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11. 发明申请

WO2007035893A3 USE OF IVT WITH SINGLE STRANDED PRIMER PROMOTER SELECTOR CONSTRUCTS 审中-公开
公开(公告)号：WO2007035893A3
公开(公告)日：2007-03-29
申请号：PCT/US2006/036889
申请日：2006-09-21
申请人： BIOARRAY SOLUTIONS, LTD. , SEUL, Michael , KORZHEVA, Nataliya
发明人： SEUL, Michael , KORZHEVA, Nataliya
IPC分类号： C12P19/34
摘要： Disclosed is a single stranded primer-pronioter-selector construct comprising (in 3' to 5' orientation) a primer subsequence annealing to the target, a T7 or other promoter subsequence (the template strand), and a selector subsequence. The primer can be extended by template mediated elongation, including reverse transcription, or ligation to another oligonucleotide. The promoter sequence is oriented to direct the in-vitro transcription (IVT) opposite to that of primer extension, where the selector subsequence serves as a template for IVT. The selector is associated with the target subsequence of interest and it, and the amplified product are unique subsequences, dissimilar to other sequence present in the sample. The constructs is useful for determination of the presence and relative abundance of designated subsequences in the sample, multiplex gene expression analysis, multiplex allele counting, determination of polymorphic/mutation site, and loss of heterozygosity.

12. 发明申请

WO2007121018A2 PROBE DENSITY CONSIDERATIONS AND ELONGATION OF SELF-COMPLEMENTARY LOOPED PROBES WHERE PROBES ARE ATTACHED TO A SOLID PHASE 审中-公开
标题翻译：探索密集度考察和自我补充循环探测器的延伸，探头附着在固体相位
公开(公告)号：WO2007121018A2
公开(公告)日：2007-10-25
申请号：PCT/US2007/064118
申请日：2007-03-16
申请人： BIOARRAY SOLUTIONS LTD. , SEUL, Michael , ZHANG, Yi , BANARJEE, Sukanta , YANG, Jiacheng , CHAU, Chiu
发明人： SEUL, Michael , ZHANG, Yi , BANARJEE, Sukanta , YANG, Jiacheng , CHAU, Chiu
IPC分类号： C12Q1/68 , C12M3/00
CPC分类号： C12Q1/6837 , C12Q1/6818 , C12Q1/6827 , C12Q2565/1015 , C12Q2537/143 , C12Q2533/101 , C12Q2535/125 , C12Q2525/301
摘要： in a multiplexed assay method earned out in solution, wherein the solution contains nucleic acid targets and., wherein several different types of oligonucleotide probes, each type having a different sequence in a region designated as a target binding domain, are used to detect the nucleic acid targets, said assay method including a method for increasing the effective concentration of the nucleic acid targets at the surface of a bead to which the oligonucleotide probes are bound, by one or more of the following steps: adjusting assay conditions so as to increase the effective concentration of the targets available for binding to the probes, by one or more of the following: (i) selecting a particular probe density on the surface of the bead; (ii) selecting a solution having an ionic strength greater than a threshold; (ii) selecting a target domain of a size less than a threshold; or (iii) selecting target domains within a specified proximity to a terminal end of the targets.
摘要翻译：在溶液中获得的多重测定方法中，其中溶液含有核酸靶标，其中使用几个不同类型的寡核苷酸探针，每种类型在被称为靶结合结构域的区域中具有不同序列，以检测核酸所述测定方法包括通过一个或多个以下步骤增加寡核苷酸探针结合珠粒表面上的核酸靶的有效浓度的方法：调节测定条件以增加通过一种或多种以下方法有效浓度可用于结合探针的靶标：（i）在珠粒表面上选择特定的探针密度; （ii）选择具有大于阈值的离子强度的溶液; （ii）选择小于阈值的大小的目标域; 或（iii）在目标的终端的指定接近范围内选择目标域。

