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11. 发明申请

US20110270067A1 Biocompatible Bonding Method 审中-公开
标题翻译：生物相容性粘合法
公开(公告)号：US20110270067A1
公开(公告)日：2011-11-03
申请号：US13097399
申请日：2011-04-29
申请人： Boozarjomehr Faraji , Robert J. Greenberg , James S. Little , Jerry Ok , Neil Hamilton Talbot , David Daomin Zhou
发明人： Boozarjomehr Faraji , Robert J. Greenberg , James S. Little , Jerry Ok , Neil Hamilton Talbot , David Daomin Zhou
IPC分类号： A61B5/04 , H05K13/04 , B32B38/00 , B32B37/12 , B32B37/16 , A61N1/36 , B32B37/02
CPC分类号： H01L21/563 , A61B5/04001 , A61B2562/125 , A61N1/0543 , A61N1/36046 , A61N1/3752 , H01L24/29 , H01L24/32 , H01L24/83 , H01L2224/16225 , H01L2224/2919 , H01L2224/32225 , H01L2224/45169 , H01L2224/48091 , H01L2224/48465 , H01L2224/73203 , H01L2224/73204 , H01L2224/73265 , H01L2224/81193 , H01L2224/81801 , H01L2224/838 , H01L2224/92125 , H01L2924/01005 , H01L2924/01006 , H01L2924/01013 , H01L2924/01033 , H01L2924/01041 , H01L2924/01045 , H01L2924/01047 , H01L2924/01073 , H01L2924/01074 , H01L2924/01077 , H01L2924/01078 , H01L2924/01079 , H01L2924/01082 , H01L2924/014 , H01L2924/0665 , H01L2924/0781 , H01L2924/12042 , H01L2924/14 , H01L2924/15787 , H01L2924/19107 , H01L2924/3011 , Y10T156/10 , H01L2924/00014 , H01L2924/00 , H01L2924/3512
摘要： The invention is a device and method for connecting a hermetic package to a flexible circuit such as for an electrode array in an implantable device. Attaching metal pads on a flexible circuit to metal pads on a hermetic device by conductive adhesive is known. A smooth metal, such as platinum, does not bond well to conductive epoxy. The invention provides a roughened surface, such as etching or applying high surface area platinum gray, to improve adhesion to platinum or other metal pads.
摘要翻译：本发明是一种用于将密封包装连接到诸如用于可植入装置中的电极阵列的柔性电路的装置和方法。通过导电粘合剂将柔性电路上的金属焊盘连接到密封设备上的金属焊盘是已知的。光滑的金属，如铂，不能很好地粘结到导电环氧树脂上。本发明提供了粗糙化的表面，例如蚀刻或施加高表面积的白金灰，以改善与铂或其它金属垫的粘合性。

12. 发明申请

US20120296444A1 Cortical Interface for Motor Signal Recording and Sensory Signal Stimulation 审中-公开
标题翻译：用于电机信号记录和感觉信号刺激的皮质接口
公开(公告)号：US20120296444A1
公开(公告)日：2012-11-22
申请号：US13473470
申请日：2012-05-16
申请人： Robert J. Greenberg , David Daomin Zhou , Brian V. Mech , Neil Hamilton Talbot , Rongqing Dai , Richard Agustin Castro , Kelly H. McClure
发明人： Robert J. Greenberg , David Daomin Zhou , Brian V. Mech , Neil Hamilton Talbot , Rongqing Dai , Richard Agustin Castro , Kelly H. McClure
IPC分类号： A61F2/72 , A61N1/04 , A61B5/0476
CPC分类号： A61N1/36082 , A61B5/04001 , A61B5/4064 , A61B5/6868 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/375 , H01L2224/05599 , H01L2224/45144 , H01L2224/48227 , H01L2224/48465 , H01L2224/85099 , H01L2224/85399 , H01L2924/3011 , H05K1/118 , H05K1/189 , H05K2201/0154 , H05K2201/10098 , H01L2924/00 , H01L2924/00014
摘要： The present invention consists of an implantable device with at least one package that houses electronics that sends and receives data or signals, and optionally power, from an external system through at least one coil attached to the at least one package and processes the data, including recordings of neural activity, and delivers electrical pulses to neural tissue through at least one array of multiple electrodes that is/are attached to the at least one package. The device is adapted to electrocorticographic (ECoG) and local field potential (LFP) signals. The output signals provide control for a motor prosthesis and the inputs signals provide sensory feedback for the motor prosthesis. The invention, or components thereof, is/are intended to be installed in the head, or on or in the cranium or on the dura, or on or in the brain.
摘要翻译：本发明包括具有至少一个封装的可植入装置，所述至少一个封装容纳电子装置，所述电子装置通过连接到所述至少一个封装件的至少一个线圈从外部系统发送和接收数据或信号，并且选择性地供电，并处理数据，包括记录神经活动，并通过连接到至少一个包装的多个电极的至少一个阵列将电脉冲传递给神经组织。该器件适用于电皮质（ECoG）和局部场电位（LFP）信号。输出信号提供对电动机假体的控制，并且输入信号为电动机假体提供感觉反馈。本发明或其组分旨在安装在头部，或在头颅或硬脑膜上，或脑中或脑中。

