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11. 发明授权

US07537920B2 Method for the production of polyunsaturated fatty acids 有权
标题翻译：生产多不饱和脂肪酸的方法
公开(公告)号：US07537920B2
公开(公告)日：2009-05-26
申请号：US10547447
申请日：2004-01-29
申请人： Andreas Renz , Ernst Heinz , Amine Abbadi , Frederic Domergue , Thorsten Zank
发明人： Andreas Renz , Ernst Heinz , Amine Abbadi , Frederic Domergue , Thorsten Zank
IPC分类号： C12N9/12 , C12N1/20 , C12N15/00 , C07H21/04
CPC分类号： C12N15/8247 , C12N9/1029 , C12P7/6427 , C12P7/6472
摘要： The present invention relates to a process for producing polyunsaturated fatty acids in an organism by introducing nucleic acids into the organism which code for polypeptides having acyl-CoA:lysophospholipid a cyltransferase activity. Advantageously, these nucleic acid sequences may, if appropriate together with further nucleic acid sequences coding for biosynthesis polypeptides of the fatty acid or lipid metabolism, be expressed in the transgenic organism. The invention furthermore relates to the nucleic acid sequences, to nucleic acid constructs comprising the nucleic acid sequences of the invention, to vectors comprising the nucleic acid sequences and/or the nucleic acid constructs and to transgenic organisms comprising the abovementioned nucleic acid sequences, nucleic acid constructs and/or vectors. A further part of the invention relates to oils, lipids and/or fatty acids produced by the process of the invention and to their use.
摘要翻译：本发明涉及通过将核酸引入生物体中来生产多不饱和脂肪酸的方法，该生物体编码具有酰基-CoA：溶血磷脂一羧酰基转移酶活性的多肽。有利地，如果合适的话，这些核酸序列可以与编码脂肪酸或脂质代谢的生物合成多肽的其它核酸序列一起在转基因生物中表达。本发明还涉及核酸序列，包含本发明的核酸序列的核酸构建体，包含核酸序列和/或核酸构建体的载体以及包含上述核酸序列的转基因生物，核酸构建体和/或载体。本发明的另一部分涉及通过本发明的方法生产的油，脂和/或脂肪酸及其用途。

12. 发明申请

US20070028326A1 Method for producing multiple unsaturated fatty acids in plants 有权
标题翻译：在植物中生产多种不饱和脂肪酸的方法
公开(公告)号：US20070028326A1
公开(公告)日：2007-02-01
申请号：US10511621
申请日：2003-04-25
申请人： Petra Cirpus , Andreas Renz , Jens Lerchl , Anne-Marie Kuijpers
发明人： Petra Cirpus , Andreas Renz , Jens Lerchl , Anne-Marie Kuijpers
IPC分类号： A01H1/00 , C12N9/04 , C12N15/82 , C12N5/04
CPC分类号： C12P7/6427 , C12N9/0083 , C12N15/8247 , C12P7/6472 , C12P7/6481
摘要： The present invention relates to a method for the production of fatty acid esters which comprise unsaturated fatty acids with at least three double bonds, and to free unsaturated fatty acids with a content of at least 1% by weight based on the total fatty acids present in the plants, by expressing at least one nucleic acid sequence which encodes a polypeptide with Δ6-desaturase activity and at least one nucleic acid sequence which encodes a polypeptide with Δ6-elongase activity. Advantageously, these nucleic acid sequences can, if appropriate, be expressed in the transgenic plant together with a third nucleic acid sequence which encodes a polypeptide with Δ5-desaturase activity. The invention furthermore relates to the use of defined nucleic acid sequences which encode polypeptides with a Δ6-desaturase activity, Δ6-elongase activity or Δ5-desaturase activity selected from a group of nucleic acid sequences, and/or to the use of nucleic acid constructs comprising the abovementioned nucleic acid sequences.
摘要翻译：本发明涉及一种生产脂肪酸酯的方法，所述脂肪酸酯包含具有至少三个双键的不饱和脂肪酸，以及游离不饱和脂肪酸，所述不饱和脂肪酸的含量为至少1重量％通过表达至少一个编码具有Δ6-去饱和酶活性的多肽的核酸序列和至少一个编码具有Δ6-延长酶活性的多肽的核酸序列的植物。有利地，如果合适，这些核酸序列可以与编码具有Δ5-去饱和酶活性的多肽的第三核酸序列一起在转基因植物中表达。本发明还涉及定义的编码具有Δ6-去饱和酶活性的多肽，Δ6-延长酶活性或选自一组核酸序列的Δ5-去饱和酶活性的定义的核酸序列的用途，和/或使用核酸构建体包含上述核酸序列。

