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11. 发明申请

WO2008156883A3 TEAR FILM MEASUREMENT 审中-公开
公开(公告)号：WO2008156883A3
公开(公告)日：2008-12-24
申请号：PCT/US2008/057578
申请日：2008-03-20
申请人： TEARSCIENCE, INC. , KORB, Donald, R. , GRAVELY, Benjamin, T.
发明人： KORB, Donald, R. , GRAVELY, Benjamin, T.
IPC分类号： A61B3/10
摘要： Apparatus for measuring the relative thickness of the lipid layer of the precorneal tear film on the surface of an eye after distribution of the lipid layer subsequent to blinking An illuminator directs light to the lipid layer of an eye The illuminator is a broad spectrum source covering the visible region and is a lambertion light emitter such that the light source is specularly reflected from the lipid layer and undergoes constructive and destructive interference in the lipid layer A collector collects and focuses the specularly reflected light such that the interference patterns on the tear film lipid layer are observable The collector produces output representative of the specularly reflected light for further analysis, such as projection on to a high resolution monitor or computer analysis The patient's head may be positioned on an observation platform when the illuminator directs light to the lipid layer of the eye.

12. 发明申请

WO2008089327A1 METHODS, SYSTEMS, AND APPARATUSES FOR HEAT TREATMENT FOR TREATING MEIBOMIAN GLAND DYSFUNCTION 审中-公开
标题翻译：用于治疗脑血管功能障碍的热处理方法，系统和装置
公开(公告)号：WO2008089327A1
公开(公告)日：2008-07-24
申请号：PCT/US2008/051309
申请日：2008-01-17
申请人： KORB, Donald, R. , GRENON, Stephen, M. , WILLIS, Timothy, R. , GRAVELY, Benjamin, Tyson , JANS, John, Martin , HUTCHINSON, Jordan, W. , GAUSMANN, Keith
发明人： KORB, Donald, R. , GRENON, Stephen, M. , WILLIS, Timothy, R. , GRAVELY, Benjamin, Tyson , JANS, John, Martin , HUTCHINSON, Jordan, W. , GAUSMANN, Keith
IPC分类号： A61M35/00
CPC分类号： A61F7/02 , A61F7/007 , A61F9/00718 , A61F2007/0004 , A61F2007/0086
摘要： Apparatuses, systems, and methods of treating meibomian gland dysfunction. Heat is applied to the patient's eyelid or surrounding tissue to apply heat to the patient's meibomian glands. The application of heat assists in the expression of obstructions or occlusions in the meibomian glands to restore sufficient sebum flow to the lipid layer to treat dry eye. A force may also be applied to the patient's eyelid or surrounding tissue to improve conductive heat transfer and reduce blood flow in the tissue that causes convective heat loss. Thus, the application of force can further increase the temperature level and/or reduce the time to reach desired temperature levels for removing obstructions. Reaching increased temperature levels may improve the melting, loosening, or softening of obstructions or occlusions in the meibomian glands while reducing the amount of time to reached desired temperature levels and/or aid in reducing discomfort to the patient during treatment.
摘要翻译：治疗睑板腺功能障碍的装置，系统和方法。对患者的眼睑或周围组织施加热量以对患者的睑板腺施加热量。热的应用有助于睑板腺中阻塞或闭塞的表达，以恢复足够的脂质流向脂质层以治疗干眼症。也可以将力施加到患者的眼睑或周围组织以改善传导性热传递并减少导致对流热损失的组织中的血液流动。因此，施加力可以进一步增加温度水平和/或减少达到期望温度水平以消除障碍物的时间。达到升高的温度水平可以改善睑板腺中的阻塞物或闭塞的熔化，松动或软化，同时减少达到所需温度水平的时间量和/或有助于减轻治疗期间患者的不适。

