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12. 发明专利

NZ221731A 5-RING HETEROCYCLES SUBSTITUTED BY A PHENYL RADICAL AND A PYRROLIDIN-2-YL RADICAL HAVING ANTIPSYCHOTIC PROPERTIES AND PHARMACEUTICAL COMPOSITIONS THEREOF 未知
公开(公告)号：NZ221731A
公开(公告)日：1990-07-26
申请号：NZ22173187
申请日：1987-09-09
申请人： DUPHAR INT RES
发明人： VAN WIJNGAARDEN INEKE , KRUSE CORNELIS GERRIT , VAN HES ROELOF , VAN DER HEYDEN JOHANNES ANTONI
IPC分类号： A61K31/40 , A61P25/00 , C07D207/32 , C07D207/333 , C07D207/335 , C07D403/04 , C07D405/04 , C07D521/00 , C07D207/09 , A61K31/415
摘要： The invention relates to a group of new phenyl, pyrrolidin-2-yl substituted 5-ring heterocyclic compounds of the formula wherein A is an unsaturated heterocylic 5-ring having at least one nitrogen or oxygen atom in the ring, with the proviso that the phenyl substituent is in a meta-position with respect to the 2-pyrrolidinyl substituent. The compounds have interesting pharmacological, notably antipsychotic properties.

13. 发明专利

DE3478573D1 BENZOYL UREA DERIVATIVES HAVING ANTI-TUMOR ACTIVITY 未知
公开(公告)号：DE3478573D1
公开(公告)日：1989-07-13
申请号：DE3478573
申请日：1984-08-27
申请人： DUPHAR INT RES
发明人： BROUWER MARIUS S , VAN HES ROELOF
IPC分类号： C07D295/18 , A61K31/17 , A61K31/215 , A61K31/22 , A61K31/275 , A61K31/445 , A61P35/00 , C07C67/00 , C07C239/00 , C07C275/54 , C07C325/00 , C07C335/26

14. 发明专利

CA1252791A BENZOYL UREA DERIVATIVES HAVING ANTI-TUMOR ACTIVITY 未知
公开(公告)号：CA1252791A
公开(公告)日：1989-04-18
申请号：CA461993
申请日：1984-08-29
申请人： DUPHAR INT RES
发明人： BROUWER MARIUS S , VAN HES ROELOF
IPC分类号： C07D295/18 , A61K31/17 , A61K31/215 , A61K31/22 , A61K31/275 , A61K31/445 , A61P35/00 , C07C67/00 , C07C239/00 , C07C275/54 , C07C325/00 , C07C335/26 , C07C127/22 , C07C149/437 , C07C157/12
摘要： The invention relates to new benzoyl urea derivatives having anti-tumor activity, to the preparation of such compounds, and to compositions comprising at least one of the new compounds as the active substance.

15. 发明专利

AT40111T 未知
公开(公告)号：AT40111T
公开(公告)日：1989-02-15
申请号：AT85200956
申请日：1985-06-18
申请人： DUPHAR INT RES
发明人： BROUWER MARIUS S , GROSSCURT ARNOLDUS C , VAN HES ROELOF
IPC分类号： A01N47/34 , A01N47/36 , C07C67/00 , C07C239/00 , C07C275/54 , C07D213/40 , C07D213/64 , C07D213/75 , C07D213/79 , C07D213/80 , C07C127/22

16. 发明专利

DE3371508D1 BENZOYLUREA COMPOUNDS, AND PESTICIDAL AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME 未知
公开(公告)号：DE3371508D1
公开(公告)日：1987-06-19
申请号：DE3371508
申请日：1983-12-30
申请人： DUPHAR INT RES
发明人： BROUWER MARIUS S , GROSSCURT ARNOLDUS C , VAN HES ROELOF
IPC分类号： A01N47/34 , A01P7/04 , C07C273/18 , C07C275/54 , C07C127/22 , A61K31/17
摘要： The invention relates to new benzoylurea compounds of the general formula wherein R1 is a hydrogen atom or represents 1 or 2 substituents which are selected from the group consisting of halogen and alkyl and haloalkyl having 1-4 carbon atoms, R2 is a hydrogen atom or represents 1 or 2 substituents which are selected from the group consisting of chlorine, methyl and trifluoromethyl, and R3 is a hydrogen atom or represents 1-3 alkyl and/or alkenyl groups each having 1-6 and/or 2-6 carbon atoms respectively, or wherein R3 together with the cyclohexyl ring to which it is attached forms a bi- or polycyclic hydrocarbyl group having 8-14 carbon atoms and, if desired, substituted with 1-3 alkyl groups each having 1-4 carbon atoms. The compounds have an insecticidal and acaricidal activity. After having been processed to compositions, the compounds may be used for the control of insects and/or mites in a dosage from 1 to 5000 g of active substance per hectare.

