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11. 发明专利

JP2012041347A Look-through mutagenesis for developing altered polypeptides with enhanced properties 审中-公开
标题翻译：用于开发具有增强性质的改性多糖的前瞻性突变
公开(公告)号：JP2012041347A
公开(公告)日：2012-03-01
申请号：JP2011201518
申请日：2011-09-15
申请人： Bioren Inc , バイオレン,インク.
发明人： CREA ROBERTO
IPC分类号： C40B40/08 , C12N15/09
CPC分类号： C12N15/102 , C07K16/00 , C07K16/18 , C07K2317/565 , C07K2317/622 , C07K2317/92 , C12N15/1093 , G01N33/6854 , G01N33/6857
摘要： PROBLEM TO BE SOLVED: To provide a method of mutagenesis by which a predetermined amino acid is introduced into each and every position of a selected set of positions in a preselected region (or several different regions) of a polypeptide to produce a library of polypeptide analogs.SOLUTION: The library of polynucleotides encodes polypeptide analogs comprising one or more functional amino acid residues within a defined region, wherein a predetermined amino acid residue is substituted at each functional amino acid position within the defined region, and the polynucleotides collectively represents all possible variants according to the following criteria: (i) each polynucleotide contains at each codon position in the defined region, either a codon required for the amino acid residue of the polypeptide or a codon for the predetermined amino acid residue; and (ii) each polynucleotide contains no more than one codon for the predetermined amino acid residue.
摘要翻译：待解决的问题：提供一种诱变方法，通过该方法将预定的氨基酸引入多肽的预选区域（或几个不同区域）中所选择的一组位置的每个位置以产生文库的多肽类似物。解决方案：多核苷酸文库编码在限定区域内包含一个或多个功能性氨基酸残基的多肽类似物，其中预定氨基酸残基在限定区域内的每个官能氨基酸位置被取代，多核苷酸共同代表所有可能的变体根据以下标准：（i）每个多核苷酸在限定区域的每个密码子位置含有多肽的氨基酸残基所需的密码子或预定的氨基酸残基的密码子; 和（ii）每个多核苷酸含有不超过一个预定氨基酸残基的密码子。版权所有（C）2012，JPO＆INPIT

12. 发明申请

WO2012109662A2 TREATMENT OF ELAEIS FRUIT PRODUCTS WITH ANTIOXIDANTS 审中-公开
标题翻译：用抗氧化剂处理水果水果产品
公开(公告)号：WO2012109662A2
公开(公告)日：2012-08-16
申请号：PCT/US2012024890
申请日：2012-02-13
申请人： CREA ROBERTO
发明人： CREA ROBERTO
IPC分类号： A61K36/88 , A61K36/889 , A61P39/00 , A61P39/06
CPC分类号： A23D7/06 , A01N65/40 , A23L33/105 , A23V2002/00 , A61K8/345 , A61K8/97 , A61K31/05 , A61K36/889 , A61K2236/31 , A61K2800/10 , A61Q19/00 , C11D3/382 , A23V2200/02 , A23V2250/2131 , A61K2300/00
摘要： Methods are disclosed to create healthier palm oil and new food additives derived from products of the processing of Elaeis fruit that were hitherto fore discarded as waste. The pressing product of Elaeis fruit and the effluent created is treated with acidified antioxidants from olive vegetation containing hydroxytyrosol and a mixture of other polyphenols. The treated POME, palm oil and palm juice are stabilized against oxidation and their inherently nutritive components may now be harvested instead of being thrown away.
摘要翻译：公开的方法是制造更健康的棕榈油和来自加工过的Elaeis果实产品的新的食品添加剂，这些产品以前被废弃为废物。 Elaeis果实的压榨产物和产生的流出物用含有羟基酪醇和其他多酚混合物的橄榄植物的酸化抗氧化剂处理。经过处理的POME，棕榈油和棕榈汁可以抵抗氧化而稳定，并且现在可以收获其固有的营养成分，而不是被扔掉。

