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11. 发明授权

EP1981516B1 USE OF PROBIOTIC MICROORGANISMS FOR THE TREATMENT AND PREVENTION OF OBESITY AND RELATED DISORDERS 有权转让
公开(公告)号：EP1981516B1
公开(公告)日：2018-08-08
申请号：EP07734501.5
申请日：2007-01-26
申请人： DuPont Nutrition Biosciences ApS
发明人： RAUTONEN, Nina , PUTAALA, Heli , OUWEHAND, Arthur , TIIHONEN, Kirsti , KORCZYNSKA, Marta, Zdzislawa , NOORDMAN, Wouter Herman
IPC分类号： A61K35/745 , A61K35/747 , A23K10/18 , A23K50/75 , A23L33/00 , A23L33/135 , A61P3/04 , A23K50/40
CPC分类号： A61K35/747 , A23K10/18 , A23K50/40 , A23K50/75 , A23L33/135 , A23L33/30 , A61K35/745
摘要： Use of at least one strain of a microorganism and/or a metabolite thereof in the manufacture of a support for administration to a subject for modulating satiety signalling, wherein the support is a pharmaceutically acceptable support or a food product. Suitably, the at least one strain of a microorganism and/or a metabolite thereof may be administered to the subject for the treatment and/or prevention of excess weight and/or a disease caused by excess weight. Likewise, the at least one strain of a microorganism and/or a metabolite thereof is administered to the subject for the treatment and/or prevention of obesity and/or a caused by obesity. Preferably, the microorganism is a probiotic microorganism. Suitably the microorganism may be a lactic acid bacterium. Li one embodiment the microorganism is a strain of Lactobacillus spp. and/or Bifidobacterium spp., for example a strain of Lactobacillus acidophilus, L. curvatus, L. salivarius and/or B. lactis.

12. 发明公开

EP2704704A1 PROBIOTIC BACTERIA FOR THE TOPICAL TREATMENT OF SKIN DISORDERS 有权转让
标题翻译： PROBIOTISCHE BAKTERIEN ZUR TOPISCHEN BEHANDLUNG VON HAUTERKRANKUNGEN
公开(公告)号：EP2704704A1
公开(公告)日：2014-03-12
申请号：EP12730161.2
申请日：2012-05-02
申请人： DuPont Nutrition Biosciences ApS
发明人： PUTAALA, Heli , OUWEHAND, Arthur , TIIHONEN, Kirsti , RAUTONEN, Nina
IPC分类号： A61K31/205 , A61K35/74 , A61P17/06 , A61P17/16
CPC分类号： A61K35/741 , A61K31/205 , A61K35/744 , A61K35/745 , A61K35/747
摘要： The present invention relates to a probiotic bacteria, and/or soluble metabolite of a probiotic bacteria and/or a cell lysate of a probiotic bacteria for use in the treatment of a disorder associated with Tight Junction function, characterised in that the probiotic bacteria, soluble metabolite of a probiotic bacteria and/or a cell lysate of a probiotic bacteria is formulated for topical administration.
摘要翻译：本发明涉及用于治疗与紧结功能相关的病症的益生菌和/或益生菌的细胞裂解物的益生菌和/或可溶性代谢物，其特征在于益生菌，可溶性将益生菌和/或益生菌的细胞裂解液的代谢物配制成局部给药。

13. 发明申请

WO2004026316A1 NOVEL USE OF CARBOHYDRATES AND COMPOSITIONS 审中-公开
标题翻译：碳水化合物和组合物的新用途
公开(公告)号：WO2004026316A1
公开(公告)日：2004-04-01
申请号：PCT/FI2003/000674
申请日：2003-09-16
申请人： DANISCO A/S , RAUTONEN, Nina , APAJALAHTI, Juha , KETTUNEN, Anu , SIIKANEN, Osmo
发明人： RAUTONEN, Nina , APAJALAHTI, Juha , KETTUNEN, Anu , SIIKANEN, Osmo
IPC分类号： A61K31/70
CPC分类号： A61K31/70 , A23C9/133 , A23C9/137 , A23G1/56 , A23G2200/06 , A23L13/426 , A23L33/10 , A23L33/135 , A23V2002/00 , A23V2250/206 , A23V2250/5026 , A23V2250/5072 , A23V2250/6414
摘要： The present invention relates to the use of carbohydrates in the preparation of a composition for treating and/or preventing diseases and/or disorders caused by imbalanced fermentation in the colon comprising providing composition capable of maintaining a sustained and controlled fermentation throughout the colon of a subject by formulating slowly fermented complex oligomeric or polymeric carbohydrate(s) into a nutritionally, nutraceutically and/or pharmacologically acceptable composition. The present invention also relates to a composition comprising a slowly fermented complex oligomer or polymer carbohydrate as an active component for sustaining and controlling the fermentation throughout the colon of a subject.
摘要翻译：本发明涉及碳水化合物在制备用于治疗和/或预防由结肠不平衡发酵引起的疾病和/或障碍的组合物中的用途，其包括提供能够维持受试者整个结肠持续和控制发酵的组合物通过将缓慢发酵的复合寡聚或聚合碳水化合物配制成营养，营养和/或药学上可接受的组合物。本发明还涉及一种组合物，其包含缓慢发酵的复合低聚物或聚合物碳水化合物作为用于维持和控制受试者整个结肠发酵的活性成分。

