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11. 发明授权

US08239034B2 Visual prosthesis 有权
标题翻译：视觉假体
公开(公告)号：US08239034B2
公开(公告)日：2012-08-07
申请号：US11875760
申请日：2007-10-19
申请人： Robert J. Greenberg , Mark S. Humayun , Kelly H. McClure , Matthew J. McMahon
发明人： Robert J. Greenberg , Mark S. Humayun , Kelly H. McClure , Matthew J. McMahon
IPC分类号： A61N1/18
CPC分类号： A61N1/36046 , A61N1/37247
摘要： A method to provide visual current feedback of a retinal stimulation system. The method comprising: providing a retinal stimulation system configured to stimulate neural tissue in a subject's eye, the retinal stimulation system comprising: an electronics package; and at least a first and a second electrode, each associated with the electronics package and configured to apply current to a subject's retina; wherein current to be applied by the first electrode and the second electrode is configured to be higher for the first electrode when the first electrode has an impedance lower than a second electrode's impedance; and providing a visual interface configured to show impedance of at least one of the electrodes.
摘要翻译：提供视网膜刺激系统的视觉电流反馈的方法。该方法包括：提供构造成刺激受试者眼睛中的神经组织的视网膜刺激系统，所述视网膜刺激系统包括：电子封装; 以及至少第一和第二电极，每个电极与电子封装相关联并且被配置为将电流施加到受试者的视网膜; 其中当所述第一电极具有低于第二电极阻抗的阻抗时，由所述第一电极和所述第二电极施加的电流被配置为高于所述第一电极; 以及提供被配置为显示至少一个所述电极的阻抗的视觉界面。

12. 发明授权

US08239033B2 Visual prosthesis 有权
标题翻译：视觉假体
公开(公告)号：US08239033B2
公开(公告)日：2012-08-07
申请号：US11875724
申请日：2007-10-19
申请人： Robert J. Greenberg , Mark S. Humayun , Kelly H. McClure , Matthew J. McMahon
发明人： Robert J. Greenberg , Mark S. Humayun , Kelly H. McClure , Matthew J. McMahon
IPC分类号： A61N1/00
CPC分类号： A61N1/36046 , A61N1/37247
摘要： A method for stimulating a subject's retina. The method comprising selecting at least a first and a second electrode each configured to apply current to a subject's retina, determining impedance for the at least first electrode and second electrode, and applying current to the subject's retina through the at least first and second electrode, wherein current to be applied by the first electrode and the second electrode is configured to be higher for the first electrode when the first electrode has an impedance lower than a second electrode's impedance.
摘要翻译：刺激受试者视网膜的方法。所述方法包括选择至少第一和第二电极，每个电极被配置为向对象的视网膜施加电流，确定至少第一电极和第二电极的阻抗，以及通过至少第一和第二电极将电流施加到对象的视网膜，其中，当所述第一电极具有比所述第二电极的阻抗低的阻抗时，由所述第一电极和所述第二电极施加的电流被配置为高于所述第一电极。

13. 发明授权

US09597495B2 Locating a neural prosthesis using impedance and electrode height 有权
公开(公告)号：US09597495B2
公开(公告)日：2017-03-21
申请号：US13452300
申请日：2012-04-20
申请人： Robert J. Greenberg , Jone Fine , Arup Roy , Matthew J. McMahon , Mark S. Humayun , James David Welland , Alan M. Horsager , Dao Min Zhou , Amy Hines , Sumit Yadav , Rongqing Dai
发明人： Robert J. Greenberg , Jone Fine , Arup Roy , Matthew J. McMahon , Mark S. Humayun , James David Welland , Alan M. Horsager , Dao Min Zhou , Amy Hines , Sumit Yadav , Rongqing Dai
IPC分类号： A61N1/05 , A61N1/36 , A61N1/372
CPC分类号： A61N1/0543 , A61N1/36046 , A61N1/37247
摘要： The invention is a method of identifying a preferred location for an electrode array to the neural characteristics of an individual subject. The response to electrical neural stimulation varies from subject to subject and array location to array location. Measure of impedance may be used to predict the electrode height from the neural tissue and, thereby, predict the preferred location. Alternatively, electrode height may be measured directly to predict the preferred location.

