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11. 发明申请

US20070086831A1 Active Pump Toothbrush 审中-公开
标题翻译：主动泵牙刷
公开(公告)号：US20070086831A1
公开(公告)日：2007-04-19
申请号：US11548558
申请日：2006-10-11
申请人： Truman Wold
发明人： Truman Wold
IPC分类号： A46B11/02 , A47L13/22
CPC分类号： A46B11/0024 , A46B11/0041 , A46B11/0058 , A46B2200/01 , A46B2200/1066
摘要： Toothbrushes are provided which incorporate in a handle portion of the toothbrush a volume of a beneficial agent that may be dispensed using an included manual pump mechanism. The volume of the beneficial agent provided in the brush and the dispense rate of the beneficial agent may be widely varied. The toothbrush may be constructed to have a beneficial agent volume and dispense rate that are estimated to provide approximately three months of usage to correspond to the length of the effective life of toothbrush bristles, thus allowing the entire unit to be disposable upon dispensing of the last of the fluid.
摘要翻译：提供了一种牙刷，其在牙刷的手柄部分中具有可以使用包括的手动泵机构分配的一定体积的有益剂。提供在刷子中的有益剂的体积和有益剂的分配速率可以是广泛变化的。牙刷可以被构造成具有有益剂量和分配速率，其估计提供大约三个月的使用以对应于牙刷刷毛的有效寿命的长度，从而允许整个单元在分配最后一个的流体。

12. 发明授权

US07149417B2 Controllable release of a volatile substance 有权
标题翻译：挥发性物质的可控释放
公开(公告)号：US07149417B2
公开(公告)日：2006-12-12
申请号：US10708253
申请日：2004-02-19
申请人： Ashok V. Joshi , Truman Wold
发明人： Ashok V. Joshi , Truman Wold
IPC分类号： F24F6/00
CPC分类号： A01M1/2044 , A01M1/2033 , A01M1/2072 , A01M1/2077 , A61L9/02 , A61L9/03 , A61L9/04 , A61L9/12 , A61L9/122
摘要： The present invention is directed to a device for releasing a controlled amount of a volatile substance into an environment while isolating the non-released amount of such a substance from the environment. The device includes a housing having an interior region, a volatile substance cartridge associated with the housing, wherein the cartridge can be replaced, or, alternatively, refilled with a desired fluid. A mechanism is provided for releasing a pre-determined amount of fluid from the housing, which is activated, as desired, by a user of the device.
摘要翻译：本发明涉及一种用于将受控量的挥发性物质释放到环境中，同时将这种物质的未释放量与环境隔离的装置。该装置包括具有内部区域的壳体，与壳体相关联的挥发性物质盒，其中可以更换墨盒，或者替换地，用期望的流体重新填充墨盒。提供了用于从外壳释放预定量的流体的机构，其根据需要由设备的使用者被激活。

13. 发明申请

US20050185940A1 CONTROLABLE RELEASE OF A VOLATILE SUBSTANCE 有权
标题翻译：易挥发物质的释放
公开(公告)号：US20050185940A1
公开(公告)日：2005-08-25
申请号：US10708253
申请日：2004-02-19
申请人： Ashok Joshi , Truman Wold
发明人： Ashok Joshi , Truman Wold
IPC分类号： A01M1/20 , A61L9/02 , A61L9/03 , A61L9/04 , A61L9/12
CPC分类号： A01M1/2044 , A01M1/2033 , A01M1/2072 , A01M1/2077 , A61L9/02 , A61L9/03 , A61L9/04 , A61L9/12 , A61L9/122
摘要： The present invention is directed to a device for releasing a controlled amount of a volatile substance into an environment while isolating the non-released amount of such a substance from the environment. The device includes a housing having an interior region, a volatile substance cartridge associated with the housing, wherein the cartridge can be replaced, or, alternatively, refilled with a desired fluid. A mechanism is provided for releasing a pre-determined amount of fluid from the housing, which is activated, as desired, by a user of the device.
摘要翻译：本发明涉及一种用于将受控量的挥发性物质释放到环境中，同时将这种物质的未释放量与环境隔离的装置。该装置包括具有内部区域的壳体，与壳体相关联的挥发性物质盒，其中可以更换墨盒，或者替换地，用期望的流体重新填充墨盒。提供了用于从外壳释放预定量的流体的机构，其根据需要由设备的使用者被激活。

