专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明申请

WO2017027646A1 CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS 审中-公开
标题翻译：循环二核苷酸化合物作为激发剂
公开(公告)号：WO2017027646A1
公开(公告)日：2017-02-16
申请号：PCT/US2016/046444
申请日：2016-08-11
申请人： MERCK SHARP & DOHME CORP. , ALTMAN, Michael, D. , ANDRESEN, Brian , CHANG, Wonsuk , CHILDERS, Matthew Lloyd , CUMMING, Jared, N. , HAIDLE, Andrew Marc , HENDERSON, Timothy, J. , JEWELL, James, P. , LIANG, Rui , LIM, Jongwon , LIU, Hong , LU, Min , NORTHRUP, Alan, B. , OTTE, Ryan, D. , SIU, Tony , TROTTER, Benjamin Wesley , TRUONG, Quang, T. , WALSH, Shawn, P. , ZHAO, Kake
发明人： ALTMAN, Michael, D. , ANDRESEN, Brian , CHANG, Wonsuk , CHILDERS, Matthew Lloyd , CUMMING, Jared, N. , HAIDLE, Andrew Marc , HENDERSON, Timothy, J. , JEWELL, James, P. , LIANG, Rui , LIM, Jongwon , LIU, Hong , LU, Min , NORTHRUP, Alan, B. , OTTE, Ryan, D. , SIU, Tony , TROTTER, Benjamin Wesley , TRUONG, Quang, T. , WALSH, Shawn, P. , ZHAO, Kake
IPC分类号： C07H21/00 , A61K31/7084 , A61P35/00
CPC分类号： C07H21/04 , A61K31/706 , A61K31/7064 , A61K31/7076 , A61K31/708 , A61K31/7084 , A61K39/39 , C07H19/20 , C07H19/23 , C07H21/00 , C07H21/02
摘要： A class of polycyclic compounds of general formula (I), of general formula (I'), or of general formula (I"), wherein Base 1 , Base 2 , Y, Y a , X a , Xa 1 , X b , X b1 , X c , X c1 , X d , X d1 , R 1 , R 1a , R 2 , R 2a , R 3 , R 4 , R 4a , R 5 , R 6 , R 6a , R 7 , R 7a , R 8 , and R 8a are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.
摘要翻译：一类通式（I），通式（I'）或通式（I“）的多环化合物，其中基团1，碱基2，Y，亚氨基，Xa，Xa1，Xb，Xb1，Xc，Xc1， Xd，Xd1，R1，R1a，R2，R2a，R3，R4，R4a，R5，R6，R6a，R7，R7a，R8和R8a在本文中定义，其可用作I型干扰素生产的电感器，提供了STING活性剂，还提供了合成和使用化合物的方法。

12. 发明申请

WO2014062596A1 2'-METHYL SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES 审中-公开
标题翻译： 2'-甲基取代的核苷衍生物及其用于治疗病毒性疾病的方法
公开(公告)号：WO2014062596A1
公开(公告)日：2014-04-24
申请号：PCT/US2013/064906
申请日：2013-10-15
申请人： MERCK SHARP & DOHME CORP. , GIRIJAVALLABHAN, Vinay , BOGEN, Stephane , TRUONG, Quang, T. , CHEN, Ping , KEREKES, Angela , BENNETT, Frank , ESPOSITE, Sara , HONG, Qingmei , DAVIES, Ian
发明人： GIRIJAVALLABHAN, Vinay , BOGEN, Stephane , TRUONG, Quang, T. , CHEN, Ping , KEREKES, Angela , BENNETT, Frank , ESPOSITE, Sara , HONG, Qingmei , DAVIES, Ian
IPC分类号： C07H19/067 , C07H19/073 , C07H19/10 , A61K31/7068 , A61K31/7072 , A61P31/14 , C07H19/06
CPC分类号： C07H19/06 , A61K31/7068 , A61K31/7072 , A61K45/06 , C07H19/067 , C07H19/073 , C07H19/10
摘要： The present invention relates to 2'-Methyl Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein R, R 1 , R 2 and R 3 , are as defined herein. The present invention also relates to compositions comprising at least one 2'-Methyl Substituted Nucleoside Derivative, and methods of using the 2'-Methyl Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient.
摘要翻译：本发明涉及式（I）的2'-甲基取代的核苷衍生物及其药学上可接受的盐，其中R，R 1，R 2和R 3如本文所定义。本发明还涉及包含至少一种2'-甲基取代的核苷衍生物的组合物，以及使用2'-甲基取代的核苷衍生物治疗或预防患者HCV感染的方法。

