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11. 发明授权

US06196306B1 Lamination type heat exchanger with pipe joint 有权
标题翻译：带管接头的层压式换热器
公开(公告)号：US06196306B1
公开(公告)日：2001-03-06
申请号：US09277320
申请日：1999-03-26
申请人： Yasukazu Aikawa , Tomohiko Nakamura
发明人： Yasukazu Aikawa , Tomohiko Nakamura
IPC分类号： F28F904
CPC分类号： F28F9/0246 , F28D1/0333 , F28D2021/0085 , F28F9/0253
摘要： A side refrigerant outlet passage and a side refrigerant inlet passage are provided between first and second protruding portions of a side plate and an end plate, which are joined to one another. The side plate has base portions protruding in an opposite direction of the end plate, and a pipe joint including an outlet pipe and an inlet pipe is joined to the base portions of the side plate. Accordingly, a strength of joining portions between the side pate and the pipe joint is improved, and simultaneously processing cost of the pipe joint is decreased.
摘要翻译：侧制冷剂出口通道和侧制冷剂入口通道设置在彼此接合的侧板和端板的第一和第二突出部分之间。侧板具有沿着端板的相反方向突出的基部，并且包括出口管和入口管的管接头连接到侧板的基部。因此，侧板和管接头之间的接合部分的强度提高，同时管接头的加工成本降低。

12. 发明授权

US09498737B2 Method of purifying nucleic acids, method of extracting nucleic acids and kit for purifying nucleic acids 有权
标题翻译：纯化核酸的方法，提取核酸的方法和用于纯化核酸的试剂盒
公开(公告)号：US09498737B2
公开(公告)日：2016-11-22
申请号：US14239340
申请日：2012-08-28
申请人： Tomohiko Nakamura , Naohisa Sakamoto , Tasuku Yotoriyama , Kazumine Ito
发明人： Tomohiko Nakamura , Naohisa Sakamoto , Tasuku Yotoriyama , Kazumine Ito
IPC分类号： B01D15/36 , B01J39/04 , B01J41/04 , C12Q1/68 , C12N15/09 , G01N30/88 , C12N15/10 , G01N30/96
CPC分类号： C12N15/101 , B01D15/34 , B01D15/362 , B01D15/363 , B01J39/04 , B01J41/04 , C12N15/09 , C12Q1/68 , C12Q1/6806 , G01N30/88 , G01N30/96 , G01N2030/8827 , C12Q2523/308 , B01J39/043 , B01J41/043 , B01J39/05 , B01J41/05
摘要： [Object] To provide a method of purifying nucleic acids where the operation is simple and the nucleic acids can be extracted in a short time with high efficiency.[Solving Means] A method of purifying nucleic acids including the step of adsorbing substances in a sample containing nucleic acids with an ion exchange resin 10 including a positive ion exchange resin and a negative ion exchange resin. As the positive ion exchange resin, a first positive ion exchange resin and a second positive ion exchange resin having an exclusion limit molecular weight lower than that of the first positive ion exchange resin may be used.
摘要翻译： [解决方案]一种纯化核酸的方法，包括使用含有正离子交换树脂和负离子交换树脂的离子交换树脂10将含有核酸的样品中的物质吸附的步骤。作为正离子交换树脂，可以使用排阻极限分子量低于第一正离子交换树脂的第一正离子交换树脂和第二正离子交换树脂。

13. 发明授权

US08806889B2 Ejector type refrigerating cycle unit 有权
标题翻译：喷射式制冷循环装置
公开(公告)号：US08806889B2
公开(公告)日：2014-08-19
申请号：US12806593
申请日：2010-08-16
申请人： Aun Ota , Tomohiko Nakamura , Hideaki Sato
发明人： Aun Ota , Tomohiko Nakamura , Hideaki Sato
IPC分类号： F25B39/02 , F28D1/03 , F25B41/00 , F28D21/00
CPC分类号： F25B41/00 , F25B39/022 , F25B2341/0011 , F25B2500/18 , F28D1/0333 , F28D2021/0085
摘要： A refrigerating cycle unit includes an ejector and a heat exchanger defined by layering a plurality of plates. Each of the plates has a refrigerant passage, and the refrigerant passages are connected by a header tank in a layering direction of the plates. At least two of the plates are fix plates having a fix portion to fix the ejector, and a communication portion through which the ejector and the header tank communicate with each other. The ejector is arranged between the fix portions of the fix plates in the layering direction, so as to be integrated with the heat exchanger.
摘要翻译：制冷循环单元包括喷射器和通过分层多个板所限定的热交换器。每个板具有制冷剂通道，并且制冷剂通道通过集水箱在板的分层方向上连接。至少两个板是具有用于固定喷射器的固定部分的固定板，以及喷射器和集水箱通过其彼此连通的连通部。喷射器在层叠方向上配置在固定板的固定部之间，与热交换器一体化。

