专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明授权

US4185106A Pyridones as antidandruff agents 失效
标题翻译：吡啶酮作为去头皮屑剂
公开(公告)号：US4185106A
公开(公告)日：1980-01-22
申请号：US605210
申请日：1975-08-15
申请人： Walter Dittmar , Eberhard Futterer , Gerhard Lohaus
发明人： Walter Dittmar , Eberhard Futterer , Gerhard Lohaus
IPC分类号： A61K8/49 , A61K31/44 , A61Q5/00
CPC分类号： A61Q5/006 , A61K8/4926 , Y10S424/04
摘要： A cosmetic composition comprising a content of an 1-hydroxy-2-pyridone of the general formula ##STR1## in which R.sub.1 stands for hydrogen, alkyl of 1 to 17 carbon atoms, alkenyl of 2 to 17 carbon atoms, cycloalkyl of 5 to 8 carbon atoms, bicycloalkyl of 7 to 9 carbon atoms, cycloalkyl-alkyl of 1 to 4 alkyl carbon atoms, the cycloalkyl groups being optionally substituted by alkyl groups of 1 to 4 carbon atoms, aryl, aralkyl of 1 to 4 alkyl carbon atoms, aryl-alkenyl of 2 to 4 alkenyl carbon atoms, aryloxy-alkyl or arylthio-alkyl of 1 to 4 alkyl carbon atoms, benzhydryl, phenylsulfonyl-alkyl of 1 to 4 alkyl carbon atoms, furyl or furyl-alkenyl of 2 to 4 alkenyl carbon atoms, the aryl groups being optionally substituted by alkyl of 1 to 4 carbon atoms, by alkoxy of 1 to 4 carbon atoms, by nitro, cyano or halogen atoms, R.sub.2 stands for hydrogen, alkyl of 1 to 4 carbon atoms, alkenyl or alkinyl of 2 to 4 carbon atoms, halogen atoms or benzyl, R.sub.3 stands for hydrogen, alkyl of 1 to 4 carbon atoms or phenyl, and R.sub.4 stands for hydrogen, alkyl of 1 to 4 carbon atoms, alkenyl of 2 to 4 carbon atoms, methoxy-methyl, halogen or benzyl, and/or salt thereof, which may be used as an anti-dandruff agent.
摘要翻译：一种化妆品组合物，其包含通式“IMAGE”的1-羟基-2-吡啶酮的含量，其中R1代表氢，1至17个碳原子的烷基，2至17个碳原子的链烯基，5至8个的环烷基碳原子数为7〜9的双环烷基，1〜4个碳原子的环烷基 - 烷基，环烷基任选被1〜4个碳原子的烷基取代，芳基，1〜4个碳原子的芳烷基，芳基 2至4个烯基碳原子的烯基，1至4个烷基碳原子的芳氧基 - 烷基或芳硫基 - 烷基，2至4个烷基碳原子的二苯甲基，苯基磺酰基 - 烷基，2至4个烯基碳原子的呋喃基或呋喃基 - 烯基，芳基任选被1至4个碳原子的烷基，1至4个碳原子的烷氧基，硝基，氰基或卤素原子取代，R2代表氢，1至4个碳原子的烷基，烯基或炔基 2至4个碳原子，卤素原子或苄基，R3代表氢，1至4个碳原子的烷基 R苯基，R4代表氢，1至4个碳原子的烷基，2至4个碳原子的链烯基，甲氧基 - 甲基，卤素或苄基，和/或其盐，可用作抗头皮屑剂。