13. 发明申请

WO2013166121A1 NOVEL TETRAGALNAC CONTAINING CONJUGATES AND METHODS FOR DELIVERY OF OLIGONUCLEOTIDES 审中-公开
标题翻译：含有结合物的新型四氯乙烯和交付寡糖的方法
公开(公告)号：WO2013166121A1
公开(公告)日：2013-11-07
申请号：PCT/US2013/039025
申请日：2013-05-01
申请人： MERCK SHARP & DOHME CORP. , TELLERS, David , COLLETTI, Steven, L. , DUDKIN, Vadim , IKEMOTO, Norihiro , LIAO, Hongbiao , PARISH, Craig , PEI, Tao , SHAW, Anthony , TRUONG, Quang , WANG, Lijun , YUAN, Yu , ZHU, Man
发明人： TELLERS, David , COLLETTI, Steven, L. , DUDKIN, Vadim , IKEMOTO, Norihiro , LIAO, Hongbiao , PARISH, Craig , PEI, Tao , SHAW, Anthony , TRUONG, Quang , WANG, Lijun , YUAN, Yu , ZHU, Man
IPC分类号： C07H19/056
CPC分类号： C12N15/113 , A61K47/549 , C07H15/26 , C12N2310/11 , C12N2310/14 , C12N2310/351
摘要： Disclosed herein is a modular composition comprising 1) an oligonucleotide; 2) one or more tetraGalNAc ligands of Formula (I), which may be the same or different; optionally, 3) one or more linkers, which may be the same or different; and optionally, 4) one or more targeting ligands, solubilizing agents, pharmacokinetics enhancing agents, lipids, and/or masking agents.
摘要翻译：本文公开了一种模块化组合物，其包含：1）寡核苷酸; 2）一种或多种式（I）的四加仑配体，其可以相同或不同; 任选地，3）一个或多个可以相同或不同的接头; 和任选地，4）一种或多种靶向配体，增溶剂，药代动力学增强剂，脂质和/或掩蔽剂。

14. 发明申请

WO2009089413A1 STAND-ALONE PUMP SHUT-OFF CONTROLLER 审中-公开
标题翻译：独立泵浦关断控制器
公开(公告)号：WO2009089413A1
公开(公告)日：2009-07-16
申请号：PCT/US2009/030544
申请日：2009-01-09
申请人： SHURFLO, LLC , CARLSON, Kevin , TRUONG, Quang, Minh
发明人： CARLSON, Kevin , TRUONG, Quang, Minh
IPC分类号： F04B49/00
CPC分类号： F04B49/02 , F04B2203/0201
摘要： Embodiments of the invention provide a stand-alone controller and a method for controlling a pump motor driven by an alternating current source. The stand-alone controller includes a power terminal for connection with the alternating current source and a load terminal for connection with the pump motor. The stand-alone controller further includes an enable switch to form a power line carrying power from the alternating current source to the pump motor. The stand-alone controller can store a first current being drawn through the power line by the pump motor when a control switch is actuated. A state of the enable switch is based on a comparison of the first current to a second current being drawn through the power line by the pump motor.
摘要翻译：本发明的实施例提供了一种独立控制器和用于控制由交流电源驱动的泵马达的方法。独立控制器包括用于与交流电源连接的电源端子和用于与泵电动机连接的负载端子。独立控制器还包括使能开关以形成从交流电源向泵电动机承载动力的电力线。当控制开关被致动时，独立控制器可以存储由泵电动机通过电力线吸取的第一电流。使能开关的状态基于通过泵电动机通过电力线吸取的第一电流与第二电流的比较。