17. 发明专利

PL195734B1 3-TETRAHYDROPYRIDIN-4-YL INDOLES FOR TREATMENT OF PSYCHOTIC DISORDERS 未知
公开(公告)号：PL195734B1
公开(公告)日：2007-10-31
申请号：PL34732999
申请日：1999-10-15
申请人： DUPHAR INT RES
发明人： TULP MARTINUS T M , VAN DER HEIJDEN JOHANNES A M , VAN VLIET BERNARD , TIPKER JACOBUS , VAN HES ROELOF , KRUSE CORNELIS G , VISSER GERBEN M
IPC分类号： C07D401/14 , A61K31/435 , A61K31/475 , A61P25/18 , A61P25/22 , A61P25/24
摘要： The invention is related to the following compounds:wherein all variables are as defined in the specification. The compounds are useful for treating psychotic disorders.

18. 发明专利

DE69904849D1 未知
公开(公告)号：DE69904849D1
公开(公告)日：2003-02-13
申请号：DE69904849
申请日：1999-10-15
申请人： DUPHAR INT RES
发明人： TULP T M , VAN DER HEIJDEN A M , VAN VLIET BERNARD , TIPKER JACOBUS , VAN HES ROELOF , KRUSE G , VISSER M
IPC分类号： A61K31/435 , A61K31/475 , A61P25/18 , A61P25/22 , A61P25/24 , C07D401/14
摘要： The invention is related to the following compounds:wherein all variables are as defined in the specification. The compounds are useful for treating psychotic disorders.

19. 发明专利

NZ511289A 3-tetrahydropyridin-4-yl indoles, which show high affinity for both the dopamine d2 receptor and the serotonin reuptake site, for treatment of psychotic disorders 未知
公开(公告)号：NZ511289A
公开(公告)日：2003-01-31
申请号：NZ51128999
申请日：1999-10-15
申请人： DUPHAR INT RES
发明人： TULP MARTINUS T M , HEIJDEN JOHANNES A M , VAN VLIET BERNARD , TIPKER JACOBUS , VAN HES ROELOF , KRUSE CORNELIS G , VISSER GERBEN M
IPC分类号： A61K31/435 , A61K31/475 , A61P25/18 , A61P25/22 , A61P25/24 , C07D401/14
摘要： Described are group 3-tetrahydropyridin-4-yl indoles that show high affinity for both the dopamine D2 receptor and the serotonin reuptake site. This combination is useful for the treatment of schizophrenia and other psychotic disorders and might allow for a more complete treatment of all disease symptoms (e.g. positive symptoms and negative symptoms). These compounds have the general formula (I) wherein: R1 is halogen, CF3, alkyl (1-3C), alkoxy (1-3C), CN or SCH3; m the value 0, 1 or 2; R2 is H or alkyl (1-3C); n has the value 3, 4, 5 or 6; R3 is halogen, alkyl (1-4C); or alkoxy (1-4C); p has the value 0, 1, or 2.

20. 发明专利

DE3162624D1 NEW SULPHONYL COMPOUNDS, METHOD OF PREPARING THE NEW COMPOUNDS, AS WELL AS APHICIDAL COMPOSITIONS ON THE BASIS OF THE NEW COMPOUNDS 未知
公开(公告)号：DE3162624D1
公开(公告)日：1984-07-12
申请号：DE3162624
申请日：1981-01-15
申请人： DUPHAR INT RES
发明人： VAN HES ROELOF , GROSSCURT ARNOLDUS CORNELIS , BALK WOUTER
IPC分类号： C07D275/04 , A01N41/06 , A01N43/36 , A01N43/40 , A01N43/80 , C07C67/00 , C07C301/00 , C07C303/38 , C07C303/40 , C07C311/16 , C07D275/06 , C07C143/78
摘要： The invention relates to new sulphonyl compounds of the general formula wherein X is a halogen atom, a phenoxy group, or an alkyl group or alkoxy group having 1-4 carbon atoms and substituted, if desired, with halogen; R1 is a cyano group, and R2 is an amino group which, if desired, may be substituted with halogen, with one or two alkenyl groups or alkynyl groups having 2-6 carbon atoms or with one or two alkyl groups having 1-6 carbon atoms, which alkyl groups, together with the nitrogen atom to which they are bound, may form a saturated heterocyclic ring, which ring may also contain a second hetero atom selected from the group consisting of nitrogen, oxygen and sulphur, or which alkyl groups may be substituted with an alkoxy group, having 1-4 carbon atoms, or with a dialkylamino group having 2-6 carbon atoms the alkyl groups of which, together with the nitrogen atom to which they are bound, may form a saturated heterocyclic ring; or wherein R1 and R2 together form a S,S-dialkylsulphoximido group the alkyl groups of which comprise 1-4 carbon atoms, or a 1-amino-2-azavinylene group, of which the amino group is substituted, if desired, with a cycloalkylcarbamoyl group having 4-8 carbon atoms, an alkylcarbamoyl group having 2-5 carbon atoms, a dialkylamino group the alkyl group of which comprise 1-4 carbon atoms, or an alkyl group having 1-4 carbon atoms which alkyl group may be substituted with a hydroxy group or one or more halogen atoms; or wherein R1 and R2 together form a 1-imino-2-azaethylene group of which the ring nitrogen is substituted with an alkyl group or alkenyl group having 1-4 carbon atoms, and of which the imino group may be substituted with a substituted or non-substituted phenylcarbamoyl group, having aphicidal activity. After having been processed to compositions, the compounds may be used for the control of aphids in agriculture, horticulture and forestry in a dosage from 20 to 5,000 g of active substance per hectare.

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