14. 发明授权

US06327426B1 Apparatus and method for delivering a beneficial agent 失效
标题翻译：用于递送有益剂的装置和方法
公开(公告)号：US06327426B1
公开(公告)日：2001-12-04
申请号：US09696839
申请日：2000-10-26
申请人： Ashok V. Joshi , Truman Wold
发明人： Ashok V. Joshi , Truman Wold
IPC分类号： A01G1306
CPC分类号： A01M1/2077
摘要： An apparatus for delivering a beneficial agent to a surrounding area comprising a first electroactive electrode, a beneficial agent, a second electroactive electrode and an electrical associating member. The first electroactive electrode includes an outer surface, a portion of which is exposable to the surrounding area. The beneficial agent is dispersed within the first electroactive electrode. The second electroactive electrode is associated with the first electroactive electrode. The electrical associating member electrically associates the first electroactive electrode and the second electroactive electrode, to, facilitate corrosion of the exposable surface of the first electroactive electrode, upon exposure of same to the surrounding area, and, in turn the release of the beneficial agent.
摘要翻译：一种用于将有益剂输送到包括第一电活性电极，有益试剂，第二电活性电极和电连接构件的周围区域的装置。第一电活性电极包括外表面，其一部分可暴露于周围区域。有益剂分散在第一电活性电极内。第二电活性电极与第一电活性电极相关联。电连接构件使第一电活性电极和第二电活性电极电连接，以便在暴露于周围区域时促进第一电活性电极的可暴露表面的腐蚀，从而促进有益剂的释放。

15. 发明授权

US5951538A Gas generating device for delivering beneficial agents to a body cavity 失效
标题翻译：用于将有益剂递送到体腔的气体发生装置
公开(公告)号：US5951538A
公开(公告)日：1999-09-14
申请号：US908687
申请日：1997-08-07
申请人： Ashok V. Joshi , Giorgio di Palma , Truman Wold
发明人： Ashok V. Joshi , Giorgio di Palma , Truman Wold
IPC分类号： A61K9/22 , A61D7/00 , A61M13/00 , A61M31/00
CPC分类号： A61M31/002
摘要： A controlled delivery device for holding and administering a biologically active agent includes a housing having a first end portion, a second end portion, and a port associated with the housing. Enclosed within the housing is a displacing member, a chemical or electrochemical gas generating cell, activation and control circuitry. The electrochemical or chemical cell generates gas within the housing, forcing the displacing member against the beneficial agents contained within the housing and forcing the beneficial agents through an outlet port and into an animal's body cavity at a predetermined rate. An anchoring mechanism may be associated with the housing for securing the housing inside the body cavity of the animal being treated. Also disclosed are methods of delivering the beneficial agents into the animal's body cavity using the delivery device of the present invention.
摘要翻译：用于保持和施用生物活性剂的受控递送装置包括具有第一端部分，第二端部部分和与壳体相关联的端口的壳体。封闭在壳体内的是移动构件，化学或电化学气体发生单元，激活和控制电路。电化学或化学电池在壳体内产生气体，迫使移位构件抵抗容纳在壳体内的有益剂，并以有利的作用力通过出口端口以预定的速率进入动物体腔。锚固机构可以与壳体相关联，用于将壳体固定在被处理动物的体腔内。还公开了使用本发明的递送装置将有益药物递送到动物体腔中的方法。

16. 发明申请

US20130026194A1 GAS GENERATION DISPENSER APPARATUS FOR ON-DEMAND FLUID DELIVERY 审中-公开
标题翻译：用于需要流体输送的气体发生分配器装置
公开(公告)号：US20130026194A1
公开(公告)日：2013-01-31
申请号：US13323341
申请日：2011-12-12
申请人： Truman Wold , John Howard Gordon , Ashok V. Joshi
发明人： Truman Wold , John Howard Gordon , Ashok V. Joshi
IPC分类号： B65D83/76
CPC分类号： A61M5/14526 , A61L9/12 , A61L2209/132 , A61M5/14244 , A61M11/007 , A61M2005/14204 , A61M2005/14513 , A61M2205/3368 , A61M2205/8206 , A61M2205/8231 , B05B11/025 , B05B11/04 , B05B11/061
摘要： An on-demand fluid dispenser to dispense fluid in response to gas generation by a gas cell. The on-demand fluid dispenser includes an expandable gas chamber, a fluid chamber, and an on-demand gas cell. The expandable gas chamber includes a moveable plunger forming a wall of the expandable gas chamber. The moveable plunger also forms a wall of the fluid chamber. The on-demand gas cell is configured to generate the gas on demand. The on-demand gas cell is also configured to direct the gas to the expandable gas chamber to expand the expandable gas chamber. Expansion of the expandable gas chamber moves the moveable plunger to reduce a volume of the fluid chamber and to dispense an amount of fluid from the fluid chamber.
摘要翻译：一种按需流体分配器，用于响应气体生成气体而分配流体。按需流体分配器包括可膨胀气体室，流体室和按需气体室。可膨胀气体室包括形成可膨胀气体室的壁的活动柱塞。可移动柱塞还形成流体室的壁。按需气体电池被配置成根据需要产生气体。按需气体室还构造成将气体引导到可膨胀气体室以膨胀可膨胀气体室。可膨胀气体室的膨胀使可移动的柱塞移动以减小流体室的体积并从流体室分配一定量的流体。

