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11. 发明申请

WO2003074007A3 MODULATORS OF LEUKOCYTE ACTIVATION, COMPOSITIONS, AND METHODS OF USE 审中-公开
公开(公告)号：WO2003074007A3
公开(公告)日：2003-09-12
申请号：PCT/US2003/006748
申请日：2003-03-03
申请人： RIGEL PHARMACEUTICALS, INC. , FRIERA, Annabelle, M. , VALLONE, Marcy, K. , WONG, Brian , MASUDA, Esteban , POWELL, Mark
发明人： FRIERA, Annabelle, M. , VALLONE, Marcy, K. , WONG, Brian , MASUDA, Esteban , POWELL, Mark
IPC分类号： C12N5/00
摘要： The present invention provides compositions and methods for modulating leukocyte activation. Nucleic acids and proteins which are capable of modulating leukocyte activation are provided. Compositions and methods for the treatment of disorders related to leukocyte dysfunction or dysregulation are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating leukocyte activation.

12. 发明申请

WO2010123708A1 SYSTEMS AND METHOD FOR INTELLIGENT LIGHTING 审中-公开
标题翻译：智能照明系统和方法
公开(公告)号：WO2010123708A1
公开(公告)日：2010-10-28
申请号：PCT/US2010/030708
申请日：2010-04-12
申请人： LSI INDUSTRIES, INC. , JALBOUT, Bassam, D. , WONG, Brian
发明人： JALBOUT, Bassam, D. , WONG, Brian
IPC分类号： H05B37/02
CPC分类号： H05B37/0227 , Y02B20/44 , Y02B20/48
摘要： Systems and methods are disclosed for the intelligent lighting of large areas and structures such as parking garages. Ultrasonic distance measuring sensors can be used to obtain occupancy data for the area or structure, such as a parking garage, and to control the intensities of the individual lights in the system for energy conservation. Persons in the area, e.g. parking their cars, can be shown the path to the exit by specific preset intensity level and / or color of light. In parking garage embodiments, persons in the process of parking their cars are shown the empty spots by lights of a specific intensity and /or color. The addition of passive infrared motion detectors enables the system to illuminate the area around a moving person, and alarm if a person is behaving unexpectedly. A controller can communicate with sensors and/or lighting elements by wireless or wire (cable) communication.
摘要翻译：系统和方法被公开用于诸如停车库的大面积和结构的智能照明。可以使用超声波测距传感器来获取区域或结构的占用数据，例如停车库，并且控制系统中各个灯的强度以进行节能。该地区的人，例如停车，可以通过特定的预设强度水平和/或光的颜色显示出口的出口路径。在停车库的实施例中，停车的人员通过特定强度和/或颜色的灯显示空白点。被动红外运动检测器的添加使得系统能够照亮移动人物周围的区域，并且如果人员意外地发生了报警。控制器可以通过无线或有线（电缆）通信与传感器和/或照明元件进行通信。

13. 发明申请

WO2005109252A1 SYSTEM AND METHOD FOR FACILITATING A CONSISTENT POINT-IN-TIME COPY 审中-公开
标题翻译：促进一致性时间复制的系统和方法
公开(公告)号：WO2005109252A1
公开(公告)日：2005-11-17
申请号：PCT/US2005/009291
申请日：2005-03-21
申请人： SUN MICROSYSTEMS, INC , WONG, Brian L. , ROBINSON, David , MCDOUGALL, Richard J. , SHEPLER, Spencer
发明人： WONG, Brian L. , ROBINSON, David , MCDOUGALL, Richard J. , SHEPLER, Spencer
IPC分类号： G06F17/30
CPC分类号： G06F17/30088
摘要： A system and method for facilitating a consistent point-in-time copy (PITC). A data provider offers access to data by one or more clients. A client issues a PITC request for a set of data to the data provider, or the provider initiates its own request. The data provider instructs one or more clients, particularly clients accessing the set of data, to flush any pending updates. The clients acknowledge the flush request, flush their data, and notify the data provider when their flushes are complete. Post-consistency updates are deferred (e.g., using a write-aside buffer). If a client fails to acknowledge the flush request or notify of flush completion, the data provider may abort the PITC or continue because the data may not be consistent or consistency may not be assured. If not aborted, the PITC may be marked to indicate that it is incomplete.
摘要翻译：一种用于促进一致的时间点复制（PITC）的系统和方法。数据提供者提供一个或多个客户端对数据的访问。客户端向数据提供者发出一组数据的PITC请求，或提供者发起自己的请求。数据提供者指示一个或多个客户端，特别是访问数据集的客户端，以刷新任何未完成的更新。客户端确认刷新请求，刷新其数据，并在其刷新完成时通知数据提供者。后续一致性更新被推迟（例如，使用写缓冲区）。如果客户端无法确认刷新请求或通知刷新完成，则数据提供者可能会中止PITC或继续，因为数据可能不一致或一致性可能无法保证。如果没有中止，PITC可能被标记为表示它是不完整的。