12. 发明授权

US5100890A Arylmethylazoles and their salts, agents which contain these compounds, and their use 失效
标题翻译：亚油嘧啶及其盐，含有这些化合物的试剂及其使用
公开(公告)号：US5100890A
公开(公告)日：1992-03-31
申请号：US411256
申请日：1989-09-25
申请人： Herbert Siegel , Klaus-Dieter Kampe , Hans-Georg Alpermann , Hermann J. Gerhards , Patricia Usinger , Ulrich Schacht , Margret Leven , Wolfgang Raether , Walter Dittmar , Burkhard Sachse
发明人： Herbert Siegel , Klaus-Dieter Kampe , Hans-Georg Alpermann , Hermann J. Gerhards , Patricia Usinger , Ulrich Schacht , Margret Leven , Wolfgang Raether , Walter Dittmar , Burkhard Sachse
IPC分类号： A61K31/41 , A61K31/415 , C07D233/60 , C07D233/64 , C07D249/08 , C07D521/00
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08
摘要： Arylmethylazoles of the formula I ##STR1## in which Aryl is (substituted) phenyl or naphthyl;Z is CH or N;R.sup.1 and Q are H or alkyl;R.sup.2 is H, alk(en)yl or alkynyl;R.sup.3 and R.sup.4 are H, alkyl or other hydrocarbons; orR.sup.3 and R.sup.4 together are a--(CH.sub.2).sub.2-11 chain or a bridged--(CH.sub.2).sub.4-5 chain,and their acid addition salts, stereoisomers and optically active enantiomers possess outstanding antimycotic and antidepressant activity.They are obtained, inter alia, from arylmethylazoles II ##STR2## which are reacted with a strong base and then with a carbonyl compound III O.dbd.CR.sup.3 R.sup.4 ; thereafter, the product is reacted with the protic acid or with an alkyl halide IV R.sup.2 Hal.If desired, the products are converted to the acid addition salts, or the stereoisomers or optically active enantiomes are resolved.

13. 发明授权

US4808606A Alkenylazoles, a process for their preparation and their use 失效
标题翻译：烯基唑，它们的制备和使用过程
公开(公告)号：US4808606A
公开(公告)日：1989-02-28
申请号：US909697
申请日：1986-09-22
申请人： Herbert Siegel , Wolfgang Raether , Walter Dittmar
发明人： Herbert Siegel , Wolfgang Raether , Walter Dittmar
IPC分类号： A01N43/50 , A01N43/653 , A01N45/02 , A61K31/41 , A61K31/415 , A61P31/04 , C07D233/56 , C07D233/58 , C07D233/60 , C07D249/08 , C07D521/00
CPC分类号： C07D231/12 , A01N43/50 , A01N43/653 , A01N45/02 , C07D233/56 , C07D249/08
摘要： Alkenylazoles of formula I a/b ##STR1## in which X/Y is H, alkyl, phenyl, Hal, alkoxy or alkylthio; Z is CH or N; R is alkyl or a bridged (CH.sub.2).sub.m chain; and A is alkylene or a bridged alkylene chain; and the salts of these alkenylazoles are antimycotic agents or fungicides. They are obtained by elimination of water from the compounds II ##STR2##
摘要翻译：其中X / Y是H，烷基，苯基，卤素，烷氧基或烷硫基的式Ⅰa的烯基唑; Z是CH或N; R是烷基或桥连（CH2）m链; A是亚烷基或桥连的亚烷基链; 并且这些烯基唑的盐是抗真菌剂或杀真菌剂。它们是通过从化合物II中除去水而获得的

14. 发明授权

US3972888A Process for the preparation of 1-hydroxy-pyridones 失效
标题翻译： 1-羟基 - 吡啶酮的制备方法
公开(公告)号：US3972888A
公开(公告)日：1976-08-03
申请号：US499988
申请日：1974-08-23
申请人： Gerhard Lohaus , Walter Dittmar
发明人： Gerhard Lohaus , Walter Dittmar
IPC分类号： C07D213/50
摘要： Method for making 6-substituted-1-hydroxy-2-pyridones, which may also be substituted in one or more of the 3-, 4-, and 5-positions, by reaction of the corresponding 2-pyrone with hydroxylamine or its salts in the presence of imidazole or a 2-aminopyridine which may be mono- or di-methyl substituted.
摘要翻译：通过相应的2-吡喃酮与羟胺或其盐的反应制备6-取代-1-羟基-2-吡啶酮的方法，其也可以在一个或多个3-，4-和5-位上被取代在咪唑或2-氨基吡啶存在下，其可以是单或二甲基取代的。

