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11. 发明授权

US08551164B2 Refractive intraocular implant lens and method 有权
$Refractive intraocular implant lens and method$
标题翻译：折射眼内植入物镜片及方法
公开(公告)号：US08551164B2
公开(公告)日：2013-10-08
申请号：US12841632
申请日：2010-07-22
申请人： Timothy R. Willis , Lyle E. Paul , Joseph Collin
发明人： Timothy R. Willis , Lyle E. Paul , Joseph Collin
IPC分类号： A61F2/16
CPC分类号： A61F2/1602 , A61F2/1608 , A61F2002/1681 , A61F2220/0008
摘要： A refractive intraocular lens (104) and method of locating the lens within the eye and attaching the lens to the iris. The refractive intraocular lens (104) may be attached via a staple (230), a fastener (312), anchor (412) or by the tip of the haptic (118). The intraocular lens (104) works in combination with the human crystalline lens to treat conditions selected from the group consisting of myopia, hyperopia and astigmatism.
摘要翻译：折射眼内透镜（104）以及将透镜定位在眼睛内并将透镜附接到虹膜的方法。屈光眼内透镜（104）可以经由钉（230），紧固件（312），锚固件（412）或由触觉件（118）的尖端附接。眼内透镜（104）与人体晶状体组合起作用以治疗选自近视，远视和散光的病症。

12. 发明申请

US20110029075A1 REFRACTIVE INTRAOCULAR IMPLANT LENS AND METHOD 审中-公开
标题翻译：折射性内植入物镜片和方法
公开(公告)号：US20110029075A1
公开(公告)日：2011-02-03
申请号：US12900931
申请日：2010-10-08
申请人： Timothy R. Willis , Lyle E. Paul , Joseph Collin
发明人： Timothy R. Willis , Lyle E. Paul , Joseph Collin
IPC分类号： A61F2/16
CPC分类号： A61F2/1602 , A61F2/1608 , A61F2002/1681 , A61F2220/0008
摘要： A refractive intraocular lens (104) and method of locating the lens within the eye and attaching the lens to the iris. The refractive intraocular lens (104) may be attached via a staple (230), a fastener (312), anchor (412) or by the tip of the haptic (118). The intraocular lens (104) works in combination with the human crystalline lens to treat conditions selected from the group consisting of myopia, hyperopia and astigmatism.
摘要翻译：折射眼内透镜（104）以及将透镜定位在眼睛内并将透镜附接到虹膜的方法。屈光眼内透镜（104）可以经由钉（230），紧固件（312），锚固件（412）或由触觉件（118）的尖端附接。眼内透镜（104）与人体晶状体组合起作用以治疗选自近视，远视和散光的病症。

13. 发明申请

US20090043365A1 METHODS, APPARATUSES, AND SYSTEMS FOR REDUCING INTRAOCULAR PRESSURE AS A MEANS OF PREVENTING OR TREATING OPEN-ANGLE GLAUCOMA 审中-公开
标题翻译：用于减少眼压的方法，装置和系统作为预防或治疗开放性角膜炎的手段
公开(公告)号：US20090043365A1
公开(公告)日：2009-02-12
申请号：US12246071
申请日：2008-10-06
申请人： Beth Friedland , Donald R. Korb , Steve Grenon , John Jans , Keith Gausmann , Timothy R. Willis
发明人： Beth Friedland , Donald R. Korb , Steve Grenon , John Jans , Keith Gausmann , Timothy R. Willis
IPC分类号： A61F7/00
CPC分类号： A61B18/04 , A61B18/10 , A61B2018/00642 , A61B2018/00791 , A61B2018/046 , A61B2018/048 , A61F9/00781 , A61F2007/0004 , A61F2007/0059 , A61F2007/0071 , A61H1/008 , A61N7/00
摘要： Embodiments include methods, apparatuses, and systems for reducing elevated intraocular pressure (IOP) in a patient to either prevent or treat open-angle glaucoma. Heat is applied to the trabecular meshwork in the patient's eye without damaging proteins in the trabecular meshwork. The application of heat to the trabecular meshwork has the effect of relaxing or loosening protein clogs or other inhibitors in the trabecular meshwork, which are either reducing or obstructing of the outflow of aqueous humor, thereby increasing the patient's IOP and causing ocular hypertension (OHT). By loosening or relaxing clogs or other inhibitors in the trabecular meshwork, the outflow path for aqueous humor is increased or restored, which can lower IOP and either prevent or treat glaucoma. Force may also be applied to the patient's eye to apply pressure to the trabecular meshwork to further assist in the loosening or relaxing of clogs or other inhibitors in the trabecular meshwork.
摘要翻译：实施方案包括用于降低患者眼内压升高（IOP）以预防或治疗开角型青光眼的方法，装置和系统。热量被施加到患者眼睛中的小梁网，而不损伤小梁网中的蛋白质。对小梁网应用热量具有放松或松动小梁网中的蛋白质堵塞物或其他抑制剂的作用，其减少或阻碍房水流出，从而增加患者的眼压并引起眼高压（OHT）。通过在小梁网中松动或松弛堵塞物或其他抑制剂，房水的流出路径增加或恢复，这可以降低IOP并预防或治疗青光眼。力也可以应用于患者的眼睛，以向小梁网施加压力，以进一步协助松动或松弛小梁网中的堵塞物或其它抑制剂。

