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11. 发明授权

US06456889B2 Lead with polymeric tubular liner for guidewire and stylet insertion 有权
标题翻译：带有用于导丝和通孔插入的聚合物管状衬垫
公开(公告)号：US06456889B2
公开(公告)日：2002-09-24
申请号：US09797281
申请日：2001-02-28
申请人： Anne M. Pianca , Gene A. Bornzin , Christopher R. Jenney , Kevin L. Morgan , Sheldon Williams
发明人： Anne M. Pianca , Gene A. Bornzin , Christopher R. Jenney , Kevin L. Morgan , Sheldon Williams
IPC分类号： A61N1100
CPC分类号： A61N1/056 , A61N2001/0585
摘要： An implantable lead for electrical stimulation of the body includes an elongated multi-lumen tube with a distal tip electrode having a longitudinally extending central bore. A cable conductor is received in one lumen of the multi-lumen tube for electrical connection to the tip electrode and an elongated polymeric tubular liner having a coefficient of friction in the range of 0.01 to 0.20 is received in another lumen of the multi-lumen tube generally aligned with the bore of the distal tip electrode for freely receiving a guidewire through the tubular liner and through the bore of the distal tip electrode. An electrically conductive proximal pin is attached to the multi-lumen tubing distant from the tip electrode and, in one embodiment, the cable conductor and the proximal end of the polymeric tubular liner are attached to the proximal pin. Initially, the guidewire is implanted into the body along a desired trajectory. With the polymeric tubular liner inserted, first the distal tip electrode, then the remainder of the multi-lumen tube, are slid onto the guidewire such that the guidewire slidably advances within the polymeric tubular liner. Thereupon, the multilumen tube is advanced along the guidewire until a desired site is achieved and the guidewire is removed from the body and the multi-lumen tube. In another embodiment, the distal tip electrode has no central bore but the elongated polymeric tubular liner is axially aligned with the distal tip electrode for freely receiving a stylet which is attached with the distal tip electrode.
摘要翻译：用于电刺激身体的可植入引线包括细长的多腔管，其具有具有纵向延伸的中心孔的远端尖端电极。电缆导体容纳在多腔管的一个内腔中，用于电连接到尖端电极，并且具有在0.01至0.20范围内的摩擦系数的细长聚合物管状衬垫被容纳在多腔管的另一内腔中通常与远侧末端电极的孔对准，用于自由地接收穿过管状衬垫的导丝并且穿过远端尖端电极的孔。导电近端针连接到远离尖端电极的多腔管，并且在一个实施例中，电缆导体和聚合物管状衬垫的近端附接到近端针。最初，导线沿着期望的轨迹植入体内。在插入聚合物管状衬垫的情况下，首先将远侧末端电极，然后多腔管的其余部分滑动到导丝上，使得导丝可在聚合物管状衬垫内滑动地前进。于是，多根管沿引导线前进，直到达到所需的位置，导线从主体和多管腔中取出。在另一个实施例中，远端尖端电极没有中心孔，但是细长的聚合物管状衬套与远端尖端电极轴向对齐，用于自由接收与远侧末端电极连接的探针。

