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11. 发明申请

WO1996000585A1 DIPHOSPHATE OR TRIPHOSPHATE ANALOGUE CONJUGATES 审中-公开
标题翻译：二磷酸酯或三磷酸酯类似物
公开(公告)号：WO1996000585A1
公开(公告)日：1996-01-11
申请号：PCT/FR1995000872
申请日：1995-06-29
申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , CREMINON, Christophe , GRASSI, Jacques , PRADELLES, Philippe , MIOSKOWSKI, Charles , LEBEAU, Luc , SAADY, Mourad
发明人： COMMISSARIAT A L'ENERGIE ATOMIQUE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： A61K47/48
CPC分类号： C07K16/44 , A61K47/62
摘要： Diphosphate or triphosphate analogue conjugates with antigenic enzymes or carriers and immunological assay using such conjugates. In these conjugates, the disphosphate or triphosphate analogue is based on formula (I) in which n is equal to 0 or 1, X and X which can be CH2, CHF, CF2, CC12, CHC1 or NR , R , R , R and R are a hydrogen atom, NH4 , a quaternary ammonium ion or M 1/v, and R is a nucleoside-derived group, linked to the antigenic enzyme or carrier, either by the nucleoside-derived R group, or by one of R , R , R or R . Such conjugated compounds are useful for assaying anti-viral phosphorylated metabolites of antiviral agents such as AZT.
摘要翻译：与抗原酶或载体的二磷酸或三磷酸酯类似物缀合物，并使用这种缀合物进行免疫测定。在这些缀合物中，磷酸盐或三磷酸类似物基于式（I），其中n等于0或1，X 1和X 2可以是CH 2，CHF，CF 2，CC 12，CHCl或NR' R 1，R 2，R 3和R 4分别是氢原子，NH 4 +，季铵离子或M + 1 / v，R 5，是通过核苷衍生的R 5基团或R 1，R 2，R 3或R 4中的一个与抗原性酶或载体连接的核苷衍生基团，。这种缀合的化合物可用于测定抗病毒剂如AZT的抗病毒磷酸化代谢物。

12. 发明申请

WO1995034858A1 MEMORY ERROR CORRECTION 审中-公开
标题翻译：内存错误修正
公开(公告)号：WO1995034858A1
公开(公告)日：1995-12-21
申请号：PCT/FR1995000767
申请日：1995-06-12
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , NICOLAIDIS, Michael , VARGAS, Fabian
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： G06F11/10
CPC分类号： G06F11/0754 , G06F11/1008 , G11C29/50
摘要： Static memory comprising memory cells (MC) arranged in rows and columns, each row of cells constituting of at least one word and a corresponding error control code. Each cell column comprises at least one specific power line (Vcc', GND') connected to a general power line (Vcc', GND') of the memory through a current detector (10, 12). Each detector activates an error signal if the associated specific supply line current exceeds a predetermined threshhold.
摘要翻译：静态存储器包括排列成行和列的存储单元（MC），每行单元构成至少一个单词和对应的错误控制代码。每个单元列包括通过电流检测器（10,12）连接到存储器的一般电力线（Vcc'，GND'）的至少一个特定电力线（Vcc'，GND'）。如果相关的特定电源线电流超过预定阈值，则每个检测器激活误差信号。