13. 发明申请

WO2006047471A9 A METHOD OF NUCLEIC ACID TYPING FOR SELECTING REGISTERED DONORS FOR CROSS-MATCHING TO TRANSFUSION RECIPIENTS 审中-公开
公开(公告)号：WO2006047471A9
公开(公告)日：2006-05-04
申请号：PCT/US2005/038296
申请日：2005-10-24
申请人： BIOARRAY SOLUTIONS LTD. , SEUL, Michael , REID, Marion, E. , HASHMI, Ghazala , PIERCE, Michael
发明人： SEUL, Michael , REID, Marion, E. , HASHMI, Ghazala , PIERCE, Michael
IPC分类号： C12Q1/68 , C12N15/12
摘要： Disclosed are a method and an algorithm for genetic cross-matching based on the comparison of recipient and donor genotypes - and the underlying combinations of alleles and haplotypes. The method of the invention, rather than focusing on phenotype prediction, instead relies on a comparison of genetic variants identified in the recipient and available donors, whose information preferably will be compiled in a widely available donor registry, to maximize molecular compatibility. The genotypes can be matched based on the weighted clinical significance of a genotypic difference between donor and recipient, such that certain mismatches are more acceptable than others.

14. 发明申请

WO2005029705A2 NUMBER CODING FOR IDENTIFICATION OF SUBTYPES OF CODED TYPES OF SOLID PHASE CARRIERS 审中-公开
标题翻译：用于识别编码类型固态相位载波子类型的编码
公开(公告)号：WO2005029705A2
公开(公告)日：2005-03-31
申请号：PCT/US2004/030499
申请日：2004-09-17
申请人： BIOARRAY SOLUTIONS, LTD. , SEUL, Michael , CHAU, Chiu , TAN, Enqing
发明人： SEUL, Michael , CHAU, Chiu , TAN, Enqing
IPC分类号： H03M
CPC分类号： G01N33/6845 , G01N33/543 , G01N33/54313 , G01N33/564
摘要： Disclosed is number coding of pairs ("doublets") or small sets ("multiplets") of solid phase carriers provides distinguishable subtypes of a given type of such carriers, where each carrier type is distinguishable on the basis of a C-code. Such number coding is useful for augmenting a coding system, such as a color code, and thereby effectively multiplying the number of "colors" (distinguishable sub-types). It can be applied, for example, in multiplexed nucleic acid or protein analysis.
摘要翻译：公开了固相载波的对（“双重”）或小集（“多重”）的编码编码提供给定类型的此类载波的可区分的子类型，其中每个载波类型是可区分的基于C代码。这种数字编码对于增强编码系统（例如色码）是有用的，并且因此有效地将“色彩” （可区分的子类型）。例如，它可以用于复合核酸或蛋白质分析。

15. 发明申请

WO2009064280A2 A TRANSFUSION REGISTRY AND EXCHANGE NETWORK 审中-公开
标题翻译：一个输血登记和交换网络
公开(公告)号：WO2009064280A2
公开(公告)日：2009-05-22
申请号：PCT/US2007/072193
申请日：2007-11-14
申请人： BIOARRAY SOLUTIONS LTD. , ZHANG, Yi , SEUL, Michael
发明人： ZHANG, Yi , SEUL, Michael
IPC分类号： G01N33/567 , G06F19/00
CPC分类号： G06Q10/00 , G06F19/00 , G06Q50/22
摘要： Disclosed is a registry for candidate transfusion donors, which invokes an inventory management policy to create and actively manage lists of candidate donors in order to minimize imbalances between demand and supply across multiple regions and across multiple categories of donors and recipients. Together with a genotyping laboratory, the registry does targeted recruitment of prospective donors who are typed for a set of genetic markers relating to clinically relevant antigens including mutations of Human Erythrocyte Antigens (HEA), genetic variants of Rh, and possibly additional antigens such as HLA and HPA. The registry monitors incoming demand for transfusion antigen genotypes, preferably stratify the demand into a set of categories representing stable subpopulations, and will apply strategies, disclosed herein, to tune the composition of candidate donor lists to match the demand, thereby avoiding excess, and unnecessary, typing of candidate donors,
摘要翻译：公开了候选输血捐献者的登记处，该登记处引用库存管理政策来创建和积极管理候选捐献者名单，以便最小化跨多个地区和多个类别的捐赠者之间的需求和供应之间的不平衡和收件人。登记处与基因分型实验室一起，确实有针对性地招募预期捐赠者，这些捐赠者被输入一系列与临床相关抗原相关的遗传标记，包括人类红细胞抗原（HEA）的突变，Rh的遗传变体，以及可能的额外抗原如HLA 和HPA。注册表监测输入抗原基因型的输入需求，优选将需求分层为表示稳定亚群的一组类别，并且将应用本文公开的策略来调整候选供体列表的组成以匹配需求，从而避免过量且不必要的，候选捐赠者的分类，

