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11. 发明授权

US6141573A Chemical signal-impermeable mask 有权
公开(公告)号：US6141573A
公开(公告)日：2000-10-31
申请号：US128891
申请日：1998-08-04
申请人： Ronald T. Kurnik , Janet Tamada , Michael Tierney
发明人： Ronald T. Kurnik , Janet Tamada , Michael Tierney
IPC分类号： G01N27/30 , A61B5/00 , A61B5/145 , A61B5/1486 , A61N1/30 , C12Q1/00 , G01N27/416
CPC分类号： A61B5/1486 , A61N1/30 , C12Q1/001 , C12Q1/002 , C12Q1/006
摘要： A chemical signal-impermeable mask is positioned in the electrolyte flow such that the mask is between a source of chemical signal and a working electrode which senses the chemical signal transported from the source (e.g., by diffusion). The configuration of the mask is such that the mask prevents substantially all chemical signal transport from the chemical signal source having a radial vector component relative to a plane of the mask and the catalytic face of the working electrode, thus allowing primarily only chemical signal transport that is substantially perpendicular to the place of the mask and the catalytic surface of the working electrode. By reducing or eliminating chemical signal radial transport toward the working electrode, the mask thus significantly reduces or eliminates edge effects. By substantially reducing edge effects created by radial transport of chemical signal, it is possible to obtain a more accurate measurement of the amount (e.g., concentration) of chemical signal that is transported from a given area of source material.

12. 发明申请

US20060105420A1 Compositions and methods for enhancement of transdermal analyte flux 审中-公开
标题翻译：用于增强透皮分析物通量的组合物和方法
公开(公告)号：US20060105420A1
公开(公告)日：2006-05-18
申请号：US11329610
申请日：2006-01-11
申请人： Janet Tamada , Michael Tierney , Stephen Williams
发明人： Janet Tamada , Michael Tierney , Stephen Williams
IPC分类号： C12Q1/26
CPC分类号： A61B5/1486 , A61N1/0436 , A61N1/044 , A61N1/325 , C08J3/075
摘要： The present invention relates to compositions for use in analyte monitoring devices. These compositions are useful to increase the flux of analyte across skin, tissue or mucosal surfaces. The compositions include hydrogels and collection reservoir systems comprising ionically conductive materials. The present invention also includes methods of making/manufacturing hydrogels or collection reservoir systems, collection assemblies comprising the hydrogels, electrode assemblies in combination with the hydrogels or collection reservoir systems, and methods of using the same.
摘要翻译：本发明涉及用于分析物监测设备的组合物。这些组合物可用于增加分析物通过皮肤，组织或粘膜表面的通量。组合物包括包含离子导电材料的水凝胶和收集储存器系统。本发明还包括制造/制造水凝胶或收集储存器系统的方法，包括水凝胶的收集组件，与水凝胶或收集储存器系统组合的电极组件及其使用方法。

13. 发明授权

US06771995B2 Chemical signal-impermeable mask 失效
标题翻译：化学信号不透水面罩
公开(公告)号：US06771995B2
公开(公告)日：2004-08-03
申请号：US10324818
申请日：2002-12-20
申请人： Ronald T. Kurnik , Janet Tamada , Michael Tierney
发明人： Ronald T. Kurnik , Janet Tamada , Michael Tierney
IPC分类号： A61B500
CPC分类号： A61B5/1486 , A61N1/30 , C12Q1/001 , C12Q1/002 , C12Q1/006
摘要： A chemical signal-impermeable mask is positioned in the electrolyte flow such that the mask is between a source of chemical signal and a working electrode which senses the chemical signal transported from the source (e.g., by diffusion). The configuration of the mask is such that the mask prevents substantially all chemical signal transport from the chemical signal source having a radial vector component relative to a plane of the mask and the catalytic face of the working electrode, thus allowing primarily only chemical signal transport that is substantially perpendicular to the place of the mask and the catalytic surface of the working electrode. By reducing or eliminating chemical signal radial transport toward the working electrode, the mask thus significantly reduces or eliminates edge effects. By substantially reducing edge effects created by radial transport of chemical signal, it is possible to obtain a more accurate measurement of the amount (e.g., concentration) of chemical signal that is transported from a given area of source material.
摘要翻译：化学信号不可渗透的掩模位于电解质流中，使得掩模位于化学信号源和感测从源传输的化学信号（例如通过扩散）的工作电极之间。掩模的配置使得掩模基本上防止具有相对于掩模的平面和工作电极的催化面的径向矢量分量的化学信号源的所有化学信号传输，因此主要仅允许化学信号传输基本上垂直于掩模的位置和工作电极的催化表面。通过减少或消除朝向工作电极的化学信号径向传输，掩模因此显着地减少或消除了边缘效应。通过显着降低由化学信号的径向传输产生的边缘效应，可以获得从源材料的给定区域输送的化学信号的量（例如，浓度）的更准确的测量。

