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11. 发明授权

US09290456B2 Pyridazinone compounds and their use as DAAO inhibitors 有权
标题翻译：哒嗪酮化合物及其作为DAAO抑制剂的用途
公开(公告)号：US09290456B2
公开(公告)日：2016-03-22
申请号：US14240045
申请日：2012-08-21
申请人： William Farnaby , Charlotte Fieldhouse , Katherine Hazel , Catrina Kerr , Natasha Kinsella , David Livermore , Kevin Merchant , David Miller
发明人： William Farnaby , Charlotte Fieldhouse , Katherine Hazel , Catrina Kerr , Natasha Kinsella , David Livermore , Kevin Merchant , David Miller
IPC分类号： C07D237/16 , C07D401/06 , A61K31/50 , A61K31/501 , C07D401/10 , C07D407/10 , A61K45/06 , C07D237/18 , C07D237/22 , C07D405/06 , C07F7/08
CPC分类号： A61K31/50 , A61K31/501 , A61K45/06 , C07D237/16 , C07D237/18 , C07D237/22 , C07D401/06 , C07D401/10 , C07D405/06 , C07D407/10 , C07F7/0812
摘要： The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1 and R2 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译：本发明提供式（I）化合物及其药学上可接受的盐，其中R1和R2如说明书中所定义，其制备方法，含有它们的药物组合物及其在治疗中的用途。

12. 发明授权

US09101735B2 Catheter control systems 有权
标题翻译：导管控制系统
公开(公告)号：US09101735B2
公开(公告)日：2015-08-11
申请号：US12499011
申请日：2009-07-07
申请人： Chris A. Rothe , Juan Diego Perea , David Miller , Vahid Saadat , Zachary J. Malchano , Ruey-Feng Peh
发明人： Chris A. Rothe , Juan Diego Perea , David Miller , Vahid Saadat , Zachary J. Malchano , Ruey-Feng Peh
IPC分类号： A61B1/01 , A61M25/01 , A61M25/00
CPC分类号： A61M25/0147 , A61M25/0074 , A61M25/0082 , A61M25/0105 , A61M25/0136 , A61M2025/015
摘要： Catheter control systems which facilitate the tracking of an angle of deflection of a catheter distal end can be used for any number of procedures where catheter orientation relative to the body is desirable, e.g., in transseptal access procedures where an accurate angle of puncture of the septal wall is desirable. Such control systems may comprise a steerable handle which is oriented relative to the catheter steerable section to provide for consistent catheter articulation upon corresponding manipulation of the steering ring. Another variation may utilize an orientation indicator to track the deflectable distal end. For instance, an orientation marker as visualized through an imaging hood on the distal end may correspond to identical orientation markers on the control handle such that articulation of a steering mechanism in a direction relative to the orientation markers deflects the catheter distal end in a corresponding direction relative to the visualized orientation markers.
摘要翻译：促进跟踪导管远端的偏转角度的导管控制系统可用于任何数量的程序，其中导管相对于身体的取向是期望的，例如在中间通道的准确的穿刺角度墙是理想的。这样的控制系统可以包括相对于导管可转向部分定向的可操纵手柄，以在相应操纵转向环时提供一致的导管关节运动。另一种变型可以利用取向指示器来跟踪可偏转的远端。例如，通过远端上的成像罩可视化的取向标记可以对应于控制手柄上的相同的取向标记，使得转向机构在相对于定向标记的方向上的关节转动导管远端在相应方向相对于可视化的取向标记。

