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11. 发明专利

DE602004012597D1 未知
公开(公告)号：DE602004012597D1
公开(公告)日：2008-04-30
申请号：DE602004012597
申请日：2004-11-17
申请人： ADVANCED CARDIOVASCULAR SYSTEM
发明人： HOSSAINY SYED F A , TANG YIWEN , MICHAL EUGENE T , GLAUSER THIERRY , PACETTI STEPHEN D , DESNOYER JESSICA R
IPC分类号： A61L29/08 , A61F2/00 , A61F2/86 , A61L29/16 , A61L31/10 , A61L31/14 , A61L31/16 , A61L33/06 , A61M29/02

12. 发明申请

WO2008008139A2 METHODS AND DEVICES FOR FORMING TREATMENT AGENT CARRIERS 审中-公开
标题翻译：用于形成处理剂载体的方法和设备
公开(公告)号：WO2008008139A2
公开(公告)日：2008-01-17
申请号：PCT/US2007013315
申请日：2007-06-05
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , BASU SHUBHAYU , MICHAL EUGENE T
发明人： BASU SHUBHAYU , MICHAL EUGENE T
IPC分类号： A61K9/14
CPC分类号： A61K9/4833 , A61K9/145 , A61K9/5031 , A61K38/30
摘要： A method is described including passing a solution having a biodegradable polymer, a solvent and a treatment agent through an electrocharged nozzle to form particles encapsulating the treatment agent. The particles emitted from the electrocharged nozzle may be exposed to a charge opposite that of the nozzle. The particles may be deposited in a collection assembly comprising a liquid phase. A further method including combining a biodegradable polymer, a solvent and a treatment agent to form a solution, electrodepositing the solution in a particle form wherein the particles encapsulate the treatment agent in a collection assembly comprising a liquid phase and mixing the particles with a bioerodable material capable of forming a gel is described. An apparatus having an electrocharged nozzle, a grounded electrode having an opposite charge to that of the nozzle and a collection assembly comprising a liquid phase is further disclosed.
摘要翻译：描述了一种方法，包括使具有生物可降解聚合物，溶剂和处理剂的溶液通过电动喷嘴以形成包封处理剂的颗粒。从电动喷嘴喷出的颗粒可能暴露在与喷嘴相反的电荷下。颗粒可以沉积在包含液相的收集组件中。另一种方法包括将生物可降解聚合物，溶剂和处理剂混合以形成溶液，将溶液电沉积成颗粒形式，其中颗粒将处理剂包封在包含液相的收集组件中，并将颗粒与生物可蚀性材料描述了能够形成凝胶的能力。还公开了具有电动喷嘴，具有与喷嘴的电荷相反的电荷的接地电极和包含液相的收集组件的设备。

13. 发明专利

AU2003245291A1 POLYACRYLATES COATINGS FOR IMPLANTABLE MEDICAL DEVICES 未知
公开(公告)号：AU2003245291A1
公开(公告)日：2004-01-06
申请号：AU2003245291
申请日：2003-05-14
申请人： ADVANCED CARDIOVASCULAR SYSTEM
发明人： MICHAL EUGENE T , SHAH ASHOK A , ROORDA WOUTER E , DING NI , PACETTI STEPHEN D
IPC分类号： A61L31/00 , A61F2/84 , A61K31/436 , A61L27/34 , A61L31/10 , A61L31/16
摘要： A coating for a medical device, particularly for a drug eluting stent, is described. The coating can include a polacylate, a blend of polyacrylates, or a blend of the polyacrylate with other polymers, for example, poly(ethylene-covinyl alcohol).

14. 发明申请

WO2008089452A3 METHODS OF MODIFYING MYOCARDIAL INFARCTION EXPANSION 审中-公开
标题翻译：改善心肌梗塞扩张的方法
公开(公告)号：WO2008089452A3
公开(公告)日：2009-08-06
申请号：PCT/US2008051505
申请日：2008-01-18
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , MICHAL EUGENE T , BASU SHUBHAYU , SHEEHY ALEXANDER J , SPINALE FRANCIS G , MUKHERJEE RUPAK
发明人： MICHAL EUGENE T , BASU SHUBHAYU , SHEEHY ALEXANDER J , SPINALE FRANCIS G , MUKHERJEE RUPAK
IPC分类号： A61L26/00
CPC分类号： A61L27/26 , A61L27/20 , A61L27/22 , A61L27/3834 , A61L27/50 , A61L27/52 , A61L2300/418 , A61L2300/64 , A61L2400/06 , A61L2430/20 , C08L5/04 , C08L89/00
摘要： A bioscaffolding can be formed within a post-myocardial infarct region sufficient to cause attenuation of a rate of myocardial infarct expansion. A bioscaffolding may further be formed in the post-myocardial infarct region to cause an increase in posterior left ventricular wall thickness. The gel or bioscaffolding can be formed from a mixture of gel components of different gelation systems. For example, a bioscaffolding can be formed by mixing at least two different components of at least two different two-component gelation systems to form a first mixture and by mixing at least two different components (other than the components that make up the first mixture) of the at least two different two-component gelation systems to form a second mixture.
摘要翻译：可以在足以引起心肌梗死扩张速率衰减的后心肌梗死区域中形成生物支架。在心肌梗死后区域可进一步形成生物支架以引起左后壁厚度的增加。凝胶或生物支架可以由不同凝胶化系统的凝胶组分的混合物形成。例如，生物支架可以通过混合至少两种不同的双组分凝胶化体系的至少两种不同组分形成第一混合物并通过混合至少两种不同组分（构成第一混合物的组分）的至少两种不同的双组分凝胶化体系以形成第二混合物。

