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11. 发明申请

US20090138067A1 Expandable supportive branched endoluminal grafts 审中-公开
标题翻译：可扩展支持性支气管内移植物
公开(公告)号：US20090138067A1
公开(公告)日：2009-05-28
申请号：US11906703
申请日：2007-10-03
申请人： Leonard Pinchuk , Rysler Alcime , Yasushi Kato
发明人： Leonard Pinchuk , Rysler Alcime , Yasushi Kato
IPC分类号： A61F2/06
CPC分类号： A61F2/90 , A61F2/07 , A61F2/88 , A61F2/885 , A61F2/89 , A61F2/91 , A61F2002/065 , A61F2002/067 , A61F2002/072 , A61F2002/075 , A61F2002/30329 , A61F2002/826 , A61F2220/0008 , A61F2220/0025 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/001 , A61F2230/0078 , A61F2240/001 , A61F2250/0039
摘要： An endoluminal graft which is both expandable and supportive is provided in a form suitable for use in a branched body vessel location. The graft expands between a first diameter and a second, larger diameter. The support component is an expandable stent endoprosthesis. A liner is applied to the endoprosthesis in the form of a compliant wall material that is porous and biocompatible in order to allow normal cellular invasion upon implantation, without stenosis, when the expandable and supportive graft is at its second diameter. The supportive endoluminal graft is preferably provided as a plurality of components that are deployed separately at the branching body vessel location, one of which has a longitudinal seam defining leg portions within which the other components fit in a telescoping manner.
摘要翻译：可膨胀和支持的腔内移植物以适合用于分支体血管位置的形式提供。移植物在第一直径和第二直径较大的直径之间膨胀。支撑部件是可扩张的支架内置假体。将内衬施用于多孔且生物相容的柔性壁材料形式的内用假体，以便当可扩张和支持性移植物处于其第二直径时，在植入时允许正常的细胞侵入而没有狭窄。支持性腔内移植物优选地被设置为在分支体血管位置处分开设置的多个部件，其中一个部件具有限定腿部的纵向接缝，其中其它部件可以以伸缩方式配合。

12. 发明申请

US20080066771A1 Nail Clipper Apparatus 审中-公开
标题翻译：指甲钳装置
公开(公告)号：US20080066771A1
公开(公告)日：2008-03-20
申请号：US11854704
申请日：2007-09-13
申请人： Leonard Pinchuk
发明人： Leonard Pinchuk
IPC分类号： A45D29/02
CPC分类号： A45D29/02 , A45D2029/026
摘要： A remotely actuated nail clipping apparatus includes a nail clipper body having upper and lower jaws with opposed cutting surfaces. An actuating lever is remotely disposed from the nail clipper body. A linkage, which operably couples the actuating lever to the nail clipper body, passes through the upper jaw of the nail clipper body and interfaces with the lower jaw and enables the user to pull the lower jaw upward toward the upper jaw into a cutting configuration whereby the opposed cutting surfaces of the two jaws engage one another to thereby clip a nail disposed therebetween. Preferably, a hollow vertical shaft rigidly couples the upper jaw of the nail clipper body to the actuating lever and the linkage extends through the interior of the shaft. A platform is preferably secured to the top end of the shaft and provides a support surface for the actuation lever.
摘要翻译：远程致动的指甲夹装置包括具有相对的切割表面的上下爪的指甲钳本体。致动杠杆远离指甲钳主体。将致动杆可操作地连接到指甲钳主体的连杆通过指甲钳主体的上颚并与下钳口相接合，并且使得使用者能够将下颚向上朝向上颚拉动成切割构型，由此两个爪的相对的切割表面彼此接合，从而夹住设置在其间的指甲。优选地，空心竖直轴将指甲钳主体的上颚刚性地联接到致动杆，并且连杆延伸穿过轴的内部。平台优选地固定到轴的顶端并提供用于致动杆的支撑表面。