14. 发明授权

US06299578B1 Methods for monitoring a physiological analyte 失效
标题翻译：监测生理分析物的方法
公开(公告)号：US06299578B1
公开(公告)日：2001-10-09
申请号：US08933025
申请日：1997-09-18
申请人： Ronald T. Kurnik , Janet Tamada , Michael Tierney , Russell Owen Potts
发明人： Ronald T. Kurnik , Janet Tamada , Michael Tierney , Russell Owen Potts
IPC分类号： A61B500
CPC分类号： A61B5/14532
摘要： A method for continual monitoring of a physiologic analyte in a subject includes steps of contacting the subject with a collection reservoir such that the analyte can move from the subject into the collection reservoir, the contents of the collection reservoir being in operative communication with a detector, collecting the analyte in the collection reservoir, using the detector to detect the analyte in the collection reservoir, and, once the analyte has been detected, rendering the analyte undetectable by the detector. Also, apparatus for continual monitoring of a physiologic analyte in a subject includes a collection reservoir for receiving the analyte from the subject, the contents of the collection reservoir being in operative relationship with a detector that detects the analyte in the reservoir, and means for rendering the analyte, once detected, undetectable by the reservoir.
摘要翻译：用于连续监测受试者中的生理分析物的方法包括以下步骤：使受试者与收集储存器接触，使得分析物可以从受试者移动到收集容器中，收集储存器的内容物与检测器操作性地通信，收集储存器中的分析物，使用检测器检测收集储存器中的分析物，一旦检测到分析物，就使检测器不能检测到分析物。此外，用于连续监测受试者中的生理分析物的装置包括用于从受试者接收分析物的收集储存器，收集储存器的内容物与检测储存器中的分析物的检测器处于操作关系，以及用于渲染的装置被检测到的分析物，不能被储存器检测到。

15. 发明授权

US06201979B1 Chemical signal-impermeable mask 有权
公开(公告)号：US06201979B1
公开(公告)日：2001-03-13
申请号：US09523826
申请日：2000-03-13
申请人： Ronald T. Kurnik , Janet Tamada , Michael Tierney
发明人： Ronald T. Kurnik , Janet Tamada , Michael Tierney
IPC分类号： A61B507
CPC分类号： A61B5/1486 , A61N1/30 , C12Q1/001 , C12Q1/002 , C12Q1/006
摘要： A chemical signal-impermeable mask is positioned in the electrolyte flow such that the mask is between a source of chemical signal and a working electrode which senses the chemical signal transported from the source (e.g., by diffusion). The configuration of the mask is such that the mask prevents substantially all chemical signal transport from the chemical signal source having a radial vector component relative to a plane of the mask and the catalytic face of the working electrode, thus allowing primarily only chemical signal transport that is substantially perpendicular to the place of the mask and the catalytic surface of the working electrode. By reducing or eliminating chemical signal radial transport toward the working electrode, the mask thus significantly reduces or eliminates edge effects. By substantially reducing edge effects created by radial transport of chemical signal, it is possible to obtain a more accurate measurement of the amount (e.g., concentration) of chemical signal that is transported from a given area of source material.

