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11. 发明授权

US06355459B1 Genes for the biosynthesis of epothilones 失效
公开(公告)号：US06355459B1
公开(公告)日：2002-03-12
申请号：US09568486
申请日：2000-05-10
申请人： Thomas Schupp , James Madison Ligon , Istvan Molnar , Ross Zirkle , Devon Dawn Cyr , Jörn Görlach
发明人： Thomas Schupp , James Madison Ligon , Istvan Molnar , Ross Zirkle , Devon Dawn Cyr , Jörn Görlach
IPC分类号： C12N900
CPC分类号： C07K14/195 , C12P17/181
摘要： Nucleic acid molecules are isolated from Sorangium cellulosum that encode polypeptides necessary for the biosynthesis of epothilone. Disclosed are methods for the production of epothilone in recombinant hosts transformed with the genes of the invention. In this manner, epothilone can be produced in quantities large enough to enable their purification and use in pharmaceutical formulations such as those for the treatment of cancer.

12. 发明授权

US06355458B1 Genes for the biosynthesis of epothilones 失效
标题翻译：埃博霉素生物合成基因
公开(公告)号：US06355458B1
公开(公告)日：2002-03-12
申请号：US09568480
申请日：2000-05-10
申请人： Thomas Schupp , James Madison Ligon , Istvan Molnar , Ross Zirkle , Devon Dawn Cyr , Jörn Görlach
发明人： Thomas Schupp , James Madison Ligon , Istvan Molnar , Ross Zirkle , Devon Dawn Cyr , Jörn Görlach
IPC分类号： C12N900
CPC分类号： C07K14/195 , C12P17/181
摘要： Nucleic acid molecules are isolated from Sorangium cellulosum that encode polypeptides necessary for the biosynthesis of epothilone. Disclosed are methods for the production of epothilone in recombinant hosts transformed with the genes of the invention. In this manner, epothilone can be produced in quantities large enough to enable their purification and use in pharmaceutical formulations such as those for the treatment of cancer.
摘要翻译：核酸分子从编码为埃坡霉素生物合成所必需的多肽的纤维索兰分离。披露了用本发明的基因转化的重组宿主中埃坡霉素生产的方法。以这种方式，埃坡霉素可以以足够大的量生产，以使其能够在诸如用于治疗癌症的药物制剂中进行纯化和使用。

13. 发明授权

US06210935B1 Staurosporin biosynthesis gene clusters 失效
标题翻译：星孢菌素生物合成基因簇
公开(公告)号：US06210935B1
公开(公告)日：2001-04-03
申请号：US09029603
申请日：1998-03-20
申请人： Thomas Schupp , Nathalie Engel , Jürg Bietenhader , Christiane Toupet , Andreas Pospiech
发明人： Thomas Schupp , Nathalie Engel , Jürg Bietenhader , Christiane Toupet , Andreas Pospiech
IPC分类号： C12P1218
CPC分类号： C12N9/1007 , C12N9/1096 , C12N9/92 , C12N15/52
摘要： The present invention relates especially to a DNA fragment that is obtainable from the gene cluster within the genome of Streptomyces or Actinomyces that is responsible for staurosporin biosynthesis and that contains at least one gene or a part of a gene that codes for a polypeptide that is involved directly or indirectly in the biosynthesis of staurosporin and to methods of preparing said DNA fragment. The present invention relates furthermore to recombinant DNA molecules containing one of the DNA fragments according to the invention and to the plasmids and vectors derived therefrom. Also included are host organisms transformed with the said plasmid or vector DNA.
摘要翻译：本发明特别涉及可从链霉菌或放线菌属基因组中的基因簇获得的DNA片段，该基因簇负责星孢菌素生物合成，并含有至少一个基因或编码涉及多肽的基因的一部分直接或间接地在星形孢菌素的生物合成中以及制备所述DNA片段的方法。本发明还涉及含有根据本发明的DNA片段之一的重组DNA分子以及衍生自其的质粒和载体。还包括用所述质粒或载体DNA转化的宿主生物。

14. 发明授权

US06194181B1 Fermentative preparation process for and crystal forms of cytostatics 有权
标题翻译：发酵制备过程和晶体形式的细胞抑制剂
公开(公告)号：US06194181B1
公开(公告)日：2001-02-27
申请号：US09248910
申请日：1999-02-12
申请人： Hans Hofmann , Marion Mahnke , Klaus Memmert , Frank Petersen , Thomas Schupp , Ernst Küsters , Michael Mutz
发明人： Hans Hofmann , Marion Mahnke , Klaus Memmert , Frank Petersen , Thomas Schupp , Ernst Küsters , Michael Mutz
IPC分类号： C12P1716
CPC分类号： C07D493/04 , C07D417/14 , C07K2299/00 , C12P17/167 , C12P17/181 , C12R1/01
摘要： The invention relates to a new process for concentrating epothilones in culture media, a new process for the production of epothilones, a new process for separating epothilones A and B and a new strain obtained by mutagenesis for the production of epothilones, as well as aspects related thereto. New crystal forms of epothilone B are also described.
摘要翻译：本发明涉及用于将埃坡霉素浓缩在培养基中的新方法，用于生产埃坡霉素的新方法，用于分离埃坡霉素A和B的新方法和通过诱变获得的用于产生埃坡霉素的新菌株，以及相关方面到此。还描述了埃坡霉素B的新晶体形式。

