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    • 20. 发明专利
    • New diphenylpyrrole derivatives useful for control of animal pests, e.g. in protection of plants, goods and materials and in veterinary medicine
    • DE19822247A1
    • 1999-11-25
    • DE19822247
    • 1998-05-18
    • BAYER AG
    • PLANT ANDREWGRAFF ALANKRAATZ UDOERDELEN CHRISTOPHTURBERG ANDREASMENCKE NORBERT
    • A01N43/36C07C205/45C07C271/18C07D207/20C07F7/10A61K31/40
    • 2,5-Diphenyl-3,4-dihydro-2H-pyrrole derivatives (I) are new. Aminoketones (VIII) and nitroketones (XVIII) used in their preparation are also new. 2-(2-Chlorophenyl)-5-(substituted phenyl)-3,4-dihydro-2H-pyrrole derivatives (I) are new: Ar = group of formula (a): m = 0-4; R = halo; CN; (alkyl)3Si; CONR R ; tetrahydropyranyl; -X-A; -B-Z-D; or -Y-E; R = H; halo; CN; NO2; alkyl, haloalkyl, alkoxy, haloalkoxy; alkoxyalkoxy; or -S(O)oR ; o = 0-2; R = alkyl or haloalkyl; R and R = H; alkyl; haloalkyl; or phenyl or phenylalkyl optionally substituted with W ; X = direct bond; O; S; C(O); C(O)O; OC(O); alkylene; alkenylene; alkynylene; alkyleneoxy; oxyalkylene; thioalkylene; alkylenedioxy; or dialkylsilylene; A = phenyl, naphthyl or tetrahydronaphthyl optionally substituted with W ; or aromatic heterocyclyl optionally substituted with W ; B = p-phenylene optionally substituted with W ; Z = O or S; D = H; alkyl; alkenyl; alkynyl; haloalkyl; haloalkenyl; cycloalkyl or cycloalkylalkyl optionally substituted with halo, alkyl or optionally halo-substituted alkenyl, phenyl or styryl; optionally halo- or alkyl-substituted cycloalkenyl or cycloalkenylalkyl; phenylalkyl, naphthylalkyl, tetrahydronaphthyl or heteroaryl optionally substituted with 6 groups; -C(O)R ; -C(O)NR R ; or a group of formula (b): -(CH2)p-(CR R )q-(CH2)r-G (b) or Z and G together form phenoxyalkyl optionally substituted with 6 groups; Y = direct bond; O; S; C(O); C(O)O; OC(O); alkylene; alkenylene; alkynylene; alkyleneoxy; oxyalkylene; thioalkylene; alkylenedioxy; or p-phenylene optionally substituted with W ; E = H; alkyl; alkenyl; alkynyl; haloalkyl; haloalkenyl; cycloalkyl optionally substituted with 8 groups; cycloalkenyl optionally substituted with halo or alkyl; phenyl optionally substituted with W ; heteroaryl optionally substituted with W ; or a group of formula (b); R = alkyl; alkoxy; alkenyl; alkenyloxy; cycloalkyl, cycloalkyloxy or cycloalkylalkoxy optionally substituted with 5 groups; or phenyl or naphthyl optionally substituted with 6 groups; R = H or alkyl; R = alkyl; haloalkyl; or cycloalkyl, cycloalkylalkyl, phenyl or phenylalkyl optionally substituted with 5 groups; p, q and r = 0-3, (p + q + r is less than 6); R and R = H or alkyl; G = CN; heterocyclyl optionally substituted with halo, alkyl or haloalkyl and on the linkage site optionally with R ; -C(O)-R ; -C(O)-OR ; -C(Q)-NR R ; -C(R )=N-R ; -C(R )(QR )2; -C(R )(NR R )(QR ); or -C(QR )=N-R ; Q = O or S; R = H; alkyl; alkenyl; haloalkyl; haloalkenyl; cycloalkyl optionally substituted with halo, alkyl or haloalkyl; or phenyl optionally substituted with alkylcarbonylamino, alkylcarbonylalkylamino and/or W ; R = H; alkyl; alkenyl; haloalkyl; haloalkenyl; cycloalkyl or cycloalkylalkyl optionally substituted with halo, alkyl or haloalkyl; or arylalkyl optionally substituted with W ; R and R = H; alkyl; alkenyl; haloalkyl; haloalkenyl; alkoxy; cycloalkyl or cycloalkylalkyl optionally substituted with halo, alkyl or haloalkyl; aryl or arylalkyl optionally substituted with W ; OR ; or NR R ; or R and R together form alkylene with 1 CH2 optionally replaced with O; R = -OR ; -NR R ; or -N(R )-COOR ; R , R and R = alkyl; W = H; halo; CN; CHO; NO2; alkyl; (alkyl)3Si; alkoxy; haloalkyl; haloalkoxy; haloalkenyloxy; alkylcarbonyl; alkoxycarbonyl; pentafluorothio; or -S(O)oR ; W = halo; CN; CHO; NO2; alkyl; (alkyl)3Si; alkoxy; haloalkyl; haloalkoxy; alkylcarbonyl; alkoxycarbonyl; pentafluorothio; -S(O)oR ; or -C(R )=N-R ; W = halo; CN; NO2; alkyl; alkoxy; haloalkyl; haloalkoxy; -N(alkyl)2; -S(O)oR ; -COOR ; or -CONR R ; R = H; alkyl; haloalkyl; cycloalkyl optionally substituted with halo, alkyl or haloalkyl; or phenyl optionally substituted with W ; R and R = H; alkyl; alkenyl; haloalkyl; haloalkenyl; alkoxy; cycloalkyl or cycloalkylalkyl optionally substituted with halo, alkyl or halo alkyl; aryl or arylalkyl optionally substituted with W ; OR ; or -NR R ; or R and R together form alkylene with 1 CH2 optionally replaced with O; W = H; halo; CN; NO2; alkyl; alkoxy; haloalkyl; haloalkoxy; -N(alkyl)2; alkoxycarbonyl; dialkylaminocarbonyl; or -S(O)oR . The full definitions are given in the DEFINITIONS (Full Definitions) Field. Independent claims are also included for: (a) the preparation of compounds (I); (b) aminoketone intermediates of formula (VIII); and (c) nitroketone intermediates of formula (XVIII).