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11. 发明申请

US20100256700A1 METHOD AND APPARATUS FOR ORGAN SPECIFIC INFLAMMATION THERAPY 审中-公开
标题翻译：用于组织特异性炎症治疗的方法和装置
公开(公告)号：US20100256700A1
公开(公告)日：2010-10-07
申请号：US12755041
申请日：2010-04-06
申请人： Allan C. Shuros , Craig Stolen , Shantha Arcot-Krishnamurthy
发明人： Allan C. Shuros , Craig Stolen , Shantha Arcot-Krishnamurthy
IPC分类号： A61N1/365 , A61N1/39
CPC分类号： A61N1/36521 , A61N1/3627 , A61N1/365 , A61N1/3702
摘要： A method and device are described for delivering cardiac therapy in which an implantable device for delivering such cardiac therapy is additionally configured to detect the presence of inflammation. Upon detection of inflammation, the device may be configured to modify its delivery of therapy in various ways and/or to communicate the information to an external agent for other types of interventions.
摘要翻译：描述了用于递送心脏疗法的方法和装置，其中用于递送这种心脏治疗的可植入装置另外配置为检测炎症的存在。在检测到炎症时，该装置可以被配置为以各种方式修改其治疗递送和/或将信息传达给外部代理以用于其他类型的干预。

12. 发明申请

US20090299269A1 VASCULAR STIMULATION TO AID INTRAVASCULAR CELL REPLACEMENT THERAPY 审中-公开
标题翻译：血管内皮细胞替代治疗的血管刺激
公开(公告)号：US20090299269A1
公开(公告)日：2009-12-03
申请号：US12473033
申请日：2009-05-27
申请人： John Foley , Jihong Qu , Craig Stolen , Roger Hastings
发明人： John Foley , Jihong Qu , Craig Stolen , Roger Hastings
IPC分类号： A61M37/00
CPC分类号： A61M25/00 , A61N1/056 , A61N1/36017
摘要： A system and method are described involving the use of a cell delivery catheter that incorporates a stimulating electrode to promote vasodilation prior to injection of cells at a target location within a blood vessel. The vasodilation may be produced locally and/or distally from the target location near the target organ. The technique may be applied not only to intra-coronary injection of cells to treat heart disease but to injection of cells in any blood vessel that feeds a target organ.
摘要翻译：描述了涉及使用细胞递送导管的系统和方法，所述细胞递送导管包含刺激电极以在血管内的靶位置注射细胞之前促进血管舒张。血管扩张可能在目标器官附近的目标位置局部和/或远端产生。该技术不仅可以应用于冠状动脉内注射细胞以治疗心脏病，而且可用于在任何进食靶器官的血管中注射细胞。

13. 发明授权

US09138596B2 Optical depolarization of cardiac tissue 有权
公开(公告)号：US09138596B2
公开(公告)日：2015-09-22
申请号：US11895022
申请日：2007-08-22
申请人： John Foley , Craig Stolen , Mark Schwartz
发明人： John Foley , Craig Stolen , Mark Schwartz
IPC分类号： A61N5/06 , A61B5/04 , A61B5/00
CPC分类号： A61N5/0622 , A61B5/04012 , A61B5/418 , A61N5/0601 , A61N5/062 , A61N2005/063 , A61N2005/0651
摘要： The invention provides a cardiac rhythm management system for stimulating a heart having photosensitive tissue, vectors useful to photosensitize cells expressing the vectors, and methods for light induced depolarization of cells.

14. 发明授权

US08568286B2 Methods to position therapeutic agents using a magnetic field 有权
标题翻译：使用磁场定位治疗剂的方法
公开(公告)号：US08568286B2
公开(公告)日：2013-10-29
申请号：US11424107
申请日：2006-06-14
申请人： Haris J. Sih , Craig Stolen , Jihong Ou , Darrell O. Wagner
发明人： Haris J. Sih , Craig Stolen , Jihong Ou , Darrell O. Wagner
IPC分类号： A61N2/00
CPC分类号： A61N1/3956 , A61M37/00 , A61N2/002
摘要： A system for controlling the location of a therapeutic agent administered to a mammal is provided. The system employs a device that is capable of generating a magnetic field and a therapeutic agent labeled with a magnetically responsive moiety. Methods which employ the device and the therapeutic agent are also provided.
摘要翻译：提供了一种用于控制给予哺乳动物的治疗剂的位置的系统。该系统使用能够产生磁场的装置和用磁响应部分标记的治疗剂。还提供了使用该装置和治疗剂的方法。