13. 发明申请

WO1995024916A1 RETROPEPTIDES, ANTIBODIES THERETO, AND USES THEREOF FOR VACCINATION AND IN VITRO DIAGNOSIS 审中-公开
标题翻译：复发，抗体及其用于疫苗接种和体外诊断的用途
公开(公告)号：WO1995024916A1
公开(公告)日：1995-09-21
申请号：PCT/FR1995000292
申请日：1995-03-13
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , GUICHARD, Gilles , MULLER, Sylviane , BRIAND, Jean-Paul , REGENMORTEL, Marc
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： A61K38/17
CPC分类号： C07K16/18 , A61K38/00 , A61K39/00 , C07K5/0212 , C07K7/02 , C07K14/47 , Y02A50/386
摘要： The invention discloses the use of (1) peptide compounds in which at least one and advantageously all of the -CO-NH- bonds in the peptide chain of the corresponding parent peptide (comprising no -NH-CO- bond in its peptide chain) is (are) replaced with one or more -NH-CO- bonds, the chirality of every aminoacyl residue, whether or not it contributes to the one or more above-mentioned -NH-CO- bonds, being either maintained or reversed relative to the corresponding aminoacyl residues constituting said parent peptide, said peptide compounds also being known as immunoretroids; or (2) antibodies to said immunoretroids (anti-immunoretroid antibodies); said immunoretroids being capable of forming a complex with said anti-immunoretroid antibodies as well as with antibodies to the parent proteins or peptides (known as anti-parent antibodies), and/or to the enantiomers of such parent proteins or peptides; for preparing a drug which is particularly useful for treating or preventing diseases related to the presence in the body of an individual of an exogenous or endogenous protein capable of being recognised by the above-mentioned anti-parent or anti-immunoretroid antibodies.
摘要翻译：本发明公开了使用（1）肽化合物，其中相应亲本肽（其肽链中不含-NH-CO-键）的肽链中至少一个且有利地全部-CO-NH-键被一个或多个-NH-CO-键取代，每个氨酰基残基的手性不管是否对上述一个或多个-NH-CO-键有贡献，相对于构成所述亲本肽的相应氨酰基残基，所述肽化合物也被称为免疫反相物; 或（2）针对所述免疫反应性的抗体（抗免疫反应性抗体）; 所述免疫型甲状腺能够与所述抗免免反应性抗体以及与亲本蛋白质或肽（称为抗亲本抗体）的抗体形成复合物，和/或与所述亲本蛋白质或肽的对映异构体形成复合物; 用于制备药物，其特别可用于治疗或预防与能够被上述抗亲本或抗免免型抗体抗体识别的外源或内源性蛋白质在体内存在相关的疾病。

14. 发明申请

WO1995005473A1 NON-HUMAN CHIMERIC MAMMALIAN MODEL FOR HUMAN PULMONARY DISEASES 审中-公开
标题翻译：非人类血液动力学模型人类疾病
公开(公告)号：WO1995005473A1
公开(公告)日：1995-02-23
申请号：PCT/FR1994001002
申请日：1994-08-12
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , PEAULT, Bruno , PERRICAUDET, Michel
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： C12N15/86
CPC分类号： A01K67/0271
摘要： The present invention relates to an experimental animal model represented by a non human chimeric mammalian as well as the utilisation of such animal model for the screening of compositions which could be active in the prevention or treatment of human pulmonary diseases.
摘要翻译：本发明涉及由非人嵌合哺乳动物表示的实验动物模型，以及利用这种动物模型筛选可能有效预防或治疗人类肺部疾病的组合物。

15. 发明申请

WO1994022143A1 MEMORY CELL INSENSITIVE TO HEAVY ION COLLISIONS 审中-公开
标题翻译：记忆细胞对重离子碰撞无效
公开(公告)号：WO1994022143A1
公开(公告)日：1994-09-29
申请号：PCT/FR1994000287
申请日：1994-03-16
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , BESSOT, Denis , VELAZCO, Raoul
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： G11C11/412
CPC分类号： G11C11/4125
摘要： A memory cell comprising two assemblies each including first to third transistors (MP1, MN1, MN5; MP2, MN2, MN6) mounted in series between high (Vdd) and low (Vss) potentials and having p-, n- and n-channels respectively. The gate of one n-channel transistor in each assembly is connected to the output node (Q, Q*) of the other assembly while the gate of the other n-channel transistor in each assembly is connected to the gate of the first transistor in the same assembly. A fourth p-channel transistor (MP3, MP5) combined with each assembly is arranged between the high potential (Vdd) and the gate of the first transistor (MP1, MP2) in the assembly. A fifth p-channel transistor (MP4, MP6) combined with each assembly is arranged between the gate of the first transistor in the assembly and a read/write line (RW) or the low potential (Vss).
摘要翻译：一种存储单元，包括两个组件，每个组件包括串联安装在高（Vdd）和低（Vss）电位之间并且具有p，n和n通道的第一至第三晶体管（MP1，MN1，MN5; MP2，MN2，MN6）分别。每个组件中的一个n沟道晶体管的栅极连接到另一组件的输出节点（Q，Q *），而每个组件中另一个n沟道晶体管的栅极连接到第一晶体管的栅极同一个装配。与组件中的每一组合组合的第四个P沟道晶体管（MP3，MP5）被布置在组件中的高电位（Vdd）和第一晶体管（MP1，MP2）的栅极之间。与组件结合的第五个p沟道晶体管（MP4，MP6）被布置在组件中的第一晶体管的栅极和读/写线（RW）或低电位（Vss）之间。

