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11. 发明专利

ES8308361A1 UN METODO PARA LA PRODUCCION DE UN POLIPEPTIDO. 未知
公开(公告)号：ES8308361A1
公开(公告)日：1983-08-16
申请号：ES515241
申请日：1982-08-25
申请人： KINGSMAN ALAN JOHN , KINGSMAN SUSAN MARY
IPC分类号： C12N15/09 , C07H21/04 , C07K14/56 , C12N1/16 , C12N15/00 , C12N15/81 , C12P21/00 , C12R1/865
摘要： PROCEDIMIENTO PARA LA OBTENCION DE POLIPEPTIDOS. CONSISTE EN EXPRESAR EL POLIPEPTIDO, QUE SE QUIERE PRODUCIR, EN UN ORGANISMO HUESPED DE LEVADURA TRANSFORMADO POR UN VECTOR DE EXPRESION DE LEVADURA, QUE CONTIENE UN MARCADOR SELECTIVO DE LEVADURA, UN ORIGEN DE REPLICACION DE LEVADURA Y UN PROMOTOR DE LEVADURA COLOCADOS RESPECTO A UN SITIO DE RESTRICCION UNICA; DE MODO QUE SE PUEDE OBTENER LA EXPRESION DE UNA SECUENCIA CODIFICANTE DE POLIPEPTIDOS. TIENE APLICACIONES EN INGENIERIA BIOMOLECULAR.

12. 发明专利

ES515241A0 未知
公开(公告)号：ES515241A0
公开(公告)日：1983-08-16
申请号：ES515241
申请日：1982-08-25
申请人： KINGSMAN ALAN JOHN , KINGSMAN SUSAN MARY
IPC分类号： C12N15/09 , C07H21/04 , C07K14/56 , C12N1/16 , C12N15/00 , C12N15/81 , C12P21/00 , C12R1/865
摘要： There are described a number of plasmid vectors suitable for the expression of genetic material, at various levels in yeasts. The plasmids each comprise a yeast selective marker, a yeast replication origin and a yeast promoter positioned relative to a unique restriction site in such a way that expression may be obtained of a polypeptide coding sequence inserted at the restriction site. The promoters used are derived from the 5' region of a gene coding for a yeast glycolytic enzyme e.g. phosphoglycerate kinase (PGK), or from the 5' region of the yeast TRP1 gene. In one Example a plasmid contains a promoter derived from both the 3' and 5' regions of the PGK gene. The replication systems used involve the yeast 2µ replication origin or an autonomous replicating sequence (ARS) stabilised with an ARS stabilising sequence (ASS). The replication systems allow for a choice of high or low copy number per cell. The promoter sequences allow for a choice of high or low expression level. A kit including vectors having a combination of these alternative features is described. Yeast expression vectors including a gene for coding for human interferon-a are described.

13. 发明专利

ZA8205959B EXPRESSION VECTORS 未知
公开(公告)号：ZA8205959B
公开(公告)日：1983-07-27
申请号：ZA8205959
申请日：1982-08-17
申请人： KINGSMAN ALAN JOHN , KINGSMAN SUSAN MARY
发明人： KINGSMAN ALAN JOHN , KINGSMAN SUSAN MARY
IPC分类号： C12N20060101 , C12P20060101 , C12R20060101 , C12N , C12P , C12R

14. 发明专利

ZA825959B EXPRESSION VECTORS 未知
公开(公告)号：ZA825959B
公开(公告)日：1983-07-27
申请号：ZA825959
申请日：1982-08-17
申请人： KINGSMAN ALAN JOHN , KINGSMAN SUSAN MARY
发明人： KINGSMAN ALAN JOHN , KINGSMAN SUSAN MARY
IPC分类号： C12N20060101 , C12P20060101 , C12R20060101 , C12N , C12P , C12R

