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11. 发明申请

US20090043191A1 OCT-IVUS CATHETER FOR CONCURRENT LUMINAL IMAGING 审中-公开
标题翻译： OCT-IVUS导管进行同步成像
公开(公告)号：US20090043191A1
公开(公告)日：2009-02-12
申请号：US12173004
申请日：2008-07-14
申请人： Paul Castella , Nathaniel J. Kemp , Thomas E. Milner , David G. Rosenbaum
发明人： Paul Castella , Nathaniel J. Kemp , Thomas E. Milner , David G. Rosenbaum
IPC分类号： A61B5/05
CPC分类号： A61B8/12 , A61B5/0066 , A61B5/02007 , A61B5/6852 , A61B8/486
摘要： The invention relates to an apparatus for in vivo imaging. More specifically, the present invention relates to a catheter that incorporates an Optical Coherence Tomography (OCT) system and an Intravascular Ultrasound (“IVUS) system for concurrent imaging of luminal systems, such as imaging the vasculature system, including, without limitation, cardiac vasculature, peripheral vasculature and neural vasculature.
摘要翻译：本发明涉及体内成像装置。更具体地，本发明涉及一种导管，其包括光学相干断层摄影（OCT）系统和用于腔内系统的并行成像的血管内超声（“IVUS”）系统，例如对脉管系统进行成像，包括但不限于心脏血管系统外周脉管系统和神经脉管系统。

12. 发明申请

US20090018393A1 CATHETER FOR IN VIVO IMAGING 有权
标题翻译：用于体检成像的导管
公开(公告)号：US20090018393A1
公开(公告)日：2009-01-15
申请号：US12172922
申请日：2008-07-14
申请人： Larry Dick , Thomas E. Milner , Daniel D. Sims
发明人： Larry Dick , Thomas E. Milner , Daniel D. Sims
IPC分类号： A61B1/04
CPC分类号： A61B5/6852 , A61B5/0062 , A61B5/0066 , A61B8/12 , A61B8/4461
摘要： A catheter for in vivo imaging comprising a monolithic outer sheath terminating in a monolithic atraumatic tip having a guidewire lumen. The catheter for in vivo imaging comprising a rotary drive shaft that passes through a central lumen of the monolithic outer sheath to impart rotary motion.
摘要翻译：一种用于体内成像的导管，其包括终止于具有导丝管腔的整体式无创伤尖端的整体外护套。用于体内成像的导管包括旋转驱动轴，该旋转驱动轴穿过整体外护套的中心腔以赋予旋转运动。

13. 发明授权

US07177491B2 Fiber-based optical low coherence tomography 有权
标题翻译：基于光纤的光学低相干断层扫描
公开(公告)号：US07177491B2
公开(公告)日：2007-02-13
申请号：US10679952
申请日：2003-10-06
申请人： Digant P. Dave , Thomas E. Milner , Taner Akkin
发明人： Digant P. Dave , Thomas E. Milner , Taner Akkin
IPC分类号： G02B6/27 , G02B6/26 , G01J4/00 , G01B9/02
CPC分类号： G01P5/26 , A61B5/0066 , A61B5/0261 , G01B9/0201 , G01B9/02027 , G01B9/02045 , G01B9/02091 , G01B2290/45 , G01B2290/70 , G01N21/4795 , G01P5/001
摘要： Generally, and in one form of the present invention, is a polarization-maintaining fiber-based polarization sensitive optical low coherence reflectometer for depth resolved birefringence measurement. With the present invention, linear birefringence of a sample may be measured from data recorded in a single A-Scan. In addition, the present invention provides for the simultaneous measurement of retardation and orientation of birefringent axes, wherein measured retardation is insensitive to sample rotation in the plane perpendicular to ranging.
摘要翻译：通常，在本发明的一种形式中，是用于深度分辨双折射测量的基于偏振保持光纤的偏振敏感光学低相干反射计。利用本发明，可以从记录在单个A-Scan中的数据测量样品的线性双折射。此外，本发明提供了同时测量双折射轴的延迟和取向，其中测量的延迟对垂直于测距的平面中的样品旋转不敏感。

