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11. 发明授权

US07433853B2 Expert system for patient medical information analysis 有权
标题翻译：患者医疗信息分析专家系统
公开(公告)号：US07433853B2
公开(公告)日：2008-10-07
申请号：US10889353
申请日：2004-07-12
申请人： Marina Brockway , Gerrard M. Carlson , Veerichetty Kadhiresan , Vladimir Kovtun
发明人： Marina Brockway , Gerrard M. Carlson , Veerichetty Kadhiresan , Vladimir Kovtun
IPC分类号： G06N5/04
CPC分类号： G06N5/04 , A61B5/0002 , A61B5/0205 , A61B5/021 , A61B5/0215 , A61B5/053 , A61B5/076 , A61B5/0816 , A61B5/7232 , A61B5/7264 , A61B5/7267 , A61B5/7475 , G06F19/00 , G06N7/005 , G16H50/20 , G16H50/30
摘要： A plurality of chronic sensors are used to facilitate diagnosis and medical decision making for an individual patient. An expert system evaluates the sensor data, combines the sensor data with stored probability data and provides an output signal for notification or medical intervention.
摘要翻译：使用多个慢性传感器来促进个体患者的诊断和医学决策。专家系统评估传感器数据，将传感器数据与存储的概率数据组合，并提供用于通知或医疗干预的输出信号。

12. 发明申请

US20070299356A1 DETECTION OF MYOCARDIAL ISCHEMIA FROM THE TIME SEQUENCE OF IMPLANTED SENSOR MEASUREMENTS 有权
标题翻译：从插入式传感器测量的时间序列检测心肌梗塞
公开(公告)号：US20070299356A1
公开(公告)日：2007-12-27
申请号：US11426835
申请日：2006-06-27
申请人： Ramesh Wariar , Veerichetty Kadhiresan , Richard Fogoros
发明人： Ramesh Wariar , Veerichetty Kadhiresan , Richard Fogoros
IPC分类号： A61B5/04
CPC分类号： A61B5/02 , A61B5/0402 , A61B5/0535 , A61N1/36521 , A61N1/36542 , A61N1/36564 , A61N1/36578 , A61N1/3702
摘要： A system including a plurality of implantable sensors, a processor, and a response circuit. Each sensor produces an electrical sensor signal related to physiologic cardiovascular events of a subject. The processor includes an event sequence detector to permit real-time detection of a time-wise sequential cascade of physiologic cardiovascular events related to myocardial ischemia of a subject and a decision module. The time-wise cascade includes at least first, second, and third physiologic cardiovascular events. The decision module declares whether an ischemic event occurred using at least one rule applied to a temporal relationship of the first, second, and third physiologic cardiovascular events. The response circuit provides a specified response if the ischemic event is declared.
摘要翻译：一种包括多个可植入传感器，处理器和响应电路的系统。每个传感器产生与受试者的生理心血管事件相关的电传感器信号。该处理器包括事件序列检测器，以允许实时检测与受试者和决策模块的心肌缺血相关的生理心血管事件的时间顺序级联。时间级联包括至少第一，第二和第三生理心血管事件。决策模块声明是否使用至少应用于第一，第二和第三生理心血管事件的时间关系的规则来发生缺血事件。如果声明缺血事件，则响应电路提供指定的响应。