15. 发明申请

WO2008059252A9 METHODS AND COMPOSITION FRO T CELL RECEPTORS WHICH RECOGNIZE 5T4 ANTIGEN 审中-公开
标题翻译：识别5T4抗原的方法和组合物FRO T细胞受体
公开(公告)号：WO2008059252A9
公开(公告)日：2008-09-18
申请号：PCT/GB2007004361
申请日：2007-11-15
申请人： OXFORD BIOMEDICA LTD , MYERS KEVIN , REDCHENKO IRINA , SHINGLER WILLIAM , HARROP RICHARD , NAYLOR STUART , KINGSMAN ALAN , KINGSMAN SUSAN
发明人： MYERS KEVIN , REDCHENKO IRINA , SHINGLER WILLIAM , HARROP RICHARD , NAYLOR STUART , KINGSMAN ALAN , KINGSMAN SUSAN
IPC分类号： C12Q1/68
CPC分类号： C07K14/4748
摘要： The present invention relates to the use of peptide epitopes of 5T4 antigen in the identification and isolation of T cell receptors which recognize 5T4 antigen.
摘要翻译：本发明涉及5T4抗原的肽表位在识别和分离识别5T4抗原的T细胞受体中的用途。

16. 发明申请

WO2004047531A3 PROTEIN PRODUCTION IN TRANSGENIC AVIANS USING LENTIVIRAL SYSTEM 审中-公开
标题翻译：使用生殖系统的转基因食品蛋白质生产
公开(公告)号：WO2004047531A3
公开(公告)日：2005-12-08
申请号：PCT/GB0305191
申请日：2003-11-27
申请人： VIRAGEN INC , OXFORD BIOMEDICA LTD , SANG HELEN , MCGREW MICHAEL , SHERMAN ADRIAN , JERVIS KAREN ELIZABETH , STIMSON WILLIAM HOWARD , MITROPHANOUS KYRIACOS , ELLARD FIONA , KINGSMAN ALAN
发明人： SANG HELEN , MCGREW MICHAEL , SHERMAN ADRIAN , JERVIS KAREN ELIZABETH , STIMSON WILLIAM HOWARD , MITROPHANOUS KYRIACOS , ELLARD FIONA , KINGSMAN ALAN
IPC分类号： A01K67/027 , C12N15/85 , C12N15/00 , C12N15/867 , G01N33/50
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/05 , A01K2227/30 , A01K2267/01 , C12N2799/027
摘要： The present invention relates to a method for the production of transgenic avians using a lentivirus vector system to deliver exogenous genetic material. The invention also relates to the production of proteins by the transgenic avians, preferably in egg whites and a method of testing the likelihood of expression in avian eggs.
摘要翻译：本发明涉及使用慢病毒载体系统产生转基因鸟类来递送外源遗传物质的方法。本发明还涉及由转基因鸟类，优选在蛋清中生产蛋白质，以及测试禽蛋中表达可能性的方法。

17. 发明申请

WO02068466A3 HYPOXIA-REGULATED GENES 审中-公开
标题翻译： HYPOXIA调节基因
公开(公告)号：WO02068466A3
公开(公告)日：2003-05-22
申请号：PCT/GB0200817
申请日：2002-02-22
申请人： OXFORD BIOMEDICA LTD , WHITE JONATHAN , MUNDY CHRISTOPHER ROBERT , WARD NEIL RAYMOND , KRIGE DAVID , KINGSMAN ALAN JOHN , HARRIS ROBERT ALAN , BARBER ROBERT
发明人： WHITE JONATHAN , MUNDY CHRISTOPHER ROBERT , WARD NEIL RAYMOND , KRIGE DAVID , KINGSMAN ALAN JOHN , HARRIS ROBERT ALAN , BARBER ROBERT
IPC分类号： A61K38/00 , C07K14/47 , C12N15/12 , C12Q1/68 , G01N33/68 , A61K38/17 , A61K48/00 , C12N5/10 , C12N15/63
CPC分类号： C12Q1/6883 , A61K38/00 , C07K14/4702 , C12Q1/6837 , C12Q2600/156 , C12Q2600/158 , G01N33/6893
摘要： This invention relates to novel genes and gene products that are implicated in certain disease states. These genes have been identified by a novel method that comprises the steps of comparing: i) the transcriptome or proteome of a first specialised cell type that is implicated in the disease or condition under conditions of both normoxia and hypoxia; with ii) the transcriptome or proteome of a second specialised cell type under conditions of both normoxia and hypoxia; and identifying as a gene implicated in the disease or physiological condition, a gene that is differentially regulated in the two specialised cell types under the two different conditions compared.
摘要翻译：本发明涉及涉及某些疾病状态的新基因和基因产物。已经通过新的方法鉴定了这些基因，其包括以下步骤：i）在常氧和缺氧条件下与疾病或病症相关的第一种特异性细胞类型的转录组或蛋白质组比较：其中ii）在常氧和缺氧条件下的第二种特殊细胞类型的转录组或蛋白质组; 并鉴定为与疾病或生理条件相关的基因，在两种不同条件下比较两种特异性细胞类型中差异调节的基因。

