专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明申请

US20070054916A1 Aryl nitrogen-containing bicyclic compounds and methods of use 审中-公开
标题翻译：芳基含氮双环化合物及其使用方法
公开(公告)号：US20070054916A1
公开(公告)日：2007-03-08
申请号：US11240590
申请日：2005-09-30
申请人： Vinod Patel , Joseph Kim , Stephanie Geuns-Meyer , Stuart Chaffee , Victor Cee , Brian Hodous , Steven Bellon , Jean-Christophe Harmange , Philip Olivieri , Maya Thaman , Erin DiMauro , John Buchanan , David McGowan , Brian Albrecht , Holly Deak , Jean Bemis , Ryan White , Matthew Martin , Gregory Habgood , Paul Tempest , Craig Masse , William Buckner , Bradley Herberich , Russell Graceffa , Dawei Zhang , Shimin Xu , Kelvin Sham , Robert Rzasa , James Falsey , Partha Chakrabarti , Guo-Qiang Cao , Susan Tomlinson , Liping Pettus , Adrian Smith , Nick Paras , Gang Liu , Frenel DeMorin , Andrew Tasker , Anthony Reed
发明人： Vinod Patel , Joseph Kim , Stephanie Geuns-Meyer , Stuart Chaffee , Victor Cee , Brian Hodous , Steven Bellon , Jean-Christophe Harmange , Philip Olivieri , Maya Thaman , Erin DiMauro , John Buchanan , David McGowan , Brian Albrecht , Holly Deak , Jean Bemis , Ryan White , Matthew Martin , Gregory Habgood , Paul Tempest , Craig Masse , William Buckner , Bradley Herberich , Russell Graceffa , Dawei Zhang , Shimin Xu , Kelvin Sham , Robert Rzasa , James Falsey , Partha Chakrabarti , Guo-Qiang Cao , Susan Tomlinson , Liping Pettus , Adrian Smith , Nick Paras , Gang Liu , Frenel DeMorin , Andrew Tasker , Anthony Reed
IPC分类号： A61K31/525 , A61K31/519 , A61K31/517
CPC分类号： C07D215/38 , C07C205/37 , C07D215/12 , C07D217/12 , C07D217/22 , C07D217/26 , C07D239/26 , C07D239/84 , C07D239/94 , C07D239/95 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D495/04
摘要： The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation, cancer and related conditions. The compounds have a general Formula I wherein A1, A2, A3, B, R1, R2, R3 and R4 are defined herein. Accordingly, the invention also comprises pharmaceutical compositions comprising the compounds of the invention, methods for the prophylaxis and treatment of kinase mediated diseases using the compounds and compositions of the invention, and intermediates and processes useful for the preparation of compounds of the invention.
摘要翻译：本发明包括一类新的可用于预防和治疗蛋白激酶介导的疾病，包括炎症，癌症和相关病症的化合物。化合物具有通式I，其中A 1，A 2，A 3，B，R 1， R 2，R 3和R 4在本文中定义。因此，本发明还包括含有本发明化合物的药物组合物，使用本发明化合物和组合物预防和治疗激酶介导的疾病的方法，以及可用于制备本发明化合物的中间体和方法。

12. 发明申请

US20070054903A1 Bis-aryl kinase inhibitors and method 有权
标题翻译：双芳基激酶抑制剂和方法
公开(公告)号：US20070054903A1
公开(公告)日：2007-03-08
申请号：US11479187
申请日：2006-06-30
申请人： Tae-Seong Kim , Jean-Christophe Harmange , Steven Bellon , Shon Booker , Noel D'Angelo , Celia Dominguez , Ingrid Fellows , Julie Germain , Timothy Harvey , Joseph Kim , Matthew Lee , Longbin Liu , Vinod Patel , Andrew Tasker
发明人： Tae-Seong Kim , Jean-Christophe Harmange , Steven Bellon , Shon Booker , Noel D'Angelo , Celia Dominguez , Ingrid Fellows , Julie Germain , Timothy Harvey , Joseph Kim , Matthew Lee , Longbin Liu , Vinod Patel , Andrew Tasker
IPC分类号： A61K31/538 , A61K31/5377 , A61K31/4709 , C07D403/02 , C07D413/02
CPC分类号： C07D333/38 , C07D217/02 , C07D217/24 , C07D401/10 , C07D401/12 , C07D409/12 , C07D417/10 , C07D417/12
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

