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11. 发明授权

US4892101A Method and apparatus for offsetting baseline portion of oximeter signal 失效
标题翻译：用于抵消血氧计信号基线部分的方法和装置
公开(公告)号：US4892101A
公开(公告)日：1990-01-09
申请号：US315330
申请日：1989-02-24
申请人： Peter W. Cheung , Karl F. Gauglitz , Lee R. Mason , Stephen J. Prosser , Robert E. Smith , Darrell O. Wagner , Scott W. Hunsaker
发明人： Peter W. Cheung , Karl F. Gauglitz , Lee R. Mason , Stephen J. Prosser , Robert E. Smith , Darrell O. Wagner , Scott W. Hunsaker
IPC分类号： A61B5/00
CPC分类号： A61B5/14551
摘要： A feedback control system is disclosed for use in processing signals employed in pulse transmittance oximetry. The signals are produced in response to light transmitted through, for example, a finger at two different wavelengths. Each signal includes a slowly varying baseline component representing the relatively fixed attenuation of light produced by bone, tissue, skin, and hair. The signals also include pulsatile components representing the attenuation produced by the changing blood volume and oxygen saturation within the finger. The signals are processed by the feedback control system before being converted by an analog-to-digital (A/D) converter (72) for subsequent analysis by a microcomputer (16). The feedback control system includes a controllable offset subtractor (66), a programmable gain amplifier (68), controllable drivers (44) for the light sources (40, 42), and the microcomputer (16). The microcomputer (16) receives signals from the offset subtractor (66), gain amplifier (68), drivers (44) and A/D converter (72) to produce signals that control the function of the subtractor (66) and drivers (44) in the following manner. Normally, the drivers ( 44) are maintained within a predetermined current range. In the event the microcomputer (16) senses an output from the converter (72) that is not within a predetermined range, the drive signal is adjusted to produce an acceptable signal. The magnitude of the offset removed by the subtractor (66), as controlled by the microcomputer (16), is maintained at a constant level when the converter (72) output is within a first predetermined range and is a predetermined function of the converter (72) output when that output falls within a second predetermined range.
摘要翻译：公开了一种反馈控制系统，用于处理脉冲透射比率测定中使用的信号。信号是响应于透过例如两个不同波长的手指的光产生的。每个信号包括缓慢变化的基线分量，其表示由骨，组织，皮肤和头发产生的光的相对固定的衰减。信号还包括表示由手指内的血液体积变化和氧饱和度产生的衰减的脉动成分。这些信号由模拟数字（A / D）转换器（72）转换之前由反馈控制系统处理，用于微计算机（16）的后续分析。反馈控制系统包括可控偏移减法器（66），可编程增益放大器（68），用于光源（40,42）的可控驱动器（44）和微计算机（16）。微型计算机（16）从偏移减法器（66），增益放大器（68），驱动器（44）和A / D转换器（72）接收信号，以产生控制减法器（66）和驱动器（44）的功能的信号）。通常，驱动器（44）保持在预定的电流范围内。在微计算机（16）感测到转换器（72）的输出不在预定范围内的情况下，调节驱动信号以产生可接受的信号。当转换器（72）输出在第一预定范围内并且是转换器的预定功能时，被微计算机（16）控制的减法器（66）去除的偏移量的幅度保持在恒定水平 72）当该输出处于第二预定范围内时输出。

