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11. 发明申请

US20100099994A1 IMPLANTABLE HEART ANALYZING DEVICE, SYSTEM AND METHOD 审中-公开
标题翻译：可植入心脏分析装置，系统和方法
公开(公告)号：US20100099994A1
公开(公告)日：2010-04-22
申请号：US12528160
申请日：2007-02-28
申请人： Nils Holmström , Andreas Blomqvist , Berit Larsson , Karin Järverud , Sven-Erik Hedberg
发明人： Nils Holmström , Andreas Blomqvist , Berit Larsson , Karin Järverud , Sven-Erik Hedberg
IPC分类号： A61B5/02
CPC分类号： A61B5/1107 , A61B5/0051 , A61B5/4519 , A61B5/6869 , A61N1/36578
摘要： An implantable heart analyzing device has a housing and a control circuit located within said housing. The control circuit generates an output signal adapted to actuate an activator, which is able to make a wall of the heart deflect or vibrate. The control circuit also communicates with a sensor, which can be identical with the activator, with which the movement of the heart wall can be sensed. The control circuit executes a procedure that involves the generation of an output signal and sensing a corresponding sensor signal, and to be able to derive information concerning the tension of the heart wall. An implantable heart analyzing includes the aforementioned heart analyzing device, as well as the activator and the sensor. The heart analyzing device and the system implement a method that results in generation of the aforementioned information concerning the tension of the heart wall.
摘要翻译：可植入心脏分析装置具有壳体和位于所述壳体内的控制电路。控制电路产生适于致动激活器的输出信号，其能够使心脏的壁发生偏转或振动。控制电路还与传感器通信，传感器可以与激活器相同，通过该传感器可以感测心脏壁的移动。控制电路执行涉及生成输出信号并感测相应的传感器信号的过程，并且能够得出关于心壁的张力的信息。可植入心脏分析包括上述心脏分析装置，以及活化剂和传感器。心脏分析装置和系统实施导致产生上述关于心脏壁张力的信息的方法。

12. 发明申请

US20100041970A1 IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：可植入医疗器械
公开(公告)号：US20100041970A1
公开(公告)日：2010-02-18
申请号：US12532186
申请日：2007-11-27
申请人： Sven-Erik Hedberg , Andreas Blomqvist , Karin Järverud , Karin Ljungström , Leif Lindkvist , Urban Lönn , Nils Holmström
发明人： Sven-Erik Hedberg , Andreas Blomqvist , Karin Järverud , Karin Ljungström , Leif Lindkvist , Urban Lönn , Nils Holmström
IPC分类号： A61B5/1459
CPC分类号： A61N1/3702 , A61B5/14542 , A61B5/1459 , A61N1/056 , A61N1/36557
摘要： An implantable medical device has an oxygen sensor adapted to measure the level of oxygen in oxygenized blood, and to generate an oxygen measurement signal in dependence of the level of oxygen. The oxygen sensor is adapted to perform measurements inside the heart, of blood entering the left atrium of a patient's heart. The obtained oxygen measurement signal is compared to a predetermined threshold level and an indication signal is generated in dependence of the comparison. The, indication signal is indicative of the lung functionality of the patient.
摘要翻译：可植入医疗装置具有适于测量氧合血液中的氧气水平的氧传感器，并且根据氧气水平产生氧测量信号。氧传感器适于在心脏内进行血液进入患者心脏左心房的血液。将获得的氧测量信号与预定阈值电平进行比较，并根据比较产生指示信号。该指示信号表示患者的肺功能。

13. 发明授权

US09026207B2 Medical device for Atrial fibrillation prediction 有权
标题翻译：用于房颤预测的医疗设备
公开(公告)号：US09026207B2
公开(公告)日：2015-05-05
申请号：US12810406
申请日：2008-01-28
申请人： Andreas Blomqvist
发明人： Andreas Blomqvist
IPC分类号： A61N1/365 , A61B5/02 , A61B5/0205 , A61B5/0452 , A61B5/053 , A61B5/08 , A61B5/00 , A61N1/362
CPC分类号： A61N1/36521 , A61B5/0031 , A61B5/02028 , A61B5/0205 , A61B5/0452 , A61B5/053 , A61B5/0809 , A61B5/4818 , A61B5/7239 , A61N1/3622
摘要： In a device and a method for providing correlated measures for predicting potential occurrence of atrial fibrillation, an impedance of the patient is measured to obtain impedance information; cardiogenic data is determined from the information; respiratory data is determined from the information; at least one hemodynamic measure is calculated from the cardiogenic data and at least one apnea measure is calculated from the respiratory data; the hemodynamic and apnea measures are correlated such that the correlated measures can be utilized for predicting potential occurrence of atrial fibrillation.
摘要翻译：在用于提供用于预测心房颤动的潜在发生的相关措施的装置和方法中，测量患者的阻抗以获得阻抗信息; 从信息确定心源生成数据; 从信息中确定呼吸数据; 从心源性数据计算出至少一种血液动力学测量，并根据呼吸数据计算至少一种呼吸暂停测量; 血流动力学和呼吸暂停测量是相关的，以便相关度量可用于预测房颤的潜在发生。