16. 发明授权

US5989409A Method for glucose sensing 失效
标题翻译：葡萄糖感测方法
公开(公告)号：US5989409A
公开(公告)日：1999-11-23
申请号：US526732
申请日：1995-09-11
申请人： Ronald T. Kurnik , Janet Tamada , Michael Tierney
发明人： Ronald T. Kurnik , Janet Tamada , Michael Tierney
IPC分类号： G01N27/30 , A61N1/30 , A61B5/00 , G01N27/26
CPC分类号： G01N27/3272
摘要： A method for measuring the concentration of glucose diffused from a source to a working electrode which assembly includes a scavenging electrode is disclosed. The electrode of the invention is comprised of 1) a working electrode; 2) a scavenging electrode; 3) an electroosmotic electrode; and 4) a electrically insulating gap defined by adjacent edges of 1) and 2) and electrically isolating 1) and 2). The scavenging electrode substantially reduces or eliminates "edge-effects" or error in signal transported to the working electrode via a path which includes a radial vector component, i.e., eliminates chemical signal other than that which moves to the catalytic surface of the working electrode via a path which is substantially perpendicular to catalytic surface of the working electrode.
摘要翻译：公开了一种测量从源极到工作电极扩散的葡萄糖浓度的方法，该方法包括清除电极。本发明的电极包括1）工作电极; 2）清扫电极; 3）电渗电极; 和4）由1）和2）的相邻边缘限定的电绝缘间隙，并电隔离1）和2）。扫气电极通过包括径向矢量分量的路径，大大减少或消除了传输到工作电极的信号的“边缘效应”或误差，即除去除了通过工作电极通孔的催化表面移动的化学信号之外的化学信号基本垂直于工作电极的催化剂表面的路径。

17. 发明授权

US06309351B1 Methods for monitoring a physiological analyte 有权
公开(公告)号：US06309351B1
公开(公告)日：2001-10-30
申请号：US09650024
申请日：2000-08-28
申请人： Ronald T. Kurnik , Janet Tamada , Michael Tierney , Russell Owen Potts
发明人： Ronald T. Kurnik , Janet Tamada , Michael Tierney , Russell Owen Potts
IPC分类号： A61B500
CPC分类号： A61B5/14532
摘要： A method for continual monitoring of a physiologic analyte in a subject includes steps of contacting the subject with a collection reservoir such that the analyte can move from the subject into the collection reservoir, the contents of the collection reservoir being in operative communication with a detector, collecting the analyte in the collection reservoir, using the detector to detect the analyte in the collection reservoir, and, once the analyte has been detected, rendering the analyte undetectable by the detector. Also, apparatus for continual monitoring of a physiologic analyte in a subject includes a collection reservoir for receiving the analyte from the subject, the contents of the collection reservoir being in operative relationship with a detector that detects the analyte in the reservoir, and means for rendering the analyte, once detected, undetectable by the reservoir.

18. 发明授权

US06284126B1 Electrode with improved signal to noise ratio 有权
标题翻译：具有提高信噪比的电极
公开(公告)号：US06284126B1
公开(公告)日：2001-09-04
申请号：US09650025
申请日：2000-08-28
申请人： Ronald T. Kurnik , Janet Tamada , Michael Tierney
发明人： Ronald T. Kurnik , Janet Tamada , Michael Tierney
IPC分类号： G02N2726
CPC分类号： A61B5/1486 , C12Q1/54
摘要： An electrode assembly for sensing an electrochemical signal diffused from a source to a working electrode which is comprised of a plurality of substantially separated working electrode surfaces is disclosed. The electrode of the invention is comprised of 1) a working electrode made up of a plurality of working electrode surfaces or components and 2) a electrically insulating gap defined by adjacent edges of 1) insulating the working electrode surfaces or components from each other. The working electrode components are configured to receive electrochemical signal from two or preferably three dimensions simultaneously. The working electrode components configured over the same surface as a single electrode provide (1) an improved signal to noise ratio as compared to a single electrode by reducing noise, and (2) provide an overall enhanced signal after sensing for a given period of time.
摘要翻译：公开了一种用于感测从源极扩散到工作电极的电化学信号的电极组件，其由多个基本上分离的工作电极表面组成。本发明的电极包括1）由多个工作电极表面或部件组成的工作电极，以及2）由相邻边缘限定的电绝缘间隙，1）将工作电极表面或部件彼此绝缘。工作电极部件被配置成从两个或优选三个维度同时接收电化学信号。配置在与单个电极相同的表面上的工作电极组件提供（1）通过降低噪声与单个电极相比提高了信噪比，以及（2）在感测到给定时间段之后提供总体增强的信号。