14. 发明申请

US20080132978A1 OUTER EYELID HEAT AND PRESSURE TREATMENT FOR TREATING MEIBOMIAN GLAND DYSFUNCTION 有权
标题翻译：用于治疗脑血管功能障碍的外眼热治疗
公开(公告)号：US20080132978A1
公开(公告)日：2008-06-05
申请号：US12015576
申请日：2008-01-17
申请人： Donald R. Korb , Stephen M. Grenon , Timothy R. Willis , Benjamin Tyson Gravely
发明人： Donald R. Korb , Stephen M. Grenon , Timothy R. Willis , Benjamin Tyson Gravely
IPC分类号： A61B18/02 , A61K31/65 , A61K38/18 , A61K38/43
CPC分类号： A61F7/12 , A61B18/12 , A61B2017/00084 , A61B2018/046 , A61B2018/048 , A61F7/007 , A61F9/00718 , A61F2007/0004 , A61F2007/0059 , A61H7/00 , A61H2015/0014 , A61K31/65 , A61K38/1841 , A61N7/00
摘要： A method of treating meibomian gland dysfunction. Heat is applied to the outside of the eyelid to provide conductive heat transfer to the meibomian glands. The application of heat assists in the expression of obstructions or occlusions in the meibomian glands to restore sufficient sebum flow to the lipid layer to treat dry eye. A force may also be applied to the outside of the patient's eyelid to improve conductive heat transfer and reduce blood flow in the eyelid that causes convective heat loss. Thus, the application of force can further increase the temperature level and/or reduce the time to reach desired temperature levels for removing obstructions or occlusions. Reaching increased temperature levels may improve the melting, loosening, or softening of obstructions or occlusions in the meibomian glands while reducing the amount of time to reach desired temperature levels and/or aid in reducing discomfort to the patient during treatment.
摘要翻译：治疗睑板腺功能障碍的方法。将热量施加到眼睑的外侧，以向睑板腺提供导电热传递。热的应用有助于睑板腺中阻塞或闭塞的表达，以恢复足够的脂质流向脂质层以治疗干眼症。也可以将力施加到患者眼睑的外侧，以改善导电传热并减少引起对流热损失的眼睑中的血流。因此，施加力可以进一步增加温度水平和/或减少达到期望温度水平以消除障碍物或闭塞的时间。达到增加的温度水平可以改善睑板腺中的阻塞物或闭塞的熔化，松动或软化，同时减少达到期望温度水平的时间量和/或有助于减轻治疗期间对患者的不适。