14. 发明授权

US08670820B2 Near field-based systems and methods for assessing impedance and admittance for use with an implantable medical device 有权
标题翻译：用于评估用于可植入医疗设备的阻抗和导纳的近场系统和方法
公开(公告)号：US08670820B2
公开(公告)日：2014-03-11
申请号：US12853130
申请日：2010-08-09
申请人： Dan E. Gutfinger , Fujian Qu , Alex Soriano , Ryan Rooke , Yelena Nabutovsky , Riddhi Shah , Andreas Blomqvist
发明人： Dan E. Gutfinger , Fujian Qu , Alex Soriano , Ryan Rooke , Yelena Nabutovsky , Riddhi Shah , Andreas Blomqvist
IPC分类号： A61B5/053
CPC分类号： A61B5/0538 , A61B5/02028 , A61B5/029 , A61B5/4878 , A61B5/686 , A61B7/00 , A61B2562/0219
摘要： A new model is provided for understanding and exploiting impedance or admittance values measured by implantable medical devices, such as pacemakers or cardiac resynchronization devices (CRTs.) The device measures impedance along vectors extending through tissues of the patient between various pairs of electrodes. The device then converts the vector-based impedance measurements into near-field individual electrode-based impedance values. This is accomplished, in at least some examples, by converting the vector-based impedance measurements into a set of linear equations to be solved while ignoring far-field contributions to the impedance measurements. The device solves the linear equations to determine the near-field impedance values for the individual electrodes, which are representative of the impedance of tissues in the vicinity of the electrodes. The device then performs or controls various device functions based on the near-field values, such as analyzing selected near-field values to detect heart failure or pulmonary edema.
摘要翻译：提供了一种新型号，用于了解和利用可植入医疗设备（例如起搏器或心脏再同步装置（CRT））测量的阻抗或导纳值。该装置测量沿着延伸穿过患者组织的不同对电极之间的阻力。然后，器件将基于矢量的阻抗测量值转换为近场单独的基于电极的阻抗值。这在至少一些示例中是通过将基于矢量的阻抗测量值转换成待解决的一组线性方程而实现的，同时忽略对阻抗测量的远场贡献。该装置解决了线性方程来确定各个电极的近场阻抗值，其代表电极附近的组织的阻抗。然后，设备基于近场值执行或控制各种设备功能，例如分析所选的近场值以检测心脏衰竭或肺水肿。

15. 发明授权

US08620432B2 Identification of pacing site 有权
标题翻译：鉴定起搏部位
公开(公告)号：US08620432B2
公开(公告)日：2013-12-31
申请号：US13171952
申请日：2011-06-29
申请人： Sven-Erik Hedberg , Nils Holmström , John Gustafsson , Andreas Blomqvist , Andreas Karlsson
发明人： Sven-Erik Hedberg , Nils Holmström , John Gustafsson , Andreas Blomqvist , Andreas Karlsson
IPC分类号： A61N1/00
CPC分类号： A61N1/3686 , A61N1/36521
摘要： An implantable medical device applies an electric signal over two electrodes and measures the resulting electric signal over a candidate pair of neighboring electrodes on a lead for a first heart ventricle or over a candidate electrode of the lead and a case electrode. An impedance signal is determined for each candidate pair or electrode based on the applied signal and the measured resulting signal. A time difference between start of contraction in a second ventricle and the timing of local myocardial contraction as identified from the impedance signal at the site of the candidate pair or electrode is determined for each candidate pair or electrode. An optimal pacing electrode is selected to correspond to one of the electrodes of the candidate pair having the largest time difference or the candidate electrode having largest time difference.
摘要翻译：可植入医疗装置在两个电极上施加电信号，并且通过在第一心室的引线上或在引线的候选电极和外壳电极上的相邻电极的候选对测量所得到的电信号。基于所施加的信号和测得的结果信号，为每个候选对或电极确定阻抗信号。针对每个候选对或电极确定从候选对或电极的位置处的阻抗信号识别的第二心室的收缩开始与局部心肌收缩的定时之间的时间差。选择最佳起搏电极以对应于具有最大时间差的候选对的电极之一或具有最大时间差的候选电极。