17. 发明授权

US08240260B2 Apparatus for delivering beneficial liquids at steady rate 有权
标题翻译：用于以稳定的速率输送有益液体的装置
公开(公告)号：US08240260B2
公开(公告)日：2012-08-14
申请号：US13281282
申请日：2011-10-25
申请人： John Howard Gordon , Ashok V. Joshi , Truman Wold , Sai Bhavaraju
发明人： John Howard Gordon , Ashok V. Joshi , Truman Wold , Sai Bhavaraju
IPC分类号： A01C23/02
CPC分类号： A01M1/2044 , A61L9/12 , Y10T137/2931
摘要： An apparatus for delivering a beneficial agent is disclosed in one embodiment of the invention as including a water collection chamber. A water-transporting membrane is provided to communicate with the water collection chamber. An extraction chamber receives water through the water-transporting membrane, expanding the extraction chamber. A dispensing chamber, containing a beneficial agent, is configured to contract upon expanding the extraction chamber. This causes the dispensing chamber to expel the beneficial agent through a subterranean delivery channel, such as a rigid hollow spike. In certain embodiments, a rate adjustment mechanism may control the rate that water is received through the water-transporting membrane, thereby controlling the rate the beneficial agent is expelled. The water-transporting membrane has features that repel osmagent from passing through to the water collection chamber. The apparatus features steady rate performance without refreshing the water chamber and low temperature sensitivity.
摘要翻译：在本发明的一个实施例中公开了一种用于递送有益剂的装置，包括水收集室。提供水输送膜以与收集室连通。提取室通过水输送膜接收水，使提取室膨胀。包含有益剂的分配腔被构造成在膨胀提取室时收缩。这使得分配室通过地下输送通道（例如刚性中空尖峰）排出有益剂。在某些实施例中，速率调节机构可以控制通过水输送膜接收水的速率，从而控制有益剂被排出的速率。水输送膜具有排斥渗透到收集室的特征。该设备具有稳定的速率性能，无需刷新水室和低温灵敏度。

18. 发明申请

US20120037242A1 APPARATUS FOR DELIVERING BENEFICIAL LIQUIDS AT STEADY RATE 有权
标题翻译：以稳定的速度递送受益液体的装置
公开(公告)号：US20120037242A1
公开(公告)日：2012-02-16
申请号：US13281282
申请日：2011-10-25
申请人： John Howard Gordon , Ashok V. Joshi , Truman Wold , Sai Bhavaraju
发明人： John Howard Gordon , Ashok V. Joshi , Truman Wold , Sai Bhavaraju
IPC分类号： B67D7/72
CPC分类号： A01M1/2044 , A61L9/12 , Y10T137/2931
摘要： An apparatus for delivering a beneficial agent is disclosed in one embodiment of the invention as including a water collection chamber. A water-transporting membrane is provided to communicate with the water collection chamber. An extraction chamber receives water through the water-transporting membrane, expanding the extraction chamber. A dispensing chamber, containing a beneficial agent, is configured to contract upon expanding the extraction chamber. This causes the dispensing chamber to expel the beneficial agent through a subterranean delivery channel, such as a rigid hollow spike. In certain embodiments, a rate adjustment mechanism may control the rate that water is received through the water-transporting membrane, thereby controlling the rate the beneficial agent is expelled. The water-transporting membrane has features that repel osmagent from passing through to the water collection chamber. The apparatus features steady rate performance without refreshing the water chamber and low temperature sensitivity.
摘要翻译：在本发明的一个实施例中公开了一种用于递送有益剂的装置，包括水收集室。提供水输送膜以与收集室连通。提取室通过水输送膜接收水，使提取室膨胀。包含有益剂的分配腔被构造成在膨胀提取室时收缩。这使得分配室通过地下输送通道（例如刚性中空尖峰）排出有益剂。在某些实施例中，速率调节机构可以控制通过水输送膜接收水的速率，从而控制有益剂被排出的速率。水输送膜具有排斥渗透到收集室的特征。该设备具有稳定的速率性能，无需刷新水室和低温灵敏度。

