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11. 发明授权

US11275084B2 Successive sampling device and associated method 有权
公开(公告)号：US11275084B2
公开(公告)日：2022-03-15
申请号：US12688193
申请日：2010-01-15
申请人： Sam Kavusi , Daniel Roser , Christoph Lang , AmirAli Haj Hossein Talasaz
发明人： Sam Kavusi , Daniel Roser , Christoph Lang , AmirAli Haj Hossein Talasaz
IPC分类号： B01L3/00 , G01N33/543 , C12Q1/6816
摘要： A method of determining a number of a solution constituent includes introducing a first number of solution constituents to a first test location, establishing a first binding environment for the introduced first number of solution constituents, creating a first residual number of solution constituents by binding a first plurality of solution constituents, establishing a second binding environment for the first residual number of solution constituents, creating a second residual number of solution constituents by binding a second plurality of solution constituents from the first residual number of solution constituents, obtaining a first signal associated with the bound first plurality of solution constituents, obtaining a second signal associated with the bound second plurality of solution constituents, and determining a second number of a constituent of interest based upon the obtained first signal and the obtained second signal.

12. 发明申请

US20120115236A1 Device and Method For Indirect Electronic Condition Control in Biomolecule Detection Platforms 有权
标题翻译：生物分子检测平台间接电子状态控制的装置与方法
公开(公告)号：US20120115236A1
公开(公告)日：2012-05-10
申请号：US13348727
申请日：2012-01-12
申请人： Michael Chen , Vincent Chen , Sam Kavusi , Christoph Lang
发明人： Michael Chen , Vincent Chen , Sam Kavusi , Christoph Lang
IPC分类号： G01N33/50
CPC分类号： G01N33/54393 , C08F20/56 , G01N33/5306 , Y10T436/11 , Y10T436/115831
摘要： A system and method of indirectly modifying an environmental condition at a test site in one embodiment includes providing a test site on a substrate, providing a hydrogel composition loaded with a chemical factor at the test site, providing an actuator configured to activate the hydrogel composition to release a chemical factor at the test site, controlling the actuator to activate the hydrogel composition to release a chemical factor at the test site, and modifying the local chemical environment at the test site with the chemical factor.
摘要翻译：在一个实施方案中间接改变测试部位的环境条件的系统和方法包括在基底上提供测试部位，在测试部位提供装载有化学因子的水凝胶组合物，提供构造成将水凝胶组合物活化的致动器在试验现场释放化学因子，控制致动器激活水凝胶组合物以释放在试验部位的化学因子，并用化学因子改变试验部位的局部化学环境。

13. 发明授权

US09188585B2 Device and method for indirect modulation of detection environment 有权
标题翻译：用于间接调制检测环境的装置和方法
公开(公告)号：US09188585B2
公开(公告)日：2015-11-17
申请号：US12779687
申请日：2010-05-13
申请人： Sam Kavusi , Yi Wei Chen , Michael Chen , Christoph Lang
发明人： Sam Kavusi , Yi Wei Chen , Michael Chen , Christoph Lang
IPC分类号： G01N1/00 , G01N33/543
CPC分类号： G01N33/54306 , G01N33/54366 , G01N33/54393 , Y10T436/25
摘要： A system and method of indirectly modifying an environmental condition at a test site in one embodiment includes providing a test site on a substrate, providing a first activatable stimulant at the test site, providing an actuator configured to activate the first activatable stimulant at the test site, controlling the actuator to activate the first activatable stimulant, and modifying the local chemical environment at the test site with the first activated stimulant.
摘要翻译：在一个实施方案中间接改变测试部位环境条件的系统和方法包括在基底上提供测试部位，在测试部位提供第一可激活的刺激剂，提供构造成在测试部位激活第一可活化刺激物的致动器控制致动器来激活第一可激活的兴奋剂，以及用第一个激活的兴奋剂改变测试部位的局部化学环境。

