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11. 发明申请

US20140176942A1 SURFACE ENHANCED RAMAN SPECTROSCOPY EMPLOYING A NANOROD IN A SURFACE INDENTATION 有权
标题翻译：表面增强拉曼光谱在表面印刷中使用纳米糖
公开(公告)号：US20140176942A1
公开(公告)日：2014-06-26
申请号：US14233957
申请日：2011-07-27
申请人： Alexandre Bratkovski , Zhiyong Li
发明人： Alexandre Bratkovski , Zhiyong Li
IPC分类号： G01N21/65 , G01N21/01
CPC分类号： G01N21/658 , G01N21/01
摘要： A surface enhanced Raman spectroscopy (SERS) apparatus employs a nanorod in an indentation in a surface of a substrate. The SERS apparatus includes the nanorod having a tip at a free end opposite to an end of the nanorod that is supported by the substrate indentation. The indentation has a tapered profile and supports the nanorod at a bottom of the indentation. The free end of the nanorod extends away from the indentation bottom. The SERS apparatus further includes a Raman-active material at a surface of one or both of the nanorod and the indentation. The indentation and the nanorod facilitate one or both of production and detection of a Raman scattering signal emitted by an analyte in a vicinity of the nanorod and indentation.
摘要翻译：表面增强拉曼光谱（SERS）装置在衬底的表面中采用在压痕中的纳米棒。 SERS装置包括在由衬底压痕支撑的纳米棒的端部相对的自由端处具有尖端的纳米棒。压痕具有锥形轮廓并且支撑在压痕底部的纳米棒。纳米棒的自由端延伸远离压痕底部。 SERS装置还包括在纳米棒和凹陷中的一个或两个的表面处的拉曼活性材料。压痕和纳米棒促进由纳米棒和压痕附近的分析物发射的拉曼散射信号的生成和检测中的一个或两个。

12. 发明授权

US08687186B2 Nanowire-based systems for performing raman spectroscopy 有权
标题翻译：用于执行拉曼光谱的基于纳米线的系统
公开(公告)号：US08687186B2
公开(公告)日：2014-04-01
申请号：US13383387
申请日：2009-07-30
申请人： Shih-Yuan Wang , Jingjing Li , Huei Pei Kuo , David A. Fattal , Nobuhiko Kobayashi , Zhiyong Li
发明人： Shih-Yuan Wang , Jingjing Li , Huei Pei Kuo , David A. Fattal , Nobuhiko Kobayashi , Zhiyong Li
IPC分类号： G01J3/44
CPC分类号： G01N21/658 , B82Y15/00 , G01J3/44
摘要： Embodiments of the present invention are directed to nanowire-based systems for performing surface-enhanced Raman spectroscopy. In one embodiment, a system comprises a substrate having a surface and a plurality of tapered nanowires disposed on the surface. Each nanowire has a tapered end directed away from the surface. The system also includes a plurality of nanoparticles disposed near the tapered end of each nanowire. When each nanowire is illuminated with light of a pump wavelength, Raman excitation light is emitted from the tapered end of the nanowire to interact with the nanoparticles and produce enhanced Raman scattered light from molecules located in close proximity to the nanoparticles.
摘要翻译：本发明的实施方案涉及用于进行表面增强拉曼光谱的基于纳米线的系统。在一个实施例中，系统包括具有设置在表面上的表面和多个锥形纳米线的基板。每个纳米线具有远离表面的锥形端。该系统还包括设置在每个纳米线的锥形端附近的多个纳米颗粒。当每个纳米线被泵浦波长的光照射时，拉曼激发光从纳米线的锥形端发射以与纳米颗粒相互作用，并从位于紧邻纳米颗粒的分子产生增强的拉曼散射光。

