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11. 发明授权

US08030050B2 Modified amylases from Pseudomonas species 有权
标题翻译：来自假单胞菌属物种的改性淀粉酶
公开(公告)号：US08030050B2
公开(公告)日：2011-10-04
申请号：US11534624
申请日：2006-09-22
申请人： Casper Tune Berg , Patrick Maria Franciscus Derkx , Carol Fioresi , Gijsbert Gerritse , Anja Hemmingen Kellet-Smith , Karsten Matthias Kragh , Wei Liu , Andrew Shaw , Bo Spange Sørensen , Charlotte Refdahl Thoudahl
发明人： Casper Tune Berg , Patrick Maria Franciscus Derkx , Carol Fioresi , Gijsbert Gerritse , Anja Hemmingen Kellet-Smith , Karsten Matthias Kragh , Wei Liu , Andrew Shaw , Bo Spange Sørensen , Charlotte Refdahl Thoudahl
IPC分类号： C12N9/28 , C12N9/26 , C12N9/24 , C12N9/00 , C12P21/06 , A21D2/00 , A23C9/12 , C07H21/04
CPC分类号： A21D8/042 , A23K20/147 , A23K50/30 , A23K50/75 , A23L33/18 , C12N9/2411 , C12N9/2414 , C12N9/2417 , C12N9/2425 , C12N9/2428
摘要： The invention describes a PS4 variant polypeptide derivable from a parent polypeptide having amylase activity selected from the group consisting of: (a) a polypeptide comprising an amino acid mutation at each of positions 33, 34, 121, 134, 141, 146, 157, 161, 178, 179, 223, 229, 272, 303, 307, 309 and 334; (b) a polypeptide comprising an amino acid mutation at each of positions 33, 34, 121, 134, 141, 145, 146, 157, 178, 179, 223, 229, 272, 303, 307 and 334; (c) a polypeptide comprising an amino acid mutation at each of positions 33, 34, 121, 134, 141, 146, 157, 178, 179, 223, 229, 272, 303, 307, 309 and 334; and (d) a polypeptide comprising an amino acid mutation at each of positions 3, 33, 34, 70, 121, 134, 141, 146, 157, 178, 179, 223, 229, 272, 303, 307, 309 and 334; with reference to the position numbering of a Pseudomonas saccharophilia exoamylase sequence shown as SEQ ID NO: 1, uses of such a polypeptide as a food or feed additive, and nucleic acids encoding such.
摘要翻译：本发明描述了可衍生自具有选自以下的淀粉酶活性的亲本多肽的PS4变体多肽： 161,178,179,223,229,272,303,307,309和334; （b）包含位置33,34,121,134,141,145,146,157,178,179,223,229,272,303,307和334的氨基酸突变的多肽; （c）包含位置33,34,121,134,141,146,157,178,179,223,229,272,303,307,309和334的氨基酸突变的多肽; 和（d）包含位置3,33,34,70,121,134,141,146,157,178,179,223,229,272,303,307,309和334中的每一个上的氨基酸突变的多肽 ; 参照SEQ ID NO：1所示的假单胞菌属酵母胞外淀粉酶序列的位置编号，这种多肽作为食品或饲料添加剂的使用，以及编码这样的核酸。