12. 发明授权

US06988007B1 Single pass telescoping cardiac lead for the left heart 失效
标题翻译：单通伸缩心脏线为左心
公开(公告)号：US06988007B1
公开(公告)日：2006-01-17
申请号：US10218353
申请日：2002-08-13
申请人： Kevin L. Morgan , Gene A. Bornzin , Joseph J. Florio , John R. Helland
发明人： Kevin L. Morgan , Gene A. Bornzin , Joseph J. Florio , John R. Helland
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N1/057 , A61N2001/0585
摘要： An implantable single-pass cardiac stimulation lead provides for placement of electrodes into electrical contact with two chambers of a patient's heart. The lead includes an inner lead body having at least one electrode at its distal end and an outer lead body having at least one electrode at its distal end. The outer lead body has an internal lumen that slidingly receives the inner lead body. The inner lead body is extendable from the outer lead body at a point proximal to the distal end of the outer lead body. The sliding of the inner lead body relative to the outer lead body enables the inner lead body distal electrode to have a varying distance from the outer lead body distal electrode and enables the inner lead body to extend into the coronary sinus region of the heart to place the inner lead body electrode into electrical contact with the left ventricle.
摘要翻译：可植入的单程心脏刺激引线提供将电极放置在与患者心脏的两个腔室电接触的位置。引线包括在其远端具有至少一个电极的内引线体和在其远端具有至少一个电极的外引线体。外引线体具有滑动地接收内引线体的内腔。内引线体可以在外引线体的远离外引线体的远端的位置处延伸。内引线体相对于外引线体的滑动能够使内引线体远端电极与外引线体远端电极间距离变化，能够使内引线体延伸到心脏的冠状窦区域内部引线体电极与左心室电接触。

13. 发明授权

US06490489B2 Implantable cardiac single pass coronary sinus lead for providing pacing and defibrillation and method of manufacture 有权
标题翻译：可植入心脏单程冠状动脉窦导管用于提供起搏和除颤及其制造方法
公开(公告)号：US06490489B2
公开(公告)日：2002-12-03
申请号：US09771505
申请日：2001-01-26
申请人： Gene A. Bornzin , Anne M. Pianca , Kevin L. Morgan , John R. Helland , Joseph J. Florio
发明人： Gene A. Bornzin , Anne M. Pianca , Kevin L. Morgan , John R. Helland , Joseph J. Florio
IPC分类号： A61N105
CPC分类号： A61N1/056
摘要： A single chronic implantable cardiac lead for use in the coronary sinus region of the heart provides both atrial and ventricular pacing and defibrillation therapy. The lead includes an elongated lead body having a distal end and a proximal end, a first electrode assembly including a ventricular pacing electrode and a ventricular defibrillation at the distal end, a second electrode assembly proximal to the first electrode assembly including at least one atrial pacing electrode and an atrial defibrillation electrode, and a further defibrillation electrode proximal to the second electrode assembly. The electrode assemblies and further defibrillation electrode are spaced apart so that when the lead is implanted within the coronary sinus region of the heart with the first electrode assembly adjacent the left ventricle, the second electrode assembly is adjacent the left atrium and the further defibrillation electrode is within the right atrium and/or the superior vena cava.
摘要翻译：用于心脏冠状静脉窦区域的单一慢性可植入心脏线可提供心房起搏和除颤治疗。引线包括具有远端和近端的细长引线主体，包括心室起搏电极和在远端处的心室除颤的第一电极组件，靠近第一电极组件的第二电极组件，包括至少一个心房起搏电极和心房除颤电极，以及靠近第二电极组件的另外的除颤电极。电极组件和另外的除颤电极间隔开，使得当铅被植入心脏的冠状窦区域内时，第一电极组件邻近左心室，第二电极组件邻近左心房，另外的除颤电极在右心房和/或上腔静脉内。

14. 发明授权

US06459937B1 Endocardial pacing lead with detachable tip electrode assembly 失效
标题翻译：心内膜起搏导联带有可拆卸的尖端电极组件
公开(公告)号：US06459937B1
公开(公告)日：2002-10-01
申请号：US09558484
申请日：2000-04-25
申请人： Kevin L. Morgan , Gene A. Bornzin , Anne M. Pianca
发明人： Kevin L. Morgan , Gene A. Bornzin , Anne M. Pianca
IPC分类号： A61N105
CPC分类号： A61N1/057 , A61N2001/0578 , A61N2001/058
摘要： A body implantable lead assembly includes a lead body and a tip electrode assembly at the distal end of the lead body. The tip electrode assembly is detachably connected to the lead body by means of a threaded coupling actuatable by a stylet inserted through the lumen of the lead body. The lead body may therefore be removed leaving behind a chronically implanted tip electrode assembly. The invention has particular utility in the context of passive endocardial heart pacing leads whose tip electrode assemblies include tines which become entangled in the trabecular network of the heart, and are therefore difficult to remove.
摘要翻译：一种身体可植入引线组件包括在引线主体的远端处的引线主体和尖端电极组件。尖端电极组件通过螺纹连接件可拆卸地连接到引线主体，螺纹连接可以通过插入穿过引线主体的内腔的探针进行激活。因此引线体可以被移除留下长时间植入的尖端电极组件。本发明在被动心内膜心脏起搏引线的上下文中具有特别的用途，其尖端电极组件包括缠结在心脏小梁网中的尖齿，因此难以移除。

