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11. 发明申请

US20080093226A1 Ammonia nanosensors, and environmental control system 有权
标题翻译：氨纳米传感器和环境控制系统
公开(公告)号：US20080093226A1
公开(公告)日：2008-04-24
申请号：US11636360
申请日：2006-12-08
申请人： Mikhail Briman , Craig Bryant , Ying-Lan Chang , Jean-Christophe Gabriel , Shripal Gandhi , Bradley Johnson , Willem-Jan Ouborg , John Passmore , Kastooriranganathan Ramakrishnan , Sergei Skarupo , Alexander Star , Christian Valcke
发明人： Mikhail Briman , Craig Bryant , Ying-Lan Chang , Jean-Christophe Gabriel , Shripal Gandhi , Bradley Johnson , Willem-Jan Ouborg , John Passmore , Kastooriranganathan Ramakrishnan , Sergei Skarupo , Alexander Star , Christian Valcke
IPC分类号： G01N27/26 , G01N27/28 , G01N27/30 , G01N27/416
CPC分类号： G01N33/0054 , B82Y15/00 , G01N27/127 , G01N27/129 , G01N27/4146 , G01N33/0062 , G01N2033/0068 , H01L29/0669 , Y10S977/957
摘要： Embodiments of nanoelectronic sensors are described, including sensors for detecting analytes such ammonia. An environmental control system employing nanoelectronic sensors is described. A personnel safety system configured as a disposable badge employing nanoelectronic sensors is described. A method of dynamic sampling and exposure of a sensor providing a number of operational advantages is described.
摘要翻译：描述了纳米电子传感器的实施例，包括用于检测分析物这种氨的传感器。描述了采用纳米电子传感器的环境控制系统。描述了配置为使用纳米电子传感器的一次性标签的人员安全系统。描述了提供多个操作优点的传感器的动态采样和曝光的方法。

12. 发明申请

US20070132043A1 Nano-electronic sensors for chemical and biological analytes, including capacitance and bio-membrane devices 有权
标题翻译：用于化学和生物分析物的纳米电子传感器，包括电容和生物膜装置
公开(公告)号：US20070132043A1
公开(公告)日：2007-06-14
申请号：US11400038
申请日：2006-04-06
申请人： Keith Bradley , Ying-Lan Chang , Jean-Christophe Gabriel , John Passmore , Sergei Skarupo , Eugene Tu , Christian Valcke
发明人： Keith Bradley , Ying-Lan Chang , Jean-Christophe Gabriel , John Passmore , Sergei Skarupo , Eugene Tu , Christian Valcke
IPC分类号： H01L29/00
CPC分类号： G01N27/4146 , B82Y10/00 , B82Y15/00 , G01N27/4145 , H01L29/0665 , H01L29/0673 , Y10S977/742
摘要： Embodiments of nanoelectronic sensors are described, including sensors for detecting analytes inorganic gases, organic vapors, biomolecules, viruses and the like. A number of embodiments of capacitive sensors having alternative architectures are described. Particular examples include integrated cell membranes and membrane-like structures in nanoelectronic sensors.
摘要翻译：描述了纳米电子传感器的实施例，包括用于检测分析物无机气体，有机蒸气，生物分子，病毒等的传感器。描述了具有替代架构的电容传感器的许多实施例。具体实例包括纳米电子传感器中的集成细胞膜和膜状结构。

13. 发明申请

US20070045756A1 Nanoelectronic sensor with integral suspended micro-heater 审中-公开
标题翻译：纳米电子传感器与集成悬浮微型加热器
公开(公告)号：US20070045756A1
公开(公告)日：2007-03-01
申请号：US11488465
申请日：2006-07-18
申请人： Ying-Lan Chang , Jean-Christophe Gabriel , Sergei Skarupo , Alexander Star , Christian Valcke , Qian Wang
发明人： Ying-Lan Chang , Jean-Christophe Gabriel , Sergei Skarupo , Alexander Star , Christian Valcke , Qian Wang
IPC分类号： H01L29/82
CPC分类号： G01K5/486 , B82Y10/00 , B82Y15/00 , G01K2211/00
摘要： A nanoelectronic sensing device includes a substrate, a nanostructure element disposed adjacent the substrate, and at least a conductive element electrically connected to the nanostructure element. The device is configured to heat at least a portion of the sensor structure including the nanostructure element. In certain embodiments, the nanostructure element comprises at least one nanotube, the nanotube being electrically connected to at least two conductors so as to permit an electric current on the order of 10 microAmps or greater to be passed through the nanotube, causing the nanotube to heat up relative to the substrate. In alternative embodiments, the sensing device includes a platform or membrane which is at least partially thermally isolated by one or more cavities, the platform supporting at least the nanostructure element adjacent to a microheater element. The heating of the sensor structure may be employed, for example, for thermoregulation, to accelerate and/or increase sensor response, and to improve other sensor characteristics.
摘要翻译：纳米电子感测装置包括衬底，邻近衬底设置的纳米结构元件和至少导电元件，电连接到纳米结构元件。该装置构造成加热包括纳米结构元件的传感器结构的至少一部分。在某些实施例中，纳米结构元件包括至少一个纳米管，纳米管电连接到至少两个导体，以便允许10微安或更大量级的电流通过纳米管，导致纳米管加热相对于基底。在替代实施例中，感测装置包括至少部分地通过一个或多个空腔热隔离的平台或膜，所述平台支撑至少与微加热器元件相邻的纳米结构元件。可以采用传感器结构的加热，例如用于温度调节，加速和/或增加传感器响应，并改善其它传感器特性。