13. 发明授权

US08603606B2 Preventing adhesion between nanostructures 有权
标题翻译：防止纳米结构之间的粘附
公开(公告)号：US08603606B2
公开(公告)日：2013-12-10
申请号：US12916239
申请日：2010-10-29
申请人： Michael Josef Stuke , Zhiyong Li , Shih-Yuan Wang , Fung Suong Ou , Min Hu , Wei Wu , Lars Helge Thylen
发明人： Michael Josef Stuke , Zhiyong Li , Shih-Yuan Wang , Fung Suong Ou , Min Hu , Wei Wu , Lars Helge Thylen
IPC分类号： B32B3/00 , B05D7/00
CPC分类号： G01N21/658 , B81B3/0005 , Y10T428/24355 , Y10T428/24612
摘要： A device for Surface Enhanced Raman Scattering (SERS). The device includes a plurality of nanostructures protruding from a surface of a substrate, a SERS active metal disposed on a portion of said plurality of nanostructures, and a low friction film disposed over the plurality of nanostructures and the SERS active metal. The low friction film is to prevent adhesion between the plurality of nanostructures.
摘要翻译：用于表面增强拉曼散射（SERS）的器件。该装置包括从衬底表面突出的多个纳米结构，设置在所述多个纳米结构的一部分上的SERS活性金属，以及设置在多个纳米结构和SERS活性金属上的低摩擦膜。低摩擦膜是为了防止多个纳米结构之间的粘附。

14. 发明授权

US08279437B2 Multi-wavelength Raman light detection for detecting a species 有权
标题翻译：用于检测物种的多波长拉曼光检测
公开(公告)号：US08279437B2
公开(公告)日：2012-10-02
申请号：US12836097
申请日：2010-07-14
申请人： Min Hu , Alexandre M. Bratkovski , Huel Pei Kuo , Jingjing Li , Zhiyong Li , Fung Suong Ou , Michael Josef Stuke , Michael Renne Ty Tan , Shih-Yuan Wang , Wei Wu
发明人： Min Hu , Alexandre M. Bratkovski , Huel Pei Kuo , Jingjing Li , Zhiyong Li , Fung Suong Ou , Michael Josef Stuke , Michael Renne Ty Tan , Shih-Yuan Wang , Wei Wu
IPC分类号： G01J3/44
CPC分类号： G01J3/18 , G01J3/44 , G01N21/65 , G01N2021/651
摘要： An apparatus for detecting at least one species using Raman light detection includes at least one laser source for illuminating a sample containing the at least one species. The apparatus also includes a modulating element for modulating a spatial relationship between the sample and the light beams to cause relative positions of the sample and the light beams to be oscillated, in which Raman light at differing intensity levels are configured to be emitted from the at least one species based upon the different wavelengths of the light beams illuminating the sample. The apparatus also includes a Raman light detector and a post-signal processing unit configured to detect the at least one species.
摘要翻译：用于使用拉曼光检测来检测至少一种物质的装置包括用于照亮含有至少一种物质的样品的至少一个激光源。该装置还包括用于调制样品与光束之间的空间关系的调制元件，以使得样品和光束的相对位置发生振荡，其中以不同强度水平的拉曼光被配置为从at 基于照射样品的光束的不同波长的至少一种物质。该装置还包括拉曼光检测器和被配置为检测至少一种物种的后信号处理单元。

15. 发明申请

US20110228266A1 SUBSTRATE FOR SURFACE ENHANCED RAMAN SCATTERING (SERS) 有权
标题翻译：表面增强拉曼散射基板（SERS）
公开(公告)号：US20110228266A1
公开(公告)日：2011-09-22
申请号：US13129571
申请日：2008-11-17
申请人： Huei Pei Kuo , Jing Tang , Fung Suong Ou , Zhiyong Li , Shih-Yuan Wang
发明人： Huei Pei Kuo , Jing Tang , Fung Suong Ou , Zhiyong Li , Shih-Yuan Wang
IPC分类号： G01J3/44 , B05D5/06 , B05D3/10 , B05D3/00 , C23C16/44 , B82Y40/00 , B82Y20/00
CPC分类号： B82Y20/00 , G01N21/658
摘要： A substrate for Surface Enhanced Raman Scattering (SERS). The substrate comprises at least one nanostructure protruding from a surface of the substrate and a SERS active metal over the at least one nanostructure, wherein the SERS active metal substantially covers the at least one nanostructure and the SERS active metal creates a textured layer on the at least one nanostructure.
摘要翻译：用于表面增强拉曼散射（SERS）的衬底。衬底包括从衬底的表面突出的至少一个纳米结构和在至少一个纳米结构上的SERS活性金属，其中SERS活性金属基本上覆盖至少一个纳米结构，并且SERS活性金属在其上形成纹理化层至少一个纳米结构。