13. 发明授权

US06716612B2 DNA molecules coding for debranching enzymes derived from plants 有权
标题翻译：编码从植物衍生的脱支酶的DNA分子
公开(公告)号：US06716612B2
公开(公告)日：2004-04-06
申请号：US10208349
申请日：2002-07-29
申请人： Jens Kossmann , Michael Emmermann , Ivar Virgin , Andreas Renz
发明人： Jens Kossmann , Michael Emmermann , Ivar Virgin , Andreas Renz
IPC分类号： C12N944
CPC分类号： C12N9/2451 , A23L29/35 , C12N9/2457 , C12N9/246 , C12N15/8245 , C12P19/16 , C12Y302/01041 , C12Y302/01068
摘要： The invention describes DNA molecules which code for plant proteins having the biological activity of a debranching enzyme. Furthermore described are transgenic plant cells and plants having reduced or increased debranching enzyme activity, as well as modified starch isolatable from the cells and plants.
摘要翻译：本发明描述了编码具有脱支酶的生物活性的植物蛋白质的DNA分子。此外还描述了具有降低或增加的脱支酶活性的转基因植物细胞和植物，以及可从细胞和植物分离的改性淀粉。

14. 发明授权

US08088974B2 Production of polyunsaturated fatty acids, novel biosynthesis genes, and novel plant expression constructs 有权
标题翻译：生产多不饱和脂肪酸，新型生物合成基因和新型植物表达构建体
公开(公告)号：US08088974B2
公开(公告)日：2012-01-03
申请号：US12565799
申请日：2009-09-24
申请人： Jens Lerchl , Andreas Renz , Ernst Heinz , Frederic Domergue , Ulrich Zähringer
发明人： Jens Lerchl , Andreas Renz , Ernst Heinz , Frederic Domergue , Ulrich Zähringer
IPC分类号： C12N15/82 , A01H5/00 , C07H21/04
CPC分类号： C12N9/0083 , C12N15/8247 , C12P7/6427 , C12P7/6472
摘要： The present invention relates to a method for the production of unsaturated fatty acids with at least two double bonds. The invention furthermore relates to the use of nucleic acid sequences SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 5 and SEQ ID NO: 11 encoding polypeptides having desaturase activity in the method and for generating a transgenic organism, preferably a transgenic plant or a transgenic microorganism, with an increased content of fatty acids, oils or lipids with unsaturated C18-, C20-, or C22-fatty acids, and to their homologs or derivatives, to gene constructs encompassing these genes, and to their use alone or in combination with biosynthesis genes of polyunsaturated fatty acids. The invention also relates to multiexpression cassettes for seed-specific expression, and to vectors or organisms which encompass a desaturase gene alone or in combination with further desaturases and/or elongase genes or homologs using said expression cassettes.
摘要翻译：本发明涉及生产具有至少两个双键的不饱和脂肪酸的方法。本发明还涉及编码在该方法中具有去饱和酶活性的多肽的核酸序列SEQ ID NO：1，SEQ ID NO：3，SEQ ID NO：5和SEQ ID NO：11，并且用于产生转基因生物，优选地具有不饱和C18-，C20-或C22-脂肪酸的脂肪酸，油或脂质含量增加的转基因植物或转基因微生物及其同源物或衍生物，包括这些基因的基因构建体，以及它们单独使用或与多不饱和脂肪酸的生物合成基因组合使用。本发明还涉及用于种子特异性表达的多表达盒以及包含去饱和酶基因单独或与进一步去饱和酶和/或延伸酶基因或使用所述表达盒的同源物组合的载体或生物体。