14. 发明授权

US08476935B2 Comparator with self-limiting positive feedback 有权
标题翻译：具有自限制正反馈的比较器
公开(公告)号：US08476935B2
公开(公告)日：2013-07-02
申请号：US12497216
申请日：2009-07-02
申请人： Robert Wolf , Christoph Lang , Xinyu Xing , Sam Kavusi
发明人： Robert Wolf , Christoph Lang , Xinyu Xing , Sam Kavusi
IPC分类号： H03K5/22
CPC分类号： H03F1/38 , H03K5/08 , H03K5/2481
摘要： A method and circuit for attenuating positive feedback in a comparator in one embodiment includes an amplifier configured to compare a first input signal with a second input signal and to provide an output based upon the comparison, a non-linear function with a first input operably connected to an output of the amplifier, and a feedback loop operably connected to the output of the non-linear function and to a second input of the non-linear function, the feedback loop including a feedback limiting circuit configured to attenuate a feedback signal to the second input of the non-linear function.
摘要翻译：在一个实施例中用于衰减比较器中的正反馈的方法和电路包括：放大器，被配置为将第一输入信号与第二输入信号进行比较，并且基于比较提供输出，非线性函数与第一输入可操作地连接耦合到放大器的输出端，以及可操作地连接到非线性功能的输出端和非线性功能的第二输入端的反馈回路，反馈回路包括反馈限制电路，该反馈限制电路被配置为将反馈信号衰减到第二输入的非线性函数。

15. 发明申请

US20120079897A1 DEVICE AND METHOD FOR SELF-REFERENCED CONFIDENCE TEST 审中-公开
标题翻译：自我信心测试的设备和方法
公开(公告)号：US20120079897A1
公开(公告)日：2012-04-05
申请号：US12895361
申请日：2010-09-30
申请人： Sam Kavusi , Christoph Lang
发明人： Sam Kavusi , Christoph Lang
IPC分类号： G01N33/00
CPC分类号： G01N33/48707
摘要： A system and method of providing a confidence test in one embodiment includes determining a first quality metric based upon a first and a second test environment wherein the second test environment is different from the first test environment, exposing a sample to a plurality of test sites, establishing the first test environment at a first of the plurality of test sites, establishing the second test environment at a second test site, obtaining a first detection signal associated with the first of the plurality of test sites exposed to the sample and at the first test environment, obtaining a second detection signal associated with the second of the plurality of test sites exposed to the sample and at the second test environment, determining a second quality metric based upon the first detection signal and the second detection signal, and comparing the second quality metric with the first quality metric.
摘要翻译：在一个实施例中提供置信度测试的系统和方法包括基于第一和第二测试环境确定第一质量度量，其中第二测试环境与第一测试环境不同，将样本暴露于多个测试位置，在所述多个测试点中的第一测试场所建立所述第一测试环境，在第二测试位置建立所述第二测试环境，获得与暴露于所述样品的所述多个测试点中的第一测试位点相关联的第一检测信号，以及在所述第一测试获得与所述多个测试站点中的第二个暴露于所述样本并在所述第二测试环境相关联的第二检测信号，基于所述第一检测信号和所述第二检测信号确定第二质量度量，以及将所述第二质量度量与第一个质量度量。

