the driving pawl positioned to engage and rotate the engagement member teeth when the lever assembly is pivoted in a forward direction. The pivotal coupling of the sidewalls to the base permit the engagement member to be lifted away from the base, to release the strap. The sidewalls are preferably biased towards the base.
摘要翻译：公开了一种与梯带（80）一起使用的棘轮式带扣（100），其中带扣包括齿形的桶状带接合构件（140），其可旋转地安装在相对设置的相对设置的侧壁（130）之间，耦合到基座（110）。接合构件定位成可驱动地接合并保持带子。保持爪（160）允许正向旋转并阻止接合构件的反向旋转。驱动棘爪（180）结合到杠杆组件（170）中，杠杆组件（170）枢转地联接到侧壁，当杠杆组件沿向前方向枢转时，驱动爪定位成接合和旋转接合构件齿。侧壁与基座的枢转联接允许接合构件被提升离开基座，以释放带子。侧壁优选地朝向基部偏压。

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