15. 发明申请

US20110295084A1 INTEGRATING DEVICE-BASED SENSORS AND BEDSIDE BIOMARKER ASSAYS TO DETECT WORSENING HEART FAILURE 有权
标题翻译：集成基于设备的传感器和双面生物标记测试以检测心脏衰竭
公开(公告)号：US20110295084A1
公开(公告)日：2011-12-01
申请号：US13118932
申请日：2011-05-31
申请人： Pramodsingh Hirasingh Thakur , Abhilash Patangay , Craig Stolen , Timothy Meyer
发明人： Pramodsingh Hirasingh Thakur , Abhilash Patangay , Craig Stolen , Timothy Meyer
IPC分类号： A61B5/00
CPC分类号： A61B5/0205 , A61B5/0022 , A61B5/0031 , A61B5/02 , A61B5/08 , A61B7/00 , A61B2505/07 , A61N1/3627 , A61N1/36521 , A61N1/3702 , A61N1/37258 , G06F19/00
摘要： Physiological sensor data can be combined with external biomarker assays, such as a bedside assay for B-type natriuretic peptide (BNP), to improve the sensitivity and specificity of heart failure detection.
摘要翻译：生理传感器数据可与外部生物标志物检测结合，如B型利尿钠肽（BNP）的床边检测，以提高心力衰竭检测的灵敏度和特异性。

16. 发明申请

US20100305632A1 TEMPERATURE ASSISTED STIMULATION 有权
标题翻译：温度辅助刺激
公开(公告)号：US20100305632A1
公开(公告)日：2010-12-02
申请号：US12775215
申请日：2010-05-06
申请人： Barun Maskara , Jason J. Hamann , Stephen Ruble , Craig Stolen
发明人： Barun Maskara , Jason J. Hamann , Stephen Ruble , Craig Stolen
IPC分类号： A61N1/36 , A61N1/362
CPC分类号： A61N1/362
摘要： Various embodiments of an implantable system for delivering therapy comprise at least one of a heat sink or source to either reduce or increase temperature of excitable tissue, a pulse generator and at least one stimulation electrode to deliver electrical stimulation to excitable tissue, a memory and a controller. The memory has instructions for performing at least one stimulation routine and at least one thermal routine, and further has integration instructions for integrating the thermal routine(s) with the stimulation routine(s). The controller is configured to operate on the instructions to perform the stimulation routine(s) using the pulse generator and the at least one stimulation electrode, to perform the thermal routine(s) using the heat sink or the heat source, and to operate on the integration instructions to integrate thermal routine(s) with the stimulation routine(s).
摘要翻译：用于递送治疗的可植入系统的各种实施例包括散热器或源的至少一个，以减少或增加可兴奋组织的温度，脉冲发生器和至少一个刺激电极，以将电刺激递送至可兴奋组织，存储器和控制器。存储器具有用于执行至少一个刺激程序和至少一个热程序的指令，并且还具有用于将热程序与刺激程序整合的积分指令。控制器被配置为根据指令操作以使用脉冲发生器和至少一个刺激电极执行刺激程序，以使用散热器或热源来执行热程序，并且操作在将热程序与刺激程序集成的集成指令。

17. 发明申请

US20100076279A1 METHOD AND APPARATUS FOR ORGAN SPECIFIC INFLAMMATION MONITORING 有权
标题翻译：用于组织特异性暴露监测的方法和装置
公开(公告)号：US20100076279A1
公开(公告)日：2010-03-25
申请号：US12565233
申请日：2009-09-23
申请人： Allan C. Shuros , Shantha Arcot-Krishnamurthy , Craig Stolen
发明人： Allan C. Shuros , Shantha Arcot-Krishnamurthy , Craig Stolen
IPC分类号： A61B5/02 , A61B5/00 , A61B5/053 , A61B5/01 , A61B5/107
CPC分类号： A61N1/3627 , A61B5/0031 , A61B5/01 , A61B5/036 , A61B5/053 , A61B5/1076 , A61B5/415 , A61B5/416 , A61B5/418 , A61B5/4205 , A61B5/4878 , A61B5/7275 , A61B8/488 , A61N1/36521
摘要： An apparatus comprises an implantable sensor and a detection circuit. The implantable sensor provides a physiologic sensor signal and is to be positioned at a lymph node of a subject. The detection circuit detects a change in a physiologic parameter of the lymph node that exceeds a threshold change, and deems that the change in the physiologic parameter indicates a change in inflammation of an organ associated with the lymph node.
摘要翻译：一种装置包括可植入传感器和检测电路。植入式传感器提供生理传感器信号并且被定位在受试者的淋巴结处。检测电路检测超过阈值变化的淋巴结生理参数的变化，认为生理参数的变化表示与淋巴结相关的器官的炎症变化。