14. 发明申请

US20070048181A1 Carbon dioxide nanosensor, and respiratory CO2 monitors 审中-公开
标题翻译：二氧化碳纳米传感器和呼吸二氧化碳监测仪
公开(公告)号：US20070048181A1
公开(公告)日：2007-03-01
申请号：US11488456
申请日：2006-07-18
申请人： Daniel Chang , Ying-Lan Chang , Jean-Christophe Gabriel , Vikram Joshi , William Mickelson , Joseph Niemann , John Passmore , Alexander Star , Christian Valcke
发明人： Daniel Chang , Ying-Lan Chang , Jean-Christophe Gabriel , Vikram Joshi , William Mickelson , Joseph Niemann , John Passmore , Alexander Star , Christian Valcke
IPC分类号： G01N31/22
CPC分类号： G01N27/4146 , B82Y15/00 , B82Y30/00 , G01N33/004 , G01N33/497
摘要： An electronic system and method for detecting analytes, such as carbon dioxide, is provided, using an improved nanostructure sensor (CO2 sensor). The CO2 sensor may comprise a substrate and a nanostructure, such as a one or more carbon nanotubes disposed over the substrate (e.g., as a network). One or more conductive elements may electrically communicate with the nanostructure. A counter or gate electrode may be positioned adjacent the nanostructure. A functionalization material reactive with carbon dioxide may be included, either disposed in contact with the nanostructure or isolated by a dielectric. The sensor may be connected to a circuit responsive to changes in CO2 concentration in the environment. Embodiments are described of medical sensing systems including one or more CO2 sensors. One embodiment comprises a breath sampling cannula which is connected to a sensor unit. In an alternative, the cannula permits supplemental oxygen to be administered, while recovering and measuring analytes in breath samples. The cannula may connect to a portable processor-display unit for monitoring one or more analytes, such as CO2. Another embodiment includes a cannula configured for the monitoring of sleep disorders, such as apnea, comprising one or more sensors disposed adjacent a breath sampling channel, optionally including flow rate or other sensors. The sensors may be connected by wired or wireless links for to a processor/input/display unit. Any of the embodiments may include filters, selectively permeable membranes, absorbents, and the like to precondition the breath sample, may be configured to include complementary chemistry measurements.
摘要翻译：提供了一种用于检测分析物（如二氧化碳）的电子系统和方法，使用改进的纳米结构传感器（CO2传感器）。 CO 2传感器可以包括衬底和纳米结构，例如设置在衬底上的一个或多个碳纳米管（例如，作为网络）。一个或多个导电元件可以与纳米结构电连通。计数器或栅电极可以邻近纳米结构定位。可以包括与二氧化碳反应的官能化材料，其被设置为与纳米结构接触或通过电介质隔离。传感器可以响应于环境中二氧化碳浓度的变化而连接到电路。描述了包括一个或多个CO 2传感器的医学感测系统的实施例。一个实施例包括连接到传感器单元的呼吸取样套管。在替代方案中，套管允许补充氧气，同时在呼吸样本中回收和测量分析物。套管可以连接到便携式处理器显示单元，用于监测一个或多个分析物，例如CO 2。另一个实施例包括配置用于监测睡眠障碍（例如呼吸暂停）的插管，其包括邻近呼吸采样通道设置的一个或多个传感器，可选地包括流速或其它传感器。传感器可以通过有线或无线链路连接到处理器/输入/显示单元。任何实施方案可以包括过滤器，选择性渗透膜，吸收剂等以预处理呼吸样品，可以被配置为包括互补的化学测量。