13. 发明申请

WO2008042002A1 METHOD AND APPARATUS FOR DIAGNOSING MEIBOMIAN GLAND DYSFUNCTION 审中-公开
标题翻译：用于诊断MEIBOMIAN GLAND DYSFUNCTION的方法和装置
公开(公告)号：WO2008042002A1
公开(公告)日：2008-04-10
申请号：PCT/US2007/000495
申请日：2007-01-09
申请人： KOLIS SCIENTIFIC, INC. , KORB, Donald, R. , GRAVELY, Benjamin, T. , JANS, John, M. , GAUSMANN, Keith, H.
发明人： KORB, Donald, R. , GRAVELY, Benjamin, T. , JANS, John, M. , GAUSMANN, Keith, H.
IPC分类号： A61B3/16
CPC分类号： A61B3/101
摘要： An apparatus for testing meibomian glands in the eyelids of humans for meibomian gland disease is provided The apparatus compπses a handle, and a probe tip mounted for movement relative to said handle such that when the probe tip is placed against the eyelid and compressive force is applied, movement of the handle a preselected distance replicates the force required for natural expression of secretion from the meibomian gland An indicator means selected from the group consisting of auditory, visual and tactile signals is provided and when activated alerts the clinician that the required force has been reached According to the method of the present invention a probe tip is located in contacting relation with the eyelid, the probe tip being connected to a handle (105) When pressure is exerted on the eyelid by pressing it against the eyelid, a preselected pressure is exerted thereon
摘要翻译：提供了一种用于测试睑板腺疾病的人类眼皮中睑板腺的装置。该装置包括手柄和安装成相对于所述手柄移动的探针尖端，使得当探针针头靠着眼睑放置并施加压缩力时手柄的移动预选距离复制了睑板腺分泌物的自然表达所需的力量提供了从听觉，视觉和触觉信号组成的组中选择的指示器，并且当激活时向临床医生警告所需的力已经被达到根据本发明的方法，探针尖端与眼睑呈接触关系，探针尖端连接到手柄（105）当通过将眼压压在眼睑上而施加压力时，预选的压力为施加于其上

14. 发明申请

WO2008039221A1 MELTING MEIBOMIAN GLAND OBSTRUCTIONS 审中-公开
标题翻译：熔化MEIBOMIAN GLAND阻塞
公开(公告)号：WO2008039221A1
公开(公告)日：2008-04-03
申请号：PCT/US2007/000508
申请日：2007-01-09
申请人： KOLIS SCIENTIFIC, INC. , GRENON, Stephen, M. , FOSHEE, David , KORB, Donald, R. , WILLIS, Timothy, R. , BARRIER, Omer, Jack
发明人： GRENON, Stephen, M. , FOSHEE, David , KORB, Donald, R. , WILLIS, Timothy, R. , BARRIER, Omer, Jack
IPC分类号： A61F7/00
CPC分类号： A61F7/007 , A61F2007/0004
摘要： Consistent with certain embodiments, an apparatus provides regulated heat to at least one of a patient's eyelids, using a heater unit (38) having a heating element (42) that produces heat that is transferred to the patient's eyelid when an electrical signal is applied thereto. A temperature regulator applies an electrical signal to the heating elements (42) in order to achieve heating of the heating elements (42) to a specified temperature range. This abstract is not to be considered limiting, since other embodiments may deviate from the features described in this abstract.
摘要翻译：根据某些实施例，一种装置使用具有加热元件（42）的加热器单元（38）向患者的眼睑中的至少一个提供调节的热量，所述加热器单元产生当向其施加电信号时传递到患者眼皮的热量。温度调节器将电信号施加到加热元件（42），以实现加热元件（42）的加热到指定的温度范围。该摘要不被认为是限制性的，因为其它实施例可能偏离本摘要中描述的特征。

15. 发明申请

WO2008039220A1 MEIBOMIAN GLAND IMAGING 审中-公开
公开(公告)号：WO2008039220A1
公开(公告)日：2008-04-03
申请号：PCT/US2007/000505
申请日：2007-01-09
申请人： KOLIS SCIENTIFIC, INC. , GRENON, Stephen, M. , WILLS, Timothy, R. , GRAVELY, Benjamin, T. , KORB, Donald, R.
发明人： GRENON, Stephen, M. , WILLS, Timothy, R. , GRAVELY, Benjamin, T. , KORB, Donald, R.
IPC分类号： A61B3/14
CPC分类号： A61B3/10 , A61B5/0066 , A61B5/0073 , A61B5/411 , A61B5/4261
摘要： A method of evaluating dry eye in humans wherein the flow of naturally occurring secretion to the eye is reduced or stopped due to the presence of an obstruction of a meibomian gland (20) in the eyelid involves applying a pressure to the eyelid that mimics pressure applied during blinking; and simultaneously imaging the glands to diagnose the condition of the meibomian gland (20). This abstract is not to be considered limiting, since other embodiments may deviate from the features described in this abstract.
摘要翻译：一种评估人眼干眼症的方法，其中由于眼睑中睑板腺（20）的阻塞的存在，减少或停止天然存在于眼睛的分泌物的流动，包括对眼睑施加压力，模拟施加的压力眨眼期间并同时对腺体进行成像以诊断睑板腺的状况（20）。该摘要不被认为是限制性的，因为其它实施例可能偏离本摘要中描述的特征。