13. 发明申请

US20070288069A1 Ambulatory repeater for use in automated patient care 有权
标题翻译：动态中继器，用于自动化病人护理
公开(公告)号：US20070288069A1
公开(公告)日：2007-12-13
申请号：US11893704
申请日：2007-08-17
申请人： Donald Goscha , Lisa Haeder , Veerichetty Kadhiresan , David Johnson , Muralidharan Srivanthsa , Marina Brockway
发明人： Donald Goscha , Lisa Haeder , Veerichetty Kadhiresan , David Johnson , Muralidharan Srivanthsa , Marina Brockway
IPC分类号： A61N1/36
CPC分类号： A61B5/0031 , G06F19/00
摘要： An ambulatory repeater for use in automated patient care is presented. A local memory store includes a cryptographic key, sensitive information, and physiological measures. The cryptographic key is uniquely assigned to the implantable medical device prior to implant of the implantable medical device into a patient. The sensitive information is preencrypted under the cryptographic key and physiological measures are measured by the implantable medical device. An authentication module is in receipt of the cryptographic key. A permissions module confirms authorization of an external data processing device against the cryptographic key. A decryption module decrypts the sensitive information with the cryptographic key into decrypted information. A processor is operatively coupled to the local memory store. A communications module exchanges the decrypted information and the physiological measures with the external data processing device over a wireless interface contingent upon the authorization confirmation. An internal power supply supplies power to the foregoing components.
摘要翻译：提出了一种用于自动病人护理的移动中继器。本地存储器包括加密密钥，敏感信息和生理措施。在将可植入医疗装置植入病人之前，将密码密钥唯一地分配给可植入医疗装置。敏感信息在加密密钥下加密，生理测量由可植入医疗设备测量。认证模块正在接收加密密钥。权限模块根据加密密钥确认外部数据处理设备的授权。解密模块将具有加密密钥的敏感信息解密为解密信息。处理器可操作地耦合到本地存储器存储器。通信模块根据授权确认，通过无线接口与外部数据处理装置交换解密信息和生理测量。内部电源为上述组件供电。

14. 发明申请

US20060200007A1 Automatic etiology sequencing system 有权
标题翻译：自动病因测序系统
公开(公告)号：US20060200007A1
公开(公告)日：2006-09-07
申请号：US11071646
申请日：2005-03-03
申请人： Marina Brockway , David Johnson , Don Goscha , Veerichetty Kadhiresan , Muralidharan Srivathsa , Lisa Haeder
发明人： Marina Brockway , David Johnson , Don Goscha , Veerichetty Kadhiresan , Muralidharan Srivathsa , Lisa Haeder
IPC分类号： A61B5/00
CPC分类号： G06F19/345 , A61B5/00 , A61B5/0002 , A61B5/0022 , A61B5/686 , A61B5/7264 , A61B5/7267 , A61B5/7275 , A61B5/7282 , G06F19/00 , G06F19/30 , G06F19/32 , G06F19/34 , G06F19/3418 , G06N3/02 , G06N3/0427 , G06Q50/24 , G16H10/20 , G16H15/00 , G16H40/63 , G16H50/20 , Y10S128/92 , Y10S128/924 , Y10S128/925 , Y10S706/924
摘要： A system and related method for identifying a trigger event to a patient health-related exacerbation. The system includes at least one sensor configured to collect data related to the patient health-related exacerbation, an analyzer configured to validate the collected data, a patient interface device configured to receive patient inputs to at least one question, and an identifier device configured to receive the patient inputs and collected data and identify the trigger event. The system may also include an expert system configured to receive the patient inputs and the validated collected data and identify a primary patient disease, and a reporting device configured to generate reports related to the identified primary patient disease, patient inputs, and sensed patient conditions.
摘要翻译：用于识别患者健康相关恶化的触发事件的系统和相关方法。该系统包括至少一个传感器，其被配置为收集与患者健康相关的恶化相关的数据，被配置为验证所收集的数据的分析器，被配置为接收患者对至少一个问题的输入的患者接口装置，以及被配置为接收患者输入和收集的数据并识别触发事件。该系统还可以包括被配置为接收患者输入和验证的收集的数据并识别主要患者疾病的专家系统，以及被配置为生成与所识别的主要患者疾病，患者输入和感测到的患者状况相关的报告的报告装置。