15. 发明授权

US4876354A Arylmethylazoles and their salts, processes for their preparation, agents which contain these compounds, and their use 失效
标题翻译：芳基甲基唑及其盐，其制备方法，含有这些化合物的试剂及其用途
公开(公告)号：US4876354A
公开(公告)日：1989-10-24
申请号：US191756
申请日：1988-05-03
申请人： Herbert Siegel , Klaus-Dieter Kampe , Hans G. Alpermann , Hermann J. Gerhards , Patricia Usinger , Ulrich Schacht , Margret Leven , Wolfgang Raether , Walter Dittmar , Burkhard Sachse
发明人： Herbert Siegel , Klaus-Dieter Kampe , Hans G. Alpermann , Hermann J. Gerhards , Patricia Usinger , Ulrich Schacht , Margret Leven , Wolfgang Raether , Walter Dittmar , Burkhard Sachse
IPC分类号： A61K31/41 , A61K31/415 , C07D233/60 , C07D233/64 , C07D249/08 , C07D521/00
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08
摘要： Arylmethylazoles of the formula I ##STR1## in which Aryl is (substituted) phenyl or naphthyl;Z is CH or N;R.sup.1 and Q are H or alkyl;R.sup.2 is H, alk(en)yl or alkynyl;R.sup.3 and R.sup.4 are H, alkyl or other hydrocarbons; orR.sup.3 and R.sup.4 together are a --(CH.sub.2).sub.2-11 chain or a bridged --(CH.sub.2).sub.4-5 chain, and their acid addition salts, stereoisomers and optically active enantiomers possess outstanding antimycotic and antidepressant activity.They are obtained, inter alia, from arylmethylazoles II ##STR2## which are reacted with a strong base and then with a carbonyl compound III O.dbd.CR.sup.3 R.sup.4 ; thereafter, the product is reacted with the protic acid or with an alkyl halide IV R.sup.2 Hal.If desired, the products are converted to the acid addition salts, or the stereoisomers or optically active enantiomers are resolved.
摘要翻译：芳基甲基唑，其中芳基是（取代的）苯基或萘基; Z是CH或N; R1和Q是H或烷基; R2是H，烷（烯）基或炔基; R3和R4是H，烷基或其他烃; 或R 3和R 4一起是 - （CH 2）2-11链或桥连 - （CH 2）4-5链，并且它们的酸加成盐，立体异构体和旋光对映异构体具有突出的抗真菌和抗抑郁活性。它们特别由芳基甲基唑II II获得，它们与强碱反应，然后与羰基化合物III = CR 3 R 4反应; 此后，产物与质子酸或烷基卤IVR 2 Hal反应。如果需要，将产物转化成酸加成盐，或者立体异构体或光学活性对映体被分解。

16. 发明授权

US4818758A 2-azolylmethyl-2-phenyl-4-[benzazol-2-yloxy-or-thio-methyl]-1,3 dioxolanes and salts thereof, pharmaceutical compositions containing them and their use 失效
标题翻译： 2-唑基甲基-2-苯基-4- [苯并唑-2-基氧基或硫代甲基] -1,3二氧戊环及其盐，含有它们的药物组合物及其用途
公开(公告)号：US4818758A
公开(公告)日：1989-04-04
申请号：US28173
申请日：1987-03-19
申请人： Klaus-Dieter Kampe , Wolfgang Raether , Walter Dittmar
发明人： Klaus-Dieter Kampe , Wolfgang Raether , Walter Dittmar
IPC分类号： C07D317/00 , A01N43/52 , A01N43/60 , A01N43/653 , A01N43/74 , A01N43/76 , C07D263/56 , C07D263/57 , C07D263/58 , C07D263/60 , C07D277/64 , C07D277/66 , C07D413/14 , C07D417/14 , C07D521/00 , A61K31/335 , A61K31/415 , C07D405/14
CPC分类号： C07D263/56 , A01N43/52 , A01N43/60 , A01N43/653 , A01N43/74 , C07D231/12 , C07D233/56 , C07D249/08 , C07D263/57 , C07D263/58 , C07D263/60 , C07D277/64 , C07D277/66
摘要： Compounds of the formula I ##STR1## and the acid-addition salts thereof, where A=CH or N; Ar=naphthyl, thienyl or phenyl; Z=oxygen or sulfur; R.sup.1 =alkyl, F or Cl; g=0-2; L=0 or 1; m=0-4; p=0 or 1; X=O, S or N--R.sup.3 ; R.sup.2 =alkyl, alkoxy, halogen, SCH.sub.3, COC.sub.6 H.sub.5, CF.sub.3, COOCH.sub.3, COOC.sub.2 H.sub.5, or NO.sub.2 ; n=0-2; R.sup.2, under certain circumstances, is alternatively --CH.dbd.CH--CH.dbd.CH-- or phenoxy are described. Processes for the preparation thereof are also described.Compounds IIIa ##STR2## are valuable intermediates for the preparation of I. The compounds I serve as antimycotics.
摘要翻译：式I的化合物及其酸加成盐，其中A = CH或N; Ar =萘基，噻吩基或苯基; Z =氧或硫; R1 =烷基，F或Cl; g = 0-2; L = 0或1; m = 0-4; p = 0或1; X = O，S或N-R 3; R2 =烷基，烷氧基，卤素，SCH3，COC6H5，CF3，COOCH3，COOC2H5或NO2; n = 0-2; 在某些情况下，R 2可以是-CH = CH-CH = CH-或苯氧基。还描述了其制备方法。化合物IIIa IIIa图像是用于制备I的有价值的中间体。化合物I用作抗真菌剂。