13. 发明申请

US20080051805A1 Hair Follicle Coring Tool and System Based Thereon 审中-公开
标题翻译：毛囊取芯工具及其系统
公开(公告)号：US20080051805A1
公开(公告)日：2008-02-28
申请号：US11467733
申请日：2006-08-28
申请人： Leonard Pinchuk
发明人： Leonard Pinchuk
IPC分类号： A61B17/50
CPC分类号： A61B17/3468 , A61B2017/00752 , A61B2017/00969 , A61F2/10
摘要： A tool for coring a portion of one or more hair follicles incorporates an elongate hollow tubular member with at least one cut-out disposed between its distal end and proximal end. The cut-out allows for removal of debris that moves it way up the hollow tubular member from the opened distal tip. The needle can also include a radially-extending projection that cooperates with zero or more ring-shaped members that are slipped concentrically over the distal end of the hollow tubular member to set the penetration depth of the coring needle. The tool can also include a stepped interface that is adapted to snag a root of a hair follicle unit cored by the hollow tubular member upon its withdrawal away from the patient's body.
摘要翻译：用于使一个或多个毛囊的一部分取芯的工具包括细长的中空管状构件，其中至少一个切口设置在其远端和近端之间。切口允许去除从开口的远侧末端向中空管状构件移动的碎屑。针还可以包括径向延伸的突起，其与零个或更多个环形构件配合，所述环形构件同心地滑过中空管状构件的远端以设定取芯针的穿透深度。该工具还可以包括阶梯式界面，该阶梯式界面适于在中空管状构件从患者身体撤出时由中空管状构件锁住毛囊单元的根部。

14. 发明申请

US20060189930A1 Methods and Apparatus for Sclerosing the Wall of a Varicose Vein 有权
标题翻译：用于硬化静脉曲张壁的方法和装置
公开(公告)号：US20060189930A1
公开(公告)日：2006-08-24
申请号：US11381372
申请日：2006-05-03
申请人： Banning Lary , Leonard Pinchuk , Saul Gottlieb , Charles Slater
发明人： Banning Lary , Leonard Pinchuk , Saul Gottlieb , Charles Slater
IPC分类号： A61M29/00
CPC分类号： A61M25/10 , A61B17/320725 , A61B2017/22038 , A61B2017/22067 , A61B2017/22082 , A61M25/1011 , A61M2025/0004 , A61M2025/0175 , A61M2025/105 , A61M2025/1052 , A61M2025/1068
摘要： A preferred apparatus for delivering an intravascular drug such as a sclerosing agent (or a microfoam sclerosing agent) to a varicose vein includes a catheter having three concentric tubes. The innermost tube has a guide wire lumen and an inflation lumen. The distal end of the innermost tube has an integral inflatable occlusion balloon in fluid communication with the inflation lumen. The intermediate tube has a lumen through which the innermost tube extends. The distal end of the intermediate tube has a self-expanding balloon with a plurality of fluid pores in fluid communication with the intermediate tube lumen. The outer tube has a lumen through which the intermediate tube extends. Sclerosing agent is dispensed through the intermediate tube to pores located at the distal end of the intermediate tube or in the self-expanding balloon. Veins are sclerosed as the self-expanding balloon is pulled through and ultimately out of the vein.
摘要翻译：用于将诸如硬化剂（或微泡硬化剂）的血管内药物递送到静脉曲张的优选装置包括具有三个同心管的导管。最内管具有导丝管腔和充气腔。最内管的远端具有与膨胀腔流体连通的整体充气闭塞球囊。中间管具有内管，最内管延伸通过该内腔。中间管的远端具有自膨胀气囊，其具有与中间管腔流体连通的多个流体孔。外管具有中空管延伸通过的内腔。硬化剂通过中间管分配到位于中间管的远端或自膨胀气囊中的孔。静脉由于自膨胀的气囊被拉过并最终脱离静脉，因此是硬化的。