15. 发明申请

US20060089856A1 Integrated pharmaceutical dispensing and patient management monitoring 审中-公开
标题翻译：综合药物配药和患者管理监测
公开(公告)号：US20060089856A1
公开(公告)日：2006-04-27
申请号：US10970286
申请日：2004-10-21
申请人： Veerichetty Kadhiresan , David Johnson , Don Goscha , Marina Brockway , Muralidharan Srivathsa
发明人： Veerichetty Kadhiresan , David Johnson , Don Goscha , Marina Brockway , Muralidharan Srivathsa
IPC分类号： G06Q10/00
CPC分类号： G06F19/3456 , G06Q50/22
摘要： A pharmaceutical monitoring system includes a communication system, a host, and an interrogator/transmitter unit. The communication system is configured to upload patient drug parameters from a pharmaceutical information source to the host, and the interrogator/transmitter unit is configured to download the patient drug parameters from the host via the communication system and provide patient prompts based on the downloaded patient drug parameters. The interrogator/transmitter unit may also be configured to receive patient inputs in response to the patient prompts and upload information to the host via the communication system that is based on the patient inputs, patient prompts, and patient drug parameters.
摘要翻译：药物监控系统包括通信系统，主机和询问器/发送器单元。通信系统被配置为将患者药物参数从药物信息源上传到主机，并且询问器/发送器单元被配置为经由通信系统从主机下载患者药物参数，并且基于所下载的患者药物提供患者提示参数。询问器/发射器单元还可以被配置为响应于患者提示接收患者输入，并且经由通信系统将信息上传到主机，所述通信系统基于患者输入，患者提示和患者药物参数。

16. 发明申请

US20050228454A1 Trending of conduction time for optimization of cardiac resynchronization therapy in cardiac rhythm management system 有权
公开(公告)号：US20050228454A1
公开(公告)日：2005-10-13
申请号：US11142165
申请日：2005-06-01
申请人： Andrew Kramer , Jeffrey Stahmann , Veerichetty Kadhiresan
发明人： Andrew Kramer , Jeffrey Stahmann , Veerichetty Kadhiresan
IPC分类号： A61N1/362 , A61N1/365 , A61N1/368
CPC分类号： A61N1/3627 , A61N1/36521 , A61N1/36542 , A61N1/3682 , A61N1/3684
摘要： A method of optimizing cardiac resynchronization therapy delay over a patient's full range of activity for use in operating an implantable cardiac pacing device and such a device are disclosed. The method includes measuring selected conduction time between selected sites in the heart for a plurality of beats and logging the values on a periodic repeating programmable basis to produce cumulative data and constructing a current template of conduction time in relation to one or more other sensed parameters of interest over a desired range of patient activity levels. The current template is used to derive suggested optimum pacing timing.

17. 发明授权

US06597951B2 Automatic selection from multiple cardiac optimization protocols 有权
公开(公告)号：US06597951B2
公开(公告)日：2003-07-22
申请号：US09995255
申请日：2001-11-27
申请人： Andrew P. Kramer , Veerichetty Kadhiresan , Jiang Ding , Lawrence Baumann , Scott Vanderlinde
发明人： Andrew P. Kramer , Veerichetty Kadhiresan , Jiang Ding , Lawrence Baumann , Scott Vanderlinde
IPC分类号： A61N1365
CPC分类号： A61N1/3627 , A61N1/3682
摘要： A method and system for setting the operating parameters of a cardiac rhythm management device in which a plurality of parameter optimization algorithms are available. A measured feature of an electrophysiological signal such as QRS width has been shown to be useful in selecting among certain parameter optimization algorithms.