15. 发明申请

WO2017205193A1 SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUNDS USEFUL AS GPR120 AGONISTS 审中-公开
标题翻译：用作GPR120激动剂的取代的四氢异喹啉化合物
公开(公告)号：WO2017205193A1
公开(公告)日：2017-11-30
申请号：PCT/US2017/033451
申请日：2017-05-19
申请人： MERCK SHARP & DOHME CORP. , ADAMS, Gregory, L. , COX, Jason, M. , DEBENHAM, John, S. , EDMONDSON, Scott , GILBERT, Eric, J. , GUO, Yan , JIANG, Yu , JOSIEN, Hubert , KIM, Hyunjin, M. , LAN, Ping , MIAO, Shouwu , PLUMMER, Christopher, W. , RAJAGOPALAN, Murali , SHAH, Unmesh , SUN, Zhongxiang , TRUONG, Quang, T. , UJJAINWALLA, Feroze , VELAZQUEZ, Francisco , VENKATRAMAN, Srikanth , SUZUKI, Takao , WANG, Nengxue
发明人： ADAMS, Gregory, L. , COX, Jason, M. , DEBENHAM, John, S. , EDMONDSON, Scott , GILBERT, Eric, J. , GUO, Yan , JIANG, Yu , JOSIEN, Hubert , KIM, Hyunjin, M. , LAN, Ping , MIAO, Shouwu , PLUMMER, Christopher, W. , RAJAGOPALAN, Murali , SHAH, Unmesh , SUN, Zhongxiang , TRUONG, Quang, T. , UJJAINWALLA, Feroze , VELAZQUEZ, Francisco , VENKATRAMAN, Srikanth , SUZUKI, Takao , WANG, Nengxue
IPC分类号： A61K31/472 , A61K31/4725 , A61P3/10 , C07D217/02
摘要： The present invention relates to a compound represented by formula (I) and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing diabetes, hyperlipidemia, obesity, NASH, inflammation related disorders, and related diseases and conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR120. Pharmaceutical compositions and methods of treatment are also included.
摘要翻译：本发明涉及用于治疗或预防糖尿病，高脂血症，肥胖症，NASH，炎症相关病症和相关疾病的式（I）代表的化合物及其药学上可接受的盐，和条件。该化合物可用作G蛋白偶联受体GPR120的激动剂。药物组合物和治疗方法也包括在内。

16. 发明申请

WO2017027645A1 CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS 审中-公开
标题翻译：循环二核苷酸化合物作为激发剂
公开(公告)号：WO2017027645A1
公开(公告)日：2017-02-16
申请号：PCT/US2016/046442
申请日：2016-08-11
申请人： MERCK SHARP & DOHME CORP. , ALTMAN, Michael, D. , ANDRESEN, Brian , CHANG, Wonsuk , CHILDERS, Matthew Lloyd , CUMMING, Jared, N. , HAIDLE, Andrew Marc , HENDERSON, Timothy, J. , JEWELL, James, P. , LU, Min , NORTHRUP, Alan, B. , OTTE, Ryan, D. , SIU, Tony , TROTTER, Benjamin Wesley , TRUONG, Quang, T.
发明人： ALTMAN, Michael, D. , ANDRESEN, Brian , CHANG, Wonsuk , CHILDERS, Matthew Lloyd , CUMMING, Jared, N. , HAIDLE, Andrew Marc , HENDERSON, Timothy, J. , JEWELL, James, P. , LU, Min , NORTHRUP, Alan, B. , OTTE, Ryan, D. , SIU, Tony , TROTTER, Benjamin Wesley , TRUONG, Quang, T.
IPC分类号： C07H21/02
CPC分类号： C07H21/04 , A61K31/706 , A61K31/7064 , A61K31/7076 , A61K31/708 , A61K31/7084 , A61K39/39 , C07H19/20 , C07H19/23 , C07H21/00 , C07H21/02
摘要： A class of polycyclic compounds of general formula (II), of general formula (II'), or of general formula (II"), wherein Base 1 , Base 2 , Y, Y a , X a , X a1 , X b , X b1 , X c , X c1 , X d , X d1 , R 1 , R 1a , R 2 , R 2a , R 3a , R 4 , R 4a , R 5 , R 6 , R 6a , R 7 , R 7a , R 8 , and R 8a are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.
摘要翻译：一类通式（II），通式（II'）或通式（II“）的通式（II）的多环化合物，其中基团1，碱基2，Y，亚氨基，Xa，Xa1，Xb，Xb1，Xc，Xc1， Xd，Xd1，R1，R1a，R2，R2a，R3a，R4，R4a，R5，R6，R6a，R7，R7a，R8和R8a在本文中定义，其可用作I型干扰素生产的电感器，提供了STING活性剂，还提供了合成和使用化合物的方法。