16. 发明申请

WO2004074913A3 A DYNAMICALLY CONFIGURABLE ELECTRODE FORMED OF PIXELS 审中-公开
公开(公告)号：WO2004074913A3
公开(公告)日：2004-09-02
申请号：PCT/US2004/005820
申请日：2004-02-14
申请人： BIOARRAY SOLUTIONS LTD. , SEUL, Michael , ZHANG, Yi
发明人： SEUL, Michael , ZHANG, Yi
IPC分类号： G01N27/447
摘要： A dynamically configurable electrode includes a first planar electrode and a planar array of pixels in a different plane, wherein a polarizable liquid medium (including electrolyte solutions) is to reside in the gap between electrodes. The pixels are individually addressable by a time-varying voltage, and adjacent pixels receive, at any instant in time, either the same voltage waveform or a different voltage waveform. Adjacent pixels receiving different voltage waveforms generate corresponding movement of dipolar entities, including dipolar particles, ions, or dipolar molecules in the polarizable liquid medium between the electrodes, which can in turn generate fluid flow and movement of particles suspended in the fluid along the planar array surface.

17. 发明申请

WO2003034029A3 MULTIPLEXED ANALYSIS OF POLYMORPHIC LOCI BY CONCURRENT INTERROGATION AND ENZYME-MEDIATED DETECTION 审中-公开
公开(公告)号：WO2003034029A3
公开(公告)日：2003-04-24
申请号：PCT/US2002/033012
申请日：2002-10-15
申请人： BIOARRAY SOLUTIONS, LTD. , LI, Alice, Xiang , HASHMI, Ghazala , SEUL, Michael
发明人： LI, Alice, Xiang , HASHMI, Ghazala , SEUL, Michael
IPC分类号： C12P19/34
摘要： The invention provides methods and processes for the identification of polymorphisms at one or more designated sites, without interference from non-designated sites located within proximity of such designated sites. Probes are provided capable of interrogation of such designated sites in order to determine the composition of each such designated site. By the methods of this invention, one or more mutations within the CFTR gene and the HLA gene complex can be identified.

18. 发明申请

WO2006028987A3 NUCLEIC ACID AMPLIFICATION WITH INTEGRATED MULTIPLEX DETECTION 审中-公开
公开(公告)号：WO2006028987A3
公开(公告)日：2006-03-16
申请号：PCT/US2005/031357
申请日：2005-09-02
申请人： BIOARRAY SOLUTIONS LTD. , SEUL, Michael , KORZHEVA, Nataliya , YANG, Jiacheng , ZHANG, Yi
发明人： SEUL, Michael , KORZHEVA, Nataliya , YANG, Jiacheng , ZHANG, Yi
IPC分类号： C12Q1/68 , C12P19/34
摘要： A method mediated with in-vitro transcription ("IVT") which permits miniaturization of multiplexed DNA and RN analysis, and in which elongation-mediated multiplexed analysis of polymorphisms (eMAP®) is used as the analysis step, is described. Also described is a method mediated with IVT is for selecting a designated strand from T7-tagged double a stranded DNA: wherein, the selected strand forms the template for RNA synthesis. In one embodiment, double stranded DNA incorporating the T7 (or other) promoter sequence at the 3' end or the 5'end is produced, for example, by amplification of genomic DNA using the Polymerase Chain Reaction (PCR). Also disclosed are nested PCR designs permitting allele analysis in combination with strand selection by IVT. Further, in one embodiment of a homogeneous format for transcription-mediated amplification and multiplexed detection (which may be particularly suited for viral or pathogen detection), encoded microparticles display "looped" capture probe configurations permitting the generation of a signal upon capture of RNA product and real-time assay monitoring.