15. 发明授权

US5152789A Fixation member for an intraocular lens 失效
标题翻译：眼内透镜固定件
公开(公告)号：US5152789A
公开(公告)日：1992-10-06
申请号：US699496
申请日：1991-05-14
申请人： Timothy R. Willis
发明人： Timothy R. Willis
IPC分类号： A61F2/16
CPC分类号： A61F2/16 , A61F2002/1683
摘要： An intraocular lens comprising a deformable optic and a fixation member for use in supporting the optic in the eye. The fixation member includes an annulus surrounding the optic and a plurality of resilient struts interconnecting the optic with the annulus. The struts tend to be compressively loaded by the posterior capsule of the eye after implantation. To prevent buckling of the resilient struts in an axial direction due to the imposed compressive loads, the struts are curved in a circumferential direction when in an unloaded state, thereby being predisposed to further bow in the same circumferential direction upon imposition of the compressive load. This predisposition to bow circumferentially avoids severe problems incurred if the struts are permitted to buckle axially, such as tilting of the optic and impaired vision for the patient.
摘要翻译：一种眼内透镜，包括可变形光学元件和用于支撑眼睛中的光学元件的固定构件。固定构件包括围绕光学元件的环形空间和将光学元件与环形空间相互连接的多个弹性支柱。支架倾向于在植入后被眼后囊压缩加载。为了防止由于施加的压缩载荷而导致的弹性支柱在轴向上的弯曲，当处于无负载状态时，支柱在圆周方向上弯曲，从而在施加压缩载荷时倾向于在相同的圆周方向上进一步弯曲。如果允许支柱轴向弯曲，例如镜片的倾斜和患者的视力受损，这种弓形周围的倾向避免了严重的问题。

16. 发明授权

US4880426A Haptic to optic attachment for a soft IOL 失效
标题翻译：触觉为软IOL的光学附件
公开(公告)号：US4880426A
公开(公告)日：1989-11-14
申请号：US228709
申请日：1988-08-04
申请人： Albert C. Ting , Timothy R. Willis , F. Richard Christ , Steven R. Bacich , Dean K. Pettit , Stanley L. Van Gent , Jeffrey C. Day
发明人： Albert C. Ting , Timothy R. Willis , F. Richard Christ , Steven R. Bacich , Dean K. Pettit , Stanley L. Van Gent , Jeffrey C. Day
IPC分类号： A61F2/16
CPC分类号： A61F2/1613 , A61F2/1608
摘要： A method of making an intraocular lens including providing a fixation member having a proximal end portion with the proximal end portion including an elongated filament, converting a region of said filament at said proximal end portion from a first configuration into a second configuration which is adapted to provide a mechanical interlock and molding an optic about the proximal end portion of the fixation member to form a mechanical interlock between the second configuration and the optic and to attach the fixation member to the optic.
摘要翻译：一种制造眼内透镜的方法，包括提供具有近端部分的固定构件，其基端部分包括细长细丝，将所述近端部分处的所述细丝的区域从第一构型转换成适于提供机械互锁并围绕固定构件的近端部分模制光学器件，以在第二构造和光学元件之间形成机械互锁并将固定构件附接到光学元件。

17. 发明授权

US11957702B2 Ophthalmic suspension vehicles and related methods for pharmaceutical ingredient delivery 有权
公开(公告)号：US11957702B2
公开(公告)日：2024-04-16
申请号：US18238721
申请日：2023-08-28
申请人： Timothy R Willis , Ralph P. Stone
发明人： Timothy R Willis , Ralph P. Stone
IPC分类号： A61K31/7076 , A61K9/00 , A61K9/10 , A61K47/02 , A61K47/06 , A61K47/36 , A61K47/44
CPC分类号： A61K31/7076 , A61K9/0048 , A61K9/10 , A61K47/02 , A61K47/06 , A61K47/36 , A61K47/44
摘要： This disclosure is directed to ophthalmic suspension vehicles for delivery of at least one pharmaceutical ingredient to a patient in need of treatment. The disclosure also provides methods of delivering at least one pharmaceutical ingredient to a patient in need of treatment.

