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11. 发明授权

US06420428B1 Treatment and prevention of hepatic disorders 失效
标题翻译：治疗和预防肝功能障碍
公开(公告)号：US06420428B1
公开(公告)日：2002-07-16
申请号：US09724600
申请日：2000-11-28
申请人： Mario Chojkier , Martina Buck
发明人： Mario Chojkier , Martina Buck
IPC分类号： A61K31167
CPC分类号： A61K31/05 , A61K31/355 , A61K31/522 , Y10S514/894
摘要： The present invention provides new methods for the treatment of viral hepatitis C involving the administration of vitamin E and other compounds with antioxidant properties. Treatment with high doses of vitamin E is effective in treating chronic hepatitis C in patients refractory to interferon. In addition, new methods are described for the treatment of hepatic fibrosis and hepatic conditions manifesting hepatic fibrosis involving the administration of butylated hydroxytoluene and a metabolite of pentoxifylline, 1-[3-carboxypropyl]-3,7-dimethylxanthine. Furthermore, new methods are described for the treatment and prevention of hepatic disorders involving the use of 2,6-di-tert-butylphenol derivatives.
摘要翻译：本发明提供了用于治疗病毒性丙型肝炎的新方法，涉及维生素E和具有抗氧化性质的其它化合物的给药。用高剂量的维生素E治疗可有效治疗难治性干扰素患者的慢性丙型肝炎。另外，描述了用于治疗肝纤维化和表现肝纤维化的肝脏病症的新方法，涉及施用丁基化羟基甲苯和己酮可可碱1- [3-羧基丙基] -3,7-二甲基黄嘌呤的代谢物。此外，描述了用于治疗和预防涉及使用2,6-二叔丁基苯酚衍生物的肝脏疾病的新方法。

12. 发明授权

US06369097B1 Treatment and prevention of hepatic disorders 失效
公开(公告)号：US06369097B1
公开(公告)日：2002-04-09
申请号：US09724695
申请日：2000-11-28
申请人： Mario Chojkier
发明人： Mario Chojkier
IPC分类号： A61K3139
CPC分类号： A61K31/05 , A61K31/355 , A61K31/522 , Y10S514/894
摘要： The present invention provides new methods for the treatment of viral hepatitis C involving the administration of vitamin E and other compounds with antioxidant properties. Treatment with high doses of vitamin E is effective in treating chronic hepatitis C in patients refractory to interferon. In addition, new methods are described for the treatment of hepatic fibrosis and hepatic conditions manifesting hepatic fibrosis involving the administration of butylated hydroxytoluene and a metabolite of pentoxifylline, 1-[3-carboxypropyl]-3,7-dimethylxanthine. Furthermore, new methods are described for the treatment and prevention of hepatic disorders involving the use of 2,6-di-tert-butylphenol derivatives.

13. 发明授权

US06218437B1 Treatment and prevention of hepatic disorders 失效
标题翻译：治疗和预防肝功能障碍
公开(公告)号：US06218437B1
公开(公告)日：2001-04-17
申请号：US09400322
申请日：1999-09-21
申请人： Mario Chojkier
发明人： Mario Chojkier
IPC分类号： A61K3105
CPC分类号： A61K31/05 , A61K31/355 , A61K31/522 , Y10S514/894
摘要： The present invention provides new methods for the treatment of viral hepatitis C involving the administration of vitamin E and other compounds with antioxidant properties. Treatment with high doses of vitamin E is effective in treating chronic hepatitis C in patients refractory to interferon. In addition, new methods are described for the treatment of hepatic fibrosis and hepatic conditions manifesting hepatic fibrosis involving the administration of butylated hydroxytoluene and a metabolite of pentoxifylline, 1-[3-carboxypropyl]-3, 7-dimethylxanthine. Furthermore, new methods are described for the treatment and prevention of hepatic disorders involving the use of 2,6-di-tert-butylphenol derivatives.
摘要翻译：本发明提供了用于治疗病毒性丙型肝炎的新方法，涉及维生素E和具有抗氧化性质的其它化合物的给药。用高剂量的维生素E治疗可有效治疗难治性干扰素患者的慢性丙型肝炎。此外，描述了治疗肝纤维化和表现肝纤维化的肝脏病症的新方法，涉及施用丁基化羟基甲苯和己酮可可碱1- [3-羧基丙基] -3,7-二甲基黄嘌呤的代谢物。此外，描述了用于治疗和预防涉及使用2,6-二叔丁基苯酚衍生物的肝脏疾病的新方法。

14. 发明授权

US6075027A Treatment and prevention of hepatic disorders 失效
标题翻译：治疗和预防肝功能障碍
公开(公告)号：US6075027A
公开(公告)日：2000-06-13
申请号：US274625
申请日：1999-03-23
申请人： Mario Chojkier , Dennis Carson
发明人： Mario Chojkier , Dennis Carson
IPC分类号： A61K31/05 , A61K31/355 , A61K31/522 , A61K31/505 , C07D487/04
CPC分类号： A61K31/355 , A61K31/05 , A61K31/522 , Y10S514/893 , Y10S514/894
摘要： New methods are described for the treatment of viral hepatitis C involving the administration of vitamin E and other compounds with antioxidant properties. Treatment with high doses of vitamin E is effective in treating chronic hepatitis C in patients refractory to interferon. In addition, new methods are described for the treatment of hepatic fibrosis and hepatic conditions manifesting hepatic fibrosis involving the administration of butylated hydroxytoluene and a metabolite of pentoxifylline, 1-[3-carboxypropyl]-3, 7-dimethylxanthine.
摘要翻译：描述了用于治疗涉及维生素E和具有抗氧化性质的其它化合物的病毒性丙型肝炎的新方法。用高剂量的维生素E治疗可有效治疗难治性干扰素患者的慢性丙型肝炎。此外，描述了治疗肝纤维化和表现肝纤维化的肝脏病症的新方法，涉及施用丁基化羟基甲苯和己酮可可碱1- [3-羧基丙基] -3,7-二甲基黄嘌呤的代谢物。

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