14. 发明申请

WO2004009791A3 MODULATORS OF B-LYMPHOCYTE ACTIVATION, MYOSIN-1F COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译： B淋巴细胞活化调节剂，MYOSIN-1F组合物及使用方法
公开(公告)号：WO2004009791A3
公开(公告)日：2004-09-16
申请号：PCT/US0323044
申请日：2003-07-22
申请人： RIGEL PHARMACEUTICALS INC , VALLONE MARCY K , WONG BRIAN R , MASUDA ESTEBAN , POWELL MARK
发明人： VALLONE MARCY K , WONG BRIAN R , MASUDA ESTEBAN , POWELL MARK
IPC分类号： C07K14/47 , C12Q1/42 , G01N33/50 , G01N33/94 , G01N33/53
CPC分类号： C12Q1/42 , C07K14/4716 , G01N33/5052 , G01N33/9493
摘要： The present invention provides compositions and methods for modulating B-lymphocyte activation. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating B-lymphocyte activation are provided. Compositions and methods for the treatment of disorders related to dysfunction or dysregulation of B-lymphocyte activation are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable for modulating B-lymphocyte activation.
摘要翻译：本发明提供了调节B淋巴细胞活化的组合物和方法。提供编码能够调节B淋巴细胞活化的编码蛋白质和蛋白质的核酸。还提供了用于治疗与B淋巴细胞活化的功能障碍或失调相关的病症的组合物和方法。还提供了预防和预防这些疾病的方法。还提供了用于这些疾病的诊断和预后测定的组合物和方法。进一步提供了用于鉴定能够调节B淋巴细胞活化的生物活性剂的测定法。

15. 发明申请

WO2004020979A9 METHODS OF ASSAYING FOR CELL CYCLE MODULATORS USING COMPONENTS OF THE UBIQUITIN LIGATION CASCADE 审中-公开
标题翻译：使用UBIQUITIN LIGATION CASCADE的组件进行细胞周期调节剂的测定方法
公开(公告)号：WO2004020979A9
公开(公告)日：2004-04-29
申请号：PCT/US0327128
申请日：2003-08-29
申请人： RIGEL PHARMACEUTICALS INC , BOOHER ROBERT , MASUDA ESTEBAN , OSSOVSKAYA VALERIA , WONG BRIAN
发明人： BOOHER ROBERT , MASUDA ESTEBAN , OSSOVSKAYA VALERIA , WONG BRIAN
IPC分类号： A61K31/713 , A61K38/53 , C12Q1/68 , G01N33/50 , G01N
CPC分类号： A61K38/53 , A61K31/713 , C12Q1/6886 , C12Q2600/136 , G01N33/5011 , G01N33/5017 , G01N2510/00
摘要： The present invention relates to regulation of the cell cycle. More particularly, the present invention is directed to nucleic acids encoding components of the ubiquitin ligation pathway, e.g., ubiquitin and ubiquitin-like molecules, E1, E2, and E3 proteins and their substrates, which are involved in modulation of cell cycle arrest. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions, antibodies, peptides, cyclic peptides, nucleic acids, RNAi, antisense nucleic acids, and ribozymes, that modulate cell cycle arrest via modulation of the ubiquitin ligation pathway; as well as to the use of expression profiles and compositions in diagnosis and therapy related to cell cycle regulation and modulation of cellular proliferation, e.g., for treatment of cancer and other diseases of cellular proliferation.
摘要翻译：本发明涉及细胞周期的调节。更具体地，本发明涉及编码泛素连接途径的组分的核酸，例如参与调节细胞周期停滞的泛素和泛素样分子，E1，E2和E3蛋白及其底物。本发明还涉及用于鉴定和使用包括小分子化学组合物，抗体，肽，环肽，核酸，RNAi，反义核酸和核酶的试剂的方法，其通过调节泛素连接途径调节细胞周期停滞; 以及在细胞周期调控和细胞增殖调节相关的诊断和治疗中使用表达谱和组合物，例如用于治疗癌症和其它细胞增殖疾病。