19. 发明申请

WO2003034029A2 MULTIPLEXED ANALYSIS OF POLYMORPHIC LOCI BY CONCURRENT INTERROGATION AND ENZYME-MEDIATED DETECTION 审中-公开
标题翻译：通过多次介入和酶介导检测对多态性位点的多重分析
公开(公告)号：WO2003034029A2
公开(公告)日：2003-04-24
申请号：PCT/US2002/033012
申请日：2002-10-15
申请人： BIOARRAY SOLUTIONS, LTD. , LI, Alice, Xiang , HASHMI, Ghazala , SEUL, Michael
发明人： LI, Alice, Xiang , HASHMI, Ghazala , SEUL, Michael
IPC分类号： G01N
CPC分类号： C12Q1/6827 , C12Q1/6837 , C12Q1/6858 , C12Q1/6883 , C12Q2600/156 , C12Q2600/16 , C12Q2565/537 , C12Q2535/125 , C12Q2527/107
摘要： The invention provides methods and processes for the identification of polymorphisms at one or more designated sites, without interference from non-designated sites located within proximity of such designated sites. Probes are provided capable of interrogation of such designated sites in order to determine the composition of each such designated site. By the methods of this invention, one or more mutations within the CFTR gene and the HLA gene complex can be identified.
摘要翻译：本发明提供用于在一个或多个指定位点识别多态性的方法和过程，而不受位于该指定位点附近的非指定位点的干扰。提供能够询问这些指定地点的探测器，以确定每个这样的指定地点的组成。通过本发明的方法，可以鉴定CFTR基因和HLA基因复合体内的一个或多个突变。

20. 发明申请

WO2006017473A2 AUTOMATED ANALYSIS OF MULTIPLEXED PROBE-TRAGET INTERACTION PATTERNS: PATTERN MATCHING AND ALLELE IDENTIFICATION 审中-公开
标题翻译：多路复用探测器相互作用模式的自动分析：图形匹配和可识别
公开(公告)号：WO2006017473A2
公开(公告)日：2006-02-16
申请号：PCT/US2005/027359
申请日：2005-08-02
申请人： BIOARRAY SOLUTIONS LTD. , XIONGWU, Xia , SEUL, Michael
发明人： XIONGWU, Xia , SEUL, Michael
IPC分类号： G01N33/48 , G01N33/50 , G06F19/00
CPC分类号： C12Q1/6827 , G06F19/18 , G06F19/22
摘要： Disclosed are methods and algorithms (and their implementation) supporting the automated analysis and interactive review and refinement ("redaction") of the analysis within an integrated software environment, for automated allele assignments. The implementation, preferably with a software system and a program referred to as the Automated Allele Assignment ("AAA") program, provides a multiplicity of functionalities including: data management by way of an integrated interface to a portal a database to permit visualizing, importing, exporting and creating customizable summery reports; system configuration ("Set-up") including user authorization, training set analysis and probe masking; Pattern Analysis including string matching and probe flipping; and Interactive Redaction combining real-time database computations and "cut-andpaste" editing, generating "warning" statements and supporting annotation. It also includes a thresholding function, a method of setting thresholds, a method of refining thresholds by matching an experimental binary string ("reaction pattern") setting for that probe, probe masking of signals produced by probes which do not contribute significantly to discriminating among alleles.
摘要翻译：公开的方法和算法（及其实现）支持在集成软件环境中进行自动化等位基因分配的自动分析和交互式审查和细化（“编辑”）分析。该实施方案优选地使用称为自动等位基因分配（“AAA”）程序的软件系统和程序提供了多种功能，包括：通过与门户的集成接口进行数据管理数据库以允许可视化，导入出口创造可定制的夏季报告; 系统配置（“设置”），包括用户授权，训练集分析和探测屏蔽; 模式分析包括字符串匹配和探针翻转; 和Interactive Redaction结合实时数据库计算和“剪切和粘贴”编辑，生成“警告”语句和支持注释。它还包括阈值功能，设置阈值的方法，通过匹配用于该探针的实验二进制串（“反应模式”）设置来精确化阈值的方法，探针对由探针产生的信号进行探针掩蔽，所述探针不对显着区别等位基因。

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