16. 发明授权

US07947485B2 Method and apparatus for molecular analysis using nanoelectronic circuits 有权
标题翻译：使用纳米电子电路进行分子分析的方法和装置
公开(公告)号：US07947485B2
公开(公告)日：2011-05-24
申请号：US11144586
申请日：2005-06-03
申请人： Wei Wu , Zhiyong Li , Shih-Yuan Wang , Philip J. Kuekes
发明人： Wei Wu , Zhiyong Li , Shih-Yuan Wang , Philip J. Kuekes
IPC分类号： C12M1/00 , G01N15/06 , C07H21/04
CPC分类号： G01N33/48721 , B82Y5/00 , B82Y10/00 , G01N27/414
摘要： Devices and methods for detecting the constituent parts of biological polymers are disclosed. A molecular analysis device comprises a molecule sensor and a molecule guide. The molecule sensor comprises a single electron transistor including a first terminal, a second terminal, and a nanogap or at least one quantum dot positioned between the first terminal and the second terminal. A nitrogenous material disposed on the at least one quantum dot is configured for an interaction with an identifiable configuration of a molecule. The molecule sensor develops an electronic effect responsive to the interaction. The molecule guide is configured for guiding at least a portion of the molecule substantially near the molecule sensor to enable the interaction.
摘要翻译：公开了用于检测生物聚合物的组成部分的装置和方法。分子分析装置包括分子传感器和分子引导件。分子传感器包括单电子晶体管，其包括位于第一端子和第二端子之间的第一端子，第二端子和纳米隙隙或至少一个量子点。设置在至少一个量子点上的含氮材料被配置用于与分子的可识别构型的相互作用。分子传感器产生响应于相互作用的电子效应。分子引导件被配置用于基本上在分子传感器附近引导分子的至少一部分，以实现相互作用。

17. 发明授权

US07805028B2 Optical sensor and method employing half-core hollow optical waveguide 失效
标题翻译：采用半芯空心光波导的光学传感器和方法
公开(公告)号：US07805028B2
公开(公告)日：2010-09-28
申请号：US12253123
申请日：2008-10-16
申请人： Zhiyong Li , Michael Tan , Shih-Yuan Wang , Wei Wu , Jing Tang
发明人： Zhiyong Li , Michael Tan , Shih-Yuan Wang , Wei Wu , Jing Tang
IPC分类号： G02B6/00 , G02B6/32 , G02B6/10
CPC分类号： G02B6/02328 , B82Y20/00 , G01N21/05 , G01N21/31 , G01N21/645 , G01N21/658 , G01N2021/0346 , G01N2021/052 , G01N2021/6467 , G01N2021/7763 , G01N2021/7783 , G02B6/1226
摘要： An optical sensor, sensing system and method of sensing employ a half-core hollow optical waveguide adjacent to a surface of an optical waveguide layer of a substrate. The half-core hollow optical waveguide and the adjacent optical waveguide layer cooperatively provide both an optical path that confines and guides an optical signal and an internal hollow channel. The optical path and channel extend longitudinally along a hollow core of the half-core hollow optical waveguide. The system further includes an optical source at an input of the optical path and an optical detector at an output of the optical path. A spectroscopic interaction between an analyte material that is introduced into the channel and an optical signal propagating along the optical path determines a characteristic of the analyte material.
摘要翻译：光学传感器，感测系统和感测方法使用与衬底的光波导层的表面相邻的半芯空心光波导。半芯空心光波导和相邻的光波导层协同地提供限制和引导光信号和内部中空通道的光路。光路和通道沿半芯空心光波导的中空芯纵向延伸。该系统还包括在光路的输入处的光源和在光路的输出处的光学检测器。引入到通道中的分析物质与沿光路传播的光信号之间的光谱相互作用决定了分析物质的特性。