19. 发明申请

US20110303760A1 APPARATUS AND METHOD FOR CONTROLLABLY RELEASING A SUBSTANCE 审中-公开
标题翻译：控制释放物质的装置和方法
公开(公告)号：US20110303760A1
公开(公告)日：2011-12-15
申请号：US12950053
申请日：2010-11-19
申请人： Ashok Joshi , Truman Wold , David Erekson , John Howard Gordon
发明人： Ashok Joshi , Truman Wold , David Erekson , John Howard Gordon
IPC分类号： A61L9/04
CPC分类号： A61L9/127 , A61L2209/131 , A61L2209/132
摘要： An apparatus for controllably releasing a substance is disclosed herein. In one embodiment, such an apparatus includes a chamber to store a non-gaseous fluid. An outlet communicates with a bottom of the chamber to dispense the non-gaseous fluid. An inlet communicates with a top of the chamber to enable gas to flow into the chamber. To regulate the flow of non-gaseous fluid through the outlet, a regulator element is coupled to the inlet to regulate the flow of gas into the chamber. In certain embodiments, to provide more consistent release rates, the chamber includes a short wide portion situated above a relatively long narrow portion. Such a configuration generates more consistent head pressure and thus more consistent release rates for the non-gaseous fluid. A corresponding method is also disclosed herein.
摘要翻译：本文公开了可控释放物质的装置。在一个实施例中，这种装置包括用于存储非气态流体的室。出口与室的底部连通以分配非气态流体。入口与室的顶部连通，以使气体能够流入腔室。为了调节通过出口的非气态流体的流动，调节器元件联接到入口以调节进入室的气体流。在某些实施例中，为了提供更一致的释放速率，腔室包括位于相对长的狭窄部分上方的短宽度部分。这种配置产生更一致的头部压力，从而产生非气态流体的更一致的释放速率。本文还公开了相应的方法。

20. 发明申请

US20100022993A1 APPARATUS AND METHOD FOR DELIVERING BENEFICIAL LIQUIDS AT STEADY RATE 有权
标题翻译：用于以稳定速率递送受益液体的装置和方法
公开(公告)号：US20100022993A1
公开(公告)日：2010-01-28
申请号：US12550050
申请日：2009-08-28
申请人： John Howard Gordon , Ashok V. Joshi , Truman Wold , Sai Bhavaraju
发明人： John Howard Gordon , Ashok V. Joshi , Truman Wold , Sai Bhavaraju
IPC分类号： A61M5/142
CPC分类号： A01M1/2044 , A61L9/12 , Y10T137/2931
摘要： An apparatus for delivering a beneficial agent is disclosed in one embodiment of the invention as including a water collection chamber. A water-transporting membrane is provided to communicate with the water collection chamber. An extraction chamber receives water through the water-transporting membrane, expanding the extraction chamber. A dispensing chamber, containing a beneficial agent, is configured to contract upon expanding the extraction chamber. This causes the dispensing chamber to expel the beneficial agent through a subterranean delivery channel, such as a rigid hollow spike. In certain embodiments, a rate adjustment mechanism may control the rate that water is received through the water-transporting membrane, thereby controlling the rate the beneficial agent is expelled. The water-transporting membrane has features that repel osmagent from passing through to the water collection chamber. The apparatus features steady rate performance without refreshing the water chamber and low temperature sensitivity.
摘要翻译：在本发明的一个实施例中公开了一种用于递送有益剂的装置，包括水收集室。提供水输送膜以与收集室连通。提取室通过水输送膜接收水，使提取室膨胀。包含有益剂的分配腔被构造成在膨胀提取室时收缩。这使得分配室通过地下输送通道（例如刚性中空尖峰）排出有益剂。在某些实施例中，速率调节机构可以控制通过水输送膜接收水的速率，从而控制有益剂被排出的速率。水输送膜具有排斥渗透到收集室的特征。该设备具有稳定的速率性能，无需刷新水室和低温灵敏度。

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