12. 发明申请

US20080292747A1 MODIFIED AMYLASE FROM PSEUDOMONAS SACCHAROPHILIA 审中-公开
标题翻译：来自PSEUDOMONAS SACCHAROPHILIA的修饰的AMYLASE
公开(公告)号：US20080292747A1
公开(公告)日：2008-11-27
申请号：US11970473
申请日：2008-01-07
申请人： Casper Tune Berg , Patrick Maria Franciscus Derkx , Carol Fioresi , Gijsbert Gerritse , Anja Hemmingen Kellet-Smith , Karsten Matthias Kragh , Wei Liu , Andrew Shaw , Bo Spange Sorensen , Charlotte Refdahl Thoudahl
发明人： Casper Tune Berg , Patrick Maria Franciscus Derkx , Carol Fioresi , Gijsbert Gerritse , Anja Hemmingen Kellet-Smith , Karsten Matthias Kragh , Wei Liu , Andrew Shaw , Bo Spange Sorensen , Charlotte Refdahl Thoudahl
IPC分类号： A21D2/08 , A21D13/06 , C12N9/28 , C12P19/00
CPC分类号： A21D8/042 , A23L33/18 , C12N9/2411 , C12N9/2414 , C12N9/2417 , C12N9/2425 , C12N9/2428
摘要： Described is a PS4 variant polypeptide derivable from a polypeptide having amylase activity selected from: (a) a polypeptide comprising an amino acid mutation at each of positions 33, 34, 121, 134, 141, 146, 157, 161, 178, 179, 223, 229, 272, 303, 307, 309 and 334; (b) a polypeptide comprising an amino acid mutation at each of positions 33, 34, 121, 134, 141, 145, 146, 157, 178, 179, 223, 229, 272, 303, 307 and 334; (c) a polypeptide comprising an amino acid mutation at each of positions 33, 34, 121, 134, 141, 146, 157, 178, 179, 223, 229, 272, 303, 307, 309 and 334; and (d) a polypeptide comprising an amino acid mutation at each of positions 3, 33, 34, 70, 121, 134, 141, 146, 157, 178, 179, 223, 229, 272, 303, 307, 309 and 334; referring to the numbering of a Pseudomonas saccharophilia exoamylase shown as SEQ ID NO: 1.
摘要翻译：描述了可衍生自具有选自以下的淀粉酶活性的多肽的PS4变体多肽： 223,229,272,303,307,309和334; （b）包含位置33,34,121,134,141,145,146,157,178,179,223,229,272,303,307和334的氨基酸突变的多肽; （c）包含位置33,34,121,134,141,146,157,178,179,223,229,272,303,307,309和334的氨基酸突变的多肽; 和（d）包含位置3,33,34,70,121,134,141,146,157,178,179,223,229,272,303,307,309和334中的每一个上的氨基酸突变的多肽 ; 指的是SEQ ID NO：1所示的假单胞菌糖酵母外切酶的编号。

13. 发明申请

US20070020727A1 Exo-specific amylase polypeptides, nucleic acids encoding those polypeptides and uses thereof 审中-公开
标题翻译：特异性淀粉酶多肽，编码那些多肽的核酸及其用途
公开(公告)号：US20070020727A1
公开(公告)日：2007-01-25
申请号：US11523977
申请日：2006-09-19
申请人： Casper Berg , Kirsten Bojsen , Patrick Derkx , Carol Fioresi , Gijsbert Gerritse , Karsten Kragh , Wei Liu , Andrew Shaw , Charlotte Thoudahl , Anja Kellett-Smith
发明人： Casper Berg , Kirsten Bojsen , Patrick Derkx , Carol Fioresi , Gijsbert Gerritse , Karsten Kragh , Wei Liu , Andrew Shaw , Charlotte Thoudahl , Anja Kellett-Smith
IPC分类号： C12P21/06 , C07H21/04 , C12N9/32 , C12N15/74 , C12N1/21
CPC分类号： C12N9/2417
摘要： This invention relates to amylase polypeptides, and nucleic acids encoding the polpypeptides and uses thereof. The amylases of the present invention have been engineered to have more beneficial qualities. Specifically, the amylases of the current invention show an altered exospecifity.
摘要翻译：本发明涉及淀粉酶多肽和编码多肽的核酸及其用途。本发明的淀粉酶已被设计成具有更多的有益品质。具体地说，本发明的淀粉酶表现出改变的促进作用。

14. 发明申请

US20050136524A1 Exo-specific amylase polypeptides, nucleic acids encoding those polypeptides and uses thereof 有权
标题翻译：特异性淀粉酶多肽，编码那些多肽的核酸及其用途
公开(公告)号：US20050136524A1
公开(公告)日：2005-06-23
申请号：US10886903
申请日：2004-07-07
申请人： Karsten Kragh , Kirsten Bojsen , Casper Berg , Patrick Derkx , Anja Kellett-Smith , Charlotte Thoudahl , Carol Fioresi , Wei Liu , Andrew Shaw , Gijsbert Gerritse
发明人： Karsten Kragh , Kirsten Bojsen , Casper Berg , Patrick Derkx , Anja Kellett-Smith , Charlotte Thoudahl , Carol Fioresi , Wei Liu , Andrew Shaw , Gijsbert Gerritse
IPC分类号： C07H21/04 , C12N9/28 , C12N9/32 , C12N15/74
CPC分类号： C12N9/2417
摘要： This invention relates to amylase polypeptides, and nucleic acids encoding the polpypeptides and uses thereof. The amylases of the present invention have been engineered to have more beneficial qualities. Specifically, the amylases of the current invention show an altered exospecifity.
摘要翻译：本发明涉及淀粉酶多肽和编码多肽的核酸及其用途。本发明的淀粉酶已被设计成具有更多的有益品质。具体地说，本发明的淀粉酶表现出改变的促进作用。