13. 发明申请

WO2008027452A3 SELF-ASSEMBLING OLIGONUCLEOTIDES AND METHODS 审中-公开
标题翻译：自组装寡核苷酸和方法
公开(公告)号：WO2008027452A3
公开(公告)日：2008-05-08
申请号：PCT/US2007019036
申请日：2007-08-29
申请人： CREA AND COMPANY R , CREA ROBERTO , CAPPUCCILLI GUIDO
发明人： CREA ROBERTO , CAPPUCCILLI GUIDO
IPC分类号： C07H21/00
CPC分类号： C07H21/04 , C07H21/00
摘要： A composition comprising individual single-stranded oligonucleotides capable of self assembling to form a pair of complementary, substantially contiguous single strands of a double-stranded nucleic acid filament, and a method for forming such filaments are disclosed.
摘要翻译：公开了包含能够自组装以形成双链核酸丝的一对互补的，基本相邻的单链的单个单链寡核苷酸的组合物和形成这种细丝的方法。

14. 发明申请

WO2004032873A2 THERAPEUTIC COMBINATION OF CARNITINE AND ANTIOXIDANT POLYPHENOLS 审中-公开
标题翻译： CARNITINE和抗氧化剂多酚的治疗组合
公开(公告)号：WO2004032873A2
公开(公告)日：2004-04-22
申请号：PCT/US0332149
申请日：2003-10-10
申请人： CREAGRI INC , CREA ROBERTO
发明人： CREA ROBERTO
IPC分类号： A61K20060101 , A61K6/00 , A61K31/045 , A61K31/047 , A61K31/05 , A61K31/197 , A61K31/198 , A61K31/205 , A61K31/221 , A61K31/70 , A61K45/06 , C12P13/22 , A61K
CPC分类号： A61K31/221 , A61K31/045 , A61K31/047 , A61K31/05 , A61K31/205 , A61K45/06 , A61K2300/00
摘要： A composition includes acety-L-carnitine or its pharmacologically acceptable salt and a mixture of polyphenols containing hydroxytyrosol in an effective weight ratio. Carnitine can be L-carnitine, proprionyl-L-carnitine, valeryl-L-carnitine, isovaleryl-L-carnitine or mixtures thereof. The composition has a weight ratio of carnitine:hydroxytyrosol of from 100:1 to 1:10. Also disclosed is a method of preventing tissue damage caused by the presence of free radicals due to environmental pollution; of preventing brain or myocardial lesions induced by free radicals following cerebral or myocardial ischemia and reperfusion; of preventing diabetic or toxic neuropathies and metabolic disorders of glucose utilization, which includes administering the composition.
摘要翻译：组合物包括乙酰-L-肉碱或其药理学上可接受的盐和含有羟基酪醇的多酚的混合物，其重量比为有效重量比。肉碱可以是左旋肉碱，丙酰基-L-肉碱，戊酰基-L-肉碱，异戊酰基-L-肉碱或其混合物。该组合物具有100：1至1:10的肉碱：羟基酪醇的重量比。还公开了一种防止由于环境污染而引起的自由基的存在引起的组织损伤的方法; 预防脑或心肌缺血和再灌注后自由基诱导的脑或心肌损伤; 预防糖尿病或毒性神经病和葡萄糖利用的代谢紊乱，其包括施用组合物。

15. 发明申请

WO2007012057A2 VEGETATION WATER COMPOSITION FOR TREATMENT OF INFLAMMATORY SKIN CONDITIONS 审中-公开
标题翻译：用于治疗炎性皮肤病症的植物水组合物
公开(公告)号：WO2007012057A2
公开(公告)日：2007-01-25
申请号：PCT/US2006028265
申请日：2006-07-19
申请人： CREAGRI INC , NUMANO FUJIO , CREA ROBERTO , WIEDEMANN TOKUKO S , BITLER CATHERINE M
发明人： NUMANO FUJIO , CREA ROBERTO , WIEDEMANN TOKUKO S , BITLER CATHERINE M
IPC分类号： A61K36/63
CPC分类号： A61K36/63 , A61K9/2059 , A61K31/05
摘要： Compositions obtained from vegetation water from olives and methods for treating patients suffering from an inflammatory skin disease with the compositions are described. Included are hydroxytyrosol rich compounds obtained from olive vegetation water.
摘要翻译：描述从橄榄植物水中获得的组合物和用该组合物治疗患有炎性皮肤病的患者的方法。包括从橄榄植物水中获得的富含羟基酪素的化合物。

