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    • 18. 发明申请
    • COSMETIC COMPOSITION AND METHOD
    • 化妆品组合物和方法
    • WO0219982A2
    • 2002-03-14
    • PCT/US0120945
    • 2001-06-29
    • QUICK MED TECHNOLOGIES INCUNIV FLORIDA
    • LERNER DAVID SSCHULTZ GREGORY
    • A61K8/00A61K8/30A61K8/37A61K8/49A61K8/63A61K8/96A61K8/97A61K31/405A61K31/565A61K36/71A61K45/00A61P17/16A61P39/06A61P43/00A61Q17/04A61Q19/00A61Q19/08A61K7/48
    • A61Q19/00A61K8/492A61K8/63A61K8/97A61K31/404A61K2800/782A61Q19/08
    • The cosmetic topical formulation of this invention is directed toward diminishing skin wrinkling, fine line, improving skin tone, and combinations thereof. Preferably, the topical formulation contains a matrix metalloproteinase inhibitor, MMPI, and advantageously includes a natural estrogen, e.g., a true estrogen compound, such as 17-beta estradiol, or an estrogen-like steroid, (such as various phytoestrogens found in herbal preparations), as opposed to a synthetic estrogen. Other forms of the cosmetic topical formulation of this invention include combinations of synthetic estrogen and MMp inhibitor. Exemplary synthetic estrogens include, but are not limited to, ethynil estradiol and clomiphine citrate. The cosmetic topical formulation is safe and effective diminishing wrinkling, and improving skin tone. Certain compositions of this invention are useful for minimizing photodamage to skin, while in other embodiments, the composition according to this invention is useful to prevent or minimize the adverse effects on skin induced by cigarette smoking.
    • 本发明的化妆品局部制剂旨在减少皮肤皱纹,细纹,改善肤色及其组合。 优选地,局部制剂含有基质金属蛋白酶抑制剂MMPI,并且有利地包括天然雌激素,例如真正的雌激素化合物,例如17-β雌二醇或雌激素样类固醇(例如在草药制剂中发现的各种植物雌激素 ),而不是合成雌激素。 本发明的其它形式的化妆品局部制剂包括合成雌激素和MMp抑制剂的组合。 示例性合成的雌激素包括但不限于乙炔雌二醇和柠檬酸氯霉素。 化妆品局部制剂安全有效地减少皱纹,改善肤色。 本发明的某些组合物可用于使对皮肤的光损伤最小化,而在其它实施方案中,根据本发明的组合物可用于预防或最小化由吸烟引起的对皮肤的不利影响。