16. 发明申请

US20130211472A1 CARDIAC RESYNCHRONIZATION THERAPY OPTIMIZATION 审中-公开
标题翻译：心脏康复治疗优化
公开(公告)号：US20130211472A1
公开(公告)日：2013-08-15
申请号：US13880345
申请日：2010-10-27
申请人： Andreas Blomqvist
发明人： Andreas Blomqvist
IPC分类号： A61N1/365
CPC分类号： A61N1/36585 , A61N1/3627 , A61N1/3684
摘要： An implantable medical device, IMD, (100) conducts CRT settings searches at multiple CRT settings search periods during an optimization time period by testing different candidate CRT settings and selecting the optimal CRT setting based on output signals of a hemodynamic sensor (240). The respective optimal CRT settings determined during the optimization time period are employed in order to predict at least one future optimal CRT setting that can be used by the IMD (100) following the end of the optimization time period. The IMD (100) then generates and applies pacing pulses to a subject's (5) heart (10) according to a CRT setting of the at least one future optimal CRT setting. The embodiments therefore enable efficient cardiac resynchronization therapy without any sensor readings after the end of the optimization time period and can therefore provide cardiac resynchronization therapy even if the hemodynamic sensor (240) becomes inoperable.
摘要翻译：可植入医疗装置IMD（100）通过测试不同的候选CRT设置并且基于血流动力学传感器（240）的输出信号选择最佳CRT设置，在优化时间段期间在多个CRT设置搜索周期进行CRT设置搜索。采用在优化时间周期期间确定的各个最佳CRT设置，以便在优化时间段结束之后预测可由IMD（100）使用的至少一个未来最佳CRT设置。 IMD（100）然后根据至少一个未来最佳CRT设置的CRT设置产生和应用起搏脉冲到对象的（5）心脏（10）。因此，实施例能够在优化时间段结束之后进行有效的心脏再同步治疗，而无需任何传感器读数，并且因此即使血液动力学传感器（240）变得不可操作也可以提供心脏再同步治疗。

17. 发明申请

US20130053917A1 PHYSIOLOGICALLY ADAPTED CARDIAC RESYNCHRONIZATION THERAPY 有权
标题翻译：生理适应心脏康复治疗
公开(公告)号：US20130053917A1
公开(公告)日：2013-02-28
申请号：US13578553
申请日：2011-08-31
申请人： Tomas Svensso , Andreas Blomqvist , Andreas Karlsson , Michael Broome
发明人： Tomas Svensso , Andreas Blomqvist , Andreas Karlsson , Michael Broome
IPC分类号： A61N1/37
CPC分类号： A61N1/368 , A61N1/36507 , A61N1/36585 , A61N1/3684 , A61N1/3702 , A61N1/371
摘要： An implantable medical device is connectable to an epicardial left ventricular lead having at least one epicardial electrode and a myocardium penetrating catheter with at least one endocardial electrode and present in a lumen of the lead. The device comprises a pulse generator controller that controls a ventricular pulse generator to generate pulses to be applied to the epicardial and endocardial electrodes. The controller uses an endocardial-to-epicardial time interval or epicardial-to-endocardial time interval to coordinate endocardial and epicardial activation of the left ventricle to thereby achieve cardiac pacing that closely mimics the natural electrical activation pattern of a healthy heart.
摘要翻译：可植入医疗装置可连接到具有至少一个心外膜电极的心外膜左心室引线和具有至少一个心内膜电极并存在于引流管腔中的心肌穿透导管。该装置包括脉冲发生器控制器，其控制心室脉冲发生器以产生要施加到心外膜和心内膜电极的脉冲。控制器使用心内膜至心外膜时间间隔或心外膜至心内膜时间间隔来协调左心室的心内膜和心外膜激活，从而实现紧密模拟健康心脏的天然电活化模式的心脏起搏。