15. 发明授权

US6121029A Genes for the biosynthesis of epothilones 有权
公开(公告)号：US6121029A
公开(公告)日：2000-09-19
申请号：US335409
申请日：1999-06-17
申请人： Thomas Schupp , James Madison Ligon , Istvan Molnar , Ross Zirkle , Devon Dawn Cyr , Jorn Gorlach
发明人： Thomas Schupp , James Madison Ligon , Istvan Molnar , Ross Zirkle , Devon Dawn Cyr , Jorn Gorlach
IPC分类号： C07K14/195 , C12N1/21 , C12P17/18 , C12N9/00 , C07H21/04 , C12N1/20
CPC分类号： C07K14/195 , C12P17/181
摘要： Nucleic acid molecules are isolated from Sorangium cellulosum that encode polypeptides necessary for the biosynthesis of epothilone. Disclosed are methods for the production of epothilone in recombinant hosts transformed with the genes of the invention. In this manner, epothilone can be produced in quantities large enough to enable their purification and use in pharmaceutical formulations such as those for the treatment of cancer.

16. 发明授权

US5698425A Method of protecting plants by transformation with genes for the synthesis of antipathogenic substances 失效
标题翻译：通过与用于合成抗病原体物质的基因转化保护植物的方法
公开(公告)号：US5698425A
公开(公告)日：1997-12-16
申请号：US458076
申请日：1995-06-01
申请人： James M. Ligon , Thomas Schupp , James Joseph Beck , Dwight Steven Hill , John Andrew Ryals , Stephen Ting Lam , Philip E. Hammer , Scott Joseph Uknes
发明人： James M. Ligon , Thomas Schupp , James Joseph Beck , Dwight Steven Hill , John Andrew Ryals , Stephen Ting Lam , Philip E. Hammer , Scott Joseph Uknes
IPC分类号： A01H5/00 , A01N37/44 , A01N63/00 , C07K14/195 , C07K14/21 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/31 , C12N15/52 , C12N15/78 , C12N15/82 , C12P17/08 , C12P17/10 , C12P21/02 , C12R1/91 , C12N5/04
CPC分类号： C07K14/195 , C07K14/21 , C12N15/52 , C12N15/78 , C12N15/8282 , C12P17/08 , C12P17/10
摘要： The present invention is directed to the production of an antipathogenic substance (APS) in a host via recombinant expression of the polypeptides needed to biologically synthesize the APS. Genes encoding polypeptides necessary to produce particular antipathogenic substances are provided, along with methods for identifying and isolating genes needed to recombinantly biosynthesize any desired APS. The cloned genes may be transformed and expressed in a desired host organisms to produce the APS according to the invention for a variety of purposes, including protecting the host from a pathogen, developing the host as a biocontrol agent, and producing large, uniform amounts of the APS.
摘要翻译：本发明涉及通过重组表达生物合成APS所需的多肽来在宿主中产生抗病原体物质（APS）。提供编码产生特定抗病原体物质所必需的多肽的基因，以及用于鉴定和分离重组生物合成任何所需APS所需的基因的方法。克隆的基因可以在所需宿主生物体中转化和表达，以产生本发明的APS用于各种目的，包括保护宿主免受病原体的侵袭，将宿主作为生物防治剂开发，并产生大量均匀的 APS。

17. 发明授权

US5686295A Process for the genetic manipulation of myxobacteria 失效
标题翻译：嗜酸性粒细胞的遗传操作过程
公开(公告)号：US5686295A
公开(公告)日：1997-11-11
申请号：US276752
申请日：1994-07-18
申请人： Samir Jaoua , Thomas Schupp , Snezana Neff
发明人： Samir Jaoua , Thomas Schupp , Snezana Neff
IPC分类号： C12N1/21 , C12N15/09 , C12N15/74 , C12R1/01 , C12N15/63
CPC分类号： C12N15/74
摘要： The present invention relates to a novel process for the genetic manipulation of myxobacteria, preferably of myxobacteria of the Sorangium/Polyangium group, which makes it possible for the first time specifically to apply recombinant DNA techniques to this group of organisms. The technical implementation of this process is based primarily on the preparation of recombinant DNA molecules which, by reason of their specific construction, are able to integrate genes or DNA sequences which code, where appropriate, for novel and desirable properties, with the aid of homologous recombination at sites, which are accurately defined by reason of the homologies present, within the bacterial genome, and on the insertion thereof into the myxobacterial cell.
摘要翻译：本发明涉及一种用于神经细菌的遗传操作的新方法，优选地是Sorangium / Polyangium组的粘液细菌，这使得它可以首次将这些重组DNA技术应用于该组生物体。该方法的技术实施主要基于重组DNA分子的制备，由于其特异性构建，能够整合在合适的情况下编码适合的新颖和所需性质的基因或DNA序列，借助于同源物在细菌基因组内，以及在其插入到粘液细菌细胞中的位点处的重组，其被精确地定义为存在的同源物。