14. 发明授权

US06665456B2 Method and apparatus for differential phase optical coherence tomography 有权
标题翻译：差分相位光学相干断层扫描的方法和装置
公开(公告)号：US06665456B2
公开(公告)日：2003-12-16
申请号：US10044421
申请日：2002-01-11
申请人： Digant P. Dave , Thomas E. Milner , Sergey Telenkov
发明人： Digant P. Dave , Thomas E. Milner , Sergey Telenkov
IPC分类号： G02B627
CPC分类号： G01P5/26 , A61B5/0066 , A61B5/0261 , G01B9/0201 , G01B9/02027 , G01B9/02028 , G01B9/02045 , G01B9/02091 , G01B2290/45 , G01B2290/70 , G01N21/4795 , G01P5/001
摘要： One form of the present invention is a dual channel optical reflectometer composed of a birefringent path coupler and an optical source path that is optically connected to the path coupler. After entering the path coupler, light is split into birefringent reference and sample paths. The reference path is optically aligned with a first collimating lens, and the collimating lens is directed into a scanning delay line. There is also a birefringent optical sample path that is also optically connected to the path coupler. The sample path is optically aligned with a polarization channel separator/combiner and a lens, to focus and direct optical beams into the turbid sample. Light backscattered from the turbid sample is collected by the second lens and orthogonal polarization channels are reunited by the polarization channel combiner. An analog-to-digital converter is connected to the amplifier, and a computer is connected to the analog-to-digital converter to analyze the output.
摘要翻译：本发明的一种形式是由双折射路径耦合器和与光路连接器光学连接的光源路径组成的双通道光反射计。进入路径耦合器后，光被分成双折射参考和采样路径。参考路径与第一准直透镜光学对准，并且准直透镜被引导到扫描延迟线中。还存在也光学地连接到路径耦合器的双折射光学样本路径。采样路径与偏振通道分离器/组合器和透镜光学对准，以将光束聚焦并引导到混浊样品中。来自浑浊样品的反向散射光由第二透镜收集，正交极化通道由偏振通道组合器重新团聚。模数转换器连接到放大器，计算机连接到模拟数字转换器以分析输出。

15. 发明授权

US09215983B2 Hemoglobin contrast in magneto-motive optical doppler tomography, optical coherence tomography, and ultrasound imaging methods and apparatus 有权
标题翻译：磁共振光学多普勒层析成像，光学相干断层扫描和超声成像方法和装置中的血红蛋白对比
公开(公告)号：US09215983B2
公开(公告)日：2015-12-22
申请号：US13229200
申请日：2011-09-09
申请人： Thomas E. Milner
发明人： Thomas E. Milner
IPC分类号： A61B5/05 , A61B5/00 , A61B5/1455 , A61B8/13
CPC分类号： A61B5/0073 , A61B5/0066 , A61B5/05 , A61B5/1455 , A61B8/13
摘要： A novel contrast mechanism for imaging blood flow using magneto-motive optical Doppler tomography (MM-ODT), Optical Coherence Tomography, and Ultrasound. MM-ODT, OCT, and ultrasound combined with an externally applied temporally oscillating high-strength magnetic field detects erythrocytes moving according to the field gradient.
摘要翻译：一种新颖的对比机制，用于使用磁动态光学多普勒超声（MM-ODT），光学相干断层扫描和超声波成像血流。 MM-ODT，OCT和超声结合外部施加的时间振荡的高强度磁场检测根据场梯度移动的红细胞。