16. 发明申请

WO2005003345A3 LOOK-THROUGH MUTAGENESIS 审中-公开
标题翻译：看起来很痛苦的MUTAGENESIS
公开(公告)号：WO2005003345A3
公开(公告)日：2005-03-24
申请号：PCT/US2004020306
申请日：2004-06-25
申请人： CREA & CO R , CREA ROBERTO
发明人： CREA ROBERTO
IPC分类号： C07K16/00 , C07K16/12 , C07K16/18 , C07K16/24 , C07K16/44 , C12N15/10
CPC分类号： C12N15/1093 , C07K16/00 , C07K16/005 , C07K16/1282 , C07K16/18 , C07K16/241 , C07K16/44 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C12N15/102 , Y02P20/582
摘要： A method of mutagenesis by which a predetermined amino acid is introduced into each and every position of a selected set of positions in a preselected region (or several different regions) of a polypeptide to produce a library of polypeptide analogs. The method is based on the premise that certain amino acids play crucial role in the structure and function of proteins. Libraries can be generated which contain only desired polypeptide analogs and are of reasonable size for screening. The libraries can be used to study the role of specific amino acids in polypeptide structure and function and to develop new or improved polypeptides such as antibodies, antibody fragments, single chain antibodies, enzymes, and ligands.
摘要翻译：一种诱变方法，通过其将预定氨基酸引入到多肽的预选区域（或几个不同区域）中所选择的一组位置的每个位置以产生多肽类似物文库。该方法基于某些氨基酸在蛋白质的结构和功能中起关键作用的前提。可以生成仅包含所需多肽类似物并且筛选合理大小的文库。文库可用于研究特定氨基酸在多肽结构和功能中的作用，并开发新的或改良的多肽，如抗体，抗体片段，单链抗体，酶和配体。

17. 发明公开

EP1499887A4 UNIVERSAL LIBRARIES FOR IMMUNOGLOBULINS 有权
标题翻译：全能银行免疫球蛋白
公开(公告)号：EP1499887A4
公开(公告)日：2006-09-13
申请号：EP03726329
申请日：2003-04-16
申请人： CREA ROBERTO
发明人： CREA ROBERTO
IPC分类号： C12N15/09 , C07K16/00 , C07K16/10 , G01N33/53
CPC分类号： C07K16/1063 , C07K2317/21 , C07K2317/565 , C07K2317/622
摘要： Libraries of immunoglobulins of interest are described, the libraries containing mutated immunoglobulins of interest in which a single predetermined amino acid has been substituted in one or more positions in one or more complementarity-determining regions of the immunoglobulin of interest. The libraries comprise a series of subset libraries, in which the predetermined amino acid is 'walked through' each of the six complementarity-determining regions (CDRs) of the immunoglobulin of interest not only individually but also for each of the possible combinatorial variations of the CDRs, resulting in subset libraries that include mutated immunoglobulins having the predetermined amino acid at one or more positions in each CDR, and collectively having the predetermined amino acid at each position in each CDR. The invention is further drawn to universal libraries containing one such library for each naturally-occurring amino acid as the single predetermined amino acid, totaling twenty libraries; and also to libraries of nucleic acids encoding the described libraries.

18. 发明公开

EP1495142A4 "DOPING" IN WALK-THROUGH MUTAGENESIS 有权
标题翻译： DOPING BEI DER WALK-THROUGH-MUTAGENESE
公开(公告)号：EP1495142A4
公开(公告)日：2005-06-29
申请号：EP03726328
申请日：2003-04-16
申请人： CREA ROBERTO , CAPPUCCILLI GUIDO
发明人： CREA ROBERTO , CAPPUCCILLI GUIDO
IPC分类号： C12N15/09 , C07K14/47 , C12N15/10 , C12Q1/68 , C12N15/63 , C07K16/18 , C12P21/00
CPC分类号： C12N15/1089 , C12N15/102 , C12Q1/6883 , C12Q1/6897
摘要： A method of walk-through mutagenesis of a nucleic acid encoding a prototype polypeptide of interest, is described, the method comprising selecting a predetermined amino acid and one or more target regions of the polypeptide, and synthesizing a mixture of oligonucleotides containing at each sequence position in the target region, either a prototype nucleotide that is required for synthesis of the prototype amino acid of the polypeptide, or a predetermined nucleotide that is required for synthesis of the predetermined amino acid, in which during the synthesis, the ratio of available prototype nucleotides, to available predetermined nucleotides, is greater than 1:1.
摘要翻译：描述了编码感兴趣的原型多肽的核酸的步骤突变的方法，所述方法包括选择预定的氨基酸和多肽的一个或多个靶区域，并且合成含有在每个序列位置处的寡核苷酸的混合物在目标区域中，或者是合成多肽的原型氨基酸所需的原型核苷酸，或者是合成预定氨基酸所需的预定核苷酸，其中合成期间可用原型核苷酸的比例，到可用的预定核苷酸，大于1：1。