17. 发明授权

US4391805A 1-(1,3-Dioxolan-2-ylmethyl)-azoles, their salts and their use 失效
标题翻译： 1-（1,3-二氧戊环-2-基甲基） - 唑，它们的盐及其用途
公开(公告)号：US4391805A
公开(公告)日：1983-07-05
申请号：US311184
申请日：1981-10-14
申请人： Ernst Blume , Wolfgang Schaper , Wolfgang Raether , Walter Dittmar
发明人： Ernst Blume , Wolfgang Schaper , Wolfgang Raether , Walter Dittmar
IPC分类号： C07D217/04 , C07D233/60 , C07D295/096 , C07D295/185 , C07D295/26 , C07D317/20 , C07D317/22 , C07D317/24 , C07D333/28 , C07D521/00 , A61K31/415 , C07D405/06
CPC分类号： C07D295/185 , C07D217/04 , C07D231/12 , C07D233/56 , C07D249/08 , C07D295/096 , C07D295/26 , C07D317/20 , C07D317/22 , C07D317/24 , C07D333/28
摘要： 1-(1,3-Dioxolan-2-ylmethyl)-azoles of the general formula ##STR1## and their stereoisomers and their salts with physiologically acceptable acids, the preparation of these compounds, pharmaceutical formulations containing the latter and their use against mycoses, protozoa and Gram-positive and Gram-negative bacteria are described.
摘要翻译：具有通式“IMAGE”的1-（1,3-二氧戊环-2-基甲基） - 唑及其立体异构体及其与生理上可接受的酸的盐，这些化合物的制备，含有后者的药物制剂及其用于治疗真菌病，描述了原生动物和革兰氏阳性和革兰氏阴性细菌。

18. 发明授权

US3968118A Process for the manufacture of 1-hydroxy-2-pyridones 失效
标题翻译： 1-羟基-2-吡啶酮的制备方法
公开(公告)号：US3968118A
公开(公告)日：1976-07-06
申请号：US502063
申请日：1974-08-30
申请人： Gerhard Lohaus , Walter Dittmar
发明人： Gerhard Lohaus , Walter Dittmar
IPC分类号： C07D213/89 , C07D221/04 , C07D213/02
CPC分类号： C07D221/04 , C07D213/89
摘要： New 1-hydroxy-2-pyridones of the general formula ##SPC1##In which R.sub.1 is alkyl of 1 to 17 carbon atoms, cycloalkyl of 5 to 8 carbon atoms, cyclohexylalkyl or phenalkyl both having 1 to 3 carbon atoms in the alkylene chain or .alpha.-furyl, all of which may be substituted by halogen, and R.sub.2 to R.sub.4 are hydrogen or lower alkyl, or two adjacent substituents together form a trimethylene or tetramethylene chain, and in which R.sub.1 to R.sub.4 together contain at least 2 carbon atoms, are prepared by contacting unsaturated .delta.-keto esters or mixtures thereof with hydroxylamine and subjecting the products to cyclization.
摘要翻译：新的具有1至17个碳原子的烷基，5至8个碳原子的环烷基，环烷基或苯烷基，其中亚烷基链中具有1至3个碳原子的α-羟基-2-吡啶酮或α-呋喃基所有这些可以被卤素取代，R 2至R 4是氢或低级烷基，或两个相邻的取代基一起形成三亚甲基或四亚甲基链，并且其中R 1至R 4一起含有至少2个碳原子。不饱和的β-酮酯或其与羟胺的混合物，并使产物环化。