16. 发明申请

US20140171807A1 MEASUREMENT OF NEURAL FUNCTIONALITY USING PHASE SENSITIVE OPTICAL COHERENCE REFLECTOMETRY 有权
标题翻译：使用相敏感光学相干反射测量法测量神经功能
公开(公告)号：US20140171807A1
公开(公告)日：2014-06-19
申请号：US13720563
申请日：2012-12-19
申请人： Taner Akkin , Thomas E. Milner , Digant P. Dave , H. Grady Rylander, III
发明人： Taner Akkin , Thomas E. Milner , Digant P. Dave , H. Grady Rylander, III
IPC分类号： A61B5/00 , A61N1/00 , A61N5/06
CPC分类号： A61B5/4041 , A61B5/0066 , A61B5/0075 , A61B5/0082 , A61B5/40 , A61B5/4029 , A61B5/6821 , A61B5/7225 , A61B5/7282 , A61N1/00 , A61N1/3605 , A61N5/0622
摘要： Optical methods, devices, and systems for noninvasively detecting transient surface displacements in a neuron are disclosed. Methods, devices, and systems provided may employ a phase-sensitive optical low coherence reflectometer. In addition, surface displacements due to action potential propagation in neural tissues may be detected in some embodiments using back-reflected light. According to some embodiments, exogenous chemicals or reflect ion coatings are not required. Transient neural surface displacement of less then 1 nm in amplitude and 1 ms in duration may be detected and may be generally coincident with action potential arrival to the optical measurement site. The systems and methods may be used for noninvasive detection of various neuropathies such as retinal neuropathies. They may also be useful in detecting the effects of various pharmacological agents.
摘要翻译：公开了用于非侵入性地检测神经元中的瞬时表面位移的光学方法，装置和系统。提供的方法，设备和系统可以采用相敏光学低相干反射计。此外，在使用反射反射光的一些实施例中，可以检测由于神经组织中的动作电位传播引起的表面位移。根据一些实施方案，不需要外源化学品或反射离子涂层。可以检测到幅度小于1nm，持续时间为1ms的瞬态神经表面位移，并且可能通常与到达光学测量位置的动作电位一致。系统和方法可以用于各种神经病如视网膜神经病的非侵入性检测。它们也可用于检测各种药理学试剂的作用。

17. 发明授权

US08593641B2 Apparatus and methods for uniform frequency sample clocking 有权
标题翻译：用于均匀频率采样时钟的装置和方法
公开(公告)号：US08593641B2
公开(公告)日：2013-11-26
申请号：US13243399
申请日：2011-09-23
申请人： Nathaniel J. Kemp , Roman Kuranov , Austin Broderick McElroy , Thomas E. Milner
发明人： Nathaniel J. Kemp , Roman Kuranov , Austin Broderick McElroy , Thomas E. Milner
IPC分类号： G01B9/02
CPC分类号： G01B9/02091 , A61B5/0066 , A61B5/0073 , A61B5/6852 , A61B5/7257 , G01B9/02004 , G01B9/02057 , G01B9/02069 , G01B9/02083 , G01B2290/25 , G01M11/3127 , G01M11/3172 , G01N21/4795
摘要： The invention provides systems and methods for producing an OCT image from a swept laser source. In certain embodiments, methods of the invention involve producing light from a swept laser source, splitting the light into a first and a second portion, in which the first portion is sent to an OCT interferometer to produce an OCT signal and the second portion is sent to a uniform frequency sample clock, processing the second portion into an external clock signal that is accepted by a digitizer, sending the OCT signal and the clock signal to the digitizer, and generating an OCT image from a combination of the OCT signal and the clock signal.
摘要翻译：本发明提供了用于从扫描的激光源产生OCT图像的系统和方法。在某些实施例中，本发明的方法涉及产生来自扫掠的激光源的光，将光分成第一和第二部分，其中第一部分被发送到OCT干涉仪以产生OCT信号，并且第二部分被发送将第二部分处理成由数字转换器接受的外部时钟信号，将OCT信号和时钟信号发送到数字转换器，以及从OCT信号和时钟的组合产生OCT图像信号。

18. 发明授权

US08401610B2 Rotating catheter probe using a light-drive apparatus 有权
标题翻译：使用光驱装置旋转导管探头
公开(公告)号：US08401610B2
公开(公告)日：2013-03-19
申请号：US12902092
申请日：2010-10-11
申请人： Thomas E. Milner , Nathaniel J. Kemp
发明人： Thomas E. Milner , Nathaniel J. Kemp
IPC分类号： A61B5/05
CPC分类号： A61B1/00163 , A61B1/0011 , A61B1/00172 , A61B5/0066 , A61B5/6852 , Y10T29/49826
摘要： The invention is a rotating tip catheter-imaging probe where electromagnetic energy is delivered to the distal end of a catheter and converted to mechanical energy using a light drive apparatus. The mechanical energy is then used to rotate a mirror that redirects light in fixed pattern on a sample. The rotating element of the light drive apparatus contains vanes, which rotate about an axis and positioned with bearings to minimize friction. A chamber encompasses the rotating element and is set to a vacuum pressure. The rotational speed of the catheter tip can be controlled by varying the optical power delivered to the vanes, the vacuum pressure in the chamber, or by a braking mechanism applied to the rotating element. The vanes may be shaped in a particular geometry to increase forces on the vanes from thermally driven gas flow.
摘要翻译：本发明是旋转尖端导管成像探针，其中电磁能量被传送到导管的远端并且使用光驱动装置转换成机械能。然后机械能用于旋转将固定模式的光重定向在样品上的反射镜。光驱装置的旋转元件包含叶片，叶片绕轴线转动并且与轴承一起定位以使摩擦力最小化。腔室包围旋转元件并被设定为真空压力。可以通过改变输送到叶片的光功率，腔室中的真空压力，或通过施加到旋转元件的制动机构来控制导管尖端的旋转速度。叶片可以成形为特定的几何形状以增加来自热驱动气流的叶片上的力。