14. 发明授权

US08244363B2 Visual prosthesis 有权
标题翻译：视觉假体
公开(公告)号：US08244363B2
公开(公告)日：2012-08-14
申请号：US11875742
申请日：2007-10-19
申请人： Robert J. Greenberg , Mark S. Humayun , Kelly H. McClure , Matthew J. McMahon
发明人： Robert J. Greenberg , Mark S. Humayun , Kelly H. McClure , Matthew J. McMahon
IPC分类号： A61N1/18
CPC分类号： A61N1/36046 , A61N1/37247
摘要： A retinal stimulation system. The retinal stimulation system comprises an electronics package; and at least a first and a second electrode, each associated with the electronics package and configured to apply current to a subject's retina; wherein current to be applied by the first electrode and the second electrode is configured to be higher for the first electrode when the first electrode has an impedance lower than a second electrode's impedance.
摘要翻译：视网膜刺激系统。视网膜刺激系统包括电子封装; 以及至少第一和第二电极，每个电极与电子封装相关联并且被配置为将电流施加到受试者的视网膜; 其中，当所述第一电极具有比所述第二电极的阻抗低的阻抗时，由所述第一电极和所述第二电极施加的电流被配置为高于所述第一电极。

15. 发明申请

US20120203293A1 Locating a Neural Prosthesis using Impedance and Electrode Height 有权
标题翻译：使用阻抗和电极高度定位神经假体
公开(公告)号：US20120203293A1
公开(公告)日：2012-08-09
申请号：US13452300
申请日：2012-04-20
申请人： Robert J. Greenberg , Jone Fine , Arup Roy , Matthew J. McMahon , Mark S. Humayun , James David Welland , Alan M. Horsager , Dao Min Zhou , Amy Hines , Sumit Yadav , Rongqing Dai
发明人： Robert J. Greenberg , Jone Fine , Arup Roy , Matthew J. McMahon , Mark S. Humayun , James David Welland , Alan M. Horsager , Dao Min Zhou , Amy Hines , Sumit Yadav , Rongqing Dai
IPC分类号： A61N1/372
CPC分类号： A61N1/0543 , A61N1/36046 , A61N1/37247
摘要： The invention is a method of identifying a preferred location for an electrode array to the neural characteristics of an individual subject. The response to electrical neural stimulation varies from subject to subject and array location to array location. Measure of impedance may be used to predict the electrode height from the neural tissue and, thereby, predict the preferred location. Alternatively, electrode height may be measured directly to predict the preferred location.
摘要翻译：本发明是一种将电极阵列的优选位置识别为个体对象的神经特征的方法。对电神经刺激的反应从主体到主体和阵列位置到阵列位置不同。可以使用阻抗测量来预测来自神经组织的电极高度，从而预测优选的位置。或者，可以直接测量电极高度以预测优选位置。

16. 发明申请

US20090287276A1 Visual Prosthesis for Phosphene Shape Control 有权
标题翻译：视觉假象的荧光形状控制
公开(公告)号：US20090287276A1
公开(公告)日：2009-11-19
申请号：US12466303
申请日：2009-05-14
申请人： Robert J. Greenberg , Mark S. Humayun , Matthew J. McMahon , Devyani Nanduri , James D. Weiland
发明人： Robert J. Greenberg , Mark S. Humayun , Matthew J. McMahon , Devyani Nanduri , James D. Weiland
IPC分类号： A61F9/08 , A61N1/36
CPC分类号： A61N1/36046 , A61N1/0543
摘要： The present invention is an improved method of stimulating visual neurons to create artificial vision. It has been found that varying current of visual stimulation can create varying percept brightness, varying percept size, and varying percept shape. By determining the attributes of predetermined current levels, and using those attributes to program a video processor, more accurate video preproduction can be obtained.The present invention also includes an electrode array having alternating large and small electrodes in rows at a 45 degree angle to horizontal in the visual field.
摘要翻译：本发明是一种刺激视觉神经元以创建人造视觉的改进方法。已经发现，视觉刺激的变化的电流可以产生变化的感知亮度，变化的感知尺寸和变化的感知形状。通过确定预定电流电平的属性，并使用这些属性对视频处理器进行编程，可以获得更准确的视频预制。本发明还包括具有在视野中与水平方向成45度角的行的交替的大电极和小电极的电极阵列。

17. 发明申请

US20080262571A1 Visual Prosthesis 有权
标题翻译：视觉假体
公开(公告)号：US20080262571A1
公开(公告)日：2008-10-23
申请号：US11875760
申请日：2007-10-19
申请人： Robert J. Greenberg , Mark S. Humayun , Kelly H. McClure , Matthew J. McMahon
发明人： Robert J. Greenberg , Mark S. Humayun , Kelly H. McClure , Matthew J. McMahon
IPC分类号： A61N1/00
CPC分类号： A61N1/36046 , A61N1/37247
摘要： A method to provide visual current feedback of a retinal stimulation system. The method comprising: providing a retinal stimulation system configured to stimulate neural tissue in a subject's eye, the retinal stimulation system comprising: an electronics package; and at least a first and a second electrode, each associated with the electronics package and configured to apply current to a subject's retina; wherein current to be applied by the first electrode and the second electrode is configured to be higher for the first electrode when the first electrode has an impedance lower than a second electrode's impedance; and providing a visual interface configured to show impedance of at least one of the electrodes.
摘要翻译：提供视网膜刺激系统的视觉电流反馈的方法。该方法包括：提供构造成刺激受试者眼睛中的神经组织的视网膜刺激系统，所述视网膜刺激系统包括：电子封装; 以及至少第一和第二电极，每个电极与电子封装相关联并且被配置为将电流施加到受试者的视网膜; 其中当所述第一电极具有低于第二电极阻抗的阻抗时，由所述第一电极和所述第二电极施加的电流被配置为高于所述第一电极; 以及提供被配置为显示至少一个所述电极的阻抗的视觉界面。