18. 发明授权

US06415183B1 Method and apparatus for diaphragmatic pacing 有权
标题翻译：膈肌起搏的方法和装置
公开(公告)号：US06415183B1
公开(公告)日：2002-07-02
申请号：US09456879
申请日：1999-12-09
申请人： Avram Scheiner , Veerichetty Kadhiresan
发明人： Avram Scheiner , Veerichetty Kadhiresan
IPC分类号： A61N136
CPC分类号： A61N1/3601 , A61N1/368
摘要： A diaphragmatic pacing system and method. The method includes monitoring a signal representing a patient's respiratory activity, and delivering an electric stimulus from a lead to the phrenic nerve when the signal indicates that the respiratory activity is below a predetermined level. Physiological state information, such as the respiration activity or minute ventilation, is sensed using the implanted lead and the method delivers an output based on such input. Another embodiment provides concurrent sensing and pacing of heart and diaphragm using a single implanted pulse generator. The implantable system includes at least one lead and a signal processing circuit coupled to the lead. The signal processing circuit processes a signal representative of a respiratory activity. A controller coupled to the signal processing circuit analyzes the signal and when the signal indicates a need for respiratory therapy the controller outputs a controller signal. An output circuit coupled to the controller, for delivering a pulse in response to the controller signal, the pulse having an amplitude high enough to stimulate a phrenic nerve.
摘要翻译：膈肌起搏系统及方法。所述方法包括监测表示患者的呼吸活动的信号，以及当所述信号指示所述呼吸活动低于预定水平时，将电刺激从导线传送到膈神经。使用植入引线感测生理状态信息，例如呼吸活动或分钟通气，并且该方法基于这样的输入递送输出。另一个实施例提供使用单个注入脉冲发生器的心脏和隔膜的并发检测和起搏。可植入系统包括耦合到引线的至少一个引线和信号处理电路。信号处理电路处理表示呼吸活动的信号。耦合到信号处理电路的控制器分析信号，并且当信号指示需要呼吸治疗时，控制器输出控制器信号。耦合到所述控制器的输出电路，用于响应于所述控制器信号递送脉冲，所述脉冲的幅度足够高以刺激膈神经。

19. 发明授权

US08145590B2 Expert system for patient medical information analysis 有权
标题翻译：患者医疗信息分析专家系统
公开(公告)号：US08145590B2
公开(公告)日：2012-03-27
申请号：US12245215
申请日：2008-10-03
申请人： Marina Brockway , Gerrard M. Carlson , Veerichetty Kadhiresan , Vladimir Kovtun
发明人： Marina Brockway , Gerrard M. Carlson , Veerichetty Kadhiresan , Vladimir Kovtun
IPC分类号： G06F9/44 , G06N7/02 , G06N7/06
CPC分类号： G06N5/04 , A61B5/0002 , A61B5/0205 , A61B5/021 , A61B5/0215 , A61B5/053 , A61B5/076 , A61B5/0816 , A61B5/7232 , A61B5/7264 , A61B5/7267 , A61B5/7475 , G06F19/00 , G06N7/005 , G16H50/20 , G16H50/30
摘要： A plurality of chronic sensors are used to facilitate diagnosis and medical decision making for an individual patient. An expert system evaluates the sensor data, combines the sensor data with stored probability data and provides an output signal for notification or medical intervention.
摘要翻译：使用多个慢性传感器来促进个体患者的诊断和医学决策。专家系统评估传感器数据，将传感器数据与存储的概率数据组合，并提供用于通知或医疗干预的输出信号。

20. 再颁专利

USRE42836E1 Method for assessing cardiac functional status 有权
标题翻译：评估心脏功能状态的方法
公开(公告)号：USRE42836E1
公开(公告)日：2011-10-11
申请号：US11906742
申请日：2007-10-03
申请人： Weimin Sun , Veerichetty Kadhiresan , Bruce H. KenKnight , Richard S. Sanders
发明人： Weimin Sun , Veerichetty Kadhiresan , Bruce H. KenKnight , Richard S. Sanders
IPC分类号： A61N1/00
CPC分类号： A61N1/36542
摘要： A method for assessing cardiac function suitable for incorporation into an implantable cardiac rhythm management device. By measuring daily exertion levels in accordance with the invention, an assessment of cardiac function can be made that has been found to correlate well with conventional clinical classifications. The invention also provides for assessing cardiac function in conjunction with different pacing schemes designed to treat heart failure and using the assessment to select the best such scheme for the patient.
摘要翻译：一种用于评估心脏功能的方法，其适于并入植入式心律管理装置。通过测量根据本发明的每日运动水平，可以进行已经发现与常规临床分类良好相关的心脏功能的评估。本发明还提供了结合用于治疗心力衰竭的不同起搏方案和使用该评估为患者选择最佳的方案来评估心脏功能。

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