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11. 发明申请

US20140235923A1 DOSE COMPUTATION FOR RADIATION THERAPY USING HETEROGENEITY COMPENSATED SUPERPOSITION 有权
标题翻译：剂量计算使用异源补偿超导辐射治疗
公开(公告)号：US20140235923A1
公开(公告)日：2014-08-21
申请号：US14346949
申请日：2012-10-01
申请人： Todd McNutt , Robert A. Jacques
发明人： Todd McNutt , Robert A. Jacques
IPC分类号： A61N5/10
CPC分类号： A61N5/1031 , A61N5/103 , A61N5/1048 , A61N5/1067 , A61N5/1071 , A61N5/1075 , A61N2005/1032 , G06F19/3481
摘要： A system for radiation therapy includes a radiation planning system. The radiation planning system includes a data processor that is adapted to receive information concerning an intended radiation treatment region of a body, receive a calculated initial energy released per unit mass for a plurality of locations within the body, compute a radiation dose at a plurality of locations within the radiation treatment region based on the calculated initial energy released per unit mass and including radiation dose contributions due to scattering from other locations within the body, and determine radiation therapy parameters for providing radiation treatment to the intended radiation treatment region based on the radiation dose computed at the plurality of locations within the radiation treatment region. Including radiation dose contributions due to scattering from other locations within the body take into account density discontinuities in the body.
摘要翻译：放射治疗系统包括辐射计划系统。辐射计划系统包括数据处理器，其适于接收关于身体的预期辐射治疗区域的信息，接收针对身体内的多个位置的每单位质量释放的计算的初始能量，计算多个位置处的辐射剂量基于计算出的每单位质量释放的初始能量并且包括由于体内其他位置的散射引起的辐射剂量贡献，以及确定放射治疗参数，用于基于辐射向预期辐射治疗区域提供辐射治疗，在辐射治疗区域内的多个位置处计算的剂量。包括由于体内其他位置的散射引起的辐射剂量贡献考虑了身体的密度不连续性。

12. 发明授权

US07708682B2 Method and device for planning a radiation therapy 有权
标题翻译：辐射治疗方法和装置
公开(公告)号：US07708682B2
公开(公告)日：2010-05-04
申请号：US10573730
申请日：2004-09-10
申请人： Vladimir Pekar , Michael R. Kaus , Todd McNutt
发明人： Vladimir Pekar , Michael R. Kaus , Todd McNutt
IPC分类号： A61N5/00
CPC分类号： A61N5/103 , A61N5/1049 , A61N5/1065 , A61N2005/1055 , A61N2005/1061 , G06F19/00 , G06F19/3481
摘要： A method and apparatus for planning a radiation therapy are disclosed. A radiation dose distribution is adapted on the basis of shape and position variations of the organs of interest determined from a comparison of a first image and a second image which were taken at different points of time during the radiation treatment process.
摘要翻译：公开了一种用于规划放射治疗的方法和装置。基于在放射治疗过程中从不同时间点拍摄的第一图像和第二图像的比较确定的感兴趣器官的形状和位置变化来调整辐射剂量分布。

13. 发明授权

US07596207B2 Method of accounting for tumor motion in radiotherapy treatment 有权
标题翻译：放射治疗肿瘤移动计算方法
公开(公告)号：US07596207B2
公开(公告)日：2009-09-29
申请号：US11995337
申请日：2006-07-10
申请人： Michael Kaus , Vladimir Pekar , Todd Mcnutt
发明人： Michael Kaus , Vladimir Pekar , Todd Mcnutt
IPC分类号： A61N5/10 , G01N23/04
CPC分类号： A61N5/103 , A61N5/1037 , A61N5/1038 , A61N5/1065 , A61N2005/1061
摘要： A method and apparatus accounting for tumor motion during radiation therapy is provided. The method allows for radiation therapy treatments based on updated radiation therapy plans. For each fractionate radiation treatment that results in an updated radiation treatment, radiation treatment images are acquired, automatically segmented, and then subject to deformable registration to develop updated contours and an updated radiation therapy plan.
摘要翻译：提供了放射治疗期间肿瘤移动的方法和装置。该方法允许基于更新的放射治疗计划的放射治疗治疗。对于导致更新的辐射治疗的每个分级放射治疗，获取放射治疗图像，自动分割，然后进行变形注册以开发更新的轮廓和更新的放射治疗计划。

14. 发明申请

US20070211939A1 REGION-COMPETITIVE DEFORMABLE MESH ADAPTATION 有权
标题翻译：区域竞争性可变网适应
公开(公告)号：US20070211939A1
公开(公告)日：2007-09-13
申请号：US11573290
申请日：2005-07-28
申请人： Michael Kaus , Todd McNutt , Vladimir Pekar , Matthias Meyer
发明人： Michael Kaus , Todd McNutt , Vladimir Pekar , Matthias Meyer
IPC分类号： G06K9/34
CPC分类号： G06T7/0083 , A61B6/00 , G06K9/6209 , G06T7/11 , G06T7/12 , G06T7/149 , G06T17/20 , G06T17/205 , G06T2207/10081 , G06T2207/20116 , G06T2207/30008 , G06T2207/30028
摘要： An image segmentation method segments a plurality of image features in an image. The plurality of image features are segmented non-simultaneously in succession. The segmenting of each image feature includes adapting an initial mesh to boundaries of the image feature. The segmenting of each image feature further includes preventing the adapted mesh from overlapping any previously adapted mesh.
摘要翻译：图像分割方法分割图像中的多个图像特征。多个图像特征被连续非同时分割。每个图像特征的分割包括使初始网格适应图像特征的边界。每个图像特征的分割还包括防止适配的网格与任何先前适应的网格重叠。