14. 发明申请

WO2005032567A2 METHOD 审中-公开
标题翻译：方法
公开(公告)号：WO2005032567A2
公开(公告)日：2005-04-14
申请号：PCT/IB2004/003273
申请日：2004-09-24
申请人： DANISCO A/S , RAUTONEN, Nina , NURMI, Jussi , NURMINEN, Päivi , PUOLAKKAINEN, Pauli
发明人： RAUTONEN, Nina , NURMI, Jussi , NURMINEN, Päivi , PUOLAKKAINEN, Pauli
IPC分类号： A61K35/74
CPC分类号： A61K35/745 , A23K10/16 , A23K10/18 , A23K50/75 , A61K31/19 , A61K31/205 , A61K45/06 , A61K2300/00
摘要： The present invention relates to the use of a microorganism and/or a metabolite thereof to at least increase the amount of a COX-1 mRNA in a cell. The present invention further relates to the use of a microorganism and/or a metabolite thereof in the manufacture of a medicament to treat the side effects associated with nonsteroidal antiinflammatory drugs (NSAIDs). The present invention further relates to a pharmaceutical preparation comprising in combination a nonsteroidal antiinflammatory drug (NSAIDs) and a microorganism and/or a metabolite thereof which is capable of at least increasing the amount of a COX-1 mRNA in a cell. The present invention yet further relates to a pharmaceutical preparation comprising in combination betaine or a pharmaceutically acceptable salt thereof and a microorganism and/or a metabolite thereof which is capable of at least increasing the amount of a COX-1 mRNA in a cell. The microorganism may suitably be a bacterium, preferably from the genus Bifidobacterium.
摘要翻译：本发明涉及使微生物和/或其代谢物至少增加细胞中COX-1mRNA的量的用途。本发明还涉及微生物和/或其代谢物在制备用于治疗与非甾体抗炎药（NSAID）相关的副作用的药物中的用途。本发明还涉及一种药物制剂，其包含非甾体抗炎药（NSAID）和能够至少增加细胞中COX-1mRNA量的微生物和/或其代谢物的组合。本发明还涉及包含组合甜菜碱或其药学上可接受的盐和能够至少增加细胞中COX-1 mRNA的量的微生物和/或其代谢物的药物制剂。微生物可以适当地是细菌，优选来自双歧杆菌属。

15. 发明申请

WO2005036979A1 METHOD FOR MODIFYING THE COMPOSITION OF MILK AND USE OF MILK 审中-公开
标题翻译：修改奶粉组合物和使用奶粉的方法
公开(公告)号：WO2005036979A1
公开(公告)日：2005-04-28
申请号：PCT/FI2004/000626
申请日：2004-10-21
申请人： SUOMEN REHU OY , NURMINEN, Päivi , RAUTONEN, Nina , VIRKKI, Markku , VUORENMAA, Juhani
发明人： NURMINEN, Päivi , RAUTONEN, Nina , VIRKKI, Markku , VUORENMAA, Juhani
IPC分类号： A23K1/00
CPC分类号： A61K36/06 , A23K10/16 , A23K20/147 , A23K20/153 , A23K50/10 , A23K50/60 , A61K36/064
摘要： The present invention relates to a method for increasing the concentration of the immunofactors of milk, a method for increasing the milk yield of a ruminant after calving, and a method for increasing the immunity of a ruminant after calving. This is achieved using hydrolytically processed yeast raw material. Furthermore, the present invention relates to the use of milk prepared by the method sin accordance with the invention for promoting growth.
摘要翻译：本发明涉及增加乳的免疫反应物的浓度的方法，提高产犊后反刍动物的产奶量的方法，以及增加产犊后反刍动物免疫力的方法。这是使用水解加工的酵母原料实现的。此外，本发明涉及通过根据本发明的方法制备的用于促进生长的乳的用途。

16. 发明申请

WO2004002240A2 NOVEL USE AND COMPOSITIONS 审中-公开
标题翻译：新的使用和组成
公开(公告)号：WO2004002240A2
公开(公告)日：2004-01-08
申请号：PCT/IB2003/003282
申请日：2003-06-20
申请人： DANISCO A/S , RAUTONEN, Nina , APAJALAHTI, Juha , SIIKANEN, Osmo
发明人： RAUTONEN, Nina , APAJALAHTI, Juha , SIIKANEN, Osmo
IPC分类号： A23L1/00
CPC分类号： A23L29/27 , A23L29/256 , A23V2002/00 , A23V2250/5086 , A23V2250/5072 , A23V2250/507 , A23V2250/5062 , A23V2250/5026
摘要： The use of a hydrocolloid as a prebiotic in the preparation of a product for consumption is described. The hydrocolloid has the advantage of reduced gas release when fermented by bacteria in the gastrointestinal tract after the consumption of said product. Compositions containing the hydrocolloid, methods for using the compositions in methods of treatment are also provided.
摘要翻译：描述了在制备用于消费的产品中使用水胶体作为益生元。水胶体具有在消耗所述产品之后在胃肠道中被细菌发酵时减少气体释放的优点。还提供了含有水胶体的组合物，在治疗方法中使用该组合物的方法。

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