15. 发明授权

US08538555B1 Cardiac access methods and apparatus 有权
标题翻译：心脏存取方法和装置
公开(公告)号：US08538555B1
公开(公告)日：2013-09-17
申请号：US12973810
申请日：2010-12-20
申请人： Yougandh Chitre , Gene A. Bornzin , John R. Helland , Eric Falkenberg , Kevin L. Morgan , Sheldon Williams , Michael Yang , Andrew W. McGarvey
发明人： Yougandh Chitre , Gene A. Bornzin , John R. Helland , Eric Falkenberg , Kevin L. Morgan , Sheldon Williams , Michael Yang , Andrew W. McGarvey
IPC分类号： A61N1/00
CPC分类号： A61F2/2478 , A61B17/00 , A61B17/0057 , A61N1/0587
摘要： A chamber or vasculature of a heart may be accessed via the pericardial space of the heart. Initially, the pericardial space may be accessed via a transmyocardial approach or a subxiphoid approach. A lead or other implantable apparatus may thus be routed into the pericardial space, through myocardial tissue and into the chamber or vasculature. The lead or other apparatus may be used to sense activity in or provide therapy to the heart.
摘要翻译：可以通过心脏的心包空间访问心脏的腔室或脉管系统。最初，心包空间可以通过心肌的方法或亚型的方法进行。因此，引线或其它可植入装置可通过心肌组织进入心包空间并进入腔室或脉管系统。铅或其他装置可用于感测心脏的活动或提供对心脏的治疗。

16. 发明授权

US08311648B1 Cardiac access methods and apparatus 有权
标题翻译：心脏存取方法和装置
公开(公告)号：US08311648B1
公开(公告)日：2012-11-13
申请号：US12973800
申请日：2010-12-20
申请人： Yougandh Chitre , Gene A. Bornzin , John R. Helland , Eric Falkenberg , Kevin L. Morgan , Sheldon Williams , Michael Yang , Andrew W. McGarvey
发明人： Yougandh Chitre , Gene A. Bornzin , John R. Helland , Eric Falkenberg , Kevin L. Morgan , Sheldon Williams , Michael Yang , Andrew W. McGarvey
IPC分类号： A61N1/05
CPC分类号： A61F2/2478 , A61B17/00 , A61B17/0057 , A61N1/0587
摘要： A delivery apparatus for accessing the pericardial space of a heart including an elongated body defining a lumen and a piercing member that extends from a distal portion of the elongated body for piercing tissue of the heart. A spring expands from a distal end of the piercing member in response to the distal end of the piercing member passing through the tissue and into the pericardial space. An electrode located on the spring in order to sense signals indicative of a distal end of the spring passing through the tissue and into the pericardial space.
摘要翻译：一种用于进入心脏的心包空间的输送装置，包括限定内腔的细长主体和从细长主体的远端部分延伸以刺穿心脏的组织的穿刺构件。响应于刺穿构件的远端穿过组织并进入心包空间，弹簧从穿刺构件的远端膨胀。位于弹簧上的电极，用于感测指示穿过组织并进入心包空间的弹簧的远端的信号。