18. 发明申请

US20080262570A1 Visual Prosthesis 有权
标题翻译：视觉假体
公开(公告)号：US20080262570A1
公开(公告)日：2008-10-23
申请号：US11875742
申请日：2007-10-19
申请人： Robert J. Greenberg , Mark S. Humayun , Kelly H. McClure , Matthew J. McMahon
发明人： Robert J. Greenberg , Mark S. Humayun , Kelly H. McClure , Matthew J. McMahon
IPC分类号： A61N1/00
CPC分类号： A61N1/36046 , A61N1/37247
摘要： A retinal stimulation system. The retinal stimulation system comprises an electronics package; and at least a first and a second electrode, each associated with the electronics package and configured to apply current to a subject's retina; wherein current to be applied by the first electrode and the second electrode is configured to be higher for the first electrode when the first electrode has an impedance lower than a second electrode's impedance
摘要翻译：视网膜刺激系统。视网膜刺激系统包括电子封装; 以及至少第一和第二电极，每个电极与电子封装相关联并且被配置为将电流施加到受试者的视网膜; 其中，当所述第一电极具有低于第二电极阻抗的阻抗时，由所述第一电极和所述第二电极施加的电流被配置为高于所述第一电极

19. 发明申请

US20080262569A1 Visual Prosthesis 有权
标题翻译：视觉假体
公开(公告)号：US20080262569A1
公开(公告)日：2008-10-23
申请号：US11875724
申请日：2007-10-19
申请人： Robert J. Greenberg , Mark S. Humayun , Kelly H. McClure , Matthew J. McMahon
发明人： Robert J. Greenberg , Mark S. Humayun , Kelly H. McClure , Matthew J. McMahon
IPC分类号： A61N1/00
CPC分类号： A61N1/36046 , A61N1/37247
摘要： A method for stimulating a subject's retina. The method comprising selecting at least a first and a second electrode each configured to apply current to a subject's retina, determining impedance for the at least first electrode and second electrode, and applying current to the subject's retina through the at least first and second electrode, wherein current to be applied by the first electrode and the second electrode is configured to be higher for the first electrode when the first electrode has an impedance lower than a second electrode's impedance.
摘要翻译：刺激受试者视网膜的方法。所述方法包括选择至少第一和第二电极，每个电极被配置为向对象的视网膜施加电流，确定至少第一电极和第二电极的阻抗，以及通过至少第一和第二电极将电流施加到对象的视网膜，其中，当所述第一电极具有比所述第二电极的阻抗低的阻抗时，由所述第一电极和所述第二电极施加的电流被配置为高于所述第一电极。

20. 发明授权

US08131375B2 Trans-retinal flexible circuit electrode array 有权
标题翻译：视网膜软电路电极阵列
公开(公告)号：US08131375B2
公开(公告)日：2012-03-06
申请号：US11521281
申请日：2006-09-13
申请人： Robert J. Greenberg , Mark S. Humayun
发明人： Robert J. Greenberg , Mark S. Humayun
IPC分类号： A61N1/36
CPC分类号： A61N1/36046 , A61F9/08 , A61N1/0543 , H05K1/028 , H05K1/0281 , H05K1/118 , H05K3/28 , H05K2201/0133
摘要： Applicant has proposed a combination of the subretinal and epiretinal methods by placing the electronics external to the eye, entering the eye through the pars plana and the piercing the retina (retinotomy) from inside the eye to stimulate subreintally.The present invention is an improved electrode array for subretinal stimulation. A hard polymer such as polyimide is biocompatible and strong for supporting an electrode array and supporting traces in a thin flex circuit array. In the present invention applicant takes advantage of the sharp nature of thin polyimide making a point on the end of the electrode array. This allows the flexible circuit electrode array to be both electrode array and surgical tool to cut the retinal and slide the array under the retina in a single action.
摘要翻译：申请人提出了通过将眼睛外部电子放置在眼睛的外部并通过平面进入眼睛并从眼睛刺穿视网膜（视网膜切开术）以刺激眼底的方式来组合视网膜下和视网膜方法。本发明是用于视网膜下刺激的改进的电极阵列。诸如聚酰亚胺之类的硬聚合物是生物相容性强的，用于支撑电极阵列和支撑在薄柔性电路阵列中的迹线。在本发明中，申请人利用薄聚酰亚胺的尖锐特性，在电极阵列的末端形成点。这使得柔性电路电极阵列既可以是电极阵列，也可以是手术工具，以切割视网膜，并在阵列下方以单一动作滑动阵列。

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