12. 发明授权

US08843196B2 Subcutaneous cardiac sensing and stimulation system 有权
标题翻译：皮下心脏感知和刺激系统
公开(公告)号：US08843196B2
公开(公告)日：2014-09-23
申请号：US13237221
申请日：2011-09-20
申请人： Apurv Kamath , Paul Haefner , Darrell O. Wagner , Marina Brockway
发明人： Apurv Kamath , Paul Haefner , Darrell O. Wagner , Marina Brockway
IPC分类号： A61N1/05 , A61N1/39 , A61N1/365 , A61B17/00 , A61B19/00 , A61B17/34 , A61N1/37 , A61B17/32 , A61B17/3203 , A61B18/00
CPC分类号： A61N1/3956 , A61B17/320068 , A61B17/3203 , A61B17/3415 , A61B17/3417 , A61B90/30 , A61B2017/00243 , A61B2017/00247 , A61B2017/320044 , A61B2017/320084 , A61B2018/00392 , A61B2090/3945 , A61B2090/3979 , A61B2217/005 , A61B2217/007 , A61N1/05 , A61N1/056 , A61N1/0568 , A61N1/0587 , A61N1/36542 , A61N1/36585 , A61N1/37 , A61N1/3925 , A61N1/3962 , A61N1/3987
摘要： Cardiac systems and methods using ECG and blood information for arrhythmia detection and discrimination. Detection circuitry is configured to produce an ECG. An implantable blood sensor configured to produce a blood sensor signal is coupled to a processor. The processor is coupled to the detection and energy delivery circuitry, and used to evaluate and treat cardiac rhythms using both the cardiac electrophysiologic and blood sensor signals. The blood sensor is configured for subcutaneous non-intrathoracic placement and provided in or on the housing, on a lead coupled to the housing, and/or separate to the housing and coupled to the processor via hardwire or wireless link. The blood sensor may be configured for optical sensing, using a blood oxygen saturation sensor or pulse oximeter. A cardiac rhythm may be evaluated using the electrocardiogram signal and the blood sensor signal, and tachyarrhythmias may be treated after confirmation using the blood sense signal.
摘要翻译：心脏系统和方法使用ECG和血液信息进行心律失常检测和辨别。检测电路被配置为产生ECG。构造成产生血液传感器信号的可植入血液传感器耦合到处理器。处理器耦合到检测和能量输送电路，并且用于使用心脏电生理学和血液传感器信号来评价和治疗心律。血液传感器被配置用于皮下非胸内放置并且设置在壳体中或外壳上，在耦合到壳体的引线上和/或分离到壳体并经由硬线或无线链路耦合到处理器。血液传感器可以被配置为使用血氧饱和度传感器或脉搏血氧计进行光学感测。可以使用心电图信号和血液传感器信号评估心律，并且可以在使用血液感测信号确认之后治疗快速性心律失常。

13. 发明授权

US5674253A Cardioversion system with cardioverting energy attenuator 失效
标题翻译：心律转复系统与心律转换能量衰减器
公开(公告)号：US5674253A
公开(公告)日：1997-10-07
申请号：US708218
申请日：1996-09-06
申请人： John M. Adams , Clifton A. Alferness , Darrell O. Wagner
发明人： John M. Adams , Clifton A. Alferness , Darrell O. Wagner
IPC分类号： A61N1/39
CPC分类号： A61N1/3931
摘要： A defibrillation system for providing post-cardiac surgery atrial cardioversion includes a lead system having defibrillation electrodes for electrical contact with the heart beneath the skin of a patient and a non-implantable external defibrillator for providing defibrillation electrical energy. An interface unit is coupled between the external defibrillator and the lead system and includes an attenuator circuit for attenuating the defibrillation electrical energy provided by the external defibrillator.
摘要翻译：用于提供心脏外手术心房复律的除颤系统包括具有用于与患者皮肤下的心脏电接触的除颤电极的引导系统和用于提供除颤电能的非植入式外部除颤器。接口单元耦合在外部除颤器和引导系统之间，并且包括用于衰减由外部除颤器提供的除颤电能的衰减器电路。