13. 发明申请

US20070049592A1 Bis-aryl urea compounds and methods of use 审中-公开
标题翻译：双芳基脲化合物及其使用方法
公开(公告)号：US20070049592A1
公开(公告)日：2007-03-01
申请号：US11506693
申请日：2006-08-18
申请人： Stephanie Geuns-Meyer , Stuart Chaffee , Rebecca Johnson , Joseph Kim , Joseph Nunes , Vinod Patel
发明人： Stephanie Geuns-Meyer , Stuart Chaffee , Rebecca Johnson , Joseph Kim , Joseph Nunes , Vinod Patel
IPC分类号： A61K31/5377 , A61K31/53 , A61K31/506 , A61K31/4709 , C07D413/02 , C07D403/02 , C07D401/02
CPC分类号： C07D213/81 , C07D213/75 , C07D239/42 , C07D239/48 , C07D239/74 , C07D239/94 , C07D251/18 , C07D251/48 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12 , C07D487/04
摘要： The present invention relates to compounds of Formulas I and II, wherein A1, A2, B1, B2, Q, X1, X2, Y and R3 are defined herein, synthetic intermediates, and pharmaceutical compositions, comprising such compounds. The compounds and compositions are capable of modulating various protein kinase receptors such as Tie-2 and, therefore, influencing kinase related disease states and conditions. The compounds, for example, are capable of treating cancer caused by unregulated angiogenesis, and inflammation as well as other proliferative disorders.
摘要翻译：本发明涉及式I和II的化合物，其中A 1，A 2，B 1，B 2，本文定义了本文所定义的含有这些化合物的合成中间体和药物组合物，其中，Q，X 1，X 2，Y和R 3，。化合物和组合物能够调节各种蛋白激酶受体如Tie-2，因此影响激酶相关的疾病状态和状况。该化合物例如能够治疗由不受调节的血管发生，炎症以及其它增殖性疾病引起的癌症。

14. 发明申请

US20050203114A1 Kinase inhibitors 失效
标题翻译：激酶抑制剂
公开(公告)号：US20050203114A1
公开(公告)日：2005-09-15
申请号：US11125614
申请日：2005-05-09
申请人： David Armistead , Jean Bemis , Lucian DiPietro , Stephanie Geuns-Meyer , Gregory Habgood , Joseph Kim , Joseph Nunes , Vinod Patel , Leticia Toledo-Sherman
发明人： David Armistead , Jean Bemis , Lucian DiPietro , Stephanie Geuns-Meyer , Gregory Habgood , Joseph Kim , Joseph Nunes , Vinod Patel , Leticia Toledo-Sherman
IPC分类号： C07D239/48 , A61K31/505 , A61K31/506 , A61P1/04 , A61P3/00 , A61P3/10 , A61P9/00 , A61P11/06 , A61P13/12 , A61P17/00 , A61P17/06 , A61P17/08 , A61P19/02 , A61P21/04 , A61P25/00 , A61P25/16 , A61P25/28 , A61P27/02 , A61P27/06 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07D401/14 , C07D403/04 , C07D403/12 , C07D413/04 , C07D413/14 , C07D417/14 , A61K31/513
CPC分类号： C07D401/14 , C07D403/04 , C07D403/12 , C07D413/04 , C07D413/14 , C07D417/14
摘要： The invention relates to inhibitors of kinases, compositions comprising the inhibitors, and methods of using the inhibitors and inhibitor compositions. The inhibitors and compositions comprising them are useful for treating disease or disease symptoms. The invention also provides for methods of making kinase inhibitor compounds, methods of inhibiting kinase activity, and methods for treating disease or disease symptoms.
摘要翻译：本发明涉及激酶抑制剂，包含抑制剂的组合物，以及使用抑制剂和抑制剂组合物的方法。包含它们的抑制剂和组合物可用于治疗疾病或疾病症状。本发明还提供了制备激酶抑制剂化合物的方法，抑制激酶活性的方法，以及治疗疾病或疾病症状的方法。

15. 发明申请

US20180245734A1 Attachment and Securement System 审中-公开
公开(公告)号：US20180245734A1
公开(公告)日：2018-08-30
申请号：US15443410
申请日：2017-02-27
申请人： Steve W. Kim , Joseph Kim , Eun-Jin Kim , Ki-Hyung Han
发明人： Steve W. Kim , Joseph Kim , Eun-Jin Kim , Ki-Hyung Han
IPC分类号： F16M13/02 , F16M11/14 , F16M11/40 , F16M11/04 , F16B1/00 , B60R11/02 , B60R7/10 , H04M1/04
CPC分类号： F16M13/022 , B60R11/02 , B60R2011/0057 , B60R2011/0059 , B60R2011/0078 , B60R2011/0089 , F16B2001/0035 , F16M11/041 , F16M11/14 , F16M11/40 , F16M13/00 , H04M1/04
摘要： An attachment and securement system that allows an item to be secured onto a surface or a structure, and to be selectively positioned. The system consists of a first assembly with a magnet and an interface, and a second assembly with a screw actuated clamp and a post that terminates at a circular metal head. The first assembly is attached to an item such as a mobile communication device, a computing device, apparel, or an apparel accessory. The item with the attached first assembly is then placed in contact with and magnetically adhered to the second assembly, which is attached to a surface or structure. The magnet secures the item to the second assembly, and the circular design of the metal head allows the head to rotate about the magnet, allowing the item to be selectively positioned.

