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11. 发明专利

FI20030652A0 未知
公开(公告)号：FI20030652A0
公开(公告)日：2003-04-30
申请号：FI20030652
申请日：2003-04-30
申请人： ERIKSSON SUSANN , PETTERSSON KIM
发明人： ERIKSSON SUSANN , PETTERSSON KIM
IPC分类号： G01N33/68

12. 发明申请

WO2005073727A1 IMPROVED METHOD FOR DIAGNOSING ACUTE CORONARY SYNDROME 审中-公开
标题翻译：用于诊断急性冠状动脉综合征的改进方法
公开(公告)号：WO2005073727A1
公开(公告)日：2005-08-11
申请号：PCT/FI2005/000036
申请日：2005-01-19
申请人： QIN, Qiu-Ping , PETTERSSON, Kim
发明人： QIN, Qiu-Ping , PETTERSSON, Kim
IPC分类号： G01N33/573
CPC分类号： C07K16/40 , G01N33/6893 , G01N2333/471 , G01N2800/324 , Y10T436/25125 , Y10T436/255
摘要： This invention concerns a bioaffinity assay for quantitative determination in a sample of free PAPP-A, defined as the pregnancy associated plasma protein A (PAPP-A) that is not complexed to the proform of major basic protein (proMBP), wherein free PAPP-A is determined either i) as a calculated difference between measured total PAPP-A and measured PAPP-A complexed to proMBP, or ii) by a direct bioaffinity assay measuring only free PAPP-A. Furthermore, the invention concerns a method for diagnosing an acute coronary syndrome in a person by using as marker either free PAPP-A as such or a ratio free PAPP-A/total PAPP-A, free PAPP-A/PAPP-A complexed to proMBP, or PAPP-A complexed to proMBP/total PAPP-A.
摘要翻译：本发明涉及用于定量测定游离PAPP-A的样品的生物亲和力测定法，其定义为与主要碱性蛋白质（proMBP）的形式不复合的妊娠相关血浆蛋白A（PAPP-A），其中游离PAPP- A确定i）作为测量的总PAPP-A与与proMBP复合的测量的PAPP-A之间的计算差异，或ii）通过仅测量游离PAPP-A的直接生物亲和测定。此外，本发明涉及一种通过使用游离PAPP-A作为标记或者无比PAPP-A /总PAPP-A，游离PAPP-A / PAPP-A复合的标记物来诊断人的急性冠状动脉综合征的方法 proMBP或PAPP-A与proMBP /总PAPP-A复合。

13. 发明申请

WO1997049994A1 METHOD AND KIT FOR THE DIAGNOSIS OF TROPONIN I 审中-公开
标题翻译： TROPONIN诊断方法和工具I
公开(公告)号：WO1997049994A1
公开(公告)日：1997-12-31
申请号：PCT/FI1997000399
申请日：1997-06-23
申请人： OY ABOATECH AB , KATRUHKA, Alex G. , SEVERIN, Sergei , BERSENIKOVA, Anastasia , ESAKOVA, Tatiana , PETTERSSON, Kim
发明人： OY ABOATECH AB
IPC分类号： G01N33/68
CPC分类号： G01N33/6887 , C07K14/4716 , C07K16/18
摘要： The object of the invention is an improved diagnostic method for assaying troponin I in a serum sample, wherein the improvement comprises bringing the sample in contact with a Ca -binding agent, and determining the human troponin I concentration in the sample using a standard, which comprises a whole troponin complex. A further object of the invention is a kit for use in a method for improving the sensitivity of a diagnostic immunoassay method for assaying troponin I in a serum sample, the kit containing an antibody to troponin I, a Ca -binding agent, and a detectable label. Still a further object of the invention is a troponin I standard preparation containing the complete troponin complex.
摘要翻译：本发明的目的是用于测定血清样品中的肌钙蛋白I的改进的诊断方法，其中改进包括使样品与Ca 2+结合剂接触，并且使用以下方法测定样品中的人肌钙蛋白I浓度一个标准，其中包括一个完整的肌钙蛋白复合物。本发明的另一个目的是一种用于提高诊断免疫测定法用于测定血清样品中的肌钙蛋白I的灵敏度的方法的试剂盒，该试剂盒含有肌钙蛋白I抗体，Ca 2+结合剂，和可检测标记。本发明的另一个目的是含有完整的肌钙蛋白复合物的肌钙蛋白I标准制剂。