18. 发明授权

US08346353B2 Implantable medical system for detecting incipient edema 有权
标题翻译：用于检测初期水肿的植入式医疗系统
公开(公告)号：US08346353B2
公开(公告)日：2013-01-01
申请号：US12531793
申请日：2007-04-24
申请人： Sven-Erik Hedberg , Andreas Blomqvist , Karin Järverud , Karin Ljungström , Leif Lindqvist , Urban Lönn
发明人： Sven-Erik Hedberg , Andreas Blomqvist , Karin Järverud , Karin Ljungström , Leif Lindqvist , Urban Lönn
IPC分类号： A61B5/05
CPC分类号： A61N1/05 , A61B5/0084 , A61B5/0086 , A61B5/08 , A61B5/1116 , A61B5/1118 , A61B5/4878 , A61B5/7207 , A61N1/025 , A61N1/056 , A61N1/362
摘要： An implantable medical system for detecting incipient edema has an implantable medical lead including an optical sensor having a light source and a light detector. The medical system further has an edema detection circuit that activates the light source to emit light, the light being directed into lung tissue of a patient and that obtains a light intensity value corresponding to an intensity of light received by the light detector, and that evaluates the light intensity value to detect a consistency with incipient edema.
摘要翻译：用于检测初期水肿的可植入医疗系统具有包括具有光源和光检测器的光学传感器的可植入医疗引线。医疗系统还具有水肿检测电路，其激活光源发光，将光引导到患者的肺组织，并获得与由光检测器接收的光的强度对应的光强度值，并且评估光强值检测与初期水肿的一致性。

19. 发明申请

US20120101397A1 LATE POTENTIAL DETECTION 有权
标题翻译：最终的潜在检测
公开(公告)号：US20120101397A1
公开(公告)日：2012-04-26
申请号：US13380933
申请日：2009-06-26
申请人： Andreas Blomqvist
发明人： Andreas Blomqvist
IPC分类号： A61B5/0472
CPC分类号： A61B5/0452 , A61B5/0006 , A61B5/002 , A61B5/0031 , A61B5/0422 , A61B5/686 , A61B5/7242 , A61B5/7275 , A61B2505/07 , A61N1/362 , G06F19/00
摘要： A late potential detecting system has an implantable medical device connected to at least one cardiac lead having implantable electrodes positioned at different sites of a ventricle myocardium. A sampling unit of the implantable medical device records electrogram samples for the different implantable electrodes to get different sample sets. The electrogram samples of the sample sets are time synchronized and magnitude potential representations of the potential data of the electrogram samples are determined. The magnitude potential representations of the time synchronized electrogram samples are then co-processed and used for determining a parameter that is indicative of any late potentials of the monitored ventricle.
摘要翻译：晚期电位检测系统具有连接到至少一个具有位于心室心肌不同部位的可植入电极的心脏引线的可植入医疗装置。可植入医疗装置的采样单元记录不同可植入电极的电描记图样品以获得不同的样品组。样本集的电描记图样本是时间同步的，并且确定电描记图样本的潜在数据的幅度电位表示。然后对时间同步电描记图样本的幅度电位表示进行协处理，并用于确定指示所监测的心室的任何后期电位的参数。

20. 发明申请

US20120083703A1 IMPLANTABLE CORONARY PERFUSION MONITORING DEVICE 有权
标题翻译：可植入冠脉灌注监测装置
公开(公告)号：US20120083703A1
公开(公告)日：2012-04-05
申请号：US13265722
申请日：2009-04-29
申请人： Andreas Blomqvist , Karin Järverud , Michael Broomè
发明人： Andreas Blomqvist , Karin Järverud , Michael Broomè
IPC分类号： A61B5/02
CPC分类号： A61B5/02158 , A61B5/02007 , A61B5/02028 , A61B5/02125 , A61B5/0295 , A61B5/053
摘要： An implantable coronary perfusion monitoring device for in-vivo determination of a coronary perfusion index (CPI) indicative of the coronary perfusion of a heart has a time measurement unit to determine a blood pressure reflection wave measure t indicating the timely position in the heart cycle of the maximum of a reflected blood pressure wave and in a time period starting at a preset point of time in systole and ending at a local maximum of blood pressure following aortic valve closure and, a diastolic peak pressure measurement unit adapted to determine a diastolic peak blood pressure measure DPP related to diastolic aortic peak pressure and a systolic arterial pressure measurement unit adapted to determine a systolic arterial blood pressure measure SAP related to systolic arterial pressure, and a coronary perfusion index calculating unit adapted to determine said coronary perfusion index CPI as (t·DPP)/SAP.
摘要翻译：用于体内确定指示心脏冠状动脉灌注的冠状动脉灌注指数（CPI）的可植入冠状动脉灌注监测装置具有时间测量单元，以确定表示心脏周期中及时位置的血压反射波测量值反射血压波的最大值和在收缩期的预设时间点开始并且在主动脉瓣关闭后结束于局部最大血压的时间段内，以及适于确定舒张峰血液的舒张峰值压力测量单元压力测量与舒张性主动脉峰值压力相关的DPP和适于确定与收缩期动脉压相关的收缩期动脉血压测量SAP的收缩期动脉压测量单元，以及适于将所述冠状动脉灌注指数CPI确定为（t）的冠状动脉灌注指数计算单元 ·DPP）/ SAP。

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