18. 发明授权

US5643774A Genes for the synthesis of antipathogenic substance 失效
标题翻译：用于合成抗病原物质的基因
公开(公告)号：US5643774A
公开(公告)日：1997-07-01
申请号：US456837
申请日：1995-06-01
申请人： James M. Ligon , Thomas Schupp , James Joseph Beck , Dwight Steven Hill , John Andrew Ryals , Thomas Deane Gaffney , Stephen Ting Lam , Philip E. Hammer , Scott Joseph Uknes
发明人： James M. Ligon , Thomas Schupp , James Joseph Beck , Dwight Steven Hill , John Andrew Ryals , Thomas Deane Gaffney , Stephen Ting Lam , Philip E. Hammer , Scott Joseph Uknes
IPC分类号： A01H5/00 , A01N37/44 , A01N63/00 , C07K14/195 , C07K14/21 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/31 , C12N15/52 , C12N15/78 , C12N15/82 , C12P17/08 , C12P17/10 , C12P21/02 , C12R1/91 , C12N9/00 , C12P21/06
CPC分类号： C07K14/195 , C07K14/21 , C12N15/52 , C12N15/78 , C12N15/8282 , C12P17/08 , C12P17/10
摘要： The present invention is directed to the production of an antipathogenic substance (APS) in a host via recombinant expression of the polypeptides needed to biologically synthesize the APS. Genes encoding polypeptides necessary to produce particular antipathogenic substances are provided, along with methods for identifying and isolating genes needed to recombinantly biosynthesize any desired APS. The cloned genes may be transformed and expressed in a desired host organisms to produce the APS according to the invention for a variety of purposes, including protecting the host from a pathogen, developing the host as a biocontrol agent, and producing large, uniform amounts of the APS.
摘要翻译：本发明涉及通过重组表达生物合成APS所需的多肽来在宿主中产生抗病原体物质（APS）。提供编码产生特定抗病原体物质所必需的多肽的基因，以及用于鉴定和分离重组生物合成任何所需APS所需的基因的方法。克隆的基因可以在所需宿主生物体中转化和表达，以产生本发明的APS用于各种目的，包括保护宿主免受病原体的侵袭，将宿主作为生物防治剂开发，并产生大量均匀的 APS。

19. 发明申请

US20090326239A1 FERMENTATIVE PREPARATION PROCESS FOR AND CRYSTAL FORMS OF CYTOSTATICS 审中-公开
标题翻译：细胞生成和晶体形态的发酵制备方法
公开(公告)号：US20090326239A1
公开(公告)日：2009-12-31
申请号：US12397620
申请日：2009-03-04
申请人： Hans Hofmann , Marion Mahnke , Klaus Memmert , Frank Petersen , Thomas Schupp , Ernst Kusters , Michael Mutz
发明人： Hans Hofmann , Marion Mahnke , Klaus Memmert , Frank Petersen , Thomas Schupp , Ernst Kusters , Michael Mutz
IPC分类号： C07D277/22
CPC分类号： C07D493/04 , C07D417/14 , C07K2299/00 , C12P17/167 , C12P17/181 , C12R1/01
摘要： The invention relates to a new process for concentrating epothilones in culture media, a new process for the production of epothilones, a new process for separating epothilones A and B and a new strain obtained by mutagenesis for the production of epothilones, as well as aspects related thereto. New crystal forms of epothilone B are also described.
摘要翻译：本发明涉及用于将埃坡霉素浓缩在培养基中的新方法，用于生产埃坡霉素的新方法，用于分离埃坡霉素A和B的新方法和通过诱变获得的用于产生埃坡霉素的新菌株，以及相关方面到此。还描述了埃坡霉素B的新晶体形式。

20. 发明授权

US06355457B1 Genes for the biosynthesis of epothilones 失效
公开(公告)号：US06355457B1
公开(公告)日：2002-03-12
申请号：US09567969
申请日：2000-05-10
申请人： Thomas Schupp , James Madison Ligon , Istvan Molnar , Ross Zirkle , Devon Dawn Cyr , Jörn Görlach
发明人： Thomas Schupp , James Madison Ligon , Istvan Molnar , Ross Zirkle , Devon Dawn Cyr , Jörn Görlach
IPC分类号： C12N900
CPC分类号： C07K14/195 , C12P17/181
摘要： Nucleic acid molecules are isolated from Sorangium cellulosum that encode polypeptides necessary for the biosynthesis of epothilone. Disclosed are methods for the production of epothilone in recombinant hosts transformed with the genes of the invention. In this manner, epothilone can be produced in quantities large enough to enable their purification and use in pharmaceutical formulations such as those for the treatment of cancer.

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