13. 发明授权

US09028705B2 Capsule 有权
标题翻译：胶囊
公开(公告)号：US09028705B2
公开(公告)日：2015-05-12
申请号：US13701357
申请日：2012-05-31
申请人： Zhao Wei , Han Zhisan , David Miller
发明人： Zhao Wei , Han Zhisan , David Miller
IPC分类号： H01F41/00 , H01F7/02 , H01F1/047 , H01F1/06 , H01F1/08 , H01F1/44
CPC分类号： H01F1/061 , C22C2202/02 , H01F1/08 , Y10T428/2989
摘要： A capsule having a solid core, a primary shell of liquid encapsulating the solid core and a secondary shell of particles encapsulating the primary shell. The primary and secondary shells are generally repulsive to each other. Also provided is a process for the manufacture of capsules and a process for the manufacture of a magnetic body.
摘要翻译：具有固体核的胶囊，包封固体核的液体的主要壳和包封主壳的颗粒的二次壳。主要和次要的壳通常是相互排斥的。还提供了制造胶囊的方法和用于制造磁性体的方法。

14. 发明申请

US20150030704A1 PYRIDAZINONE COMPOUNDS AND THEIR USE AS DAAO INHIBITORS 有权
标题翻译：吡咯烷酮化合物及其作为DAAO抑制剂的用途
公开(公告)号：US20150030704A1
公开(公告)日：2015-01-29
申请号：US14240045
申请日：2012-08-21
申请人： William Farnaby , Charlotte Fieldhouse , Katherine Hazel , Catrina Kerr , Natasha Kinsella , David Livermore , Kevin Merchant , David Miller
发明人： William Farnaby , Charlotte Fieldhouse , Katherine Hazel , Catrina Kerr , Natasha Kinsella , David Livermore , Kevin Merchant , David Miller
IPC分类号： C07D237/16 , C07D401/06 , A61K45/06 , C07D237/18 , C07D237/22 , C07D405/06 , A61K31/50 , A61K31/501
CPC分类号： A61K31/50 , A61K31/501 , A61K45/06 , C07D237/16 , C07D237/18 , C07D237/22 , C07D401/06 , C07D401/10 , C07D405/06 , C07D407/10 , C07F7/0812
摘要： The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1 and R2 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译：本发明提供式（I）化合物及其药学上可接受的盐，其中R1和R2如说明书中所定义，其制备方法，含有它们的药物组合物及其在治疗中的用途。

15. 发明授权

US08882847B2 Patient selectable knee joint arthroplasty devices 有权
标题翻译：患者可选膝关节置换装置
公开(公告)号：US08882847B2
公开(公告)日：2014-11-11
申请号：US10997407
申请日：2004-11-24
申请人： Albert G. Burdulis, Jr. , Wolfgang Fitz , Philipp Lang , Daniel Steines , Konstantinos Tsougarakis , Rene Vargas-Voracek , Hacene Bouadi , David Miller
发明人： Albert G. Burdulis, Jr. , Wolfgang Fitz , Philipp Lang , Daniel Steines , Konstantinos Tsougarakis , Rene Vargas-Voracek , Hacene Bouadi , David Miller
IPC分类号： A61F2/38 , A61F2/30 , A61F2/46 , A61B5/00
CPC分类号： A61F2/3859 , A61B5/4504 , A61B5/4514 , A61B5/4528 , A61F2/30942 , A61F2/38 , A61F2/4657 , A61F2002/30535 , A61F2250/0058
摘要： Disclosed herein are methods and devices for repairing articular surfaces in a knee joint. The articular surface repairs are customizable or highly selectable for each patient and geared toward providing optimal fit and function. Kits are also provided to enable customized repairs to be performed.
摘要翻译：本文公开了用于修复膝关节中的关节表面的方法和装置。关节面维修是可定制的或高度可选择的每个患者和面向提供最佳配合和功能。还提供工具包以实现定制维修。

16. 发明申请

US20140248378A1 PYRIMIDINONE COMPOUNDS AND THEIR USE 审中-公开
标题翻译：吡咯烷酮化合物及其用途
公开(公告)号：US20140248378A1
公开(公告)日：2014-09-04
申请号：US14131337
申请日：2012-07-05
申请人： Xiao-Ling Fan Cockcroft , William Farnaby , Natasha Kinsella , Kevin Merchant , David Miller
发明人： Xiao-Ling Fan Cockcroft , William Farnaby , Natasha Kinsella , Kevin Merchant , David Miller
IPC分类号： A61K31/513 , C07D239/22 , C07D403/12 , C07D401/12 , A61K45/06 , C07D471/04 , C07D413/12 , C07D405/12
CPC分类号： A61K31/513 , A61K45/06 , C07D239/22 , C07D239/54 , C07D239/60 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/04
摘要： The present invention provides compounds of formula (1) and pharmaceutically acceptable salts thereof, wherein R1, R2, Y and Z are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译：本发明提供式（1）化合物及其药学上可接受的盐，其中R1，R2，Y和Z如说明书中所定义，其制备方法，含有它们的药物组合物及其在治疗中的用途。