16. 发明授权

US07478111B2 System and method for carrying out legacy application transitions 失效
标题翻译：用于执行传统应用程序转换的系统和方法
公开(公告)号：US07478111B2
公开(公告)日：2009-01-13
申请号：US10921451
申请日：2004-08-19
申请人： Tack Tong , Joseph Kim
发明人： Tack Tong , Joseph Kim
IPC分类号： G06F12/00 , G06F17/30
CPC分类号： G06F17/30297 , Y10S707/99931 , Y10S707/99953
摘要： A system and method for carrying out transitions from legacy to new applications includes the definition of relational database views to permit relational queries defined for a database having a legacy schema to be run against a database having a new schema. The relational database views for the database having a new schema are generated with reference to and by selection from a set of database views defined for possible schema changes. The post-transition display of legacy display pages is handled by the preferred embodiment through the use of a view registry that associates a defined display view with a legacy view engine and a legacy display page.
摘要翻译：用于执行从旧应用到新应用的转换的系统和方法包括关系数据库视图的定义，以允许为具有旧模式的数据库定义的关系查询针对具有新模式的数据库运行。参考并通过为可能的模式更改定义的一组数据库视图进行选择来生成具有新模式的数据库的关系数据库视图。遗留显示页面的过渡后显示由优选实施例通过使用将定义的显示视图与传统视图引擎和传统显示页面相关联的视图注册表来处理。

17. 发明申请

US20070185171A1 Compounds and methods of use 失效
标题翻译：化合物和使用方法
公开(公告)号：US20070185171A1
公开(公告)日：2007-08-09
申请号：US11584151
申请日：2006-10-20
申请人： Julie Germain , Benny Askew , David Bauer , Deborah Choquette , Lucian Dipietro , Russell Graceffa , Jean-Christophe Harmange , Qi Huang , Joseph Kim , Daniel La , Aiwen Li , Nobuko Nishimura , Rana Nomak , Vinod Patel , Michele Potashman , Babak Riahi , Thomas Storz , Simon Van Der Plas , Kevin Yang , Chester Yuan
发明人： Julie Germain , Benny Askew , David Bauer , Deborah Choquette , Lucian Dipietro , Russell Graceffa , Jean-Christophe Harmange , Qi Huang , Joseph Kim , Daniel La , Aiwen Li , Nobuko Nishimura , Rana Nomak , Vinod Patel , Michele Potashman , Babak Riahi , Thomas Storz , Simon Van Der Plas , Kevin Yang , Chester Yuan
IPC分类号： C07D209/04 , C07D213/16
CPC分类号： C07D471/04 , C07D487/04
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：所选化合物对于预防和治疗诸如血管生成介导的疾病等疾病是有效的。本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

18. 发明申请

US20070010952A1 Molecules comprising a calcineurin-like binding pocket and encoded data storage medium capable of graphically displaying them 审中-公开
标题翻译：包含钙调神经磷酸酶结合口袋的分子和能够图形显示它们的编码数据存储介质
公开(公告)号：US20070010952A1
公开(公告)日：2007-01-11
申请号：US11471290
申请日：2006-06-19
申请人： David Armistead , Matthew Fitzgibbon , Mark Fleming , James Griffith , Eunice Kim , Joseph Kim , Michael Sintchak , John Thomson , Keith Wilson
发明人： David Armistead , Matthew Fitzgibbon , Mark Fleming , James Griffith , Eunice Kim , Joseph Kim , Michael Sintchak , John Thomson , Keith Wilson
IPC分类号： G06F19/00 , C07K14/705
CPC分类号： C07K14/705 , C12N9/16
摘要： The present invention relates to crystallized molecules and molecular complexes which comprise the active site binding pocket or the FKBP12/FK506 binding pocket of calcineurin or close structural homologues to either binding pocket. This invention also relates to a data storage material encoded with the corresponding structure coordinates of those crystallized molecules or molecular complexes. Such data storage material is capable of displaying such molecules and molecular complexes as a graphical three-dimensional representation on a computer screen. In addition, this invention relates to methods of using the structure coordinates of those molecules or molecular complexes to solve the structure of homologous proteins. This invention also relates to methods of using the structure coordinates to screen and design compounds that bind to calcineurin or homologues thereof.
摘要翻译：本发明涉及结晶分子和分子复合物，其包含活性位点结合口袋或钙调神经磷酸酶的FKBP12 / FK506结合口袋或紧密结构同源物至结合口袋。本发明还涉及用这些结晶分子或分子复合物的对应结构坐标编码的数据存储材料。这样的数据存储材料能够在计算机屏幕上显示作为图形三维表示的分子和分子复合物。此外，本发明涉及使用这些分子或分子复合物的结构坐标来解决同源蛋白质结构的方法。本发明还涉及使用结构坐标来筛选和设计结合钙调神经磷酸酶或其同系物的化合物的方法。