18. 发明授权

US07639354B2 Raman signal-enhancing structures for Raman spectroscopy and methods for performing Raman spectroscopy 有权
标题翻译：用于拉曼光谱的拉曼信号增强结构和用于进行拉曼光谱的方法
公开(公告)号：US07639354B2
公开(公告)日：2009-12-29
申请号：US11701045
申请日：2007-01-31
申请人： Shih-Yuan Wang , Zhiyong Li
发明人： Shih-Yuan Wang , Zhiyong Li
IPC分类号： G01J3/44
CPC分类号： G01J3/44 , G01N21/658
摘要： Raman systems include a radiation source, a radiation detector configured to detect Raman scattered radiation, and a Raman signal-enhancing structure. The Raman signal-enhancing structure includes a first layer of Raman signal-enhancing material, a substantially monomolecular layer of molecules disposed on at least a portion of the first layer of Raman signal-enhancing material, and a second layer of Raman signal-enhancing material disposed on at least a portion of the substantially monomolecular layer of molecules. The second layer of Raman signal-enhancing material is disposed on a side of the layer of molecules opposite the first layer of Raman signal-enhancing material. Methods of performing Raman spectroscopy include providing such a Raman signal-enhancing structure, providing an analyte on the Raman signal-enhancing structure, irradiating the analyte and the structure, and detecting Raman scattered radiation.
摘要翻译：拉曼系统包括辐射源，被配置为检测拉曼散射辐射的辐射检测器和拉曼信号增强结构。拉曼信号增强结构包括第一层拉曼信号增强材料，设置在第一层拉曼信号增强材料的至少一部分上的基本上单分子层的分子，以及第二层拉曼信号增强材料设置在分子的基本单分子层的至少一部分上。第二层拉曼信号增强材料设置在与第一层拉曼信号增强材料相对的分子层的一侧。执行拉曼光谱的方法包括提供这样的拉曼信号增强结构，在拉曼信号增强结构上提供分析物，照射分析物和结构，以及检测拉曼散射辐射。

19. 发明授权

US07391511B1 Raman signal-enhancing structures and Raman spectroscopy systems including such structures 有权
标题翻译：包括这种结构的拉曼信号增强结构和拉曼光谱系统
公开(公告)号：US07391511B1
公开(公告)日：2008-06-24
申请号：US11700986
申请日：2007-01-31
申请人： Alexandre M. Bratkovski , Shih-Yuan Wang , Zhiyong Li
发明人： Alexandre M. Bratkovski , Shih-Yuan Wang , Zhiyong Li
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/658
摘要： A Raman signal-enhancing structure includes a substrate and a plurality of protrusions located at predetermined positions relative to a surface of the substrate. Each protrusion includes a Raman signal-enhancing material and has cross-sectional dimensions of less than about 50 nanometers. The structure also includes an edge that includes an intersection between two nonparallel surfaces of at least one protrusion. A Raman spectroscopy system includes such a Raman signal-enhancing structure, and Raman spectroscopy may be performed on an analyte using such structures and systems. A method for forming such a Raman signal-enhancing structure includes nanoimprint lithography.
摘要翻译：拉曼信号增强结构包括基板和位于相对于基板的表面的预定位置处的多个突起。每个突起包括拉曼信号增强材料并且具有小于约50纳米的横截面尺寸。该结构还包括边缘，其包括至少一个突起的两个不平行表面之间的交叉点。拉曼光谱系统包括这样的拉曼信号增强结构，并且可以使用这种结构和系统对分析物进行拉曼光谱。形成这种拉曼信号增强结构的方法包括纳米压印光刻。

20. 发明申请

US20070252980A1 Raman and hyper-rman excitation using superlensing 有权
标题翻译：拉曼和超雷曼激发使用超透镜
公开(公告)号：US20070252980A1
公开(公告)日：2007-11-01
申请号：US11413377
申请日：2006-04-28
申请人： Shih-Yuan Wang , Zhiyong Li
发明人： Shih-Yuan Wang , Zhiyong Li
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01J3/02 , G01J3/0208 , G01N21/658
摘要： Raman-enhancing structures include a layer of dielectric material, a superlens configured to focus electromagnetic radiation having a wavelength greater than about 100 nanometers to a two-dimensional focal area having linear dimensions less than about 100 nanometers on a surface of the layer of dielectric material, and at least two nanoparticles comprising a Raman-enhancing material disposed proximate the focal area. Additional Raman-enhancing structures include a layer of dielectric material, a layer of conductive material, and at least two nanoparticles comprising a Raman-enhancing material disposed on a second, opposite surface of the layer of dielectric material. The layer of conductive material has a plurality of apertures therethrough that are arranged in a two-dimensional array. Methods for conducting Raman spectroscopy are performed using such structures and systems.
摘要翻译：拉曼增强结构包括介电材料层，配置成将具有大于约100纳米的波长的电磁辐射聚焦到具有小于约100纳米的线性尺寸的二维聚焦区域的超薄膜在电介质材料层的表面上以及至少两个纳米颗粒，其包含靠近焦点区域设置的拉曼增强材料。附加的拉曼增强结构包括电介质材料层，导电材料层，以及至少两个包含拉曼增强材料的纳米颗粒，该拉曼增强材料设置在电介质材料层的第二相对表面上。导电材料层具有以二维阵列布置的穿过其中的多个孔。使用这种结构和系统进行拉曼光谱的方法。

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