14. 发明授权

US5813999A Implantable atrial defibrillator providing reduced cardioversion discomfort 失效
标题翻译：植入性心房除颤器提供减少心脏复律不适
公开(公告)号：US5813999A
公开(公告)日：1998-09-29
申请号：US576671
申请日：1995-12-21
申请人： Gregory M. Ayers , Darrell O. Wagner
发明人： Gregory M. Ayers , Darrell O. Wagner
IPC分类号： A61N1/39 , A61N1/00
CPC分类号： A61N1/3956 , A61N1/3906 , A61N1/3912 , A61N1/395
摘要： An implantable atrial cardiovertor applies cardioverting electrical energy to atria of a heart with reduced discomfort to a patient. The cardiovertor includes a storage capacitor having a capacitance and a discharge control for controlling discharge of the storage capacitor to apply the cardioverting electrical energy to the atria of the heart. The discharge control causes the applied cardioverting electrical energy to have a biphasic waveform having a first phase and a second phase of opposite polarity and equal time duration. The time durations of the first and second phases are each greater than four milliseconds, and the capacitance of the storage capacitor is greater than or equal to 120 .mu.F.
摘要翻译：可植入心房心律转换器将心脏转换电能施加到心脏的心房，使患者的不适感降低。心律转换器包括具有电容和放电控制的存储电容器，用于控制存储电容器的放电，以将心电转换电能施加到心脏的心房。放电控制使得所施加的心脏转换电能具有具有相反极性和相等持续时间的第一相位和第二相位的双相波形。第一相和第二相的持续时间大于四毫秒，并且存储电容器的电容大于或等于120μF。

15. 发明授权

US07142912B2 Method and apparatus for assessing and treating atrial fibrillation risk 有权
标题翻译：评估和治疗房颤风险的方法和装置
公开(公告)号：US07142912B2
公开(公告)日：2006-11-28
申请号：US10194435
申请日：2002-07-12
申请人： Darrell O. Wagner , Robert J. Sweeney , Adam W. Cates , Apurv Kamath , Eric G. Lovett
发明人： Darrell O. Wagner , Robert J. Sweeney , Adam W. Cates , Apurv Kamath , Eric G. Lovett
IPC分类号： A61N1/08
CPC分类号： A61N1/3622 , A61N1/395 , A61N1/3962
摘要： A method and apparatus for assessing the risk of atrial fibrillation in a patient by calculating the relative frequency of short and long intervals between successive heart beats during sinus rhythm is presented. An imbalance of short over long sinus intervals has been found to indicate a higher risk of atrial fibrillation. An implantable cardiac device may be configured to automatically deliver interventional therapy to restore sinus interval balance when such an imbalance is detected.
摘要翻译：提出了一种通过计算窦性心律连续心脏跳动之间的短间隔和长间隔的相对频率来评估患者心房颤动风险的方法和装置。发现短窦间隔短暂的不平衡表明心房颤动的风险更高。可植入的心脏装置可以被配置为当检测到这种不平衡时，自动地进行介入治疗以恢复窦间隔平衡。

16. 发明授权

US06546287B1 Controlled-power defibrillator and method of defibrillation 失效
标题翻译：控制功率除颤器和除颤方法
公开(公告)号：US06546287B1
公开(公告)日：2003-04-08
申请号：US09680790
申请日：2000-10-06
申请人： William J. Havel , Joe D. Bourland , Leslie A. Geddes , Willis A. Tacker , Darrell O. Wagner
发明人： William J. Havel , Joe D. Bourland , Leslie A. Geddes , Willis A. Tacker , Darrell O. Wagner
IPC分类号： A61N136
CPC分类号： A61N1/3937 , A61N1/3912
摘要： A controlled-power defibrillator and method of defibrillation for automatically compensating for changes in patient resistance during delivery of a defibrillation pulse. A switching power converter is connected between a storage capacitor and a pair of electrodes adapted for connection to a patient's body, either internally or externally. A closed-loop power control circuit is operatively connected to the power converter for control of the power delivered to the patient, the power control circuit generating a target voltage signal for the storage capacitor, the target voltage signal having a defined relationship with the waveform of the power desired to be delivered to the patient. The power control circuit monitors the actual voltage on the storage capacitor and adjusts the delivery of power to the patient as a function of the difference between desired and actual storage capacitor voltage. The power converter is adapted to capture energy from the discharge of an existing defibrillator and to convert captured energy from the existing defibrillator to a waveform different from that generated by the existing defibrillator.
摘要翻译：一种控制功率除颤器和除颤方法，用于在除颤脉冲输送期间自动补偿患者阻力的变化。开关功率转换器连接在存储电容器和适于连接到患者身体的一对电极之间，内部或外部。闭环功率控制电路可操作地连接到功率转换器，用于控制传递给患者的功率，功率控制电路产生用于存储电容器的目标电压信号，目标电压信号与期望输送给患者的功率。功率控制电路监视存储电容器上的实际电压，并根据期望的和实际的存储电容器电压之间的差异来调整向患者的电力输送。功率转换器适于从现有除颤器的放电中捕获能量，并且将来自现有除颤器的捕获能量转换为与现有除颤器产生的波形不同的波形。