14. 发明申请

WO0244725A8 BIOANALYTICAL ASSAY 审中-公开
标题翻译：生物分析
公开(公告)号：WO0244725A8
公开(公告)日：2002-10-17
申请号：PCT/FI0101024
申请日：2001-11-26
申请人： INNOTRAC DIAGNOSTICS OY , PETTERSSON KIM
发明人： PETTERSSON KIM
IPC分类号： B82B1/00 , G01N33/53 , G01N33/543 , G01N33/545
CPC分类号： G01N33/54346 , Y10T428/2982
摘要： The present invention relates to a nanoparticle comprising a specific binding reactant, said nanoparticle being useful for determining an analyte to which analyte or complex comprising said analyte said binding reactant is specific. Characteristic for the nanoparticle is that the diameter of said nanoparticle is less than 200 nm, said nanoparticle is coated with multiple said specific binding reactants to the extent that the affinity constant of said nanoparticle towards said analyte essentially exceeds that of free said binding reactant towards said analyte and/or the association rate constant between said nanoparticle and said analyte essentially exceeds the association rate constant between free said binding reactant and said analyte; and said nanoparticle comprises a detectable feature. The invention also relates to biochemical assays using said nanoparticle. The assay further relates to a proximity based homogenous assay comprising a first group labeled with an energy donating compound (donor) and a second group labeled with an energy accepting compound (acceptor), wherein the donor is luminescent and has a long excited state lifetime and the acceptor is luminescent having a short or long excited state lifetime or the acceptor is non-luminescent, and the increase or decrease, respectively, in the energy transfer from the donor to the acceptor resulting from shortening or lengthening, respectively, of the distance between said groups, is measured. Characteristic for the assay is that the donor is a nanoparticle.
摘要翻译：本发明涉及包含特异性结合反应物的纳米颗粒，所述纳米颗粒可用于确定包含所述分析物的分析物或复合物的分析物，所述分析物所述结合反应物是特异性的。纳米颗粒的特征在于所述纳米颗粒的直径小于200nm，所述纳米颗粒用多种所述特异性结合反应物涂覆至所述纳米颗粒对所述分析物的亲和常数基本上超过所述游离的所述结合反应物对所述所述纳米颗粒与所述分析物之间的分析物和/或缔合速率常数基本上超过游离所述结合反应物与所述分析物之间的缔合速率常数; 并且所述纳米颗粒包含可检测特征。本发明还涉及使用所述纳米颗粒的生物化学测定。该测定还涉及基于接近度的均相测定法，其包含用供能化合物（供体）标记的第一组和用能量受体化合物（受体）标记的第二组，其中供体是发光的并且具有长激发态寿命和受主发光具有短的或长的激发态寿命或者受体不发光，并且分别在从供体到受体的能量转移中分别由缩短或延长所述组，是测量的。测定的特征是供体是纳米颗粒。

15. 发明申请

WO1997038311A1 ONE-STEP ALL-IN-ONE DRY REAGENT IMMUNOASSAY 审中-公开
标题翻译：一步一体式干燥试剂免疫测定
公开(公告)号：WO1997038311A1
公开(公告)日：1997-10-16
申请号：PCT/FI1997000153
申请日：1997-03-07
申请人： PETTERSSON, Kim , LÖVGREN, Timo
IPC分类号： G01N33/543
CPC分类号： G01N33/54393 , G01N2333/4712 , G01N2333/9123 , Y10S435/81 , Y10S435/962 , Y10S435/969 , Y10S436/80 , Y10S436/809
摘要： The invention relates to a novel competitive or non-competitive immunoassay comprising the steps of: immobilizing an assay specific component on a solid phase in a reaction well; adding a labelled assay specific component; drying said components; adding the sample containing the marker to be analyzed; allowing the marker to react with the assay specific components; and detecting the signal from the label. Furthermore, the invention relates to a device useful in carrying out the novel assay.
摘要翻译：本发明涉及新的竞争性或非竞争性免疫测定法，其包括以下步骤：将测定特异性成分固定在反应井中的固相上; 添加标记的测定特异性组分; 干燥组分; 加入含有待分析标记物的样品; 使标记物与测定特异性组分反应; 并检测来自标签的信号。此外，本发明涉及可用于进行新型测定的装置。

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