15. 发明申请

US20070141693A1 Polypeptide 审中-公开
标题翻译：多肽
公开(公告)号：US20070141693A1
公开(公告)日：2007-06-21
申请号：US11483220
申请日：2006-07-07
申请人： Casper Berg , Patrick Maria Derkx , Carol Fioresi , Gijsbert Gerritse , Anja Kellet-Smith , Karsten Kragh , Wei Liu , Andrew Shaw , Bo Sorensen , Charlotte Thoudahl
发明人： Casper Berg , Patrick Maria Derkx , Carol Fioresi , Gijsbert Gerritse , Anja Kellet-Smith , Karsten Kragh , Wei Liu , Andrew Shaw , Bo Sorensen , Charlotte Thoudahl
IPC分类号： C12N9/32 , C12N1/21
CPC分类号： A21D8/042 , A23L33/18 , C12N9/2411 , C12N9/2414 , C12N9/2417 , C12N9/2425 , C12N9/2428
摘要： The invention provides for a PS4 variant polypeptide derivable from a parent polypeptide having amylase activity which may be selected from the group consisting of: (a) a polypeptide comprising an amino acid mutation at each of positions 33, 34, 121, 134, 141, 146, 157, 161, 178, 179, 223, 229, 272, 303, 307, 309 and 334; (b) a polypeptide comprising an amino acid mutation at each of positions 33, 34, 121, 134, 141, 145, 146, 157, 178, 179, 223, 229, 272, 303, 307 and 334; (c) a polypeptide comprising an amino acid mutation at each of positions 33, 34, 121, 134, 141, 146, 157, 178, 179, 223, 229, 272, 303, 307, 309 and 334; and (d) a polypeptide comprising an amino acid mutation at each of positions 3, 33, 34, 70, 121, 134, 141, 146, 157, 178, 179, 223, 229, 272, 303, 307, 309 and 334; with reference to the position numbering of a Pseudomonas saccharophilia exoamylase sequence shown as SEQ ID NO: 1, uses of such a polypeptide as a food or feed additive, and nucleic acids encoding such.
摘要翻译：本发明提供可衍生自具有淀粉酶活性的亲本多肽的PS4变体多肽，其可以选自： 146，157，161，178，179，223，229，272，303，307，309和334; （b）包含位置33,34,121,134,141,145,146,157,178,179,223,229,272,303,307和334的氨基酸突变的多肽; （c）包含位置33,34,121,134,141,146,157,178,179,223,229,272,303,307,309和334的氨基酸突变的多肽; 和（d）包含位置3,33,34,70,121,134,141,146,157,178,179,223,229,272,303,307,309和334中的每一个上的氨基酸突变的多肽 ; 参考如SEQ ID NO：1所示的假单胞菌属酵母内切酶序列的位置编号，这种多肽作为食品或饲料添加剂的使用，以及编码其的核酸。

16. 发明申请

US20070020731A1 Thermostable amylase polypeptides, nucliec acids encoding those polypeptides and uses thereof 有权
标题翻译：热稳定淀粉酶多肽，编码这些多肽的核酸及其用途
公开(公告)号：US20070020731A1
公开(公告)日：2007-01-25
申请号：US11528999
申请日：2006-09-27
申请人： Karsten Kragh , Casper Berg , Patrick Derkx , Anja Kellett-Smith , Charlotte Thoudahl , Oene Veltman , Carol Fioresi , Gijsbert Gerritse , Wei Liu , Andrew Shaw
发明人： Karsten Kragh , Casper Berg , Patrick Derkx , Anja Kellett-Smith , Charlotte Thoudahl , Oene Veltman , Carol Fioresi , Gijsbert Gerritse , Wei Liu , Andrew Shaw
IPC分类号： C12P21/06 , C07H21/04 , C12N9/32 , C12N15/74 , C12N1/21
CPC分类号： C12N9/2417 , A21D8/042 , A23L29/06 , A23L29/35 , A23L33/17 , A23V2002/00 , A23V2300/21
摘要： This is invention relates to amylase polypeptides, and nucleic acids encoding the polpypeptides and uses thereof. The amylases of the present invention have been engineered to have more beneficial qualities. Specifically, the amylases of the current invention show an altered thermostability.
摘要翻译：本发明涉及淀粉酶多肽和编码多肽的核酸及其用途。本发明的淀粉酶已被设计成具有更多的有益品质。具体地说，本发明的淀粉酶显示出改变的热稳定性。