14. 发明授权

US08661845B2 Heat exchanger 有权
标题翻译：热交换器
公开(公告)号：US08661845B2
公开(公告)日：2014-03-04
申请号：US12455320
申请日：2009-06-01
申请人： Thuya Aung , Nobuharu Kakehashi , Tomohiko Nakamura , Hideaki Sato
发明人： Thuya Aung , Nobuharu Kakehashi , Tomohiko Nakamura , Hideaki Sato
IPC分类号： F25B1/06 , F25B39/02 , F25B1/00 , B29C47/88 , F24F3/04 , F28F7/00 , F28F9/02 , B05B1/14 , F16L41/00
CPC分类号： F25B39/02 , B60H2001/3298 , F28F9/0273 , F28F9/028 , Y10T137/85938
摘要： A heat exchanger includes a heat exchanging section for performing heat exchange between a refrigerant and a cooling medium and a passage section. The passage section includes a first passage and a second passage for supplying the refrigerant to the heat exchanging section and a supply passage for supplying the refrigerant to the first passage and the second passage. The first passage and the second passage define a first opening portion and a second opening portion opening at an end of the supply passage. A minimum distance between an opening edge of the first opening portion and an inner surface of the supply passage is equal to a minimum distance between an opening edge of the second opening portion and the inner surface of the supply passage.
摘要翻译：热交换器包括用于在制冷剂和冷却介质之间进行热交换的热交换部分和通道部分。通道部分包括用于将制冷剂供应到热交换部分的第一通道和第二通道以及用于向第一通道和第二通道供应制冷剂的供应通道。第一通道和第二通道限定在供应通道的端部处的第一开口部分和第二开口部分。第一开口部分的开口边缘和供给通道的内表面之间的最小距离等于第二开口部分的开口边缘和供给通道的内表面之间的最小距离。

15. 发明申请

US20140027282A1 METHOD OF ELECTROPHORESING NUCLEIC ACIDS, METHOD OF CONCENTRATING AND PURIFYING NUCLEIC ACIDS, CARTRIDGE FOR NUCLEIC ACID ELECTROPHORESIS, AND METHOD OF PRODUCING CARTRIDGE FOR NUCLEIC ACID ELECTROPHORESIS 审中-公开
标题翻译：电解核酸的方法，浓缩和纯化核酸的方法，用于核酸电泳的盒子，以及生产用于核酸电泳的盒的方法
公开(公告)号：US20140027282A1
公开(公告)日：2014-01-30
申请号：US14110375
申请日：2012-03-28
申请人： Tomohiko Nakamura
发明人： Tomohiko Nakamura
IPC分类号： C12N15/10
CPC分类号： C12N15/101 , C12Q1/6806 , G01N27/44791 , C12Q2563/173 , C12Q2565/125
摘要： [Object] To provide a method for electrophoresing nucleic acids, which enables highly efficiently concentrating and purifying nucleic acids quickly by simple operation.[Solving Means] A method of electrophoresis includes electrophoresing a nucleic acid in which an intercalator having an anionic functional group has been inserted. The method includes mixing a sample containing a nucleic acid, a compound having a functional group which undergoes dehydration condensation reaction with carboxyl groups included in substances contained in the sample and a condensing agent of dehydration condensation reaction; and electrophoresing the nucleic acid. The method of concentrating and recovering nucleic acids, by increasing the negative charge of the nucleic acid bound with the intercalator, can increase electrophoretic velocity of nucleic acids. The method of electrophoresing nucleic acids, by subjecting carboxyl groups in the substances in the sample to dehydration condensation reaction, can stably separate nucleic acids and substances by electrophoresis.
摘要翻译：提供一种电泳核酸的方法，其能够通过简单的操作快速浓缩和纯化核酸。 [解决方法]电泳方法包括电泳其中插入了具有阴离子官能团的嵌入剂的核酸。该方法包括将含有核酸的样品，具有脱水缩合反应的官能团的化合物与包含在样品中的物质中的羧基和脱水缩合反应的缩合剂混合; 并对核酸进行电泳。通过增加与嵌入剂结合的核酸的负电荷来浓缩和回收核酸的方法可以增加核酸的电泳速度。通过将样品中的物质中的羧基进行脱水缩合反应来核酸的电泳方法可以通过电泳来稳定地分离核酸和物质。