16. 发明申请

WO1993026057A1 IONICALLY CONDUCTIVE MATERIAL HAVING A BLOCK COPOLYMER AS THE SOLVENT 审中-公开
标题翻译：具有作为溶剂的嵌段共聚物的非导电材料
公开(公告)号：WO1993026057A1
公开(公告)日：1993-12-23
申请号：PCT/FR1992000542
申请日：1992-06-16
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , HYDRO-QUEBEC , ARMAND, Michel , SANCHEZ, Jean-Yves , ALLOIN, Fannie
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , HYDRO-QUEBEC
IPC分类号： H01M10/40
CPC分类号： H01M10/052 , C08F293/00 , C08G65/329 , C08L71/02 , G02F1/1525 , H01B1/122 , H01G9/025 , H01M10/0565 , Y02E60/13
摘要： An ionically conductive material and its use are described. The material comprises at least one salt dissolved in a polymeric solvent and is characterized in that the polymeric solvent essentially consists of a block copolymer comprising at least one solvating segment (A) and at least one segment (B) having excellent mechanical properties, either intrinsically or once a number of segments (B) have been cross-linked. Said material may be used as an electrolyte in various electrochemical systems.
摘要翻译：描述了离子导电材料及其用途。该材料包含溶解在聚合物溶剂中的至少一种盐，其特征在于聚合溶剂基本上由嵌段共聚物组成，该嵌段共聚物包含至少一个溶剂化区段（A）和至少一个具有优异机械性能的区段（B）或者一次已经交联的段（B）。所述材料可用作各种电化学系统中的电解质。

17. 发明申请

WO1993025907A1 REDOX SYSTEM MARKED ANTIGEN, ELECTROCHEMICAL DETECTION IMMUNOASSAY AND ASSAY KIT 审中-公开
标题翻译： REDOX系统标记抗原，电化学检测免疫测定试剂盒
公开(公告)号：WO1993025907A1
公开(公告)日：1993-12-23
申请号：PCT/FR1993000561
申请日：1993-06-11
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , DEGRAND, Chantal , BLANKESPOOR, Ronald , LIMOGES, Benoit , BROSSIER, Pierre
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： G01N33/532
CPC分类号： G01N33/58 , G01N33/532 , G01N33/536 , G01N33/5438 , G01N33/581 , G01N2458/30
摘要： Antigen marked by a redox system, process for the immunoassay of at least one antigen, and assay kit. The object of the invention is to provide a reliable multiassay homogenous phase process which is speedy, specific and capable of being automated. The object is attained by a process consisting in allowing at least one of the antigens to be assayed (1, 1') to compete with the same antigen (7, 7') marked by a redox system, one of the forms being ionic (3, 3'), against a specific antibody (5, 5') of said antigens (1, 7; 1', 7') present in limited quantity; gathering on an electrode (13), comprising a polyionic film (11) with a polarity opposite to that of the redox system (3, 3'), the marked antigens (7, 7') not bound to the specific antibody (5, 5'), so that said marked antigens (7, 7') become concentrated in said film (11); and measuring the amplified signal supplied by said electrode (13) using electrochemical detection means (15) connected to said electrode.