13. 发明授权

US09643002B2 Method of manufacturing a flexible circuit electrode array with at least one tack opening 有权
公开(公告)号：US09643002B2
公开(公告)日：2017-05-09
申请号：US13167074
申请日：2011-06-23
申请人： Robert J. Greenberg , Neil Hamilton Talbot , Jordan Matthew Neysmith , James Singleton Little , Brian V. Mech
发明人： Robert J. Greenberg , Neil Hamilton Talbot , Jordan Matthew Neysmith , James Singleton Little , Brian V. Mech
IPC分类号： A61N1/05 , A61N1/36 , H05K1/11 , H05K3/00
CPC分类号： A61N1/0543 , A61N1/36046 , H05K1/036 , H05K1/0393 , H05K1/118 , H05K3/0014 , H05K2201/05 , H05K2201/053 , H05K2201/09063 , H05K2201/09409 , Y10T29/49002 , Y10T29/49117 , Y10T29/49155 , Y10T29/49156 , Y10T29/49158 , Y10T29/49174 , Y10T29/49176
摘要： The present invention provides a flexible circuit electrode array adapted for neural stimulation, comprising: a polymer base layer; metal traces deposited on the polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on the polymer base layer and the metal traces at least one tack opening. The present invention provides further a method of making a flexible circuit electrode array comprising depositing a polymer base layer; depositing metal on the polymer base layer; patterning the metal to form metal traces; depositing a polymer top layer on the polymer base layer and the metal traces; and preparing at least one tack opening.

14. 发明授权

US07937153B2 Electrode with increased stability and method of manufacturing the same 有权
标题翻译：增加稳定性的电极及其制造方法
公开(公告)号：US07937153B2
公开(公告)日：2011-05-03
申请号：US11820744
申请日：2007-06-19
申请人： Dao Min Zhou , Jerry Ok , Neil Hamilton Talbot , Brian V. Mech , James Singleton Little , Robert J. Greenberg
发明人： Dao Min Zhou , Jerry Ok , Neil Hamilton Talbot , Brian V. Mech , James Singleton Little , Robert J. Greenberg
IPC分类号： A61N1/00
CPC分类号： A61N1/0543 , A61N1/36046
摘要： An implantable electrode with increased stability having a clustered structure wherein the surface of the electrode is covered with a material comprising openings which are filled with sticks or posts. An implantable electrode with increased stability wherein the surface is of the electrode comprises mesh grids which are filled with sticks which are filed with a conducting or insulating material. A method of manufacturing an electrode with increased stability, comprising: depositing a metal layer on an base layer; applying photoresist layer on the metal layer; patterning the photoresist layer providing openings; electroplating the openings with metal; removing the photoresist layer leaving spaces; and filling the spaces with polymer. A method of manufacturing an electrode with increased stability, comprising: depositing a metal layer on an base layer; applying a polymer layer on the metal layer; applying photoresist layer on the polymer layer; patterning the photoresist layer providing openings; electroplating the openings with metal; and removing the photoresist layer.
摘要翻译：具有增加的稳定性的可植入电极具有聚集结构，其中电极的表面被包括充满棒或柱的开口的材料覆盖。具有增加的稳定性的可植入电极，其中电极的表面包括填充有用导电或绝缘材料填充的棒的网状网格。一种制造具有增加的稳定性的电极的方法，包括：在基底层上沉积金属层; 在金属层上施加光致抗蚀剂层; 图案化提供开口的光致抗蚀剂层; 用金属电镀开口; 去除留下空间的光致抗蚀剂层; 并用聚合物填充空间。一种制造具有增加的稳定性的电极的方法，包括：在基底层上沉积金属层; 在金属层上施加聚合物层; 在聚合物层上施加光致抗蚀剂层; 图案化提供开口的光致抗蚀剂层; 用金属电镀开口; 并除去光致抗蚀剂层。