15. 发明申请

WO2008013743A3 METHODS FOR INHIBITING REPERFUSION INJURY 审中-公开
标题翻译：抑制再灌注损伤的方法
公开(公告)号：WO2008013743A3
公开(公告)日：2008-07-03
申请号：PCT/US2007016432
申请日：2007-07-19
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , MICHAL EUGENE T , CALLAS PETER L , LUDWIG FLORIAN N
发明人： MICHAL EUGENE T , CALLAS PETER L , LUDWIG FLORIAN N
IPC分类号： A61K31/4433 , A61K31/56 , A61M25/00 , A61P9/10
CPC分类号： A61M25/104 , A61M2025/1095
摘要： A method that includes introducing a catheter assembly to an obstructed region of a blood vessel lumen and recanalizing the obstructed region with the catheter assembly is disclosed. Prior to or during recanalization, a treatment agent may be delivered through the catheter assembly to a vessel region downstream to the obstructed region. The treatment agent may have a property that will inhibit reperfusion injury. Alternatively, a medical device may be introduced to an obstructed region of a blood vessel lumen and the obstructed region recanalized with the medical device. The treatment agent may be delivered to a vessel region downstream to the obstructed region. The treatment agent may include at least one of an immunosuppresant and an antioxidant. In other methods, a delivery cannula may be introduced to an unperfused region of an occluded vessel without disrupting the occlusion and the treatment agent having a property that will inhibit reperfusion injury may be delivered to the unperfused region through the delivery cannula. After delivering the treatment agent, the occluded vessel may be recanalized by advancing an angioplasty device into the occluded vessel.
摘要翻译：公开了一种方法，该方法包括将导管组件引入血管内腔的阻塞区域并用导管组件重新阻塞阻塞区域。在再通之前或再通过期间，可以通过导管组件将治疗剂递送至受阻区域下游的脉管区域。治疗剂可能具有抑制再灌注损伤的性质。或者，可以将医疗装置引入血管腔的阻塞区域，并且利用医疗装置对阻塞区域进行再通。处理剂可被输送至受阻区域下游的容器区域。治疗剂可以包括免疫抑制剂和抗氧化剂中的至少一种。在其他方法中，可将输送套管引入闭塞血管的未灌注区域而不破坏闭塞，并且具有抑制再灌注损伤性质的治疗剂可通过输送套管输送至未灌注区域。在递送治疗剂之后，可以通过将血管成形术装置推进到闭塞的血管中来使闭塞的血管再通。

16. 发明申请

WO2010030995A3 LOCAL DELIVERY OF WATER-SOLUBLE OR WATER-INSOLUBLE THERAPEUTIC AGENTS TO THE SURFACE BODY LUMENS 审中-公开
标题翻译：将水溶性或不溶于水的治疗剂局部递送至表面身体内腔
公开(公告)号：WO2010030995A3
公开(公告)日：2010-05-14
申请号：PCT/US2009056842
申请日：2009-09-14
申请人： CV INGENUITY , MICHAL EUGENE T , LERNER DANIEL J , POLLMAN MATTHEW J
发明人： MICHAL EUGENE T , LERNER DANIEL J , POLLMAN MATTHEW J
IPC分类号： A61K47/02 , A61F2/958 , A61K31/337 , A61K31/4353 , A61K31/436 , A61L31/08 , A61L31/16
CPC分类号： A61L29/106 , A61K47/02 , A61L29/10 , A61L29/16 , A61L2300/114 , A61L2300/216 , A61L2300/41 , A61L2300/416
摘要： A method and device for local delivery of water-soluble or water-insoluble therapeutic agents to the surface of a normal or diseased body lumen is disclosed. An expandable structure of a medical disposable device, such as a balloon of a balloon catheter, is coated with an amphiphilic polymer coating comprising a therapeutic agent and an amphiphilic polymer or co-polymer. The medical disposable device is inserted into a body lumen, and expanded to contact the amphiphilic polymer coating against the body lumen. The total solubility of the polymer or co-polymer in vivo prevents any embolic hazard associated with the amphiphilic polymer coating.
摘要翻译：公开了用于将水溶性或水不溶性治疗剂局部递送至正常或患病体腔表面的方法和装置。诸如气囊导管的球囊的医疗一次性装置的可扩张结构涂覆有包含治疗剂和两亲聚合物或共聚物的两亲聚合物涂层。医用一次性装置插入体腔中，并且扩张以使两亲聚合物涂层与体腔接触。聚合物或共聚物在体内的总溶解度防止了与两亲聚合物涂层相关的任何栓塞危险。

17. 发明申请

WO2004000383A3 POLYACRYLATES COATINGS FOR IMPLANTABLE MEDICAL DEVICES 审中-公开
标题翻译：聚丙烯酸酯涂层用于可植入医疗器械
公开(公告)号：WO2004000383A3
公开(公告)日：2004-05-27
申请号：PCT/US0315544
申请日：2003-05-14
申请人： ADVANCED CARDIOVASCULAR SYSTEM
发明人： ROORDA WOUTER E , DING NI , PACETTI STEPHEN D , MICHAL EUGENE T , SHAH ASHOK A , HOSSAINY SYED F A
IPC分类号： A61L31/00 , A61F2/84 , A61K31/436 , A61L27/34 , A61L31/10 , A61L31/16
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61L2420/08 , C08L33/10 , C08L33/06
摘要： A coating for a medical device, particularly for a drug eluting stent, is described. The coating can include a polyacylate, a blend of polyacrylates, or a blend of the polyacrylate with other polymers, for example, poly(ethylene-covinyl alcohol).
摘要翻译：描述了用于医疗装置的涂层，特别是用于药物洗脱支架的涂层。涂层可以包括聚丙烯酸酯，聚丙烯酸酯的共混物或聚丙烯酸酯与其它聚合物的共混物，例如聚（乙烯 - 共聚乙烯醇）。

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