16. 发明申请

US20120295257A1 METHOD, MICROCHIP AND MIXED REAGENT FOR ANALYSIS OF NUCLEIC ACID BASE SEQUENCE 审中-公开
标题翻译：核酸碱基序列分析方法，微波和混合试剂
公开(公告)号：US20120295257A1
公开(公告)日：2012-11-22
申请号：US13468224
申请日：2012-05-10
申请人： Tomohiko Nakamura , Yuji Segawa , Hidetoshi Watanabe , Takanori Anaguchi
发明人： Tomohiko Nakamura , Yuji Segawa , Hidetoshi Watanabe , Takanori Anaguchi
IPC分类号： G01N25/04 , C12M1/34
CPC分类号： C12Q1/6827 , C12Q2527/107
摘要： A technology is provided for achieving high efficiency of nucleic acid amplification reaction and high precision of melting curve analysis when performing melting curve analysis in a nucleic acid amplification process of obtaining an amplification product in which the target nucleic acids are continuously arranged via a loop. A method for analysis of nucleic acid base sequence is provided, and includes: performing amplification reaction of target nucleic acid which is targeted for amplification, in presence of a probe nucleic acid that is capable of hybridizing with the target nucleic acid, to obtain an amplification product in which the target nucleic acids are continuously arranged via a loop site and employing as the probe nucleic acid, a probe nucleic acid having a melting temperature which is lower than the reaction temperature of the amplification reaction; and performing melting curve analysis of the amplification product and the probe nucleic acid.
摘要翻译：在获得扩增产物的核酸扩增过程中进行解链曲线分析时，提供核酸扩增反应的高效率和解链曲线分析的高精度的技术，其中靶核酸通过环路连续排列。提供了一种分析核酸碱基序列的方法，包括：在能够与靶核酸杂交的探针核酸的存在下，进行靶向扩增的靶核酸的扩增反应，得到扩增其中靶核酸通过环状位点连续排列并使用探针核酸的产物，具有低于扩增反应的反应温度的熔解温度的探针核酸; 并进行扩增产物和探针核酸的熔解曲线分析。

17. 发明申请

US20120070841A1 NUCLEIC ACID QUANTIFICATION METHOD AND MICROCHIP FOR NUCLEIC ACID AMPLIFICATION REACTION 失效
标题翻译：核酸扩增反应的核酸定量方法和微波
公开(公告)号：US20120070841A1
公开(公告)日：2012-03-22
申请号：US13231179
申请日：2011-09-13
申请人： Tomoteru Abe , Yuji Segawa , Junji Kajihara , Tomohiko Nakamura , Masaki Sato
发明人： Tomoteru Abe , Yuji Segawa , Junji Kajihara , Tomohiko Nakamura , Masaki Sato
IPC分类号： C12Q1/68 , C12M1/40
CPC分类号： B01L3/5027 , B01L7/52 , B01L2200/0694 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2300/0883
摘要： A nucleic acid quantification method that uses a microchip for nucleic acid amplification reaction, the microchip including an inlet through which a liquid is introduced from outside, a plurality of reaction regions provided as reaction sites of a nucleic acid amplification reaction, and a channel through which the liquid introduced through the inlet is supplied into each of the reaction regions, wherein the likelihood of the nucleic acid amplification reaction varies between the reaction regions, includes: flowing a detection target nucleic acid chain-containing solution through the channel and introducing the solution into each of the reaction regions to perform a nucleic acid amplification reaction; and detecting an amplification product in each of the reaction regions to specify the reaction regions in which the nucleic acid amplification reaction occurred.
摘要翻译：一种使用微芯片进行核酸扩增反应的核酸定量方法，所述微芯片包括从外部引入液体的入口，作为核酸扩增反应的反应位点提供的多个反应区域，通过入口引入的液体被供应到每个反应区域中，其中核酸扩增反应在反应区域之间变化的可能性包括：使含有检测目标的含有核酸链的溶液流过该通道并将溶液引入每个反应区进行核酸扩增反应; 并检测每个反应区域中的扩增产物，以指定发生核酸扩增反应的反应区域。