15. 发明授权

US07631424B2 Method of making electrode array with a tack opening 有权
标题翻译：制作具有开口的电极阵列的方法
公开(公告)号：US07631424B2
公开(公告)日：2009-12-15
申请号：US11928698
申请日：2007-10-30
申请人： Robert J. Greenberg , Neil Hamilton Talbot , Jordan Matthew Neysmith , James Singleton Little , Brian V. Mech
发明人： Robert J. Greenberg , Neil Hamilton Talbot , Jordan Matthew Neysmith , James Singleton Little , Brian V. Mech
IPC分类号： H01R41/00 , A61B5/04 , A61N1/00
CPC分类号： A61N1/0543 , A61N1/36046 , H05K1/036 , H05K1/0393 , H05K1/118 , H05K3/0014 , H05K2201/05 , H05K2201/053 , H05K2201/09063 , H05K2201/09409 , Y10T29/49002 , Y10T29/49117 , Y10T29/49155 , Y10T29/49156 , Y10T29/49158 , Y10T29/49174 , Y10T29/49176
摘要： The present invention provides a flexible circuit electrode array adapted for neural stimulation, comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces at least one tack opening; wherein said polymer base layer, said metal traces and said polymer top layer are thermoformed in a three dimensional shape.The present invention provides further a method of making a flexible circuit electrode array comprising depositing a polymer base layer; depositing metal on said polymer base layer; patterning said metal to form metal traces; depositing a polymer top layer on said polymer base layer and said metal traces; preparing at least one tack opening; and heating said flexible circuit electrode array in a mold to form a three dimensional shape in said flexible circuit electrode array.
摘要翻译：本发明提供一种适用于神经刺激的柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基层上的聚合物顶层和所述金属迹线至少一个粘性开口; 其中所述聚合物基层，所述金属迹线和所述聚合物顶层被热成型为三维形状。本发明还提供一种制造柔性电路电极阵列的方法，包括沉积聚合物基层; 在所述聚合物基层上沉积金属; 图案化所述金属以形成金属痕迹; 在所述聚合物基底层和所述金属迹线上沉积聚合物顶层; 准备至少一个开口; 并将所述柔性电路电极阵列加热到模具中，以在所述柔性电路电极阵列中形成三维形状。

16. 发明授权

US09861809B2 Flexible circuit electrode array with wire or film support 有权
公开(公告)号：US09861809B2
公开(公告)日：2018-01-09
申请号：US12032627
申请日：2008-02-15
申请人： Robert J. Greenberg , Eugene de Juan , Mark S. Humayun , Kelly H. McClure , Neil Hamilton Talbot , Jordan Matthew Neysmith , Brian V. Mech , James Singleton Little , Mohamed Khaldi
发明人： Robert J. Greenberg , Eugene de Juan , Mark S. Humayun , Kelly H. McClure , Neil Hamilton Talbot , Jordan Matthew Neysmith , Brian V. Mech , James Singleton Little , Mohamed Khaldi
IPC分类号： A61N1/00 , A61N1/05 , H05K1/03 , H05K1/11
CPC分类号： A61N1/0543 , A61N1/05 , A61N1/0541 , H05K1/0393 , H05K1/118
摘要： The disclosure relates to a flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and at least one support embedded in said array. The disclosure further relates to a flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a folded flexible circuit cable connecting the electrode array with an interconnection pad. The disclosure further relates to a method of making a flexible circuit electrode array comprising: depositing a polymer base layer; depositing metal on said polymer base layer; patterning said metal to form metal traces; depositing a polymer top layer on said polymer base layer and said metal traces; heating said flexible circuit electrode array in a mold to form a three dimensional shape in said flexible circuit electrode array, embedding a support at least in the base layer, top layer or between the base and top layer, and/or folding a flexible circuit cable at least once connecting the electrode array with an interconnection pad the array.

17. 发明授权

US08391987B2 Implantable package to facilitate inspection 有权
公开(公告)号：US08391987B2
公开(公告)日：2013-03-05
申请号：US13360480
申请日：2012-01-27
申请人： Boozarjomehr Faraji , Kevin Jun Ha , Neil Hamilton Talbot , James Singleton Little , Robert J. Greenberg
发明人： Boozarjomehr Faraji , Kevin Jun Ha , Neil Hamilton Talbot , James Singleton Little , Robert J. Greenberg
IPC分类号： A61N1/00
CPC分类号： A61N1/0543 , A61N1/0526 , A61N1/36046 , A61N1/375 , G01N29/00 , G01N29/26
摘要： The present invention is a non-destructive method of inspecting a bond, particularly a braze bond, in a hermetic package. The invention involves a unique hermetic package design adapted for ultrasonic inspection and a method of inspecting the package. This package and non-destructive inspection process are particularly useful in implantable neural stimulators such as visual prostheses.