19. 发明申请

US20060241115A1 Compounds and methods of use 有权
公开(公告)号：US20060241115A1
公开(公告)日：2006-10-26
申请号：US11042634
申请日：2005-01-24
申请人： Michele Potashman , Tae-Seong Kim , Steven Bellon , Shon Booker , Yuan Cheng , Joseph Kim , Andrew Tasker , Ning Xi , Shimin Xu , Jean-Christophe Harmange , George Borg , Matthew Weiss , Brian Hodous , Russell Graceffa , William Buckner , Craig Masse , Deborah Choquette , Matthew Martin , Julie Germain , Lucian DiPietro , Stuart Chaffee , Joseph Nunes , John Buchanan , Gregory Habgood , David McGowan , Douglas Whittington
发明人： Michele Potashman , Tae-Seong Kim , Steven Bellon , Shon Booker , Yuan Cheng , Joseph Kim , Andrew Tasker , Ning Xi , Shimin Xu , Jean-Christophe Harmange , George Borg , Matthew Weiss , Brian Hodous , Russell Graceffa , William Buckner , Craig Masse , Deborah Choquette , Matthew Martin , Julie Germain , Lucian DiPietro , Stuart Chaffee , Joseph Nunes , John Buchanan , Gregory Habgood , David McGowan , Douglas Whittington
IPC分类号： A61K31/517 , A61K31/502 , A61K31/498 , A61K31/4709 , C07D43/02
CPC分类号： C07D213/64 , C07D213/81 , C07D215/233 , C07D215/38 , C07D215/48 , C07D215/54 , C07D237/34 , C07D239/34 , C07D239/47 , C07D239/84 , C07D239/94 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

20. 发明申请

US20050153960A1 Substituted arylamine derivatives and methods of use 审中-公开
标题翻译：取代的芳基胺衍生物和使用方法
公开(公告)号：US20050153960A1
公开(公告)日：2005-07-14
申请号：US10996035
申请日：2004-11-22
申请人： Daniel Elbaum , Benny Askew , Shon Booker , Julie Germain , Gregory Habgood , Michael Handley , Tae-Seong Kim , Aiwen Li , Nobuko Nishimura , Vinod Patel , Chester Yuan , Joseph Kim , Guolin Cai , Guoqing Chen , Michael Croghan , Lucian Di Pietro , Celia Dominguez , Qi Huang , Leon Smith , Andrew Tasker , Ning Xi , Shimin Xu
发明人： Daniel Elbaum , Benny Askew , Shon Booker , Julie Germain , Gregory Habgood , Michael Handley , Tae-Seong Kim , Aiwen Li , Nobuko Nishimura , Vinod Patel , Chester Yuan , Joseph Kim , Guolin Cai , Guoqing Chen , Michael Croghan , Lucian Di Pietro , Celia Dominguez , Qi Huang , Leon Smith , Andrew Tasker , Ning Xi , Shimin Xu
IPC分类号： A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/498 , A61K31/501 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K31/538 , A61P1/04 , A61P3/00 , A61P3/04 , A61P3/10 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P15/00 , A61P15/08 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/00 , A61P19/02 , A61P21/00 , A61P25/28 , A61P27/02 , A61P27/06 , A61P29/00 , A61P31/12 , A61P31/18 , A61P31/22 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/02 , A61P37/04 , A61P37/08 , A61P43/00 , C07D213/81 , C07D213/82 , C07D237/04 , C07D237/24 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , A61K31/4545 , C07D413/02 , C07D41/02
CPC分类号： C07D213/81 , C04B35/632 , C07D213/82 , C07D237/04 , C07D237/24 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：所选化合物对于预防和治疗诸如血管生成介导的疾病等疾病是有效的。本发明包括新型化合物，类似物，前药及其药学上可接受的衍生物，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式