15. 发明授权

US07077836B2 Methods and apparatus for sclerosing the wall of a varicose vein 有权
公开(公告)号：US07077836B2
公开(公告)日：2006-07-18
申请号：US09898867
申请日：2001-07-03
申请人： Banning G. Lary , Leonard Pinchuk , Saul Gottlieb , Charles R. Slater
发明人： Banning G. Lary , Leonard Pinchuk , Saul Gottlieb , Charles R. Slater
IPC分类号： A61M31/00
CPC分类号： A61M25/10 , A61B17/320725 , A61B2017/22038 , A61B2017/22067 , A61B2017/22082 , A61M25/1011 , A61M2025/0004 , A61M2025/0175 , A61M2025/105 , A61M2025/1052 , A61M2025/1068
摘要： A preferred apparatus for delivering an intravascular drug such as a sclerosing agent (or a microfoam sclerosing agent) to a varicose vein includes a catheter having three concentric tubes. The innermost tube has a guide wire lumen and an inflation lumen. The distal end of the innermost tube has an integral inflatable occlusion balloon in fluid communication with the inflation lumen. The intermediate tube has a lumen through which the innermost tube extends. The distal end of the intermediate tube has a self-expanding balloon with a plurality of fluid pores in fluid communication with the intermediate tube lumen. The outer tube has a lumen through which the intermediate tube extends. Sclerosing agent is dispensed through the intermediate tube to pores located at the distal end of the intermediate tube or in the self-expanding balloon. Veins are sclerosed as the self-expanding balloon is pulled through and ultimately out of the vein.

16. 发明申请

US20050125059A1 Ocular lens 有权
标题翻译：眼镜片
公开(公告)号：US20050125059A1
公开(公告)日：2005-06-09
申请号：US11004538
申请日：2004-12-03
申请人： Leonard Pinchuk , Jean-Marie Parel
发明人： Leonard Pinchuk , Jean-Marie Parel
IPC分类号： A61F2/16 , A61F9/00 , A61L27/16 , G02C20060101
CPC分类号： A61L27/16 , A61F2/1613 , A61F2/1629 , A61F2/1648 , A61F9/0017 , A61F2250/0067 , A61L27/54 , A61L2300/416 , A61L2430/16 , G02B1/041 , C08L53/02 , C08L23/22 , C08L25/08
摘要： An ocular lens has a refractive optics structure formed from a polyisobutylene-based material and a glassy segment that is non-reactive to ocular fluid and that maintains in vivo transparency for a substantial time period. The material has a central elastomeric polyolefinic block and thermoplastic end blocks (such as a triblock polymer backbone comprising polystyrene-polyisobutylene-polystyrene). The material is preferably flexible such that the refractive optics structure can be folded upon itself and introduced through a small scleral incision. The lens device includes an optic portion and preferably either an annular haptic element or one or more haptic elements adapted to rest within a capsular bag formed by a surgical procedure. A portion of the lens device may be loaded with at least one therapeutic agent that interferes with proliferation of the epithelial cells of the eye to protect against PCO.
摘要翻译：眼透镜具有由聚异丁烯基材料形成的折射光学结构和与眼液无反应性的玻璃质片段，并且在相当长的时间内维持体内透明度。该材料具有中心弹性聚烯烃嵌段和热塑性端嵌段（例如包含聚苯乙烯 - 聚异丁烯 - 聚苯乙烯的三嵌段聚合物主链）。该材料优选是柔性的，使得折射光学结构可以自身折叠并通过小的巩膜切口引入。透镜装置包括光学部分，并且优选地是环形触觉元件或适于搁置在通过外科手术形成的囊袋内的一个或多个触觉元件。透镜装置的一部分可以装载有至少一种治疗剂，其干扰眼睛上皮细胞的增殖以防止PCO。