17. 发明申请

WO2015187437A1 C2-CARBOCYCLIC IMINOTHIAZINE DIOXIDES AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE 审中-公开
标题翻译：作为BACE抑制剂，组合物及其使用的C2-碳氢化合物三氮嗪二氧化物
公开(公告)号：WO2015187437A1
公开(公告)日：2015-12-10
申请号：PCT/US2015/032782
申请日：2015-05-28
申请人： MERCK SHARP & DOHME CORP. , WALSH, Shawn, P. , CUMMING, Jared, N. , HE, Shuwen , TAOKA, Brandon, M. , TRUONG, Quang, T. , WU, Wen-Lian
发明人： WALSH, Shawn, P. , CUMMING, Jared, N. , HE, Shuwen , TAOKA, Brandon, M. , TRUONG, Quang, T. , WU, Wen-Lian
IPC分类号： C07D417/14
CPC分类号： C07D487/04 , C07D471/04
摘要： In its many embodiments, the present invention provides certain C2-carbocyclic iminothiazine dioxide compounds, including compounds Formula (I); or a tautomers thereof, and pharmaceutically acceptable salts of said compounds and said tautomers, wherein R 1 , R 2 , ring A, R A , m, ring B, RB, n, ring C, R C and p are as defined herein. The novel compounds of the invention are useful as BACE inhibitors and/or for the treatment and prevention of various pathologies related thereto. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use, including for the possible treatment of Alzheimer's disease, are also disclosed.
摘要翻译：在其许多实施方案中，本发明提供某些C2-碳环亚氨基噻嗪二氧化物化合物，包括式（I）化合物; 或其互变异构体和所述化合物和所述互变异构体的药学上可接受的盐，其中R 1，R 2，环A，RA，m，环B，RB，n，环C，RC和p如本文所定义。本发明的新化合物可用作BACE抑制剂和/或用于治疗和预防与其相关的各种病症。还公开了包含一种或多种这样的化合物（单独和与一种或多种其它活性剂组合）的药物组合物及其制备和使用方法，包括用于治疗阿尔茨海默氏病的药物组合物。

18. 发明申请

WO2014078463A1 2 -ALKYNYL SUBSTITUTED NUCLEOSIDE DERIVATIVES FOR TREATING VIRAL DISEASES 审中-公开
标题翻译：用于治疗病毒的2-羟基取代的核苷衍生物
公开(公告)号：WO2014078463A1
公开(公告)日：2014-05-22
申请号：PCT/US2013/069965
申请日：2013-11-14
申请人： MERCK SHARP & DOHME CORP. , BENNETT, Frank , HUANG, Yuhua , WANG, Lingyan , BOGEN, Stephane, L. , KEREKES, Angela, D. , GIRIJAVALLABHAN, Vinay M. , BUTORA, Gabor , TRUONG, Quang , DAVIES, Ian , WEBER, Anne E.
发明人： BENNETT, Frank , HUANG, Yuhua , WANG, Lingyan , BOGEN, Stephane, L. , KEREKES, Angela, D. , GIRIJAVALLABHAN, Vinay M. , BUTORA, Gabor , TRUONG, Quang , DAVIES, Ian , WEBER, Anne E.
IPC分类号： A61K31/7068 , C07H19/02 , C07H19/10
CPC分类号： C07H19/10 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K45/06 , C07H19/06 , C07H19/067 , C07H19/09 , C07H19/11
摘要： The present invention relates to 2'-Alkynyl Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein B, X, R1, R2, R3 and R4 are as defined herein. The present invention also relates to compositions comprising at least one 2'-Alkynyl Substituted Nucleoside Derivative, and methods of using the 2'-Alkynyl Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient.
摘要翻译：本发明涉及式（I）的2'-炔炔基取代的核苷衍生物及其药学上可接受的盐，其中B，X，R 1，R 2，R 3和R 4如本文所定义。本发明还涉及包含至少一种2'-炔基取代的核苷衍生物的组合物，以及使用2'-炔基取代的核苷衍生物治疗或预防患者HCV感染的方法。