15. 发明申请

US20100047901A1 SYSTEM AND METHOD FOR ELECTRONIC SENSING OF BIOMOLECULES 审中-公开
标题翻译：电子感应生物分子的系统和方法
公开(公告)号：US20100047901A1
公开(公告)日：2010-02-25
申请号：US12607912
申请日：2009-10-28
申请人： Keith Bradley , Jean-Christophe P. Gabriel , George Grüner , Alexander Star , Eugene Tu , Christian Valcke
发明人： Keith Bradley , Jean-Christophe P. Gabriel , George Grüner , Alexander Star , Eugene Tu , Christian Valcke
IPC分类号： G01N33/53
CPC分类号： B82Y30/00 , B01L3/50857 , B01L2300/0636 , B01L2300/0663 , B01L2300/0819 , B01L2300/0851 , B01L2300/0893 , B01L2300/0896 , B01L2300/16 , B82Y10/00 , G01N33/5438 , G01N33/551 , G01N33/566 , G01N33/582
摘要： A nanoelectronic device is combined with a cellular membrane component to provide a sensor for biomolecules or to provide information about the structure of the membrane. The nanoelectronic device may comprise a network of randomly-oriented nanotubes, or other nanostructure, arranged on a substrate with adjacent electrodes so as to operate as a field-effect transistor sensor or as a capacitive sensor. A cellular membrane is disposed over the nanostructure element.
摘要翻译：纳米电子器件与细胞膜组件组合以提供用于生物分子的传感器或提供关于膜结构的信息。纳米电子器件可以包括布置在具有相邻电极的衬底上的随机取向的纳米管或其他纳米结构的网络，以便作为场效应晶体管传感器或电容式传感器工作。细胞膜设置在纳米结构元件上。

16. 发明申请

US20100056892A1 NANOELECTRONIC MEASUREMENT SYSTEM FOR PHYSIOLOGIC GASES AND IMPROVED NANOSENSOR FOR CARBON DIOXIDE 有权
标题翻译：用于生物气体的纳米电子测量系统和改进的二氧化碳纳米传感器
公开(公告)号：US20100056892A1
公开(公告)日：2010-03-04
申请号：US11390493
申请日：2006-03-27
申请人： Nadav Ben-Barak , Daniel M. Chang , Jean-Christophe P. Gabriel , Vikram Joshi , Joseph Niemann , Alexander Star , Christian Valcke
发明人： Nadav Ben-Barak , Daniel M. Chang , Jean-Christophe P. Gabriel , Vikram Joshi , Joseph Niemann , Alexander Star , Christian Valcke
IPC分类号： A61B5/05 , A61N1/36
CPC分类号： G01N33/5438 , A61B5/073 , A61B2562/0285 , B82Y10/00 , B82Y15/00 , B82Y20/00 , H01L51/0048 , H01L51/0052 , H01L51/0545
摘要： A system for measuring an analyte of interest, particularly carbon dioxide, dissolved in a fluid media of a patient including a nanoelectronic sensor and a measurement instrument in communication with the sensor and configured to receive at least a signal from the sensor indicative of a response of the sensor to at least the analyte of interest.
摘要翻译：一种用于测量感兴趣的分析物，特别是二氧化碳的系统，其溶解在患者的流体介质中，包括与所述传感器通信的纳米电子传感器和测量仪器，并且被配置为从所述传感器接收表示响应的信号传感器至少是所关注的分析物。

17. 发明授权

US07714398B2 Nanoelectronic measurement system for physiologic gases and improved nanosensor for carbon dioxide 有权
标题翻译：用于生理气体的纳米电子测量系统和改进的二氧化碳纳米传感器
公开(公告)号：US07714398B2
公开(公告)日：2010-05-11
申请号：US11390493
申请日：2006-03-27
申请人： Nadav Ben-Barak , Daniel M. Chang , Jean-Christophe P. Gabriel , Vikram Joshi , Joseph Niemann , Alexander Star , Christian Valcke
发明人： Nadav Ben-Barak , Daniel M. Chang , Jean-Christophe P. Gabriel , Vikram Joshi , Joseph Niemann , Alexander Star , Christian Valcke
IPC分类号： G01N27/414
CPC分类号： G01N33/5438 , A61B5/073 , A61B2562/0285 , B82Y10/00 , B82Y15/00 , B82Y20/00 , H01L51/0048 , H01L51/0052 , H01L51/0545
摘要： A system for measuring an analyte of interest, particularly carbon dioxide, dissolved in a fluid media of a patient including a nanoelectronic sensor and a measurement instrument in communication with the sensor and configured to receive at least a signal from the sensor indicative of a response of the sensor to at least the analyte of interest.
摘要翻译：一种用于测量感兴趣的分析物，特别是二氧化碳的系统，其溶解在患者的流体介质中，包括与所述传感器通信的纳米电子传感器和测量仪器，并且被配置为从所述传感器接收表示响应的信号传感器至少是所关注的分析物。