18. 发明申请

US20120192416A1 Flexible Circuit Electrode Array 有权
标题翻译：柔性电路电极阵列
公开(公告)号：US20120192416A1
公开(公告)日：2012-08-02
申请号：US13422892
申请日：2012-03-16
申请人： Jordan Matthew Neysmith , Neil Hamilton Talbot , James Singleton Little , Brian V. Mech , Robert J. Greenberg , Qingfang Yao , Dao Min Zhou
发明人： Jordan Matthew Neysmith , Neil Hamilton Talbot , James Singleton Little , Brian V. Mech , Robert J. Greenberg , Qingfang Yao , Dao Min Zhou
IPC分类号： H05K3/46 , H05K3/42 , H05K3/02
CPC分类号： A61N1/0543 , A61N1/0541 , A61N1/36046 , H05K1/028 , H05K1/0353 , H05K1/09 , H05K1/111 , H05K1/115 , H05K1/118 , H05K3/0014 , H05K3/0017 , H05K3/0041 , H05K3/06 , H05K3/188 , H05K3/22 , H05K3/388 , H05K3/4644 , H05K2201/0129 , H05K2201/0133 , H05K2201/0141 , H05K2201/0154 , Y10T29/49156 , Y10T29/49158
摘要： A flexible circuit electrode array with more than one layer of metal traces comprising: a polymer base layer; more than one layer of metal traces, separated by polymer layers, deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; and a polymer top layer deposited on said polymer base layer and said metal traces. Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow.
摘要翻译：一种具有多于一层金属迹线的柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的多于一层由聚合物层隔开的金属痕迹层，包括适于刺激神经组织的电极; 以及沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层。聚合物材料可用作神经刺激的电极阵列体。它们对视网膜刺激特别有用，用于创建人造视觉，人工耳蜗刺激以创建人造听觉或皮质刺激许多目的。通过电极阵列对视网膜或其他神经组织施加的压力是至关重要的。太小的压力会导致电阻增加以及电场分散。太大的压力可能会阻止血液流动。

19. 发明申请

US20090270958A1 Simply Supported Neural Stimulation Electrode Array for Applying Pressure on Neural Tissue 审中-公开
标题翻译：用于神经组织施加压力的简单支持的神经刺激电极阵列
公开(公告)号：US20090270958A1
公开(公告)日：2009-10-29
申请号：US12429890
申请日：2009-04-24
申请人： Robert J. Greenberg , Mohamed Khaldi , James Singleton Little , Jordan Matthew Neysmith , Neil Hamilton Talbot
发明人： Robert J. Greenberg , Mohamed Khaldi , James Singleton Little , Jordan Matthew Neysmith , Neil Hamilton Talbot
IPC分类号： A61N1/05
CPC分类号： A61N1/0543 , A61N1/36046
摘要： The present invention is an electrode array for neural stimulation suitable to be attached to neural tissue such that the attachment point acts as a fulcrum like point and contact with an end of the array body presses the other end of the array body into the neural tissue to be stimulated. This invention is particularly useful in a retinal electrode array for a visual prosthesis. By curving an electrode portion of an array body to approximate but not exceed (never more tightly curved) the curvature of the retina and applying force to the array by external means at the fulcrum like point, approximately even pressure across all electrodes is achieved.
摘要翻译：本发明是一种用于神经刺激的电极阵列，其适用于附着于神经组织，使得附着点作为支点，并且与阵列体的端部接触将阵列体的另一端压入神经组织，被刺激。本发明在用于视觉假体的视网膜电极阵列中特别有用。通过将阵列体的电极部分弯曲成近似但不超过（从不更紧密地弯曲）视网膜的曲率并且通过外部装置在支点点处向阵列施加力，实现了跨所有电极的大致均匀的压力。

20. 发明申请

US20080221653A1 FLEXIBLE CIRCUIT ELECTRODE ARRAY 审中-公开
标题翻译：柔性电路阵列
公开(公告)号：US20080221653A1
公开(公告)日：2008-09-11
申请号：US12044830
申请日：2008-03-07
申请人： Rajat Agrawal , Robert J. Greenberg , Mark S. Humayun , James Singleton Little , Brian V. Mech , Jordan Matthew Neysmith , Neil Hamilton Talbot , Dao Min Zhou
发明人： Rajat Agrawal , Robert J. Greenberg , Mark S. Humayun , James Singleton Little , Brian V. Mech , Jordan Matthew Neysmith , Neil Hamilton Talbot , Dao Min Zhou
IPC分类号： A61N1/00
CPC分类号： A61N1/05 , A61N1/0541 , A61N1/0543 , A61N1/36046
摘要： A flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a central opening in the area of the metal traces. A flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a soft polymer filling an attachment point. A flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a hump to avoid a touching of the flexible electrode array and the optic nerve.
摘要翻译：一种柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层; 和金属痕迹区域的中心开口。一种柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层; 和填充附着点的软质聚合物。一种柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层; 和一个驼峰以避免触摸柔性电极阵列和视神经。

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