16. 发明申请

WO2004020979A2 METHODS OF ASSAYING FOR CELL CYCLE MODULATORS USING COMPONENTS OF THE UBIQUITIN LIGATION CASCADE 审中-公开
标题翻译：使用泛素结合分子组分测定细胞周期调节剂的方法
公开(公告)号：WO2004020979A2
公开(公告)日：2004-03-11
申请号：PCT/US2003/027128
申请日：2003-08-29
申请人： RIGEL PHARMACEUTICALS, INC. , BOOHER, Robert , MASUDA, Esteban , OSSOVSKAYA, Valeria , WONG, Brian
发明人： BOOHER, Robert , MASUDA, Esteban , OSSOVSKAYA, Valeria , WONG, Brian
IPC分类号： G01N
CPC分类号： A61K38/53 , A61K31/713 , C12Q1/6886 , C12Q2600/136 , G01N33/5011 , G01N33/5017 , G01N2510/00
摘要： The present invention relates to regulation of the cell cycle. More particularly, the present invention is directed to nucleic acids encoding components of the ubiquitin ligation pathway, e.g., ubiquitin and ubiquitin-like molecules, E1, E2, and E3 proteins and their substrates, which are involved in modulation of cell cycle arrest. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions, antibodies, peptides, cyclic peptides, nucleic acids, RNAi, antisense nucleic acids, and ribozymes, that modulate cell cycle arrest via modulation of the ubiquitin ligation pathway; as well as to the use of expression profiles and compositions in diagnosis and therapy related to cell cycle regulation and modulation of cellular proliferation, e.g., for treatment of cancer and other diseases of cellular proliferation.
摘要翻译：本发明涉及细胞周期的调节。更具体地说，本发明涉及编码遍在蛋白连接途径组分的核酸，例如涉及调节细胞周期停滞的遍在蛋白和泛素样分子，E1，E2和E3蛋白及其底物。本发明进一步涉及鉴定和使用通过调节泛素连接途径来调节细胞周期停滞的试剂（包括小分子化学组合物，抗体，肽，环肽，核酸，RNAi，反义核酸和核酶）的方法; 以及涉及表达谱和组合物在与细胞周期调节和细胞增殖调节相关的诊断和治疗中的用途，例如用于治疗癌症和其他细胞增殖疾病。

17. 发明申请

WO2004009791A2 MODULATORS OF B-LYMPHOCYTE ACTIVATION, MYOSIN-1F COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译： B淋巴细胞活化调节剂，MYOSIN-1F组合物及其使用方法
公开(公告)号：WO2004009791A2
公开(公告)日：2004-01-29
申请号：PCT/US2003/023044
申请日：2003-07-22
申请人： RIGEL PHARMACEUTICALS, INC. , VALLONE, Marcy, K. , WONG, Brian, R. , MASUDA, Esteban , POWELL, Mark
发明人： VALLONE, Marcy, K. , WONG, Brian, R. , MASUDA, Esteban , POWELL, Mark
IPC分类号： C12N
CPC分类号： C12Q1/42 , C07K14/4716 , G01N33/5052 , G01N33/9493
摘要： The present invention provides compositions and methods for modulating B-lymphocyte activation. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating B-lymphocyte activation are provided. Compositions and methods for the treatment of disorders related to dysfunction or dysregulation of B-lymphocyte activation are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable for modulating B-lymphocyte activation.
摘要翻译：本发明提供用于调节B-淋巴细胞活化的组合物和方法。提供编码能够调节B淋巴细胞活化的蛋白质和蛋白质的核酸。还提供了用于治疗与B淋巴细胞活化的功能障碍或失调相关的疾病的组合物和方法。还提供了预防和预防这种疾病的方法。还提供了用于诊断和预测这些疾病的组合物和方法。还提供了用于鉴定能够调节B-淋巴细胞活化的生物活性剂的测定法。