17. 发明申请

US20050074399A1 Minimally invasive vascular surgery 有权
标题翻译：微创血管手术
公开(公告)号：US20050074399A1
公开(公告)日：2005-04-07
申请号：US10901409
申请日：2004-07-27
申请人： G. Lary , Leonard Pinchuk
发明人： G. Lary , Leonard Pinchuk
IPC分类号： A61M36/14
CPC分类号： A61K9/0019 , A61K47/02
摘要： A mixture for intravenous injection to treat damaged vascular structures contains a mixture of carbamide peroxide and a sclerosing agent. The injected mixture expresses blood from the affected vascular structure by formation of bubbles, in situ. The bubbles carry the sclerosing agent into contact with the lining of the vascular structure resulting in destruction. The size of the bubbles may be varied by adding hydrogen peroxide and varying the proportions of carbamide peroxide and hydrogen peroxide in the mixture.
摘要翻译：用于静脉注射以治疗受损血管结构的混合物含有过氧化脲和硬化剂的混合物。注射的混合物通过原位形成气泡从受影响的血管结构中表达血液。气泡携带硬化剂与血管结构的衬里接触导致破坏。可以通过加入过氧化氢和改变混合物中过氧化脲和过氧化氢的比例来改变气泡的大小。

18. 发明授权

US06348066B1 Modular endoluminal stent-grafts and methods for their use 有权
标题翻译：模块化腔内支架移植物及其使用方法
公开(公告)号：US06348066B1
公开(公告)日：2002-02-19
申请号：US09134887
申请日：1998-08-14
申请人： Leonard Pinchuk , Jean-Pierre Dereume
发明人： Leonard Pinchuk , Jean-Pierre Dereume
IPC分类号： A61F206
CPC分类号： A61F2/90 , A61F2/07 , A61F2/89 , A61F2002/065 , A61F2002/072 , A61F2002/075 , A61F2002/826 , A61F2220/0025 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/0067 , A61F2230/0078 , A61F2230/008 , A61F2230/0097 , A61F2250/0039
摘要： Modular endoluminal stent-grafts include at least two different sized stent-grafts which are deployed one within the other. According to one embodiment of the invention, a first stent-graft is provided having a flared end which is expandable to a first diameter and a midsection which is expandable to a second diameter smaller than the first diameter. A second stent-graft is also provided having an end which is expandable to a diameter which engages the midsection of the first stent-graft. The first embodiment of the invention is deployed by expanding the first stent-graft such that its flared end engages a large diameter vessel, then expanding the second stent-graft inside the midsection of the first stent graft and inside a small diameter vessel such that the second stent graft engages the small diameter vessel and the midsection of the first stent-graft. According to a second embodiment of the invention, the midsection of the first stent-graft is reinforced with a flexible member to restrict the midsection from ballooning. According to other aspects of the invention, the first stent-graft is provided with two flared ends and the second stent graft is provided with or without flared ends. According to still another embodiment of the invention, three or more stent-grafts of different expanded diameter are deployed one within the other.
摘要翻译：模块化腔内支架移植物包括至少两个不同尺寸的支架移植物，其在另一个内展开。根据本发明的一个实施例，提供第一支架移植物，其具有可扩张至第一直径的扩口端和可扩张至小于第一直径的第二直径的中段。还提供了第二支架移植物，其具有可扩张至与第一支架移植物的中部接合的直径的端部。本发明的第一个实施例通过使第一支架移植物膨胀，使得其扩口端接合大直径容器，然后将第二支架移植物在第一支架移植物的中部内部扩张并在小直径容器内部扩张，第二支架移植物接合小直径血管和第一支架移植物的中部。根据本发明的第二实施例，第一支架移植物的中部用柔性构件加强，以限制中央部分的膨胀。根据本发明的其他方面，第一支架移植物设置有两个扩张端，并且第二支架移植物设置有或不具有扩张端。根据本发明的另一个实施例，三个或更多个不同扩张直径的支架移植物在另一个内展开。