17. 发明授权

US5620467A Implantable atrial defibrillator having cardioverting output voltage limiting for simulating larger storage capacitors 失效
标题翻译：具有心律转换输出电压限制的植入式心房除颤器用于模拟较大的储存电容器
公开(公告)号：US5620467A
公开(公告)日：1997-04-15
申请号：US541682
申请日：1995-10-10
申请人： Darrell O. Wagner
发明人： Darrell O. Wagner
IPC分类号： A61N1/39 , A61N1/00
CPC分类号： A61N1/3937 , A61N1/395
摘要： An implantable atrial defibrillator includes a storage capacitor for storing electrical energy. A switch discharges at least a portion of the stored energy into a patient's heart as a discharge voltage and a charger charges the storage capacitor with the stored energy to a peak voltage. A voltage limiter precludes the discharge voltage from exceeding a voltage limit during capacitor discharge to permit a reduced applied cardioverting voltage with a lengthened discharge time. The voltage limit is a substantially constant fraction of the peak voltage.
摘要翻译：可植入心房除颤器包括用于存储电能的存储电容器。开关将存储的能量的至少一部分放电到患者的心脏中作为放电电压，并且充电器将存储的电容器与存储的能量充电至峰值电压。电压限制器排除放电电压超过电容器放电期间的电压限制，允许减小施加的心跳转换电压，延长放电时间。电压极限是峰值电压的基本恒定分数。

18. 发明授权

US4913150A Method and apparatus for the automatic calibration of signals employed in oximetry 失效
标题翻译：用于自动校准血氧饱和度信号的方法和装置
公开(公告)号：US4913150A
公开(公告)日：1990-04-03
申请号：US897663
申请日：1986-08-18
申请人： Peter W. Cheung , Karl F. Gauglitz , Scott W. Hunsaker , Stephen J. Prosser , Darrell O. Wagner , Robert E. Smith
发明人： Peter W. Cheung , Karl F. Gauglitz , Scott W. Hunsaker , Stephen J. Prosser , Darrell O. Wagner , Robert E. Smith
IPC分类号： G01N21/31 , A61B5/00 , A61B5/024 , A61B5/145 , A61B5/1455 , G01N21/27
CPC分类号： A61B5/02427 , A61B5/14552 , A61B5/1495 , G01N21/274 , A61B2560/0252 , A61B2562/08
摘要： Under the present invention, a method and apparatus are provided for compensating for the effect temperature variations have on the wavelength of light emitted by the oximeter sensor light sources (40, 42). In pulse oximetry, LEDs are typically employed to expose tissue to light at two different wavelengths. The light illuminating the tissue is received by a detector (38) where signals proportional to the intensity of light are produced. These signals are then processed by the oximeter circuitry to produce an indication of oxygen saturation. Because current oximetry techniques are dependent upon the wavelengths of light emitted by the LEDs (40-42), the wavelengths must be known. Even when predetermined combinations of LEDs (40-42) having relatively precise wavelengths are employed, variations in the wavelength of light emitted may result. Because the sensor (12) may be exposed to a significant range of temperatures while in use, the effect of temperature on the wavelengths may be significant. To compensate for this effect, a temperature sensor (50) is included in the sensor (12) to produce a signal indicative of sensor temperature. This signal is interpreted by the oximeter circuitry including, for example, a microcomputer (16), where the effect of temperature on wavelength is compensated for. In a preferred arrangement, this compensation takes the form of a computation of an alternative calibration curve from which the oxygen saturation is indicated, given a particular processing of signals from the detector (38).

