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11. 发明申请

US20190022235A1 OSTEOTROPIC NANOPARTICLES FOR PREVENTION OR TREATMENT OF BONE METASTASES 审中-公开
公开(公告)号：US20190022235A1
公开(公告)日：2019-01-24
申请号：US16068235
申请日：2017-01-06
申请人： Paul N. Durfee , Charles Jeffrey Brinker , Yu-shen Lin , Hon Leong
发明人： Paul N. Durfee , Charles Jeffrey Brinker , Yu-shen Lin , Hon Leong
IPC分类号： A61K47/54 , A61K47/69 , A61K47/10 , A61K9/16 , A61P35/00
摘要： The present disclosure is directed to protocells or nanoparticles, which are optionally coated with a lipid bilayer, which can be used for targeting bone tissue for the delivery of bioactive agents useful in the treatment and/or diagnosis of bone cancer, often metastatic bone cancer which often occurs secondary to a primary cancer such as prostate cancer, breast cancer, lung cancer and ovarian cancer, among numerous others. These protocells or nanoparticles target bone cancer especially metastatic bone cancer with bioactive agents including anticancer agents and/or diagnostic agents for purposes of treating, diagnosing and/or monitoring the therapy of the bone cancer. Osteotropic protocells or nanoparticles, pharmaceutical compositions comprising a population of osteotropic protocells or nanoparticles and methods of diagnosing, treating and/or monitoring therapy of bone cancer are representative aspects.

12. 发明授权

US06471761B2 Prototyping of patterned functional nanostructures 有权
公开(公告)号：US06471761B2
公开(公告)日：2002-10-29
申请号：US09838153
申请日：2001-04-20
申请人： Hongyou Fan , Gabriel P. Lopez , Charles Jeffrey Brinker , Yunfeng Lu
发明人： Hongyou Fan , Gabriel P. Lopez , Charles Jeffrey Brinker , Yunfeng Lu
IPC分类号： C09D500
CPC分类号： C08G77/04 , C09D4/00 , C09D183/02 , C09D183/08 , C30B7/00 , C30B7/005 , C30B29/605 , Y10T428/31663 , C08G77/28 , C08G77/26
摘要： The present invention provides a coating composition comprising: A coating composition comprising: TEOS; a surfactant; at least one organosilane; HCl; water; and ethanol. The present invention also provides films made from such a coating composition and a method for making such films.

13. 发明授权

US5935646A Molecular sieving silica membrane fabrication process 失效
标题翻译：分子筛二氧化硅膜的制造工艺
公开(公告)号：US5935646A
公开(公告)日：1999-08-10
申请号：US13346
申请日：1998-01-26
申请人： Narayan K. Raman , Charles Jeffrey Brinker
发明人： Narayan K. Raman , Charles Jeffrey Brinker
IPC分类号： B01D53/22 , B01D67/00 , B01D71/02 , B01J35/06 , B01J37/02 , B01J37/03 , C01B37/02 , B05D5/00
CPC分类号： B01D53/228 , B01D67/0046 , B01D67/0058 , B01D71/027 , B01D71/028 , B01J35/065 , B01J37/0246 , C01B37/02 , B01D2323/08 , B01J37/03
摘要： A process for producing a molecular sieve silica membrane comprising depositing a hybrid organic-inorganic polymer comprising at least one organic constituent and at least one inorganic constituent on a porous substrate material and removing at least a portion of the at least one organic constituent of the hybrid organic-inorganic polymer, forming a porous film.
摘要翻译：一种生产分子筛二氧化硅膜的方法，包括将包含至少一种有机成分和至少一种无机成分的杂化有机 - 无机聚合物沉积在多孔基材上，并除去杂化物的至少一种有机成分的至少一部分有机 - 无机聚合物，形成多孔膜。

14. 发明授权

US5772735A Supported inorganic membranes 失效
标题翻译：支持无机膜
公开(公告)号：US5772735A
公开(公告)日：1998-06-30
申请号：US896716
申请日：1997-07-18
申请人： Rakesh Sehgal , Charles Jeffrey Brinker
发明人： Rakesh Sehgal , Charles Jeffrey Brinker
IPC分类号： B01D53/22 , B01D71/02 , B01J37/02
CPC分类号： B01D67/0048 , B01D53/228 , B01D71/024 , B01D71/027 , B01J37/0246 , B01D2323/08 , B01D2325/04
摘要： Supported inorganic membranes capable of molecular sieving, and methods for their production, are provided. The subject membranes exhibit high flux and high selectivity. The subject membranes are substantially defect free and less than about 100 nm thick. The pores of the subject membranes have an average critical pore radius of less than about 5 .ANG., and have a narrow pore size distribution. The subject membranes are prepared by coating a porous substrate with a polymeric sol, preferably under conditions of low relative pressure of the liquid constituents of the sol. The coated substrate is dried and calcined to produce the subject supported membrane. Also provided are methods of derivatizing the surface of supported inorganic membranes with metal alkoxides. The subject membranes find use in a variety of applications, such as the separation of constituents of gaseous streams, as catalysts and catalyst supports, and the like.
摘要翻译：提供了能够进行分子筛的负载型无机膜及其制造方法。主题膜表现出高通量和高选择性。主体膜基本上无缺陷且小于约100nm厚。目标膜的孔的平均临界孔半径小于约5，具有窄的孔径分布。通过用聚合物溶胶涂覆多孔基材，优选在溶胶的液体组分的相对压力低的条件下制备目标膜。将涂覆的基底干燥并煅烧以产生受试者支撑的膜。还提供了用金属醇盐衍生负载的无机膜的表面的方法。本发明的膜可用于各种应用，例如气流成分的分离，作为催化剂和催化剂载体等。

