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11. 发明申请

US20070231339A1 Fungal immunostimulatory compositions 有权
标题翻译：真菌免疫刺激成分
公开(公告)号：US20070231339A1
公开(公告)日：2007-10-04
申请号：US11549215
申请日：2006-10-13
申请人： Alice Yu , John Yu , Kuo-I Lin , Wen-Bin Yang , Chi-Huey Wong
发明人： Alice Yu , John Yu , Kuo-I Lin , Wen-Bin Yang , Chi-Huey Wong
IPC分类号： A61K38/16 , A61K39/00 , C12N5/02
CPC分类号： A61K36/074 , A61K39/39 , A61K2039/57 , C12N5/0639 , C12N2500/74
摘要： Methods are disclosed which are useful in increasing maturation of dendritic cells from CD14+ mononuclear cells, by contact with a composition comprising a fucose-containing glycoprotein fraction from Ganoderma lucidum. The extract can also be used for increasing production of a cytokine or a chemokine in a dendritic cell or CD19+ B cell. In addition, a fucose-containing glycoprotein fraction from Ganoderma lucidum can be administered to a subject identified as needing increased immunoglobulin, cytokine, or chemokine production.
摘要翻译：通过与含有来自灵芝的含岩藻糖的糖蛋白部分的组合物的接触，公开了可用于从CD14 + +单核细胞增加树突状细胞成熟的方法。提取物也可用于增加树突状细胞或CD19 + B细胞中细胞因子或趋化因子的产生。此外，来自灵芝的含岩藻糖的糖蛋白部分可以施用于被鉴定为需要增加的免疫球蛋白，细胞因子或趋化因子产生的受试者。

12. 发明授权

US09255130B2 Puf-A and related compounds for treatment of retinopathies and sight-threatening ophthalmologic disorders 有权
标题翻译： Puf-A和相关化合物用于治疗视网膜病变和眼睛威胁眼科疾病
公开(公告)号：US09255130B2
公开(公告)日：2016-02-09
申请号：US13056975
申请日：2009-07-29
申请人： John Yu , Alice Yu , Ming-Wei Kuo , Jui-Chin Chang
发明人： John Yu , Alice Yu , Ming-Wei Kuo , Jui-Chin Chang
IPC分类号： A61K48/00 , C07K14/47 , C07K16/18 , C12N15/113 , C12Q1/68 , G01N33/68
CPC分类号： C07K14/4747 , A61K48/005 , C07K16/18 , C12N15/113 , C12N2799/025 , C12Q1/6876 , G01N33/6854
摘要： Methods and compositions for treating retinal diseases comprising therapeutic amounts of a compound selected from a normal Puf-A gene product, an active polypeptide fragment thereof, an analog thereof or a peptidomimetic thereof. Vectors, including AAV vectors comprising the therapeutic compound are provided. Puf-A compositions suitable for subretinal, intravitreal, topical, subconjunctival, retrobulbar, periocular, suprachoroidal, or intraocular administration are provided. Methods for screening siRNA, RNAi and shRNA, small molecules and monoclonal antibodies that inhibit Puf-A target activity and reduce apoptosis are provided.
摘要翻译：用于治疗视网膜疾病的方法和组合物包括治疗量的选自正常Puf-A基因产物，其活性多肽片段，其类似物或肽模拟物的化合物。提供载体，包括包含治疗化合物的AAV载体。提供适用于视网膜下，玻璃体内，局部，结膜下结膜，球后，眼周，脉络膜或眼内给药的Puf-A组合物。提供了筛选siRNA，RNAi和shRNA，抑制Puf-A靶活性和减少细胞凋亡的小分子和单克隆抗体的方法。