18. 发明申请

US20120006682A1 NUCLEIC ACID CONCENTRATION RECOVERY CARTRIDGE, NUCLEIC ACID CONCENTRATION RECOVERY METHOD, AND FABRICATION PROCESS OF CARTRIDGE 审中-公开
标题翻译：核酸浓度恢复盒，核酸浓度恢复方法及其制备方法
公开(公告)号：US20120006682A1
公开(公告)日：2012-01-12
申请号：US13173192
申请日：2011-06-30
申请人： Tomohiko Nakamura
发明人： Tomohiko Nakamura
IPC分类号： C25B7/00 , G01N33/559
CPC分类号： B01D57/02 , C12N15/1006 , Y02P20/582
摘要： A nucleic acid concentration recovery cartridge includes a substrate, a channel with which the substrate is provided to permit introduction of a liquid therein, a high molecular gel arranged in the channel at a predetermined position thereof, and a cathode and anode arranged at opposite ends of the channel, respectively.
摘要翻译：核酸浓度恢复盒包括基板，设置基板以允许其中引入液体的通道，布置在通道中的预定位置处的高分子凝胶，以及布置在其中两端的阴极和阳极渠道。

19. 发明申请

US20090107171A1 Evaporator unit 有权
标题翻译：蒸发器单元
公开(公告)号：US20090107171A1
公开(公告)日：2009-04-30
申请号：US12288787
申请日：2008-10-23
申请人： Bradley Brodie , Yoshiaki Takano , Shigeki Ito , Mika Gocho , Haruyuki Nishijima , Tomohiko Nakamura
发明人： Bradley Brodie , Yoshiaki Takano , Shigeki Ito , Mika Gocho , Haruyuki Nishijima , Tomohiko Nakamura
IPC分类号： F25B1/06 , F25B39/02
CPC分类号： F25B41/00 , B60H2001/3298 , F25B39/02 , F25B2341/0011 , F25B2500/01 , F25B2500/18
摘要： In an evaporator unit for a refrigerant cycle device, an evaporator is connected to an ejector to evaporate refrigerant to be drawn into a refrigerant suction port of the ejector or the refrigerant flowing out of the outlet of the ejector. The evaporator includes a plurality of tubes in which the refrigerant flows, and a tank configured to distribute the refrigerant into the tubes or to collect the refrigerant from the tubes. The ejector is located in the tank, and the nozzle portion is brazed to the tank to be fixed into the tank. The tank may be a header tank directly connected to the tubes or may be a separate tank separated from the header tank.
摘要翻译：在用于制冷剂循环装置的蒸发器单元中，蒸发器连接到喷射器以蒸发制冷剂以被吸入喷射器的制冷剂吸入口或从喷射器的出口流出的制冷剂。蒸发器包括制冷剂流过的多个管，以及构造成将制冷剂分配到管中或从管收集制冷剂的箱。喷射器位于罐中，喷嘴部分被钎焊到罐上以固定到罐中。罐可以是直接连接到管的集水箱，或者可以是与集水箱分离的单独的罐。

20. 发明申请

US20070289318A1 Refrigerant cycle device and heat-exchanger integrated unit with temperature sensor for the same 审中-公开
标题翻译：制冷循环装置和热交换器集成单元与温度传感器相同
公开(公告)号：US20070289318A1
公开(公告)日：2007-12-20
申请号：US11810523
申请日：2007-06-06
申请人： Tomohiko Nakamura
发明人： Tomohiko Nakamura
IPC分类号： F25D21/00 , F25B47/00 , F25B1/06
CPC分类号： F25B41/00 , F25B5/00 , F25B47/006 , F25B2341/0011 , F25B2500/18 , F25B2700/21173 , F25D29/005
摘要： A refrigerant cycle device includes an ejector having a nozzle portion for decompressing refrigerant and a refrigerant suction port from which refrigerant is drawn by a high-speed refrigerant stream jetted from the nozzle portion, and a refrigerant branch passage branched from an upstream side of the nozzle portion in a refrigerant flow such that refrigerant flows into the refrigerant suction port through the refrigerant branch passage. Furthermore, a first heat exchanger is disposed to evaporate refrigerant flowing out of the ejector, a second heat exchanger is disposed in the refrigerant branch passage to evaporate refrigerant, and a temperature sensor is located to detect a temperature so as to detect a frost in the second heat exchanger. In addition, a controller performs a frost prevention control for reducing the frost in the second heat exchanger, in accordance with the temperature detected by the temperature sensor.
摘要翻译：制冷剂循环装置包括具有用于减压制冷剂的喷嘴部分的喷射器和从喷嘴部分喷射的高速制冷剂流从制冷剂吸入制冷剂的制冷剂吸入口，以及从喷嘴的上游侧分支的制冷剂分支通路制冷剂流动的部分，使得制冷剂通过制冷剂分支通道流入制冷剂吸入口。此外，设置第一热交换器来蒸发从喷射器流出的制冷剂，在制冷剂分支通道中设置第二热交换器以蒸发制冷剂，并且设置温度传感器以检测温度，以便检测在第二换热器。此外，控制器根据由温度传感器检测到的温度，执行防止第二热交换器中的霜冻的防霜控制。

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