16. 发明申请

US20110091870A1 MULTISITE BIOSENSOR AND ASSOCIATED METHOD 有权
标题翻译：多生物传感器及相关方法
公开(公告)号：US20110091870A1
公开(公告)日：2011-04-21
申请号：US12580113
申请日：2009-10-15
申请人： Christoph Lang , Sam Kavusi , Daniel Roser , AmirAli Haj Hossein Talasaz
发明人： Christoph Lang , Sam Kavusi , Daniel Roser , AmirAli Haj Hossein Talasaz
IPC分类号： C12Q1/68 , G01N33/566
CPC分类号： G01N33/54393 , G01N29/32 , G01N33/53 , G01N33/543 , G01N33/54366
摘要： A method of detecting a biomarker in one embodiment includes identifying a quantity of biomolecule types in a sample, exposing the sample to a plurality of test sites, wherein the number of test sites in the plurality of test sites is equal to or greater than the identified quantity of biomolecule types, establishing, for each of the plurality of test sites, a respective test environment, wherein the test environment for each of the plurality of test sites is different from the test environment for each of the other of the plurality of test sites, obtaining a detection signal associated with each of the plurality of test sites, and determining the concentration of one of the biomolecule types based upon the obtained detection signals.
摘要翻译：在一个实施方案中检测生物标志物的方法包括鉴定样品中的生物分子类型的数量，将样品暴露于多个测试位点，其中多个测试位点中的测试位点的数目等于或大于所鉴定的生物分子类型的数量，为多个测试点中的每一个建立相应的测试环境，其中，所述多个测试位置中的每一个的测试环境与所述多个测试位置中的每一个的每个测试位置中的每一个的测试环境不同获得与所述多个测试点中的每一个相关联的检测信号，以及基于所获得的检测信号来确定所述生物分子类型之一的浓度。

17. 发明申请

US20120197534A1 BIOMARKER MONITORING DEVICE AND METHOD 有权
标题翻译：生物标记监测装置和方法
公开(公告)号：US20120197534A1
公开(公告)日：2012-08-02
申请号：US13017391
申请日：2011-01-31
申请人： Sam Kavusi , Christoph Lang
发明人： Sam Kavusi , Christoph Lang
IPC分类号： G06F19/00
CPC分类号： G06F19/28 , G16H10/40 , G16H15/00 , G16H50/30
摘要： A biomarker monitoring method and system in one embodiment includes a communications network, a portable wellness device configured to form a communication link with the communications network, the portable wellness device including a detector configured to detect at least one biomarker in a biologic sample, a first memory, a plurality of program instructions stored in the first memory, and a processing circuit operably connected to the first memory and configured to execute the program instructions to generate wellness data based upon detection of the at least one biomarker in the biologic sample, and a remote user interface operably connected to the communications network and configured to render the wellness data.
摘要翻译：在一个实施方案中的生物标志物监测方法和系统包括通信网络，配置为与通信网络形成通信链路的便携式健康设备，便携式健康设备包括被配置成检测生物样品中的至少一种生物标志物的检测器，存储器，存储在第一存储器中的多个程序指令以及可操作地连接到第一存储器并且被配置为执行程序指令以基于生物样本中的至少一个生物标志物的检测来生成健康数据的处理电路，以及远程用户界面可操作地连接到通信网络并且被配置为呈现健康数据。

18. 发明申请

US20110195853A1 Array with Extended Dynamic Range and Associated Method 有权
标题翻译：具有扩展动态范围和关联方法的阵列
公开(公告)号：US20110195853A1
公开(公告)日：2011-08-11
申请号：US12701712
申请日：2010-02-08
申请人： Sam Kavusi , Michaela Laupheimer , Christoph Lang
发明人： Sam Kavusi , Michaela Laupheimer , Christoph Lang
IPC分类号： C40B30/04
CPC分类号： G01N33/54306 , G01N33/558
摘要： A system and method of quantitating the concentration of a molecule of interest in one embodiment includes establishing a plurality of test environments at a plurality of test sites, each of the plurality of test environments associated with one of a plurality of response curves, each of the plurality of response curves different from the other of the plurality of response curves, storing a combined response curve resulting from a summation of the plurality of response curves, exposing the plurality of test sites to a sample having a concentration of a molecule of interest, obtaining a plurality of quantitation signals, each of the plurality of quantitation signals associated with one of the plurality of test sites, associating a summation of the plurality of quantitation signals with the stored combined response curve, and generating a signal related to the concentration of the molecule of interest based upon the association.
摘要翻译：在一个实施方案中定量感兴趣的分子的浓度的系统和方法包括在多个测试位置建立多个测试环境，所述多个测试环境中的每一个与多个响应曲线之一相关联，每个测试环境多个响应曲线不同于多个响应曲线中的另一个响应曲线，存储由多个响应曲线的总和产生的组合响应曲线，将多个测试位置暴露于具有感兴趣分子浓度的样本，获得多个定量信号，所述多个定量信号中的每一个与所述多个测试点之一相关联，将所述多个定量信号的总和与所存储的组合响应曲线相关联，并产生与所述分子的浓度相关的信号基于协会的兴趣。