19. 发明专利

JP2012097107A Antibody ultrahumanization by predicted mature cdr blasting and cohort library generation and screening 有权
标题翻译：通过预测成像进行抗体超声心动图扫描和联合图书馆生成和筛选
公开(公告)号：JP2012097107A
公开(公告)日：2012-05-24
申请号：JP2011288823
申请日：2011-12-28
申请人： Bioren Inc , バイオレン・インク
发明人： CAPPUCILLI GUIDO , CREA ROBERTO , BAYEZ NURTEN , TAKEUCHI TOSHIHIKO , SHEN RANDY , BHATT RAMESH
IPC分类号： C07K14/705 , C40B30/04 , C40B40/06 , C40B40/10 , G01N33/53
CPC分类号： C07K16/005 , C07K16/22 , C07K16/241 , C07K2317/21 , C07K2317/565 , C07K2317/622
摘要： PROBLEM TO BE SOLVED: To provide methods and compositions directed to improved universal antibody libraries that rationally exploit human diversity information contained within reference antibody libraries, such as universal antibody libraries.SOLUTION: The disclosed processes involve use of a query CDR sequence to guide incorporation of human antibody diversity present within the reference library into cohort libraries. Methods for making and screening such cohort libraries for isolating therapeutics suitable for treating disease are also disclosed.

20. 发明专利

JP2011182794A Look-through mutagenesis 有权
标题翻译：看起来很痛苦的MUTAGENESIS
公开(公告)号：JP2011182794A
公开(公告)日：2011-09-22
申请号：JP2011062697
申请日：2011-03-22
申请人： Bioren Inc , バイオレン,インク.
发明人： CREA ROBERTO
IPC分类号： C12Q1/68 , C07K16/00 , C07K16/12 , C07K16/18 , C07K16/24 , C07K16/44 , C12N15/09 , C12N15/10 , C40B30/00
CPC分类号： C12N15/1093 , C07K16/00 , C07K16/005 , C07K16/1282 , C07K16/18 , C07K16/241 , C07K16/44 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C12N15/102 , Y02P20/582
摘要： PROBLEM TO BE SOLVED: To provide a method of mutagenesis for generating a new or improved protein (or polypeptide) and a method for screening and selecting a library of polypeptide analogs and a predetermined polypeptide generated by the method of mutagenesis. SOLUTION: There is provided the method of mutagenesis by which a predetermined amino acid is introduced into each and every position of a selected set of positions in a preselected region (or several different regions) of the polypeptide to generate the library of the polypeptide analogs. The Library can be generated which contains only desired polypeptide analogs and is of reasonable size for screening. The library can be used to study the role of a specific amino acid in a polypeptide structure and function and to develop new or improved polypeptides such as antibodies, antibody fragments, single chain antibodies, enzymes, and ligands. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供用于产生新的或改良的蛋白质（或多肽）的诱变方法以及筛选和选择多肽类似物文库和通过诱变方法产生的预定多肽的方法。提供了诱变方法，通过该方法将预定的氨基酸引入多肽的预选区域（或几个不同区域）中所选择的一组位置的每个位置，以产生该多肽的文库多肽类似物。可以生成仅包含所需多肽类似物并且筛选合理大小的文库。该文库可用于研究特定氨基酸在多肽结构和功能中的作用，并开发新的或改良的多肽，如抗体，抗体片段，单链抗体，酶和配体。版权所有（C）2011，JPO＆INPIT

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