19. 发明授权

US08352022B2 Measurement of neural functionality using phase sensitive optical coherence reflectometry 有权
标题翻译：使用相敏光学相干反射测量神经功能
公开(公告)号：US08352022B2
公开(公告)日：2013-01-08
申请号：US12717735
申请日：2010-03-04
申请人： Taner Akkin , Thomas E. Milner , Digant P. Dave , H. Grady Rylander
发明人： Taner Akkin , Thomas E. Milner , Digant P. Dave , H. Grady Rylander
IPC分类号： A61B5/00
CPC分类号： A61B5/0059 , A61B3/102 , A61B3/1225 , A61B5/0066 , G01N21/4795 , G01N2021/1782
摘要： Optical methods, devices, and systems for noninvasively detecting transient surface displacements in a neuron are disclosed. Methods, devices, and systems provided may employ a phase-sensitive optical low coherence reflectometer. In addition, surface displacements due to action potential propagation in neural tissues may be detected in some embodiments using back-reflected light. According to some embodiments, exogenous chemicals or reflect ion coatings are not required. Transient neural surface displacement of less then 1 nm in amplitude and 1 ms in duration may be detected and may be generally coincident with action potential arrival to the optical measurement site. The systems and methods may be used for noninvasive detection of various neuropathies such as retinal neuropathies. They may also be useful in detecting the effects of various pharmacological agents.
摘要翻译：公开了用于非侵入性地检测神经元中的瞬时表面位移的光学方法，装置和系统。提供的方法，设备和系统可以采用相敏光学低相干反射计。此外，在使用反射反射光的一些实施例中，可以检测由于神经组织中的动作电位传播引起的表面位移。根据一些实施方案，不需要外源化学品或反射离子涂层。可以检测到幅度小于1nm，持续时间为1ms的瞬态神经表面位移，并且可能通常与到达光学测量位置的动作电位一致。系统和方法可以用于各种神经病如视网膜神经病的非侵入性检测。它们也可用于检测各种药理学试剂的作用。

20. 发明申请

US20120184847A1 HEMOGLOBIN CONTRAST IN ULTRASOUND AND OPTICAL COHERENCE TOMOGRAPHY FOR DIAGNOSING DISEASED TISSUE, CANCERS, AND THE LIKE 有权
标题翻译：超声波和光学相干测量中的HEMOGLOBIN对比诊断疾病组织，癌症和类似物
公开(公告)号：US20120184847A1
公开(公告)日：2012-07-19
申请号：US13330258
申请日：2011-12-19
申请人： Marc D. FELDMAN , Thomas E. MILNER , Junghwan OH
发明人： Marc D. FELDMAN , Thomas E. MILNER , Junghwan OH
IPC分类号： A61B8/06 , A61B6/00 , A61B6/02 , A61B8/08
CPC分类号： A61B5/0066 , A61B5/0073 , A61B5/05 , A61B5/14546 , A61B8/06 , A61B8/488
摘要： A novel contrast mechanism for diagnosing diseased tissue using Ultrasound, Doppler Ultrasonography, Optical Coherence Tomography, or optical Doppler tomography coupled with an externally applied temporally oscillating high-strength magnetic field.
摘要翻译：一种用于使用超声，多普勒超声，光学相干断层扫描或与外部施加的时间振荡的高强度磁场耦合的光学多普勒层析成像来诊断患病组织的新型对比机制。

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