18. 发明申请

US20200315778A1 INTRAOCULAR LENSES (IOLs) AND RELATED ASSEMBLIES AND INTRAOCULAR ATTACHMENT METHODS 审中-公开
公开(公告)号：US20200315778A1
公开(公告)日：2020-10-08
申请号：US16905483
申请日：2020-06-18
申请人： Timothy R. Willis
发明人： Timothy R. Willis , Steven Bacich
IPC分类号： A61F2/16 , A61F9/007
摘要： Intraocular lenses and related assemblies and intraocular attachment methods are disclosed herein. In one embodiment, an intraocular lens assembly comprises a helical-shaped coil fastener to affix an intraocular lens to an iris to correct for astigmatism, presbyopia, and/or myopia or hyperopia. The helical-shaped coil fastener comprises a head and a helical wire extending from a bottom surface of the head and comprising a pointed tip opposite the head. The helical-shaped coil fastener is configured to be affixed to the iris by rotatable penetration of the iris, and thus can be removed from the iris by reverse rotation of the helical-shaped coil fastener. The helical-shaped coil fastener has a low volume, large surface area, low cross-sectional area of penetration, and an oblique angle of penetration. Thus, the helical-shaped coil fastener is easy to apply, easy to remove, minimizes tissue damage, maximizes stability, and minimizes penetration force.

19. 发明授权

US08915253B2 Method and apparatus for treating gland dysfunction employing heated medium 有权
标题翻译：使用加热培养基治疗腺体功能障碍的方法和装置
公开(公告)号：US08915253B2
公开(公告)日：2014-12-23
申请号：US11434033
申请日：2006-05-15
申请人： Stephen M. Grenon , Donald R. Korb , Timothy R. Willis , Benjamin T. Gravely
发明人： Stephen M. Grenon , Donald R. Korb , Timothy R. Willis , Benjamin T. Gravely
IPC分类号： A61F7/00 , A61H7/00 , A61F9/007 , A61H15/00 , A61N7/00 , A61B18/04 , A61B18/12
CPC分类号： A61N5/0625 , A61B18/12 , A61B2018/046 , A61B2018/048 , A61F9/00772 , A61F2007/0004 , A61F2007/0059 , A61H7/00 , A61H2015/0014 , A61N1/403 , A61N5/025 , A61N7/00 , A61N2005/0643 , A61N2005/0659 , A61N2005/067
摘要： A method and apparatus for treating gland dysfunction caused by gland obstruction in order to restore the natural flow of secretion from the gland comprises the application of a combination of energy, suction, vibration, heat, aspiration, chemical agents and pharmacological agents to loosen and thereafter remove the obstructive material.
摘要翻译：用于治疗由腺体阻塞引起的腺体功能障碍以便恢复从腺体分泌的天然流动的方法和装置包括施加能量，吸力，振动，热，吸入，化学药剂和药理学物质的组合以松动其后清除阻塞物。

20. 发明授权

US08685073B2 Apparatus for treating meibomian gland dysfunction 有权
标题翻译：用于治疗睑板腺功能障碍的装置
公开(公告)号：US08685073B2
公开(公告)日：2014-04-01
申请号：US13242068
申请日：2011-09-23
申请人： Donald R. Korb , Timothy R. Willis , Benjamin T. Gravely
发明人： Donald R. Korb , Timothy R. Willis , Benjamin T. Gravely
IPC分类号： A61F7/02
CPC分类号： A61N5/0625 , A61B18/12 , A61B2018/046 , A61B2018/048 , A61F9/00772 , A61F2007/0004 , A61F2007/0059 , A61H7/00 , A61H2015/0014 , A61N1/403 , A61N5/025 , A61N7/00 , A61N2005/0643 , A61N2005/0659 , A61N2005/067
摘要： An apparatus for treating meibomian gland dysfunction caused by meibomian gland obstruction in order to restore the natural flow of secretion from the meibomian gland comprises the application of a combination of energy, suction, vibration, heat, aspiration, chemical agents and pharmacological agents to loosen and thereafter remove the obstructive material.
摘要翻译：用于治疗由睑板腺阻塞引起的睑板腺功能障碍以恢复睑板腺分泌物的自然流动的装置包括施加能量，吸力，振动，热，吸入，化学药剂和药物剂的组合以松动和之后除去阻塞物质。

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