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    • 15. 发明授权
    • Implantable or insertable medical devices visible under magnetic resonance imaging
    • 可植入或可插入的医疗器械在磁共振成像下可见
    • US08163326B2
    • 2012-04-24
    • US11637263
    • 2006-12-12
    • Sheng-Ping ZhongRonald A. SahatjianEnxin Ma
    • Sheng-Ping ZhongRonald A. SahatjianEnxin Ma
    • B05D3/02B05D3/06A61B5/05
    • G01R33/286A61L29/145A61L29/18A61L31/145A61L31/18A61M25/0045A61M25/0108
    • Disclosed is an implantable or insertable medical device comprising (a) a substrate and (b) a hydrogel polymer coating at a least a portion of the surface of the substrate, wherein the hydrogel polymer is adapted to render the medical device visible under magnetic resonance imaging (MRI) upon insertion or implantation of the medical device into a patient. Also disclosed is the use of such a hydrogel coated implantable or insertable medical device in a medical procedure, wherein during or after insertion or implantation of the medical device in a patient, the position of the medical device is viewed under MRI. The use of a hydrogel polymer for coating a medical device wherein the hydrogel polymer is adapted to render a medical device coated with the hydrogel polymer visible under MRI and a hydrogel polymer adapted to render a medical device coated therewith visible under MRI are also disclosed.
    • 公开了一种可植入或可插入的医疗装置,其包括(a)基底和(b)在所述基底表面的至少一部分表面上的水凝胶聚合物涂层,其中所述水凝胶聚合物适于使所述医疗装置在磁共振成像 (MRI)在将医疗装置插入或植入患者体内时。 还公开了在医疗过程中使用这种水凝胶涂覆的可植入或可插入的医疗装置,其中在将医疗装置插入或植入患者体内或之后,在MRI下观察医疗装置的位置。 还公开了使用水凝胶聚合物涂覆医疗装置,其中水凝胶聚合物适于使涂覆有水凝胶聚合物的医疗装置在MRI下可见,并且还公开了适于使其涂覆的医疗装置在MRI下可见的水凝胶聚合物。
    • 17. 发明授权
    • Medical device balloons containing thermoplastic elastomers
    • 包含热塑性弹性体的医疗装置气球
    • US07781038B2
    • 2010-08-24
    • US10855816
    • 2004-05-27
    • Bruce HamiltonRonald A. Sahatjian
    • Bruce HamiltonRonald A. Sahatjian
    • B29C47/00A61M29/00
    • A61M25/1029A61L29/049A61M25/0045A61M25/1002A61M2025/1075Y10T428/1334Y10T428/1352Y10T428/139Y10T428/1393
    • A dilatation balloon and catheter for insertion into a bodily conduit. The catheter (10) includes shaft (12) and a dilatation balloon (24) at the distal end of the shaft. The balloon is inflated via a central lumen (14) in the shaft for delivery of a fluid inflation media. The balloon is fabricated from a combination of a thermoplastic elastomer (TPE), preferably an engineering thermoplastic elastomer (ETE), with a non-compliant structural polymeric material. The combination may be a blend of the non-compliant structural polymer and the TPE. Alternatively, the combination may be a layered balloon having, for example, a non-compliant structural polymer inner layer and a soft, abrasion resistant, elastomeric outer layer. Methods for fabricating the balloon from the combination of a TPE and a non-compliant structural polymer are also disclosed.
    • 用于插入身体导管的扩张球囊和导管。 导管(10)在轴的远端包括轴(12)和膨胀气球(24)。 气球通过轴中的中心腔(14)膨胀,用于输送流体充气介质。 气球由热塑性弹性体(TPE),优选工程热塑性弹性体(ETE)与非柔顺结构聚合材料的组合制成。 该组合可以是不顺应结构聚合物和TPE的混合物。 或者,组合可以是具有例如不顺应结构聚合物内层和柔软,耐磨损的弹性体外层的分层气囊。 还公开了从TPE和不顺应结构聚合物的组合制造球囊的方法。
    • 18. 发明授权
    • Medical devices comprising non cross-linked, thin and flexible aqueous coatings, and methods related thereto
    • 包含非交联,薄和柔性水性涂料的医疗装置及其相关方法
    • US07709046B1
    • 2010-05-04
    • US11777234
    • 2007-07-12
    • Ronald A. Sahatjian
    • Ronald A. Sahatjian
    • B05D3/02B05D1/00B05D1/18H05H1/00A61M25/00A61B1/01
    • A61M25/0045B05D3/142B05D7/20B05D7/52
    • Disclosed are medical devices comprising a coil, coated with a multi-layer coating system and possess the flexibility, lubricity and trackability desired in applications where such devices are utilized. The coating system comprises a non-hydrophilic polymer primer coat and a hydrophilic polymer topcoat. These coating materials do not comprise any cross-linkers or reactive functional groups, and do not require the use of a hazardous solvent. The multi-layer coating system is very thin; having a maximum dry thickness in the range of about 15 microns to about 40 microns. Also disclosed are methods for coating and using these medical devices. The coatings are applied at low temperatures, in an aqueous environment, and in such a way that the coil is coated discretely, without forming a thick layer between the coil portions. Such coating prevents substantial bridging between the loops of the coil, thus preventing the coil tip from being stiff or non-trackable.
    • 公开了包括涂覆有多层涂覆系统的线圈的医疗装置,并且具有在使用这种装置的应用中期望的柔性,润滑性和跟踪性。 该涂层系统包括非亲水聚合物底漆涂层和亲水聚合物面漆。 这些涂层材料不包含任何交联剂或反应性官能团,并且不需要使用有害溶剂。 多层涂层系统非常薄; 其最大干燥厚度在约15微米至约40微米的范围内。 还公开了用于涂覆和使用这些医疗装置的方法。 涂层在低温下,在水性环境中以这样的方式施加,使得线圈分散地涂覆,而不在线圈部分之间形成厚层。 这种涂层防止线圈的环之间的实质桥接,从而防止线圈尖端变硬或不可追踪。