17. 发明申请

US20050137111A1 Thermostable amylase polypeptides, nucleic acids encoding those polypeptides and uses thereof 有权
标题翻译：热稳定淀粉酶多肽，编码那些多肽的核酸及其用途
公开(公告)号：US20050137111A1
公开(公告)日：2005-06-23
申请号：US10886905
申请日：2004-07-07
申请人： Karsten Kragh , Casper Berg , Patrick Derkx , Anja Kellett-Smith , Charlotte Thoudahl , Oene Veltman , Carol Fioresi , Wei Liu , Andrew Shaw , Gijsbert Gerritse
发明人： Karsten Kragh , Casper Berg , Patrick Derkx , Anja Kellett-Smith , Charlotte Thoudahl , Oene Veltman , Carol Fioresi , Wei Liu , Andrew Shaw , Gijsbert Gerritse
IPC分类号： A21D8/02 , A21D8/04 , A23L1/03 , A23L1/09 , A23L1/305 , C07H21/04 , C11D3/386 , C12N1/21 , C12N9/28 , C12N9/32 , C12N15/74
CPC分类号： C12N9/2417 , A21D8/042 , A23L29/06 , A23L29/35 , A23L33/17 , A23V2002/00 , A23V2300/21
摘要： This invention relates to amylase polypeptides, and nucleic acids encoding the polpypeptides and uses thereof. The amylases of the present invention have been engineered to have more beneficial qualities. Specifically, the amylases of the current invention show an altered thermostability.
摘要翻译：本发明涉及淀粉酶多肽和编码多肽的核酸及其用途。本发明的淀粉酶已被设计成具有更多的有益品质。具体地说，本发明的淀粉酶显示出改变的热稳定性。

18. 发明授权

US06225106B1 Expression system for altered expression levels 有权
标题翻译：表达系统改变表达水平
公开(公告)号：US06225106B1
公开(公告)日：2001-05-01
申请号：US09479409
申请日：2000-01-06
申请人： Gijsbert Gerritse , Wilhelmus J. Quax
发明人： Gijsbert Gerritse , Wilhelmus J. Quax
IPC分类号： C12N1578
CPC分类号： C07K14/21 , C12N9/20 , C12N15/78
摘要： A new expression system is provided which comprises component(s) of a lipase regulation cascade. The lipase regulation cascade as disclosed herein includes a kinase, a DNA binding regulator, a polymerase, a promoter, an upstream activating sequence, and secretion factors. Plasmids and transformed cells are also provided as well as methods of transforming host cells using the plasmids. Further, there is provided a kinase that can regulate the expression of a protein, a DNA binding regulator that can regulate the expression of a protein, a Pseudomonas alcaligenes polymerase, a Pseudomonas alcaligenes sigma 54 promoter, a Pseudomonas alcaligenes upstream activating sequence, the Pseudomonas alcaligenes secretion factors XcpP, XcpQ, XcpR, XcpS, XcpT, XcpU, XcpV, XcpW, XcpX, XcpY, XcpZ and the xcp regulators OrfV, OrfX.
摘要翻译：提供了一种新的表达系统，其包含脂肪酶调节级联的组分。如本文所公开的脂肪酶调节级联包括激酶，DNA结合调节剂，聚合酶，启动子，上游激活序列和分泌因子。还提供质粒和转化细胞以及使用质粒转化宿主细胞的方法。此外，提供了可以调节蛋白质的表达的激酶，可调节蛋白质表达的DNA结合调节剂，产碱假单胞菌聚合酶，产碱假马杆菌54启动子，产碱假单胞菌（Pseudomonas alcaligenes）上游激活序列，假单胞菌产碱分泌因子XcpP，XcpQ，XcpR，XcpS，XcpT，XcpU，XcpV，XcpW，XcpX，XcpY，XcpZ和xcp调节剂OrfV OrfX。