18. 发明申请

US20080021339A1 Anesthesia monitor, capacitance nanosensors and dynamic sensor sampling method 审中-公开
标题翻译：麻醉监护仪，电容式纳米传感器和动态传感器取样方法
公开(公告)号：US20080021339A1
公开(公告)日：2008-01-24
申请号：US11588845
申请日：2006-10-26
申请人： Jean-Christophe Gabriel , Vikram Joshi , John Passmore , Sergei Skarupo , Alexander Star , Christian Valcke
发明人： Jean-Christophe Gabriel , Vikram Joshi , John Passmore , Sergei Skarupo , Alexander Star , Christian Valcke
IPC分类号： A61B5/08 , G01N31/22
CPC分类号： A61B5/0833 , A61B5/097 , A61B5/4821 , A61B5/6819 , A61B2562/0285 , B82Y30/00
摘要： Embodiments of nanoelectronic sensors are described, including sensors for detecting analytes such as anesthesia gases, CO2 and the like in human breath. An integrated monitor system and disposable sensor unit is described which permits a number of different anesthetic agents to be identified and monitored, as well as concurrent monitoring of other breath species, such as CO2. The sensor unit may be configured to be compact, light weight, and inexpensive. Wireless embodiments provide such enhancements as remote monitoring. A simulator system for modeling the contents and conditions of human inhalation and exhalation with a selected mixture of a treatment agent is also described, particularly suited to the testing of sensors to be used in airway sampling.
摘要翻译：描述了纳米电子传感器的实施例，包括用于在人呼吸中检测分析物例如麻醉气体，CO 2等的传感器。描述了一种集成监视器系统和一次性传感器单元，其允许识别和监视多个不同的麻醉剂，以及对其它呼吸物质（例如CO 2）的并发监测。传感器单元可以被配置为紧凑，重量轻并且便宜。无线实施例提供诸如远程监视的增强。还描述了一种用于用选定的处理剂混合物对人吸入和呼出的内容物和条件进行建模的模拟器系统，特别适合于用于气道取样的传感器的测试。

19. 发明授权

US08425745B2 Electrochemical nanosensors for biomolecule detection 有权
标题翻译：用于生物分子检测的电化学纳米传感器
公开(公告)号：US08425745B2
公开(公告)日：2013-04-23
申请号：US11868373
申请日：2007-10-05
申请人： Mikhail Briman , Ray Radtkey , Eugene Tu , Christian Valcke
发明人： Mikhail Briman , Ray Radtkey , Eugene Tu , Christian Valcke
IPC分类号： G01N27/416
CPC分类号： G01N27/026 , G01N27/3271 , G01N27/3275 , G01N27/3277 , G01N27/3278 , G01N33/5438
摘要： Sensor devices, methods and kits for detection of biomolecules are provided. According to various embodiments, the devices, methods and kits provide enhanced sensitivity through the measurement of electrochemical impedance and related properties. Certain embodiments employ nanostructured electrode elements including nanotubes, nanoparticles, nanowires, and nanocones. In a particular embodiment, single walled carbon nanotubes disposed in interconnected networks are used as electrodes. The device, methods and kits described herein have application for detection and measurement of biomolecular species including polynucleotides, proteins, polysaccharides and the like.
摘要翻译：提供了用于检测生物分子的传感器装置，方法和试剂盒。根据各种实施例，器件，方法和试剂盒通过测量电化学阻抗和相关性质提供增强的灵敏度。某些实施例采用包括纳米管，纳米颗粒，纳米线和纳米骨的纳米结构电极元件。在特定实施例中，布置在互连网络中的单壁碳纳米管用作电极。本文描述的装置，方法和试剂盒具有用于检测和测量生物分子物质的应用，包括多核苷酸，蛋白质，多糖等。

20. 发明授权

US08778269B2 Nanoelectronic electrochemical test device 有权
标题翻译：纳米电子电化学试验装置
公开(公告)号：US08778269B2
公开(公告)日：2014-07-15
申请号：US13092869
申请日：2011-04-22
申请人： Kanchan A. Joshi , Ray Radtkey , Christian Valcke
发明人： Kanchan A. Joshi , Ray Radtkey , Christian Valcke
IPC分类号： D01F9/12
CPC分类号： G01N27/3272 , A61B5/14532 , A61B5/14535 , A61B5/1486 , A61B5/14865 , B82Y10/00 , B82Y15/00 , C12Q1/006 , G01N27/4145 , G01N27/4146 , H01L51/0049 , H01L51/0093 , H01L51/0545 , Y10S977/723
摘要： Nanoelectronic devices for the detection and quantification of biomolecules are provided. In certain embodiments, the devices are configured to detect and measure blood glucose levels. Also provided are methods of fabricating nanoelectronic devices for the detection of biomolecules.
摘要翻译：提供了用于检测和定量生物分子的纳米电子器件。在某些实施例中，装置被配置为检测和测量血糖水平。还提供了制造用于检测生物分子的纳米电子器件的方法。

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