19. 发明申请

WO2010083136A1 OXADIAZOLE BETA CARBOLINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS 审中-公开
标题翻译：作为抗菌化合物的奥沙唑苯甲酰胺衍生物
公开(公告)号：WO2010083136A1
公开(公告)日：2010-07-22
申请号：PCT/US2010/020695
申请日：2010-01-12
申请人： MERCK SHARP & DOHME CORP. , DU, Wu , HAGMANN, William, K. , HE, Shuwen , LAI, Zhong , SHAH, Shrenik, K. , TRUONG, Quang, T.
发明人： DU, Wu , HAGMANN, William, K. , HE, Shuwen , LAI, Zhong , SHAH, Shrenik, K. , TRUONG, Quang, T.
IPC分类号： C07D471/04 , A61K31/407 , A61K31/437
CPC分类号： C07D471/04
摘要： Beta-carboline derivatives of structural formula I are selective antagonists of the somatostatin subtype receptor 3 (SSTR3) and are useful for the treatment of Type 2 diabetes mellitus and of conditions that are often associated with this disease, including hyperglycemia, insulin resistance, obesity, lipid disorders, and hypertension. The compounds are also useful for the treatment of depression and anxiety. Formula (I).
摘要翻译：结构式I的β-咔啉衍生物是生长抑素亚型受体3（SSTR3）的选择性拮抗剂，可用于治疗2型糖尿病和通常与该疾病相关的病症，包括高血糖症，胰岛素抵抗，肥胖症，脂质障碍和高血压。这些化合物也可用于治疗抑郁症和焦虑症。式（I）。

20. 发明申请

WO2009011836A1 BETA CARBOLINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS 审中-公开
标题翻译：作为抗菌化合物的碳氢化合物衍生物
公开(公告)号：WO2009011836A1
公开(公告)日：2009-01-22
申请号：PCT/US2008/008611
申请日：2008-07-15
申请人： MERCK & CO., INC. , DOBBELAAR, Peter, H. , DU, Wu , GUO, Liangqin , HAGMANN, William, K. , HE, Shuwen , JIAN, Tianying , LIU, Jian , NARGUND, Ravi, P. , PASTERNAK, Alexander , SHAH, Shrenik, K. , TRUONG, Quang, T. , YE, Zhixiong , DELLUREFICIO, James , BAKSHI, Raman
发明人： DOBBELAAR, Peter, H. , DU, Wu , GUO, Liangqin , HAGMANN, William, K. , HE, Shuwen , JIAN, Tianying , LIU, Jian , NARGUND, Ravi, P. , PASTERNAK, Alexander , SHAH, Shrenik, K. , TRUONG, Quang, T. , YE, Zhixiong , DELLUREFICIO, James , BAKSHI, Raman
IPC分类号： A61K31/535
CPC分类号： C07D471/04
摘要： Beta-carboline derivatives of structural formula I are selective antagonists of the somatostatin subtype receptor 3 (SSTR3) and are useful for the treatment of Type 2 diabetes mellitus and of conditions that are often associated with this disease, including hyperglycemia, insulin resistance, obesity, lipid disorders, and hypertension. The compounds are also useful for the treatment of depression and anxiety.
摘要翻译：结构式I的β-咔啉衍生物是生长抑素亚型受体3（SSTR3）的选择性拮抗剂，可用于治疗2型糖尿病和通常与该疾病相关的病症，包括高血糖症，胰岛素抵抗，肥胖症，脂质障碍和高血压。这些化合物也可用于治疗抑郁症和焦虑症。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式