19. 发明授权

US06295714B1 Process for fabricating a prosthesis 有权
标题翻译：制造假体的方法
公开(公告)号：US06295714B1
公开(公告)日：2001-10-02
申请号：US09510209
申请日：2000-02-22
申请人： Suranjan Roychowdhury , Leonard Pinchuk , Eugen Hofmann , Susanne Hankh , Michael G. O'Connor , Jennifer E. Raeder-Devens , Jeannine B. Baden , Daniel J. Klima
发明人： Suranjan Roychowdhury , Leonard Pinchuk , Eugen Hofmann , Susanne Hankh , Michael G. O'Connor , Jennifer E. Raeder-Devens , Jeannine B. Baden , Daniel J. Klima
IPC分类号： B21D3900
CPC分类号： A61F2/90 , A61F2/958 , A61F2002/30451 , A61F2002/9522 , A61F2220/0058 , A61F2240/001 , Y10T29/49798 , Y10T29/49927
摘要： A body implantable stent is formed of a plurality of strands arranged in two sets of coaxial helices, wound in opposite directions to form multiple crossings. At selected crossings, the adjacent strands are welded to one another, while at the remaining crossings the strands are free for limited movement relative to one another. The welds are formed in patterns that preferably enhance radial strength and rigidity, while having a minimal impact on axial bending flexibility. Preferred weld patterns in this regard include rings or circumferential rows, and helices, particularly with a steeper pitch than that of the strands. Stent fabrication preferably involves resistance welding at the crossings, and use of a tool to reuniformly compress the stent around and against the distal end region of a balloon catheter used later to deliver the stent to a treatment site.
摘要翻译：身体可植入支架由多个绞合线构成，所述股线布置成两组同轴螺旋，沿相反方向缠绕以形成多个交叉。在所选的交叉处，相邻的线条彼此焊接，而在剩余的交叉处，线条相对于彼此有限的移动是自由的。焊缝以优选增强径向强度和刚度的图案形成，同时对轴向弯曲柔性具有最小的影响。在这方面，优选的焊接图案包括环或周向排和螺旋，特别是具有比线的陡峭的间距。支架制造优选地涉及在交叉点处的电阻焊接，以及使用工具将支架均匀地压缩在球囊导管的远端区域周围并抵靠以后用于将支架输送到治疗部位的远端区域。

20. 发明授权

US06254633B1 Delivery device for a medical device having a constricted region 失效
标题翻译：具有收缩区域的医疗装置的输送装置
公开(公告)号：US06254633B1
公开(公告)日：2001-07-03
申请号：US08989119
申请日：1997-12-11
申请人： Leonard Pinchuk , John B. Martin, Jr.
发明人： Leonard Pinchuk , John B. Martin, Jr.
IPC分类号： A61F200
CPC分类号： A61B17/12109 , A61B17/12022 , A61B17/12172 , A61B2017/00557 , A61B2017/1205
摘要： A delivery device for delivering an implantable, radially expandable medical device having a constricted region for occluding fluid flow to a desired location in a body lumen. The delivery device includes an outer sleeve, an inner tube terminating at its distal end in a plunger, and a tapered guide member. In one embodiment, the tapered guide member is attached to and extends away from the constricted region of the occlusion device, and is thus implanted in the body lumen along with the occlusion device upon deployment of the occlusion device at the desired treatment location. In a second embodiment, the tapered guide member is integrated into the constricted region of the occlusion device. In a third embodiment, an inflatable balloon is positioned distally of the medical device, and when inflated provides a tapered guide surface that eases the navigation of the delivery device through the body lumen. Upon deployment of the medical device at the desired location, the balloon is deflated to such a size as to be able to be withdrawn through the constricted region of the occlusion device, and is thus removed from the body lumen.
摘要翻译：一种递送装置，用于递送具有收缩区域的可植入的可径向扩张的医疗装置，用于将流体流阻塞到体腔内的期望位置。输送装置包括一个外套管，一个在其远端终止于柱塞的内管，以及一锥形导向件。在一个实施例中，锥形引导构件附接到闭塞装置的收缩区域并且远离咬合装置的收缩区域，并且因此在将闭塞装置展开在期望的治疗位置时与闭塞装置一起植入体腔内。在第二实施例中，锥形引导构件集成到闭塞装置的收缩区域中。在第三实施例中，可充气气囊位于医疗装置的远侧，并且当充气时提供锥形的引导表面，其减轻了输送装置通过体腔的导航。在将医疗装置部署在期望的位置时，气囊被放气到能够通过闭塞装置的收缩区域取出的尺寸，并且因此被从身体腔排出。

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