19. 发明申请

US20110177962A1 SUCCESSIVE SAMPLING DEVICE AND ASSOCIATED METHOD 审中-公开
标题翻译：成功采样设备及相关方法
公开(公告)号：US20110177962A1
公开(公告)日：2011-07-21
申请号：US12688193
申请日：2010-01-15
申请人： Sam Kavusi , Daniel Roser , Christoph Lang , AmirAli Haj Hossein Talasaz
发明人： Sam Kavusi , Daniel Roser , Christoph Lang , AmirAli Haj Hossein Talasaz
IPC分类号： C40B30/04 , C40B60/12
CPC分类号： G01N33/54366 , B01L3/5027 , C12Q1/6816 , G01N33/54393 , C12Q2565/501
摘要： A method of determining a number of a solution constituent includes introducing a first number of solution constituents to a first test location, establishing a first binding environment for the introduced first number of solution constituents, creating a first residual number of solution constituents by binding a first plurality of solution constituents, establishing a second binding environment for the first residual number of solution constituents, creating a second residual number of solution constituents by binding a second plurality of solution constituents from the first residual number of solution constituents, obtaining a first signal associated with the bound first plurality of solution constituents, obtaining a second signal associated with the bound second plurality of solution constituents, and determining a second number of a constituent of interest based upon the obtained first signal and the obtained second signal.
摘要翻译：确定溶液成分的数量的方法包括将第一数量的溶液成分引入到第一测试位置，为所引入的第一数量的溶液成分建立第一结合环境，通过将第一数量的溶液成分结合到第一残留数量的溶液成分多个溶液成分，为第一剩余数量的溶液组分建立第二结合环境，通过将第二多个溶液组分与第一剩余数量的溶液组分结合而产生第二剩余数量的溶液组分，获得与绑定的第一多个解决方案组成部分，获得与绑定的第二多个解决方案组成部分相关联的第二信号，以及基于获得的第一信号和获得的第二信号来确定感兴趣的组成部分的第二数量。

20. 发明申请

US20110001515A1 COMPARATOR WITH SELF-LIMITING POSITIVE FEEDBACK 有权
标题翻译：具有自限定正反馈的比较器
公开(公告)号：US20110001515A1
公开(公告)日：2011-01-06
申请号：US12497216
申请日：2009-07-02
申请人： Robert Wolf , Christoph Lang , Xinyu Xing , Sam Kavusi
发明人： Robert Wolf , Christoph Lang , Xinyu Xing , Sam Kavusi
IPC分类号： G01R19/00
CPC分类号： H03F1/38 , H03K5/08 , H03K5/2481
摘要： A method and circuit for attenuating positive feedback in a comparator in one embodiment includes an amplifier configured to compare a first input signal with a second input signal and to provide an output based upon the comparison, a non-linear function with a first input operably connected to an output of the amplifier, and a feedback loop operably connected to the output of the non-linear function and to a second input of the non-linear function, the feedback loop including a feedback limiting circuit configured to attenuate a feedback signal to the second input of the non-linear function.
摘要翻译：在一个实施例中用于衰减比较器中的正反馈的方法和电路包括：放大器，被配置为将第一输入信号与第二输入信号进行比较，并且基于比较提供输出，非线性函数与第一输入可操作地连接耦合到放大器的输出端，以及可操作地连接到非线性功能的输出端和非线性功能的第二输入端的反馈回路，反馈回路包括反馈限制电路，该反馈限制电路被配置为将反馈信号衰减到第二输入的非线性函数。

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