13. 发明申请

US20060085340A1 Methods and systems for managing consumer transactional accounts 有权
标题翻译：管理消费者交易账户的方法和系统
公开(公告)号：US20060085340A1
公开(公告)日：2006-04-20
申请号：US11169526
申请日：2005-06-29
申请人： Kevin Hung , Susan Moon , Eric Yellin , Alice Yu
发明人： Kevin Hung , Susan Moon , Eric Yellin , Alice Yu
IPC分类号： G06Q40/00
CPC分类号： G06Q40/02 , G06Q20/10 , G06Q20/102 , G06Q20/108 , G06Q30/04
摘要： Computer-implemented methods and systems for managing consumer transactional accounts provides a temporary line of credit with an installment option that a consumer can use for specific occasions or life events. The account remains open for only a limited period of time during which interest does not accrue. Thereafter, the account automatically expires, interest begins to accrue on the amount charged on the account, and an invoice is sent to the consumer with a number of payment options.
摘要翻译：用于管理消费者交易账户的计算机实现的方法和系统为消费者可以用于特定场合或生活事件的分期付款选项提供临时信用额度。该帐户只有在不产生利息的有限期间内才开放。此后，帐户自动到期，利息开始累积在帐户上的金额，发票将发送给具有多个付款方式的消费者。

14. 发明申请

US20130202678A1 PUF-A AND RELATED COMPOUNDS FOR TREATMENT OF RETINOPATHIES AND SIGHT-THREATENING OPHTHALMOLOGIC DISORDERS 有权
标题翻译： PUF-A及相关化合物治疗复发性眼病和视力障碍性眼病
公开(公告)号：US20130202678A1
公开(公告)日：2013-08-08
申请号：US13056975
申请日：2008-07-29
申请人： John Yu , Alice Yu , Ming-Wei Kuo , Jui-Chin Chang
发明人： John Yu , Alice Yu , Ming-Wei Kuo , Jui-Chin Chang
IPC分类号： C07K14/47 , G01N33/68 , C12Q1/68 , C12N15/113 , C07K16/18
CPC分类号： C07K14/4747 , A61K48/005 , C07K16/18 , C12N15/113 , C12N2799/025 , C12Q1/6876 , G01N33/6854
摘要： Methods and compositions for treating retinal diseases comprising therapeutic amounts of a compound selected from a normal Puf-A gene product, an active polypeptide fragment thereof, an analog thereof or a peptidomimetic thereof. Vectors, including AAV vectors comprising the therapeutic compound are provided. Puf-A compositions suitable for subretinal, intravitreal, topical, subconjunctival, retrobulbar, periocular, suprachoroidal, or intraocular administration are provided. Methods for screening siRNA, RNAi and shRNA, small molecules and monoclonal antibodies that inhibit Puf-A target activity and reduce apoptosis are provided.
摘要翻译：用于治疗视网膜疾病的方法和组合物包括治疗量的选自正常Puf-A基因产物，其活性多肽片段，其类似物或肽模拟物的化合物。提供载体，包括包含治疗化合物的AAV载体。提供适用于视网膜下，玻璃体内，局部，结膜下结膜，球后，眼周，脉络膜或眼内给药的Puf-A组合物。提供了筛选siRNA，RNAi和shRNA，抑制Puf-A靶活性和减少细胞凋亡的小分子和单克隆抗体的方法。

15. 发明申请

US20070087332A1 Pulmonary stem cells, related methods and kits of parts 审中-公开
标题翻译：肺干细胞，相关方法和成套工具
公开(公告)号：US20070087332A1
公开(公告)日：2007-04-19
申请号：US11252458
申请日：2005-10-17
申请人： John Yu , Alice Yu , Thai-Yen Ling
发明人： John Yu , Alice Yu , Thai-Yen Ling
IPC分类号： C12Q1/70 , C12N7/00 , C12N5/08 , C12N15/86
CPC分类号： C12N7/00 , C12N5/0689 , C12N2500/25 , C12N2501/11 , C12N2760/16011 , C12N2770/20011
摘要： Isolated pulmonary stem cells, the isolated pulmonary stem cells being slowly dividing Oct-4 expressing cells forming individual colonies and able to undergoing terminal differentiation into a mature phenotype in vitro; a method to identify stem cells of a tissue; a kit for the identification of stem cell of a tissue; a method for identifying an infective agent able to infect pulmonary cells; a method for the production of a virus able to infect pulmonary cells and method for identifying a compound interfering with infection of a cell by an infective agent.
摘要翻译：分离的肺干细胞，分离的肺干细胞正在缓慢分化形成单个菌落的Oct-4表达细胞，并能够在体外进行末端分化成成熟表型; 识别组织干细胞的方法; 用于鉴定组织干细胞的试剂盒; 用于鉴定能够感染肺细胞的感染剂的方法; 用于生产能够感染肺细胞的病毒的方法和用于鉴定通过感染剂干扰细胞感染的化合物的方法。