15. 发明授权

US07536041B2 3D image segmentation 失效
标题翻译： 3D图像分割
公开(公告)号：US07536041B2
公开(公告)日：2009-05-19
申请号：US10560185
申请日：2004-06-09
申请人： Vladimir Pekar , Michael Reinhold Kaus , Todd McNutt
发明人： Vladimir Pekar , Michael Reinhold Kaus , Todd McNutt
IPC分类号： G06K9/00 , G06K9/34
CPC分类号： G06T17/20 , G06T7/12 , G06T7/149 , G06T2207/10081 , G06T2207/20092 , G06T2207/30004
摘要： A delineation of a structure of interest can be performed by fitting 3D deformable models, for example, represented by polygonal measures, to the boundaries of the structure of interest. The deformable model fitting process is guided by minimization of the sum of an external energy, based on image feature information, which attracts the mesh to the organ boundaries and an internal energy, which preserves the consistent shape of the mesh. A frequent problem is that the images do not contain sufficient reliable image feature information, such as image gradients, to attract the mesh. According to the present invention, manually drawn attractors in the form of complete or partial contours corresponding to boundaries of the structure of interest are placed into the images which do not contain sufficient feature information. These attractors may easily be discriminated by a subsequent segmentation process. Due to this, advantageously, a 3D deformable model can be fitted to structures of interest in images with poor contrast, noise or image artifacts.
摘要翻译：可以通过将例如由多边形度量表示的3D可变形模型拟合到感兴趣的结构的边界来执行感兴趣的结构的描绘。可变形模型拟合过程是基于图像特征信息的最小化引导的，该图像特征信息将网格吸引到器官边界和内部能量，这保留了网格的一致形状。一个常见的问题是，图像不包含足够可靠的图像特征信息，如图像梯度，以吸引网格。根据本发明，将对应于感兴趣结构的边界的完整或部分轮廓形式的手动吸引器放置在不包含足够的特征信息的图像中。这些吸引子可以容易地被随后的分割过程区分开。因此，有利地，可以将3D可变形模型拟合到具有差的对比度，噪声或图像伪像的图像中的感兴趣的结构。

16. 发明申请

US20090046831A1 BENCH-TOP IMAGE-GUIDED CONFORMAL IRRADIATION SYSTEM FOR LABORATORY ANIMALS 审中-公开
标题翻译：用于实验动物的BENCH-TOP图像导向一致辐射系统
公开(公告)号：US20090046831A1
公开(公告)日：2009-02-19
申请号：US12281944
申请日：2007-03-12
申请人： John Wai-chiu Wong , Todd McNutt , Elwood P. Armour , Eric Cassel Ford
发明人： John Wai-chiu Wong , Todd McNutt , Elwood P. Armour , Eric Cassel Ford
IPC分类号： A61B6/00
CPC分类号： G01T1/2985 , A61B6/035 , A61B6/04 , A61B6/0457 , A61B6/4233 , A61B6/4441 , A61B6/4476 , A61B6/508 , A61B2503/40 , A61N5/1049 , A61N2005/1061 , A61N2005/1091
摘要： An image-guided irradiation system has a support stage, a stage-positioning assembly connected to the support stage, an x-ray source attached to a support arm in which the support arm is movable relative to the support stage, a flat-panel x-ray detector disposed proximate the support stage, and at least one of a collimator or an x-ray lens selectively disposable between the x-ray source and the support stage. The x-ray source is suitable to provide an imaging beam of X-rays at a first photon energy and is suitable to provide an irradiation beam of X-rays at a second photon energy. The collimator or x-ray lens is structured and arranged to define at least a width of the irradiation beam when it is disposed between the x-ray source and the support stage while the x-ray source is in operation.
摘要翻译：图像引导照射系统具有支撑台，连接到支撑台的平台定位组件，附接到支撑臂的X射线源，支撑臂可相对于支撑台移动到支撑台中，平板x 设置在支撑台附近的射线检测器以及可选地一次性地在x射线源和支撑台之间的准直器或x射线透镜中的至少一个。 x射线源适合于以第一光子能量提供X射线的成像束，并且适于在第二光子能量处提供X射线的照射束。准直器或X射线透镜被构造和布置成当X射线源在操作中时被放置在x射线源和支撑台之间时限定照射束的至少一个宽度。

17. 发明申请

US20080267351A1 Radio-Therapeutic Treatment Planning Incorporating Functional Imaging Information 有权
标题翻译：放射治疗计划纳入功能成像信息
公开(公告)号：US20080267351A1
公开(公告)日：2008-10-30
申请号：US11914765
申请日：2006-05-01
申请人： Lothar Spies , Matthieu Bal , Todd McNutt
发明人： Lothar Spies , Matthieu Bal , Todd McNutt
IPC分类号： A61N5/10 , H05G1/42
CPC分类号： A61N5/103 , A61B6/03 , A61N5/1039 , A61N5/1042
摘要： A radiation therapy planning procedure and device provides a model-based segmentation of co-registered anatomical and functional imaging information to provide a more precise radiation therapy plan. The biology-based segmentation models the imaging information to produce a parametric map, which is then clustered into regions of similar radiation sensitivity or other biological parameters relevant for treatment definition. Each clustered region is prescribed its own radiation prescription dose.
摘要翻译：辐射治疗计划程序和装置提供共同注册的解剖和功能成像信息的基于模型的分割，以提供更精确的放射治疗计划。基于生物学的分割模拟成像信息以产生参数图，然后将其聚类到具有相似辐射敏感性的区域或与治疗定义相关的其他生物参数。每个聚簇区域规定自己的辐射处方剂量。

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