17. 发明授权

US07389134B1 Trans-septal intra-cardiac lead system 失效
标题翻译：跨隔间心脏引导系统
公开(公告)号：US07389134B1
公开(公告)日：2008-06-17
申请号：US11053374
申请日：2005-02-07
申请人： Annapurna Karicherla , Kevin L. Morgan , Gene A. Bornzin , Sheldon Williams
发明人： Annapurna Karicherla , Kevin L. Morgan , Gene A. Bornzin , Sheldon Williams
IPC分类号： A61B5/04 , A61B5/02
CPC分类号： A61B5/0215 , A61B5/042
摘要： An apparatus for and method of measuring pressure through a septum in a patient's heart is disclosed. A lead inserted into the right side of a heart is routed through the septum to gain access to the left side of the heart. The lead includes an attachment structure that secures the lead to one or both of the septal walls. The attachment structure may include at least one protruding tine, membrane, inflatable balloon, involuted spiral or J-lead that engage one or more sides of the septum. The lead also includes one or more sensors for measuring cardiac pressure on the left side of the heart and, as necessary, the right side of the heart.
摘要翻译：公开了一种通过患者心脏中的隔膜测量压力的装置和方法。插入心脏右侧的导线穿过隔膜，以进入心脏的左侧。引线包括将引线固定到一个或两个隔膜壁的附接结构。附接结构可以包括接合隔膜的一侧或多侧的至少一个突出的齿，膜，可充气气囊，渐开线螺旋或J-引线。引线还包括一个或多个用于测量心脏左侧的心脏压力和根据需要的心脏的右侧的传感器。

18. 发明授权

US5628779A Single-pass A-V pacing lead 失效
标题翻译：单程A-V起搏线
公开(公告)号：US5628779A
公开(公告)日：1997-05-13
申请号：US629960
申请日：1996-04-03
申请人： Gene A. Bornzin , Kevin L. Morgan , Joseph J. Florio , Wendy K. Wolsleger
发明人： Gene A. Bornzin , Kevin L. Morgan , Joseph J. Florio , Wendy K. Wolsleger
IPC分类号： A61N1/05
CPC分类号： A61N1/056
摘要： A single-pass atrio-ventricular (A-V) pacing lead includes an elongated main lead body having an atrial electrode at the distal end thereof, and includes a ventricular branch which departs from the main lead body just proximal to the tip of the atrial electrode. The ventricular branch has a ventricular electrode at its distal tip. The main lead body includes a preformed "J"-shaped portion which, following proper implantation, projects the atrial electrode against a wall of the atrial appendage. The ventricular branch includes a preformed bend which curves in the opposite direction of the J-shaped portion so as to maintain the ventricular branch generally away from the wall of the atrial appendage. The lead includes a single lumen which extends through both the main lead body and the ventricular branch, allowing the lead to be implanted using a single stylet. When the styler is fully inserted within the lumen, an extension portion of the atrial electrode, including the electrode tip, rests alongside the straightened ventricular branch so as to present a low cross-sectional profile, facilitating transvenous implantation.
摘要翻译：单通道心房（A-V）起搏引线包括细长的主引线体，其在其远端具有心房电极，并且包括心室分支，该心室分支离开主导体正好靠近心房电极的尖端。心室分支在其远端具有心室电极。主引线体包括预成形的“J”形部分，其在适当植入之后将心房电极投射到心房的壁上。心室分支包括在J形部分的相反方向上弯曲的预成形弯曲部，以便使心室分支通常远离心房壁。引线包括延伸穿过主引线主体和心室分支的单个内腔，允许使用单个通丝针植入引线。当造型器完全插入管腔中时，包括电极末端的心房电极的延伸部分位于矫正的心室分支旁边，以便呈现低横截面轮廓，便于经静脉植入。