15. 发明申请

US20110088201A1 Vacuum cleaner 有权
标题翻译：吸尘器
公开(公告)号：US20110088201A1
公开(公告)日：2011-04-21
申请号：US12924623
申请日：2010-09-29
申请人： Stefan Hess , Martin Foell , Andreas Kramer , Andreas Renz
发明人： Stefan Hess , Martin Foell , Andreas Kramer , Andreas Renz
IPC分类号： A47L9/00
CPC分类号： A47L9/0036 , A47L5/365 , A47L9/26
摘要： The invention relates to a vacuum cleaner comprising a lower housing part, on which wheels are mounted for moving the vacuum cleaner along a floor surface, and which forms a dirt collection container with a suction inlet to which a suction hose is connectable, and an upper housing part which is mountable on the lower housing part and accommodates an electrically drivable suction unit, and an electric supply cable for connecting the suction unit to an electrical voltage source. In order to develop the vacuum cleaner so that it is easier to handle, and the supply cable and the suction hose can be held in a simple way for storage on the vacuum cleaner and removed from the vacuum cleaner for use, it is proposed, in accordance with the invention, that the vacuum cleaner have a cable receptacle for storing the supply cable and a hose mount for storing the suction hose, the cable receptacle surrounding the upper housing part on the outside in the circumferential direction, and the hose mount being arranged below the cable receptacle.
摘要翻译：本发明涉及一种真空吸尘器，它包括一个下部壳体部分，其上安装有用于沿地板表面移动吸尘器的轮子，并且形成具有吸入口的吸尘容器的吸尘容器，吸入软管可连接到该吸尘器上，壳体部分，其可安装在下壳体部分上并且容纳电驱动的抽吸单元，以及用于将抽吸单元连接到电压源的电源电缆。为了开发真空吸尘器以使其更容易处理，并且供电电缆和抽吸软管可以以简单的方式保存在真空吸尘器上并从真空吸尘器中除去以供使用，因此在根据本发明，真空吸尘器具有用于存储供应电缆的电缆插座和用于存储抽吸软管的软管安装座，围绕周围方向上的外壳部分的电缆插座，并且软管安装件被布置在电缆插座下面。

16. 发明授权

US07893320B2 Method for producing multiple unsaturated fatty acids in plants 有权
标题翻译：在植物中生产多种不饱和脂肪酸的方法
公开(公告)号：US07893320B2
公开(公告)日：2011-02-22
申请号：US10511621
申请日：2003-04-25
申请人： Petra Cirpus , Andreas Renz , Jens Lerchl , Anne-Marie Kuijpers
发明人： Petra Cirpus , Andreas Renz , Jens Lerchl , Anne-Marie Kuijpers
IPC分类号： C12N15/82 , A01H5/00
CPC分类号： C12P7/6427 , C12N9/0083 , C12N15/8247 , C12P7/6472 , C12P7/6481
摘要： The present invention relates to a method for the production of fatty acid esters which comprise unsaturated fatty acids with at least three double bonds, and to free unsaturated fatty acids with a content of at least 1% by weight based on the total fatty acids present in the plants, by expressing at least one nucleic acid sequence which encodes a polypeptide with Δ6-desaturase activity and at least one nucleic acid sequence which encodes a polypeptide with Δ6-elongase activity. Advantageously, these nucleic acid sequences can, if appropriate, be expressed in the transgenic plant together with a third nucleic acid sequence which encodes a polypeptide with Δ5-desaturase activity. The invention furthermore relates to the use of defined nucleic acid sequences which encode polypeptides with a Δ6-desaturase activity, Δ6-elongase activity or Δ5-desaturase activity selected from a group of nucleic acid sequences, and/or to the use of nucleic acid constructs comprising the abovementioned nucleic acid sequences.
摘要翻译：本发明涉及一种生产脂肪酸酯的方法，所述脂肪酸酯包含具有至少三个双键的不饱和脂肪酸，以及游离不饱和脂肪酸，所述不饱和脂肪酸的含量为至少1重量％通过表达编码具有＆Dgr.6-去饱和酶活性的多肽的至少一个核酸序列和至少一个编码具有＆Dgr.6-延伸酶活性的多肽的核酸序列的植物。有利的是，如果合适，这些核酸序列可以与编码具有＆Dgr。5-去饱和酶活性的多肽的第三核酸序列一起在转基因植物中表达。本发明进一步涉及定义的核酸序列的用途，所述核酸序列编码具有选自一组核酸序列的＆Dgr .6-去饱和酶活性和/或Dgr。5-去饱和酶活性的多肽，和/或使用包含上述核酸序列的核酸构建体。