19. 发明授权

US5827183A Method of measuring chemical concentration iontophoretically using impermeable mask 失效
标题翻译：使用不透水面膜离子电渗法测定化学浓度的方法
公开(公告)号：US5827183A
公开(公告)日：1998-10-27
申请号：US959599
申请日：1997-10-29
申请人： Ronald T. Kurnik , Janet Tamada , Michael Tierney
发明人： Ronald T. Kurnik , Janet Tamada , Michael Tierney
IPC分类号： G01N27/30 , A61B5/00 , A61B5/145 , A61B5/1486 , A61N1/30 , C12Q1/00 , G01N27/416
CPC分类号： A61B5/1486 , A61N1/30 , C12Q1/001 , C12Q1/002 , C12Q1/006
摘要： A method for measuring the concentration of a chemical present in a blood stream of a mammalian subject is disclosed. The method involves contacting the subject's skin with a sensor assembly comprised of an ionically conducting material which contacts the skin, a working electrode which is in contact with the ionically conducting material which electrode has a catalytic surface and a mask having an opening therein. The mask is positioned between the skin and the working electrode. When the electrode is activated, chemical is transported through the skin and the ionically conductive material. The mask is positioned so that it blocks the flow into the catalytic surface except for flow which is substantially axially to the catalytic surface. Electrical signal generated at the working electrode is monitored over a period of time and correlated with a concentration of chemical present in the blood stream of the mammalian subject. The mask reduces or eliminates chemical signal which can radially transport toward the working electrode thereby reducing or eliminating edge effects making it possible to obtain a more accurate measurement.
摘要翻译：公开了一种用于测量哺乳动物受试者血液中存在的化学物质浓度的方法。该方法包括使受试者的皮肤与由与皮肤接触的离子导电材料组成的传感器组件接触，与离子导电材料接触的工作电极，该电极具有催化表面和在其中具有开口的掩模。面罩位于皮肤和工作电极之间。当电极被激活时，化学物质通过皮肤和离子导电材料传输。掩模被定位成使得其阻止流入催化表面的流体，除了基本上轴向到催化表面的流动。在一段时间内监测在工作电极处产生的电信号，并与哺乳动物受试者的血流中存在的化学物质的浓度相关。掩模减少或消除可以径向向工作电极输送的化学信号，从而减少或消除边缘效应，使得可以获得更准确的测量。

20. 发明授权

US5735273A Chemical signal-impermeable mask 失效
公开(公告)号：US5735273A
公开(公告)日：1998-04-07
申请号：US527061
申请日：1995-09-12
申请人： Ronald T. Kurnik , Janet Tamada , Michael Tierney
发明人： Ronald T. Kurnik , Janet Tamada , Michael Tierney
IPC分类号： G01N27/30 , A61B5/00 , A61B5/145 , A61B5/1486 , A61N1/30 , C12Q1/00 , G01N27/416
CPC分类号： A61B5/1486 , A61N1/30 , C12Q1/001 , C12Q1/002 , C12Q1/006
摘要： A chemical signal-impermeable mask is positioned in the electrolyte flow such that the mask is between a source of chemical signal and a working electrode which senses the chemical signal transported from the source (e.g., by diffusion). The configuration of the mask is such that the mask prevents substantially all chemical signal transport from the chemical signal source having a radial vector component relative to a plane of the mask and the catalytic face of the working electrode, thus allowing primarily only chemical signal transport that is substantially perpendicular to the place of the mask and the catalytic surface of the working electrode. By reducing or eliminating chemical signal radial transport toward the working electrode, the mask thus significantly reduces or eliminates edge effects. By substantially reducing edge effects created by radial transport of chemical signal, it is possible to obtain a more accurate measurement of the amount (e.g., concentration) of chemical signal that is transported from a given area of source material.

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