19. 发明授权

US09017341B2 Multi-piece dual-chamber leadless intra-cardiac medical device and method of implanting same 有权
标题翻译：多片双室无引线心脏内心脏医疗器械及其植入方法
公开(公告)号：US09017341B2
公开(公告)日：2015-04-28
申请号：US13352005
申请日：2012-01-17
申请人： Gene A. Bornzin , John W. Poore , Zoltan Somogyi , Xiaoyi Min
发明人： Gene A. Bornzin , John W. Poore , Zoltan Somogyi , Xiaoyi Min
IPC分类号： A61B19/00 , A61N1/05 , A61N1/375 , A61N1/372 , A61N1/365
CPC分类号： A61N1/059 , A61N1/0573 , A61N1/36521 , A61N1/37288 , A61N1/3756
摘要： A leadless intra-cardiac medical device (LIMD) includes an electrode assembly configured to be anchored within a first wall portion of a first chamber of a heart. The electrode assembly includes an electrode main body having a first securing helix, an electrode wire segment extending from the body, and a first segment-terminating contact positioned on the electrode wire segment. The device further includes a housing assembly configured to be anchored within a second wall portion of a second chamber of the heart. The housing assembly includes a body having a second securing helix, a housing wire segment extending from the body, and a second segment-terminating contact positioned on the housing wire segment. The device also includes a connector block that electrically connects the electrode wire segment to the housing wire segment by retaining the first and second segment-terminating contacts.
摘要翻译：无引线心脏内心脏医疗装置（LIMD）包括被配置为锚定在心脏的第一腔室的第一壁部分内的电极组件。电极组件包括具有第一固定螺旋线的电极主体，从主体延伸的电极线段和位于电极线段上的第一段终止触点。该装置还包括壳体组件，其构造成锚固在心脏的第二腔室的第二壁部分内。壳体组件包括具有第二固定螺旋的主体，从主体延伸的壳体线段和位于壳体线段上的第二段终止触点。该装置还包括连接器块，其通过保持第一和第二段终止触点将电极线段电连接到壳体线段。

20. 发明授权

US09008777B2 Leadless intra-cardiac medical device with reduced number of feed-thrus 有权
标题翻译：无铅心脏内心脏医疗器械，饲料数量减少
公开(公告)号：US09008777B2
公开(公告)日：2015-04-14
申请号：US13529226
申请日：2012-06-21
申请人： Ali Dianaty , Gabriel A. Mouchawar , Gene A. Bornzin , John W. Poore , Xiaoyi Min , Zoltan Somogyi , Richard Williamson
发明人： Ali Dianaty , Gabriel A. Mouchawar , Gene A. Bornzin , John W. Poore , Xiaoyi Min , Zoltan Somogyi , Richard Williamson
IPC分类号： A61N1/00 , A61N1/375 , A61N1/368
CPC分类号： A61N1/3756 , A61B5/042 , A61N1/362 , A61N1/368 , Y10T29/49002
摘要： A leadless implantable medical device (LIMD) includes a housing formed from a battery and an end cap. A proximal end of the end cap forms an LIMD proximal end and a distal end of the battery case forms an LIMD distal end. A non-conductive coupler mechanically secures a terminal end of the battery case to a mating end of the end cap, while maintaining the battery case and end cap electrically separated. A first electrode projects from the proximal end of the end cap. An intra-cardiac (IC) device extension projects from the distal end of the battery case. The extension includes a second electrode that is electrically connected to the battery case. The second electrode is located remote from the LIMD distal end. An electronics module is located within an internal cavity of the end cap and communicates with the first and second electrodes.
摘要翻译：无引线植入式医疗装置（LIMD）包括由电池和端盖形成的壳体。端盖的近端形成LIMD近端，并且电池壳体的远端形成LIMD远端。非导电耦合器将电池壳体的终端机械地固定到端盖的配合端，同时保持电池壳体和端盖电气分离。第一电极从端盖的近端突出。心脏内（IC）装置延伸部从电池盒的远端伸出。该延伸部包括电连接到电池壳体的第二电极。第二电极远离LIMD远端。电子模块位于端盖的内部空腔内并与第一和第二电极连通。

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