15. 发明授权

US06913832B2 Prototyping of patterned functional nanostructures 有权
标题翻译：图案化功能纳米结构的原型
公开(公告)号：US06913832B2
公开(公告)日：2005-07-05
申请号：US10163425
申请日：2002-06-07
申请人： Hongyou Fan , Gabriel P. Lopez , Charles Jeffrey Brinker , Yunfeng Lu
发明人： Hongyou Fan , Gabriel P. Lopez , Charles Jeffrey Brinker , Yunfeng Lu
IPC分类号： C09D183/04 , C09D4/00 , C09D5/00 , C09D183/02 , C09D183/08 , C09D183/14 , C30B7/00 , B32B25/20
CPC分类号： C08G77/04 , C09D4/00 , C09D183/02 , C09D183/08 , C30B7/00 , C30B7/005 , C30B29/605 , Y10T428/31663 , C08G77/28 , C08G77/26
摘要： The present invention provides a coating composition comprising: A coating composition comprising: TEOS; a surfactant; at least one organosilane; HCl; water; and ethanol. The present invention also provides films made from such a coating composition and a method for making such films.
摘要翻译：本发明提供一种涂料组合物，其包含：涂料组合物，其包含：TEOS; 表面活性剂; 至少一种有机硅烷; HCl; 水; 和乙醇。本发明还提供了由这种涂料组合物制成的薄膜和制造这种薄膜的方法。

16. 发明授权

US5948482A Ambient pressure process for preparing aerogel thin films reliquified sols useful in preparing aerogel thin films 失效
标题翻译：用于制备气凝胶薄膜的环境压力方法用于制备气凝胶薄膜的重新溶解的溶胶
公开(公告)号：US5948482A
公开(公告)日：1999-09-07
申请号：US530543
申请日：1995-09-19
申请人： Charles Jeffrey Brinker , Sai Sivasankaran Prakash
发明人： Charles Jeffrey Brinker , Sai Sivasankaran Prakash
IPC分类号： C01B13/14 , C01B33/158 , B05D1/18 , B05D3/00
CPC分类号： C01B33/1585 , C01B13/145 , C01P2006/14 , Y02P20/544
摘要： A method for preparing aerogel thin films by an ambient-pressure, continuous process. The method of this invention obviates the use of an autoclave and is amenable to the formation of thin films by operations such as dip coating. The method is less energy intensive and less dangerous than conventional supercritical aerogel processing techniques.
摘要翻译：一种通过环境压力连续工艺制备气凝胶薄膜的方法。本发明的方法避免了高压釜的使用，并且可以通过诸如浸涂的操作来形成薄膜。该方法比传统的超临界气凝胶处理技术更少能量密集和危险性较小。

17. 发明授权

US5770275A Molecular sieving silica membrane fabrication process 失效
公开(公告)号：US5770275A
公开(公告)日：1998-06-23
申请号：US702745
申请日：1996-08-23
申请人： Narayan K. Raman , Charles Jeffrey Brinker
发明人： Narayan K. Raman , Charles Jeffrey Brinker
IPC分类号： B01D53/22 , B01D67/00 , B01D71/02 , B01J35/06 , B01J37/02 , B01J37/03 , C01B37/02 , H05H1/00
CPC分类号： B01D67/0058 , B01D53/228 , B01D67/0046 , B01D71/027 , B01D71/028 , B01J35/065 , B01J37/0246 , C01B37/02 , B01D2323/08 , B01J37/03 , Y02C10/10
摘要： A process for producing a molecular sieve silica membrane comprising depositing a hybrid organic-inorganic polymer comprising at least one organic constituent and at least one inorganic constituent on a porous substrate material and removing at least a portion of the at least one organic constituent of the hybrid organic-inorganic polymer, forming a porous film.