18. 发明申请

WO1993020431A1 METHOD FOR MEASURING THE CONCENTRATION OF CARBON DIOXIDE DISSOLVED IN SEA WATER, AND DEVICE THEREFOR 审中-公开
标题翻译：用于测量海水中二氧化碳浓度浓度的方法及其装置
公开(公告)号：WO1993020431A1
公开(公告)日：1993-10-14
申请号：PCT/FR1993000325
申请日：1993-03-31
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , MERLIVAT, Liliane , MICHARD, Gil , CIABRINI, Jean-Pierre , DU CHAFFAUT, Maurice , LEFEVRE, Nathalie , BRIENT, Bernard , DANGUY, Théodore
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： G01N21/77
CPC分类号： G01N33/182 , G01N21/314 , G01N21/80 , G01N2021/3177
摘要： A method and a device for measuring the dissolved CO2 content of sea water, wherein pH is measured by colorimetry on a solution with a CO2 concentration matching that of sea water. The optical absorbance of the solution is measured at a wavelength (μM) which is characteristic of a peak absorption value of the basic form of the colouring agent; a complementary measurement is performed at a wavelength (μB) at which the colouring agent is not absorbent; and a complementary absorbance measurement is performed at a wavelength (μI) near the isobestic point of the colouring agent. The device comprises a measurement cell (3) containing the coloured indicator solution and means (26, 27a, 27b, 27c) for successively filtering the optical beam as it leaves the cell (3) at the various wavelengths required to perform said measurements.

19. 发明申请

WO1993016988A1 PERHALOGENATED SULTONE-DERIVED MONOMERS AND POLYMERS PRODUCED THEREFROM 审中-公开
标题翻译： PERHALOGENATED SULTONE衍生的单体和生产的聚合物
公开(公告)号：WO1993016988A1
公开(公告)日：1993-09-02
申请号：PCT/FR1993000167
申请日：1993-02-19
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , HYDRO-QUEBEC , ARMAND, Michel , SANCHEZ, Jean-Yves , SYLLA, Salime
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , HYDRO-QUEBEC
IPC分类号： C07C309/83
CPC分类号： H01M10/052 , C07C309/07 , C07C309/09 , C07C309/17 , C07C309/82 , C07C309/84 , C07F7/0834 , C07F7/1804 , C08G65/14 , C08G65/22 , C08G65/226 , C08G65/3346 , C08G65/337 , C08G79/02 , H01B1/122 , H01M6/181 , H01M8/1027 , H01M8/103 , H01M8/1032 , H01M8/1039 , H01M8/1072 , H01M10/0565 , Y02P70/56
摘要： PCT No. PCT/FR93/00167 Sec. 371 Date Mar. 8, 1994 Sec. 102(e) Date Mar. 8, 1994 PCT Filed Feb. 19, 1993 PCT Pub. No. WO93/16988 PCT Pub. Date Sep. 2, 1993.The invention relates to monomers derived from perhalogenated sultones, to a process for their preparation, to the polymers obtained from the said monomers and to their use for the production of ion-conductive materials. The monomers are compounds corresponding to the formula A-CFX-SO2Z in which A denotes one groups [sic] R3-O-CF2- or R3- or R1R2N-CO-; Z denotes F, Cl, -OSi(CH3)3 or an ionic group, Z being other than F when A denotes R3-O-CF2- or R3-; X denotes F, Cl, H or RF, X being RF when A denotes R3-; the radicals R1, R2 and R3 are chosen from polymerizable nonperfluorinated organic radicals; RF is chosen from perfluoroalkyl radicals and perfluoroaryl radicals. The polymers obtained from these monomers can be employed for the production of ion-conductive materials.

20. 发明申请

WO1993016789A1 ELECTROPHORESIS AND ELECTROPHORESIS OPTIMIZATION METHODS AND APPARATUS THEREFOR 审中-公开
标题翻译：电泳和电泳优化方法及其设备
公开(公告)号：WO1993016789A1
公开(公告)日：1993-09-02
申请号：PCT/FR1993000182
申请日：1993-02-24
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , VIOVY, Jean-Louis , PROST, Jacques , SERGOT, Philippe
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： B01D57/02
CPC分类号： B01D57/02 , G01N27/44769
摘要： A liquid stream electrophoresis apparatus including a body (12, 14, 16, 18, 32, 38) defining a substantially parallelepiped space, and a first set of electrodes (24, 26) placed on the smaller sides as defined lengthwise and widthwise. Said apparatus comprises a second set of electrodes (44, 46) placed on the sides which are parallel to the plane containing the length and width, and providing capacitive coupling. For instance, these electrodes (44, 46) have a polyethylene terephthalate passivating layer. The apparatus may be used to prepare substances of biological origin.

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