19. 发明授权

US6017866A Lipases with improved surfactant resistance 失效
标题翻译：具有改善的表面活性剂抵抗力的脂肪酶
公开(公告)号：US6017866A
公开(公告)日：2000-01-25
申请号：US732412
申请日：1996-10-22
申请人： Wolfgang Aehle , Gijsbert Gerritse , Hermanus B. M. Lenting
发明人： Wolfgang Aehle , Gijsbert Gerritse , Hermanus B. M. Lenting
IPC分类号： C12N15/09 , C11D3/386 , C12N9/20 , C07H21/04 , C12N1/20 , C12N15/00
CPC分类号： C12N9/20 , C11D3/38627 , Y10S435/874
摘要： The present invention provides mutant lipases which retain lipase activity, but have improved surfactant resistance and are thus highly advantageous for use in detergent compositions. Preferred lipases of this type include modified functional forms of a lipase of Pseudomonas alcaligenes having one or more amino acid substitutions at or near the surface of the lipase which effect interaction of the hydrophobic portions of surfactant molecules with initiation sites on the enzyme for surfactant denaturation.
摘要翻译： PCT No.PCT / EP95 / 01687 Sec。 371日期1996年10月22日第 102（e）日期1996年10月22日PCT提交1995年4月28日PCT公布。 WO95 / 30744PC PCT出版物日期1995年11月16日本发明提供了保留脂肪酶活性但具有改善的表面活性剂抗性的突变脂肪酶，因此在洗涤剂组合物中的使用非常有利。这种类型的优选脂肪酶包括在脂肪酶表面处或附近具有一个或多个氨基酸取代的产碱假单胞菌的脂肪酶的修饰的功能形式，其影响表面活性剂分子的疏水部分与用于表面活性剂变性的酶的起始位点的相互作用。

20. 发明授权

US06313283B1 Expression system for altered expression levels 有权
标题翻译：表达系统改变表达水平
公开(公告)号：US06313283B1
公开(公告)日：2001-11-06
申请号：US09479453
申请日：2000-01-06
申请人： Gijsbert Gerritse , Wilhelmus J. Quax
发明人： Gijsbert Gerritse , Wilhelmus J. Quax
IPC分类号： C12N1531
CPC分类号： C07K14/21 , C12N9/20 , C12N15/78
摘要： A new expression system is provided which comprises component(s) of a lipase regulation cascade. the lipase regulation cascade as disclosed herein includes a kinase, a DNA binding regulator, a polymerase, a promoter, an upstream activating sequence, and secretion factors. Plasmids and transformed cells are also provided as well as methods of transforming host cells using the plasmids. Further, there is provided a kinase that can regulate the expression of a protein, a DNA binding regulator that can regulate the expression of a protein, a Pseudomonas alcaligenes polymerase, a Pseudomonas alcaligenes sigma 54 promoter, a Pseudomonas alcaligenes upstream activating sequence, the Pseudomonas alcaligenes secretion factors XcpP, XcpQ, XcpR, XcpS, XcpT, XcpU, XcpV, XcpW, XcpX, XcpY, XcpZ and the xcp regulators OrfV, OrfX.
摘要翻译：提供了一种新的表达系统，其包含脂肪酶调节级联的组分。如本文所公开的脂肪酶调节级联包括激酶，DNA结合调节剂，聚合酶，启动子，上游激活序列和分泌因子。还提供质粒和转化细胞以及使用质粒转化宿主细胞的方法。此外，提供了可以调节蛋白质的表达的激酶，可调节蛋白质表达的DNA结合调节剂，产碱假单胞菌聚合酶，产碱假马杆菌54启动子，产碱假单胞菌（Pseudomonas alcaligenes）上游激活序列，假单胞菌产碱分泌因子XcpP，XcpQ，XcpR，XcpS，XcpT，XcpU，XcpV，XcpW，XcpX，XcpY，XcpZ和xcp调节剂OrfV OrfX。

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