17. 发明授权

US08555999B2 Twist-handled power tool with locking system 有权
标题翻译：带锁定系统的扭转式电动工具
公开(公告)号：US08555999B2
公开(公告)日：2013-10-15
申请号：US12783850
申请日：2010-05-20
申请人： Jason C. McRoberts , Ashok S. Baskar , David Miller
发明人： Jason C. McRoberts , Ashok S. Baskar , David Miller
IPC分类号： B25B23/00
CPC分类号： B25F5/02
摘要： A power tool with first and second housing portions, a powertrain, a mounting hub and a lock bar. The powertrain has an output member that extends from the second housing portion and which is movable relative to an output member axis. The mounting hub is fixedly coupled to one of the first and second housing portions. The lock bar is movably mounted to the other one of the first and second housing portions between a locked position and a first unlocked position. The lock bar cooperates with the mounting hub in the locked position to inhibit relative rotation between the first and second housing portions. Placement of the lock bar in the first unlocked position permits relative rotation between the first and second housing portions.
摘要翻译：具有第一和第二壳体部分的动力工具，动力系，安装轮毂和锁杆。动力系具有从第二壳体部分延伸并且可相对于输出构件轴线移动的输出构件。安装毂固定地联接到第一和第二壳体部分中的一个。锁定杆在锁定位置和第一解锁位置之间可移动地安装到第一和第二壳体部分中的另一个。锁定杆在锁定位置与安装毂配合以阻止第一和第二壳体部分之间的相对旋转。锁定杆在第一解锁位置的放置允许第一和第二壳体部分之间的相对旋转。

18. 发明申请

US20130247401A1 SYSTEMS AND METHODS FOR MOUNTING PICTURE FRAMES 审中-公开
标题翻译：用于安装图像框架的系统和方法
公开(公告)号：US20130247401A1
公开(公告)日：2013-09-26
申请号：US13430573
申请日：2012-03-26
申请人： David Miller
发明人： David Miller
IPC分类号： A47B81/00 , G01C9/10 , G01C9/24 , B23P11/00
CPC分类号： G01C9/12 , A47G1/06 , A47G1/1633 , A47G2001/0666 , G01C9/24 , Y10T29/49826
摘要： A frame assembly is provided for easily hanging a frame at a desired orientation. The base frame has a central mount that is fastened to a wall, to permit the base frame to be rotated to the desired orientation. Off-center mounts are thereafter fastened to the wall to maintain the desired orientation. The base frame is configured to fit within an outer frame, which holds an artistic or functional insert. Once the outer frame is mounted over the base frame, the base frame is obscured and the outer frame is flush with the wall surface. Further, multiple base frames can be hung in alignment by simply marking the desired center point for each base frame. The outer frame is removably secured to the base frame by a catch, to permit the easy exchange of the artistic insert or outer frame.
摘要翻译：提供了一种框架组件，用于以期望的方向容易地将框架悬挂在框架上。基座框架具有固定在墙壁上的中央支架，以允许基座框架旋转到所需的方向。偏心安装件此后固定在墙上以保持所需的方位。底架被配置成装配在外框架内，该框架具有艺术性或功能性的插入物。一旦外框架被安装在基架上方，基架被遮蔽，外框架与墙壁表面齐平。此外，通过简单地标记每个基架的期望的中心点，可以将多个基架悬挂在对准中。外框架通过卡扣可拆卸地固定到基座上，以便容易地更换艺术插入件或外框架。