18. 发明授权

US11672866B2 Osteotropic nanoparticles for prevention or treatment of bone metastases 有权
公开(公告)号：US11672866B2
公开(公告)日：2023-06-13
申请号：US16068235
申请日：2017-01-06
申请人： Paul N. Durfee , Charles Jeffrey Brinker , Yu-Shen Lin , Hon Leong
发明人： Paul N. Durfee , Charles Jeffrey Brinker , Yu-Shen Lin , Hon Leong
IPC分类号： A61K47/54 , A61K9/51 , A61P35/00 , A61K9/16 , B82Y5/00 , A61K47/69 , C12N15/88 , A61K47/10 , A61K45/06
CPC分类号： A61K47/548 , A61K9/16 , A61K9/5115 , A61K9/5123 , A61K9/5192 , A61K47/10 , A61K47/6923 , A61P35/00 , C12N15/88 , A61K45/06 , A61K2300/00 , B82Y5/00
摘要： The present disclosure is directed to protocells or nanoparticles, which are optionally coated with a lipid bilayer, which can be used for targeting bone tissue for the delivery of bioactive agents useful in the treatment and/or diagnosis of bone cancer, often metastatic bone cancer which often occurs secondary to a primary cancer such as prostate cancer, breast cancer, lung cancer and ovarian cancer, among numerous others. These protocells or nanoparticles target bone cancer especially metastatic bone cancer with bioactive agents including anticancer agents and/or diagnostic agents for purposes of treating, diagnosing and/or monitoring the therapy of the bone cancer. Osteotropic protocells or nanoparticles, pharmaceutical compositions comprising a population of osteotropic protocells or nanoparticles and methods of diagnosing, treating and/or monitoring therapy of bone cancer are representative aspects.

19. 发明申请

US20200009264A1 ACTIVE TARGETING OF CELLS BY MONOSIZED PROTOCELLS 审中-公开
公开(公告)号：US20200009264A1
公开(公告)日：2020-01-09
申请号：US16490280
申请日：2018-03-01
申请人： Charles Jeffrey Brinker , Kimberly Butler , Paul N. Durfee
发明人： Charles Jeffrey Brinker , Kimberly Butler , Paul N. Durfee
IPC分类号： A61K47/69 , C07K16/30 , A61P35/02 , C07K16/28
摘要： In one aspect, the disclosure provides mesoporous silica nanoparticles (MSNPs), monodisperse populations of MSNPs and related protocells which exhibit cell binding specificity. For example, MSNPs and protocells of the disclosure may be used to target specific delivery of therapeutic agents to CD19 or EGFR expressing cancer cells, or target specific delivery of therapeutic agents to other cell types. Related protocells, pharmaceutical compositions and therapeutic and diagnostic methods are also provided.

20. 发明申请

US20180049984A1 Carriers for Plasmid and RNP Delivery in the Treatment of Cancer and Other Disease States 审中-公开
公开(公告)号：US20180049984A1
公开(公告)日：2018-02-22
申请号：US15474810
申请日：2017-03-30
申请人： Charles Jeffrey Brinker , Eric C. Carnes , Carlee Erin Ashley , Joshua Santarpia , Adrienne Celeste Greene , Oscar Negrete , Steven Branda , Ayse Muniz , Jacob Ongundi Agola , Kimberly Butler
发明人： Charles Jeffrey Brinker , Eric C. Carnes , Carlee Erin Ashley , Joshua Santarpia , Adrienne Celeste Greene , Oscar Negrete , Steven Branda , Ayse Muniz , Jacob Ongundi Agola , Kimberly Butler
IPC分类号： A61K9/127 , C12N9/22 , A61K9/51 , A61K49/00
CPC分类号： A61K9/1274 , A61K9/501 , A61K9/5115 , A61K9/5123 , A61K31/7088 , A61K45/06 , A61K48/005 , A61K49/005 , C12N9/22 , C12N15/8206 , C12N2310/11 , C12N2310/20
摘要： The present disclosure relates to the delivery of polynucleotides and/or oligonucleotides using silica delivery platforms, e.g., silica carriers or protocells. In particular, in the present disclosure, polynucleotides in the form of plasmids expressing siRNA may be administered as cargo in the silica delivery platform to a patient or subject to inhibit and/or treat cancer in a patient. In one aspect, the silica delivery platform that have been charged with cargo comprising plasmid DNA (in particular, CRISPR ds plasmid DNA) which expresses siRNA, shRNA, mRNA and other RNA which may be used to administer these plasmids to patients in order to effect inhibition of cancer cells (especially including apoptosis of those cancer cells) and effective and/or prophylaxis of cancer, as well as numerous pathogens, including viruses, bacteria, fungi, and/or other disease states and/or conditions. In another aspect, the silica delivery platform comprises a biological package (e.g., plasmid nucleic acid, such as a for a CRISPR/Cas system) that interacts with a genomic sequence to either activate or inhibit gene expression. Such vehicles can be employed to control gene activation and repression in a host (e.g., a patient) and/or a pathogen.

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