18. 发明申请

US20080058922A1 METHODS AND DEVICES EMPLOYING VAP-1 INHIBITORS 审中-公开
标题翻译：使用VAP-1抑制剂的方法和设备
公开(公告)号：US20080058922A1
公开(公告)日：2008-03-06
申请号：US11469064
申请日：2006-08-31
申请人： Craig Stolen
发明人： Craig Stolen
IPC分类号： A61F2/06
CPC分类号： C07D263/18
摘要： An implantable device which employs inhibitors of VAP-1, e.g., inhibitors that reversibly or irreversibly bind to VAP-1, and methods of using the devices is provided.
摘要翻译：提供使用VAP-1抑制剂的可植入装置，例如可逆地或不可逆地结合VAP-1的抑制剂，以及使用该装置的方法。

19. 发明申请

US20080006281A1 METHODS TO POSITION THERAPEUTIC AGENTS USING A MAGNETIC FIELD 有权
标题翻译：使用磁场的位置治疗药物的方法
公开(公告)号：US20080006281A1
公开(公告)日：2008-01-10
申请号：US11424107
申请日：2006-06-14
申请人： Haris J. Sih , Craig Stolen , Jihong Ou , Darrell O. Wagner
发明人： Haris J. Sih , Craig Stolen , Jihong Ou , Darrell O. Wagner
IPC分类号： A61B19/00
CPC分类号： A61N1/3956 , A61M37/00 , A61N2/002
摘要： A system for controlling the location of a therapeutic agent administered to a mammal is provided. The system employs a device that is capable of generating a magnetic field and a therapeutic agent labeled with a magnetically responsive moiety. Methods which employ the device and the therapeutic agent are also provided.
摘要翻译：提供了一种用于控制给予哺乳动物的治疗剂的位置的系统。该系统使用能够产生磁场的装置和用磁响应部分标记的治疗剂。还提供了使用该装置和治疗剂的方法。

20. 发明申请

US20090318749A1 METHOD AND APPARATUS FOR PACING AND INTERMITTENT ISCHEMIA 审中-公开
标题翻译：方法和装置用于切割和间歇性间断
公开(公告)号：US20090318749A1
公开(公告)日：2009-12-24
申请号：US12484822
申请日：2009-06-15
申请人： Craig Stolen , Allan C. Shuros , Shantha Arcot-Krishnamurthy , Eric A. Mokelke
发明人： Craig Stolen , Allan C. Shuros , Shantha Arcot-Krishnamurthy , Eric A. Mokelke
IPC分类号： A61M1/12 , A61N1/365
CPC分类号： A61N1/056 , A61B5/02028 , A61B5/0215 , A61B5/026 , A61F2/95 , A61N1/3625 , A61N1/3627 , A61N1/36514 , A61N1/36564 , A61N1/36571
摘要： A system delivers multiple enhanced therapies to limit myocardial damage post-revascularization. The system includes a catheter that incorporates features for delivering cardiac protection pacing therapy (CPPT) and intermittent ischemia therapy. In one embodiment, a method for delivering cardiac protection therapies to a heart is provided. One or more catheters are provided having a balloon, at least one pacing electrode and at least one hemodynamic sensor. Cardiac protection pacing therapy (CPPT) and intermittent ischemia therapy are concurrently delivered using the one or more catheters. The pacing and ischemia are adapted to protect the heart from ischemic and reperfusion injuries. The delivery of the CPPT and the intermittent ischemia are controlled using a closed-loop system monitoring a signal sensed by the at least one hemodynamic sensor.
摘要翻译：系统提供多种增强疗法以限制血运重建后的心肌损伤。该系统包括导管，其包括用于递送心脏保护起搏治疗（CPPT）和间歇性缺血治疗的特征。在一个实施方案中，提供了将心脏保护治疗递送至心脏的方法。提供一个或多个导管，其具有球囊，至少一个起搏电极和至少一个血流动力学传感器。使用一个或多个导管同时输送心脏保护起搏治疗（CPPT）和间歇性缺血治疗。起搏和缺血适应于保护心脏免于缺血和再灌注损伤。 CPPT的传送和间歇性缺血通过监视由至少一个血流动力学传感器感测到的信号的闭环系统来控制。

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