19. 发明申请

US20130006287A1 Endoscopic Helix Tissue Grasping Device 有权
标题翻译：内窥镜螺旋组织抓取装置
公开(公告)号：US20130006287A1
公开(公告)日：2013-01-03
申请号：US13539777
申请日：2012-07-02
申请人： Stephen West , David Miller , Vladimir Mitelberg , Donald K. Jones
发明人： Stephen West , David Miller , Vladimir Mitelberg , Donald K. Jones
IPC分类号： A61B17/94
CPC分类号： A61B1/018 , A61B1/04 , A61B17/00234 , A61B17/0401 , A61B17/0469 , A61B17/0482 , A61B17/0487 , A61B17/0491 , A61B17/06123 , A61B17/0625 , A61B17/068 , A61B2017/00296 , A61B2017/00349 , A61B2017/0042 , A61B2017/00477 , A61B2017/0409 , A61B2017/0417 , A61B2017/0454 , A61B2017/0464 , A61B2017/0496 , A61B2017/06047 , A61B2017/0608 , A61B2017/0649 , A61B2017/2912
摘要： An endoscopic tissue grasper device includes a flexible tubular member, a flexible shaft extending through the tubular member, a proximal handle for moving the shaft and tubular member relative to each other, and a distal helical coil having a sharpened end for engaging tissue. The helical coil has a proximal close wound portion, a distal open wound portion, and an intermediate transition portion between the proximal and distal portions. The flexible shaft extends into the proximal and intermediate portions and is secured thereto, which prevents tissue engaged by the helical coil from becoming wedged in the transition portion and thereby facilitates release of the coil from engaged tissue. In addition, a bearing sheath is provided between the shaft and tubular member to prevent the shaft from binding during operation.
摘要翻译：内窥镜组织抓取装置包括柔性管状构件，延伸穿过管状构件的柔性轴，用于相对于彼此移动轴和管状构件的近侧手柄，以及具有用于接合组织的尖端的远端螺旋线圈。螺旋线圈具有近端紧密缠绕部分，远侧开口缠绕部分以及近端部分和远端部分之间的中间过渡部分。柔性轴延伸到近侧和中间部分并且固定到其上，这防止由螺旋线圈接合的组织楔入过渡部分，从而有助于将线圈从接合的组织释放。此外，在轴和管状构件之间设置有轴承护套以防止轴在操作期间装订。

20. 再颁专利

USRE43526E1 Rod introduction apparatus 有权
标题翻译：杆引导装置
公开(公告)号：USRE43526E1
公开(公告)日：2012-07-17
申请号：US12052465
申请日：2008-03-20
申请人： Matthew M. Morrison , Eric A. Loveless , David L. Brumfield , B. Thomas Barker , Catalina J. Carroll , David Miller , Dominique Petit
发明人： Matthew M. Morrison , Eric A. Loveless , David L. Brumfield , B. Thomas Barker , Catalina J. Carroll , David Miller , Dominique Petit
IPC分类号： A61B17/56
CPC分类号： A61B17/7088 , A61B17/7091
摘要： An introduction apparatus for approximating a longitudinal member and an implant to permit fixation therebetween. The introduction apparatus having a gripping nose for securely engaging an implant, a lateral approximation mechanism for laterally aligning an implant and an offset longitudinal member, and a reduction mechanism for reducing the vertical distance between the implant and the longitudinal member. The introduction apparatus is provide with a gripping nose actuated by axial movement of a clamping shaft in an outer sleeve. The clamping shaft further includes an axial cannula for passage of a fastener to the implant.
摘要翻译：用于近似纵向构件和植入物以允许其间固定的引入装置。所述引入装置具有用于牢固地接合植入物的夹持鼻，用于横向对准植入物和偏移纵向构件的横向近似机构，以及用于减小植入物和纵向构件之间的垂直距离的减速机构。引入装置具有通过夹紧轴在外套筒中的轴向运动而致动的抓持头。夹紧轴还包括用于将紧固件通过到植入物的轴向插管。

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