18. 发明申请

WO2003038098A2 5T4 LIGAND 审中-公开
标题翻译： 5T4配对
公开(公告)号：WO2003038098A2
公开(公告)日：2003-05-08
申请号：PCT/GB2002/004965
申请日：2002-11-04
申请人： OXFORD BIOMEDICA (UK) LIMITED , CARROLL, Miles , LAMIKANRA, Abigail , KINGSMAN, Alan
发明人： CARROLL, Miles , LAMIKANRA, Abigail , KINGSMAN, Alan
IPC分类号： C12N15/13
CPC分类号： C07K16/30 , C07K16/28 , C07K2317/77 , C07K2319/00
摘要： The present invention relates to a novel method for the delivery of agents to tumour cells. In particular it relates to a method for the specific delivery of agents to the interior of tumour cells. Uses of the method are also described.
摘要翻译：本发明涉及一种将药物递送到肿瘤细胞的新方法。特别地，它涉及用于将药剂特异性递送至肿瘤细胞内部的方法。还描述了该方法的用途。

19. 发明申请

WO0031280A2 VECTOR 审中-公开
标题翻译：向量
公开(公告)号：WO0031280A2
公开(公告)日：2000-06-02
申请号：PCT/GB9903866
申请日：1999-11-19
申请人： OXFORD BIOMEDICA LTD , MITROPHANOUS KYRIACOS , UDEN MARK , ROHLL JONATHAN , KINGSMAN SUSAN MARY , KINGSMAN ALAN JOHN
发明人： MITROPHANOUS KYRIACOS , UDEN MARK , ROHLL JONATHAN , KINGSMAN SUSAN MARY , KINGSMAN ALAN JOHN
IPC分类号： C12N15/09 , A61K35/76 , A61K48/00 , A61P1/04 , A61P9/00 , A61P11/06 , A61P17/00 , A61P25/00 , A61P25/28 , A61P27/02 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/00 , C12N5/10 , C12N7/00 , C12N15/867 , C12N15/67
CPC分类号： C12N15/86 , A61K48/00 , C12N2740/13043
摘要： A retroviral vector capable of delivering an NOI and comprising an exogenous second synthesis element.
摘要翻译：能够递送NOI并包含外源性第二合成元件的逆转录病毒载体。

20. 发明申请

WO0162965A3 DIFFERENTIAL EXPRESSION SCREENING METHOD 审中-公开
标题翻译：差分表达式筛选方法
公开(公告)号：WO0162965A3
公开(公告)日：2002-09-06
申请号：PCT/GB0100758
申请日：2001-02-22
申请人： OXFORD BIOMEDICA LTD , KINGSMAN ALAN JOHN
发明人： KINGSMAN ALAN JOHN
IPC分类号： G01N33/50 , C12N15/09 , C12Q1/68 , G01N33/68
CPC分类号： C12Q1/6809
摘要： A differential expression screening method is provided for identifying a genetic element involved in a cellular process, which method comprises comparing: (a) gene expression in a first cell of interest; and (b) gene expression in a second cell of interest, which cell comprises altered levels, relative to physiological levels, of a biological molecule implicated in the cellular process, due to the introduction into the second cell of a heterologous nucleic acid directing expression of a polypeptide; and identifying a genetic element whose expression differs, wherein gene expression in said first and/or second cell of interest is compared under at least two different environmental conditions relevant to the cellular process.
摘要翻译：提供用于鉴定涉及细胞过程的遗传元件的差异表达筛选方法，该方法包括比较：（a）感兴趣的第一细胞中的基因表达; 和（b）在第二细胞中的基因表达，该细胞包括与细胞过程相关的生物分子相对于生理水平的改变的水平，这是由于引入到第二细胞中的异源核酸的指导表达多肽; 并鉴定其表达不同的遗传元件，其中在与细胞过程相关的至少两个不同环境条件下比较所述第一和/或第二细胞中的基因表达。

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