16. 发明申请

WO2008027069A1 METHOD AND APPARATUS FOR TREATING MEIBOMIAN GLAND DYSFUNCTION EMPLOYING FLUID 审中-公开
标题翻译：用于处理使用流体的MEIBOMIAN GLAND DYSFUNCTION的方法和装置
公开(公告)号：WO2008027069A1
公开(公告)日：2008-03-06
申请号：PCT/US2007/000493
申请日：2007-01-09
申请人： KOLIS SCIENTIFIC, INC. , GRENON, Stephen, M. , ROE, Steven , KORB, Donald, R. , PAUL, Lyle
发明人： GRENON, Stephen, M. , ROE, Steven , KORB, Donald, R. , PAUL, Lyle
IPC分类号： B08B3/10
CPC分类号： A61F9/00 , A61B17/3203 , A61B18/04 , A61B2018/046 , A61F9/00772 , A61F2007/0004 , A61F2007/0059
摘要： According to the present invention, there is provided a method of treating meibomian gland dysfunction in a mammal wherein an occlusion blocks at least a portion of the flow of naturally occurring secretion out of a gland channel orifice (O). The invention comprises selecting a device capable of delivering a jet of heated medium. The device is positioned such that when the jet is applied to the exterior surface of the eyelid, proximate to the gland channel orifice (O), a jet of heated medium is applied to the exterior surface of the eyelid proximate to the gland channel orifice at a pressure of from about 2 psi to about 30 psi. Application of the jet of heated medium is maintained for sufficient time to loosen, break up, fracture, soften or liquefy at least a portion of the occlusion such that at least a portion of the occlusion is removed.
摘要翻译：根据本发明，提供了一种在哺乳动物中治疗睑板腺功能障碍的方法，其中闭塞将至少一部分天然存在的分泌物流出腺体通道孔口（O）。本发明包括选择能够输送加热介质射流的装置。该装置被定位成使得当喷射器施加到眼睑的外表面时，靠近腺体通道孔口（O），加热介质射流被施加到靠近腺体通道孔的眼睑外表面约2psi至约30psi的压力。维持加热介质喷射器的足够时间以松开，分解，断裂，软化或液化至少一部分闭塞，使得至少一部分堵塞被去除。

17. 发明申请

WO1997016166A1 SKIN CARE PREPARATION AND METHOD 审中-公开
标题翻译：皮肤护理准备和方法
公开(公告)号：WO1997016166A1
公开(公告)日：1997-05-09
申请号：PCT/US1996017693
申请日：1996-11-01
申请人： OCULAR RESEARCH OF BOSTON, INCORPORATED , KORB, Donald, R. , GLONEK, Thomas , GREINER, Jack, V.
发明人： OCULAR RESEARCH OF BOSTON, INCORPORATED
IPC分类号： A61K07/48
CPC分类号： A61Q19/00 , A61K8/375 , A61K8/553 , A61Q19/007 , Y10S514/844 , Y10S514/861 , Y10S514/863 , Y10S514/864 , Y10S514/937
摘要： A composition and method for treatment of skin. The composition comprises a pharmaceutically acceptable carrier containing a bilayer (1, 2) component having one or more polar terminus groups and one or more non-polar terminus groups separated from said polar terminus groups capable of penetrating the outer surface of the skin to form an aligned bilayer within the stratum corneum. The bilayer assists in the formation of bilayer (1, 2) lamellae that is believed to replicate the bilayer lamellae present in healthy skin. The composition is topically applied to the skin as often as is required.
摘要翻译：用于治疗皮肤的组合物和方法。该组合物包含含有具有一个或多个极性末端基团的一个或多个极性末端基团和一个或多个非极性末端基团的双层（1,2）组分的药学上可接受的载体，所述非极性末端基团能够穿透皮肤的外表面以形成排列在角质层内的双层。双层帮助形成双层（1,2）薄片，据信它可以复制存在于健康皮肤中的双层薄片。该组合物经常按需要局部施用于皮肤。

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