17. 发明授权

US07615679B2 Method of producing polyunsaturated fatty acids, novel biosynthesis genes, and novel plant expression constructs 失效
标题翻译：生产多不饱和脂肪酸的方法，新型生物合成基因和新型植物表达构建体
公开(公告)号：US07615679B2
公开(公告)日：2009-11-10
申请号：US10250553
申请日：2002-01-18
申请人： Jens Lerchl , Andreas Renz , Ernst Heinz , Frederic Domergue , Ulrich Zähringer
发明人： Jens Lerchl , Andreas Renz , Ernst Heinz , Frederic Domergue , Ulrich Zähringer
IPC分类号： C12N15/82 , A01H5/00 , C07H21/04
CPC分类号： C12N9/0083 , C12N15/8247 , C12P7/6427 , C12P7/6472
摘要： The present invention relates to a method for the production of unsaturated fatty acids with at least two double bonds. The invention further relates to the use of the nucleic acid sequence of SEQ ID NO: 1 encoding a polypeptide having delta-5 desaturase activity in the method and for generating a transgenic organism, preferably a transgenic plant or microorganism with an increased content of fatty acids, oil or lipids with unsaturated long chain fatty acids, to their homologs or derivatives, and to gene constructs encompassing these genes. The invention also relates to the use of the nucleic acid sequences alone or in combination with further desaturases and/or elongase genes in the method and for generating transgenic organisms.
摘要翻译：本发明涉及生产具有至少两个双键的不饱和脂肪酸的方法。本发明还涉及编码具有Δ-5去饱和酶活性的多肽的SEQ ID NO：1的核酸序列在该方法中的用途，并且用于产生转基因生物，优选具有增加的脂肪酸含量的转基因植物或微生物，具有不饱和长链脂肪酸的油或脂质，其同系物或衍生物，以及包含这些基因的基因构建体。本发明还涉及本方法中单核酸序列或其它去饱和酶和/或延伸酶基因与生成转基因生物体的组合的用途。

18. 发明申请

US20080160054A1 Novel elongase gene, and process for the preparation of polyunsaturated fatty acids 审中-公开
标题翻译：新型延伸酶基因，以及制备多不饱和脂肪酸的方法
公开(公告)号：US20080160054A1
公开(公告)日：2008-07-03
申请号：US11682269
申请日：2007-03-05
申请人： Ernst Heinz , Thorsten Zank , Ulrich Zahringer , Jens Lerchl , Andreas Renz
发明人： Ernst Heinz , Thorsten Zank , Ulrich Zahringer , Jens Lerchl , Andreas Renz
IPC分类号： A61K8/02 , C07H21/04 , C07K16/00 , C12N15/00 , C12N5/00 , A23D7/00 , C12N5/02 , C12P21/04 , G01N33/53 , A61K36/00
CPC分类号： C12N9/1029 , C12N15/8247 , C12P7/6427 , C12P7/6472
摘要： The invention relates to a novel elongase gene with the sequences stated in sequence SEQ ID NO:1, SEQ ID NO: 3, SEQ ID NO: 5 and SEQ ID NO: 7 or their homologs, derivatives or analogs, to a gene construct comprising this gene or its homologs, derivatives and analogs, and to its use. The invention also relates to vectors or transgenic organisms comprising an elongase gene with the sequence SEQ ID NO:1, SEQ ID NO: 3, SEQ ID NO: 5 and SEQ ID NO: 7 or its homologs, derivatives and analogs. The invention furthermore relates to the use of the elongase gene sequences alone or in combination with further elongases and/or further fatty acid biosynthesis genes. The present invention relates to a novel elongase gene with the sequence SEQ ID NO:1 or its homologs, derivatives and analogs.Furthermore, the invention relates to a process for the preparation of polyunsaturated fatty acids and to a process for introducing DNA into organisms which produce large amounts of oils and, in particular, oils with a high content of unsaturated fatty acids. Moreover, the invention relates to an oil and/or a fatty acid preparation with a higher content of polyunsaturated fatty acids with at least two double bonds and/or a triacylglycerol preparation with a higher content of polyunsaturated fatty acids with at least two double bonds.
摘要翻译：本发明涉及具有序列SEQ ID NO：1，SEQ ID NO：3，SEQ ID NO：5和SEQ ID NO：7所示序列的新型延伸酶基因或其同源物，衍生物或类似物，其包含该基因或其同系物，衍生物和类似物，以及其用途。本发明还涉及包含具有序列SEQ ID NO：1，SEQ ID NO：3，SEQ ID NO：5和SEQ ID NO：7的延伸酶基因或其同源物，衍生物和类似物的载体或转基因生物。本发明还涉及单独使用延伸酶基因序列或与其它延伸酶和/或其它脂肪酸生物合成基因组合的用途。本发明涉及具有序列SEQ ID NO：1或其同系物，衍生物和类似物的新型延伸酶基因。此外，本发明涉及一种制备多不饱和脂肪酸的方法，以及将DNA引入生产大量油，特别是具有高含量不饱和脂肪酸的油的生物体中的方法。此外，本发明涉及具有较高含量的具有至少两个双键的多不饱和脂肪酸的油和/或脂肪酸制剂和/或具有至少两个双键的具有较高含量的多不饱和脂肪酸的三酰基甘油制剂。