16. 发明申请

US20060129471A1 Methods and systems for managing financial accounts 审中-公开
标题翻译：管理财务账目的方法和系统
公开(公告)号：US20060129471A1
公开(公告)日：2006-06-15
申请号：US11186278
申请日：2005-07-21
申请人： Susan Moon , B. Ballman , Evan Minskoff , Alice Yu , Kevin Hung
发明人： Susan Moon , B. Ballman , Evan Minskoff , Alice Yu , Kevin Hung
IPC分类号： G06Q40/00
CPC分类号： G06Q40/02 , G06Q40/00
摘要： Computer-implemented methods and systems for managing a special-purpose financial account involve establishing the account by a financial institution for a consumer relating to at least one consumer-designated future purchase for a pre-determined purchase price. Thereafter, contributions to a principal balance of the account are received and interest is accrued on the principal balance by the financial institution until the principal balance and accrued interest reaches a consumer-designated target amount, at which time, the principal balance and accrued interest are disposed of according to pre-defined parameters that can involve forfeiture of the accrued interest, depending on the consumer's actions.
摘要翻译：用于管理专用金融账户的计算机实现的方法和系统涉及由金融机构为消费者建立与至少一个消费者指定的未来购买预定购买价格的消费者的账户。此后，收到对该账户本金余额的会费，并由金融机构在本金余额上计提利息，直至本金余额和应计利息达到消费者指定的目标金额，此时本金余额和应计利息为根据预先定义的参数进行处置，这些参数可能涉及到没收应计利息，具体取决于消费者的行为。

17. 发明申请

US20060129454A1 Methods and systems for implementing a group buy 审中-公开
标题翻译：实施小组购买的方法和系统
公开(公告)号：US20060129454A1
公开(公告)日：2006-06-15
申请号：US11205825
申请日：2005-08-17
申请人： Susan Moon , Eric Yellin , Alice Yu , Kevin Hung , Evan Minskoff , B. Ballman
发明人： Susan Moon , Eric Yellin , Alice Yu , Kevin Hung , Evan Minskoff , B. Ballman
IPC分类号： G06Q30/00
CPC分类号： G06Q30/02 , G06Q30/0255 , G06Q30/06 , G06Q30/0601
摘要： Methods and systems for utilizing consumer transaction data to target and aggregate consumers for a group purchase involve maintaining a database storing transaction data consisting at least in part of data related to product purchase transactions for a plurality of consumers and analyzing the data related to product purchase transactions to identify members of a group of said plurality of consumers with a purchase history indicative of a preference for purchasing products in at least one pre-defined category of products. Based on such “data mining”, each member of the identified group of consumers is provided an offer to participate in a group purchase in which each member of the group who accepts the offer agrees to purchase a pre-designated product within the at least one category of products, and a purchase of a quantity of the pre-designated product from a vendor is negotiated at a discounted price based at least on part on an aggregation of purchasing power of the members of the group who accept the offer to participate in the group purchase.
摘要翻译：用于利用消费者交易数据来定价和聚集消费者进行组购买的方法和系统包括维护数据库，存储至少部分由多个消费者的产品购买交易相关数据组成的数据，并分析与产品购买交易有关的数据以具有指示在至少一个预定义类别的产品中购买产品的偏好的购买历史来识别一组所述多个消费者的成员。基于这样的“数据挖掘”，所识别的消费群体的每个成员被提供参与群组购买的提议，其中接受该优惠的组的每个成员同意在至少一个内部购买预先指定的产品至少部分地基于接受要约参与的组的成员的购买力的集合，以折扣价格协商商品类别和从供应商购买一定数量的预先指定的产品。团购。

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