19. 发明授权

US5023357A Arylmethylazole preparation processes 失效
标题翻译：芳基唑制备方法
公开(公告)号：US5023357A
公开(公告)日：1991-06-11
申请号：US411045
申请日：1989-09-21
申请人： Herbert Siegel , Klaus-Dieter Kampe , Hans-Georg Alpermann , Hermann J. Gerhards , Patricia Usinger , Ulrich Schacht , Margret Leven , Wolfgang Raether , Walter Dittmar , Burkhard Sachse
发明人： Herbert Siegel , Klaus-Dieter Kampe , Hans-Georg Alpermann , Hermann J. Gerhards , Patricia Usinger , Ulrich Schacht , Margret Leven , Wolfgang Raether , Walter Dittmar , Burkhard Sachse
IPC分类号： A61K31/41 , A61K31/415 , C07D233/60 , C07D233/64 , C07D249/08 , C07D521/00
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08
摘要： Arylmethylazoles of the formula I ##STR1## in which Aryl is (substituted) phenyl or naphthyl;Z is CH or N;R.sup.1 and Q are H or alkyl;R.sup.2 is H, alk(en)yl or alkynyl;R.sup.3 l and R.sup.4 are H, alkyl or other hydrocarbons; orR.sup.3 and R.sup.4 together are a --(CH.sub.2).sub.2-11 chain or a bridged --(CH.sub.2).sub.4-5 chain,and their acid addition salts, stereoisomers and optically active enantiomers possess outstanding antimycotic and antidepressant activity.They are obtained, inter alia, from arylmethylazoles II ##STR2## which are reacted with a strong base and then with a carbonyl compound III 0=CR.sup.3 R.sup.4 ; thereafter, the product is reacted with the protic acid or with an alkyl halide IV R.sup.2 Hal.If desired, the products are converted to the acid addition salts, or the stereoisomers or optically active enantiomers are resolved.

20. 发明授权

US4877878A 2-azolylmethyl-2-aryl-1,3-dioxolanes and the salts thereof, processes for the preparation thereof, agents containing same, and the use thereof 失效
标题翻译： 2-吡唑基甲基-2-芳基-1,3-二氧戊环及其盐，其制备方法，含有它们的试剂及其用途
公开(公告)号：US4877878A
公开(公告)日：1989-10-31
申请号：US291952
申请日：1988-12-29
申请人： Klaus-Dieter Kampe , Wolfgang Raether , Walter Dittmar
发明人： Klaus-Dieter Kampe , Wolfgang Raether , Walter Dittmar
IPC分类号： C07D317/00 , A01N43/52 , A01N43/60 , A01N43/653 , A01N43/74 , A01N43/76 , C07D263/56 , C07D263/57 , C07D263/58 , C07D263/60 , C07D277/64 , C07D277/66 , C07D413/14 , C07D417/14 , C07D521/00
CPC分类号： C07D263/56 , A01N43/52 , A01N43/60 , A01N43/653 , A01N43/74 , C07D231/12 , C07D233/56 , C07D249/08 , C07D263/57 , C07D263/58 , C07D263/60 , C07D277/64 , C07D277/66
摘要： Compounds of the formula I ##STR1## and the acid-addition salts thereof, where A=CH or N; Ar=naphthyl, thienyl or phenyl; Z=oxygen or sulfur; R.sup.1 =alkyl, F or Cl; g=0-2; L=0 or 1; m=0-4; p=0 or 1; X=O, S or N-R.sup.3 ; R.sup.2 =alkyl, alkoxy, halogen, SCH.sub.3, COC.sub.6 H.sub.5, CF.sub.3, COOCH.sub.3, COOC.sub.2 H.sub.5, or NO.sub.2 ; n=0-2; R.sup.2, under certain circumstances, is alternatively --CH.dbd.CH--CH.dbd.CH-- or phenoxy are described. Processes for the preparation thereof are also described. ##STR2## are valuable intermediates for the preparation of I. The compounds I serve as antimycotics.
摘要翻译：式I的化合物及其酸加成盐，其中A = CH或N; Ar =萘基，噻吩基或苯基; Z =氧或硫; R1 =烷基，F或Cl; g = 0-2; L = 0或1; m = 0-4; p = 0或1; X = O，S或N-R 3; R2 =烷基，烷氧基，卤素，SCH3，COC6H5，CF3，COOCH3，COOC2H5或NO2; n = 0-2 在某些情况下，R 2可以是-CH = CH-CH = CH-或苯氧基。还描述了其制备方法。 IIIa 是制备I的有价值的中间体。化合物I用作抗真菌剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式