19. 发明申请

US20060174376A1 Novel plant acyltransferases specific for long-chained, multiply unsaturated fatty acids 有权
标题翻译：新型植物酰基转移酶特异于长链，多不饱和脂肪酸
公开(公告)号：US20060174376A1
公开(公告)日：2006-08-03
申请号：US10552013
申请日：2004-03-26
申请人： Andreas Renz , Jorg Bauer , Margit Frentzen , Nursen Sozer , Stobart Keith
发明人： Andreas Renz , Jorg Bauer , Margit Frentzen , Nursen Sozer , Stobart Keith
IPC分类号： A01H1/00 , C07H21/04 , C12P7/64 , C12N15/82 , C12N5/04
CPC分类号： C12P7/6427 , C12N9/1029 , C12N15/8247 , C12P7/6472
摘要： The present invention relates to a process for the production of long-chain polyunsaturated fatty acids in an organism by introducing, into the organism, nucleic acids which code for polypeptides with acyl transferase activity. These nucleic acid sequences, if appropriate together with further nucleic acid sequences which code for polypeptides of the fatty acid or lipid metabolism biosynthesis, can advantageously be expressed in the organism. Furthermore, the invention relates to a method for the production of oils and/or triacylglycerides with an elevated content of long-chain polyunsaturated fatty acids. The invention furthermore relates to the nucleic acid sequences, nucleic acid constructs, vectors and organisms comprising the nucleic acid sequences according to the invention, vectors comprising the nucleic acid sequences and/or the nucleic acid constructs and to transgenic organisms comprising the abovementioned nucleic acid sequences, nucleic acid constructs and/or vectors. A further part of the invention relates to oils, lipids and/or fatty acids produced by the process according to the invention and to their use.
摘要翻译：本发明涉及通过向生物体中引入编码具有酰基转移酶活性的多肽的核酸来生产生物体中长链多不饱和脂肪酸的方法。如果合适的话，这些核酸序列与编码脂肪酸或脂质代谢生物合成的多肽的其它核酸序列一起可以有利地在生物体中表达。此外，本发明涉及一种具有升高的多链多不饱和脂肪酸含量的油和/或三酰基甘油酯的生产方法。本发明还涉及包含本发明的核酸序列的核酸序列，核酸构建体，载体和生物，包含核酸序列和/或核酸构建体的载体以及包含上述核酸序列的转基因生物，核酸构建体和/或载体。本发明的另一部分涉及通过根据本发明的方法生产的油，脂质和/或脂肪酸及其用途。

20. 发明申请

US20060168687A1 Method for the production of polyunsaturated fatty acids 有权
标题翻译：生产多不饱和脂肪酸的方法
公开(公告)号：US20060168687A1
公开(公告)日：2006-07-27
申请号：US10547447
申请日：2004-01-29
申请人： Andreas Renz , Ernst Heinz , Amine Abbadi , Frederic Domergue , Thorsten Zank
发明人： Andreas Renz , Ernst Heinz , Amine Abbadi , Frederic Domergue , Thorsten Zank
IPC分类号： A01H1/00 , C11B1/00 , C07H21/04 , C12P21/06 , C12P7/64 , C12N9/10 , C12N5/04 , A61K8/36
CPC分类号： C12N15/8247 , C12N9/1029 , C12P7/6427 , C12P7/6472
摘要： The present invention relates to a process for producing polyunsaturated fatty acids in an organism by introducing nucleic acids into said organism which code for polypeptides having acyl-CoA:lysophospholipid acyltransferase activity. Advantageously, these nucleic acid sequences may, if appropriate together with further nucleic acid sequences coding for biosynthesis polypeptides of the fatty acid or lipid metabolism, be expressed in the transgenic organism. The invention furthermore relates to the nucleic acid sequences, to nucleic acid constructs comprising the nucleic acid sequences of the invention, to vectors comprising said nucleic acid sequences and/or said nucleic acid constructs and to transgenic organisms comprising the abovementioned nucleic acid sequences, nucleic acid constructs and/or vectors. A further part of the invention relates to oils, lipids and/or fatty acids produced by the process of the invention and to their use.
摘要翻译：本发明涉及通过将核酸引入所述生物体中来生产多不饱和脂肪酸的方法，其编码具有酰基-CoA：溶血磷脂酰基转移酶活性的多肽。有利地，如果合适的话，这些核酸序列可以与编码脂肪酸或脂质代谢的生物合成多肽的其它核酸序列一起在转基因生物中表达。本发明还涉及包含本发明的核酸序列的核酸构建体的核酸序列与包含所述核酸序列和/或所述核酸构建体的载体以及包含上述核酸序列的转基因生物体，核酸构建体和/或载体。本发明的另一部分涉及通过本发明的方法生产的油，脂和/或脂肪酸及其用途。

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