19. 发明授权

US4819646A Feedback-controlled method and apparatus for processing signals used in oximetry 失效
标题翻译：用于处理血氧饱和度信号的反馈控制方法和装置
公开(公告)号：US4819646A
公开(公告)日：1989-04-11
申请号：US897664
申请日：1986-08-18
申请人： Peter W. Cheung , Karl F. Gauglitz , Lee R. Mason , Stephen J. Prosser , Robert E. Smith , Darrell O. Wagner , Scott W. Hunsaker
发明人： Peter W. Cheung , Karl F. Gauglitz , Lee R. Mason , Stephen J. Prosser , Robert E. Smith , Darrell O. Wagner , Scott W. Hunsaker
IPC分类号： A61B5/145 , A61B5/00 , A61B5/1455 , A61B6/00
CPC分类号： A61B5/14551
摘要： A feedback control system is disclosed for use in processing signals employed in pulse transmittance oximetry. The signals are produced in response to light transmitted through, for example, a finger at two different wavelengths. Each signal includes a slowly varying baseline component representing the relatively fixed attenuation of light produced by bone, tissue, skin, and hair. The signals also include pulsatile components representing the attenuation produced by the changing blood volume and oxygen saturation within the finger. The signals are processed by the feedback control system before being converted by an analog-to-digital (A/D) converter (72) for subsequent analysis by a microcomputer (16). The feedback control system includes a controllable offset subtractor (66), a programmable gain amplifier (68), controllable drivers (44) for the light sources (40,42), and the microcomputer (16). The microcomputer receives signals from the offset subtractor (66), gain amplifier (68), drivers (44) and A/D converter (72) to produce signals that control the function of the subtractor (66) and drivers (44) in the following manner. Normally, the drivers (44) are maintained within a predetermined current range. In the event the microcomputer (16) senses an output from the converter (72) that is not within a predetermined range, the drive signal is adjusted to produce an acceptable signal. The magnitude of the offset removed by the subtractor (66), as controlled by the microcomputer (16), is maintained at a constant level when the converter (72) output is within a first predetermined range and is a predetermined function of the converter (72) output when that output falls within a second predetermined range.

20. 发明授权

US6006132A Atrial defibrillation system including a portable audible speech communication device 失效
标题翻译：心房除颤系统包括便携式声音通话装置
公开(公告)号：US6006132A
公开(公告)日：1999-12-21
申请号：US60544
申请日：1998-04-15
申请人： Willis A. Tacker, Jr. , Darrell O. Wagner
发明人： Willis A. Tacker, Jr. , Darrell O. Wagner
IPC分类号： A61N1/39
CPC分类号： A61N1/3925 , A61N1/395
摘要： An atrial defibrillation system monitors activity of a heart, detects atrial fibrillation, and cardioverts detected atrial fibrillation. The system includes an implantable atrial defibrillator including a plurality of operating stages for monitoring heart activity, detecting atrial fibrillation, and cardioverting atrial fibrillation, a message generator for generating messages indicative of operating stage operation status, and a transmitter to transmit the messages indicative of operating stage operating status. A nonimplantable communication device is dimensioned to be hand-held and includes a receiver for receiving the transmitted messages indicative of operating stage operation status, an addressable memory for storing a plurality of voice signals, a decoder responsive to received messages indicative of operating stage operation status for addressing selected ones of the stored voice signals, and a converter for converting the selected voice signals to audible sound.
摘要翻译：心房除颤系统监测心脏的活动，检测心房颤动，以及心律失常检测心房颤动。该系统包括可植入心房除颤器，其包括用于监测心脏活动的多个操作阶段，检测心房纤维性颤动和心律转复心房颤动，用于产生指示操作阶段操作状态的消息的消息发生器，以及发送器，用于发送指示操作的消息阶段运行状态。不可植入通信设备的尺寸被设计为手持式的，并且包括用于接收指示操作级操作状态的所发送消息的接收器，用于存储多个语音信号的可寻址存储器，响应于接收到的指示操作级操作状态的消息的解码器用于寻址所存储的语音信号中的所选择的一个;以及用于将所选择的语音信号转换成可听见的声音的转换器。

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