18. 发明申请

WO2004004666A2 MODULATORS OF LEUKOCYTE ACTIVATION, HCK COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：低密度脂蛋白激活剂，HCK组合物的调节剂和使用方法
公开(公告)号：WO2004004666A2
公开(公告)日：2004-01-15
申请号：PCT/US2003/022243
申请日：2003-07-10
申请人： RIGEL PHARMACEUTICALS, INC. , FRIERA, AnnaBelle , WONG, Brian, R. , MASUDA, Esteban , POWELL, Mark
发明人： FRIERA, AnnaBelle , WONG, Brian, R. , MASUDA, Esteban , POWELL, Mark
IPC分类号： A61K
CPC分类号： C12Q1/485 , G01N33/5047 , G01N2500/02
摘要： The present invention provides compositions and methods for modulating leukocyte activation. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating leukocyte activation are provided. Compositions and methods for the treatment of disorders related to leukocyte dysfunction or dysregulation are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating leukocyte activation.
摘要翻译：本发明提供了调节白细胞活化的组合物和方法。提供编码能够调节白细胞活化的蛋白质和蛋白质的核酸。还提供了用于治疗与白细胞功能障碍或失调相关的疾病的组合物和方法。还提供了预防和预防这种疾病的方法。还提供了用于诊断和预测这些疾病的组合物和方法。还提供了用于鉴定能够调节白细胞活化的生物活性剂的测定法。

19. 发明申请

WO2003074007A2 MODULATORS OF LEUKOCYTE ACTIVATION, COMPOSITIONS, AND METHODS OF USE 审中-公开
标题翻译：荧光素激活的调节剂，组合物和使用方法
公开(公告)号：WO2003074007A2
公开(公告)日：2003-09-12
申请号：PCT/US2003/006748
申请日：2003-03-03
申请人： RIGEL PHARMACEUTICALS, INC. , FRIERA, Annabelle, M. , VALLONE, Marcy, K. , WONG, Brian , MASUDA, Esteban , POWELL, Mark
发明人： FRIERA, Annabelle, M. , VALLONE, Marcy, K. , WONG, Brian , MASUDA, Esteban , POWELL, Mark
IPC分类号： A61K
CPC分类号： C07K14/47 , A61K38/00 , G01N33/5047
摘要： The present invention provides compositions and methods for modulating leukocyte activation. Nucleic acids and proteins which are capable of modulating leukocyte activation are provided. Compositions and methods for the treatment of disorders related to leukocyte dysfunction or dysregulation are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating leukocyte activation.
摘要翻译：本发明提供了调节白细胞活化的组合物和方法。提供能够调节白细胞活化的核酸和蛋白质。还提供了用于治疗与白细胞功能障碍或失调相关的疾病的组合物和方法。还提供了预防和预防这种疾病的方法。还提供了用于诊断和预测这些疾病的组合物和方法。还提供了用于鉴定能够调节白细胞活化的生物活性剂的测定法。

20. 发明申请

WO02079436A3 MODULATORS OF LEUKOCYTE ACTIVATION, COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：白蛋白激活剂，组合物和使用方法的调节剂
公开(公告)号：WO02079436A3
公开(公告)日：2003-05-22
申请号：PCT/US0209761
申请日：2002-03-29
申请人： RIGEL PHARMACEUTICALS INC , WONG BRIAN , FU ALAN C , MACEMBO HELENA , ZHOU XIULAN
发明人： WONG BRIAN , FU ALAN C , MACEMBO HELENA , ZHOU XIULAN
IPC分类号： C12N15/12 , G01N33/50 , G01N33/94 , C07H21/04 , C07K14/00 , C12N15/00 , C12N15/63
CPC分类号： G01N33/9493 , G01N33/5047 , G01N33/505 , G01N33/5052
摘要： The present invention provides compositions and methods for modulating leukocyte activation. Nucleic acids encoding proteins and proteins so encodend which are capable of modulating leukocyte activation are provided. Compositions and methods for the treatment of disorders related to leukocyte dysfunction or dysregulation are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating leukocyte activation.
摘要翻译：本发明提供了调节白细胞活化的组合物和方法。提供编码蛋白质和蛋白质的核酸，因此编码能够调节白细胞活化。还提供了用于治疗与白细胞功能障碍或失调相关的疾病的组合物和方法。还提供了预防和预防这种疾病的方法。还提供了用于这种障碍的诊断和预后测定的组合物。还提供了用于鉴定能够调节白细胞活化的生物活性剂的测定法。

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