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11. 发明授权

US4087436A Methylation of de-A steroids 失效
标题翻译： de-A类固醇的甲基化
公开(公告)号：US4087436A
公开(公告)日：1978-05-02
申请号：US589650
申请日：1975-06-23
申请人： Paul Buchschacher , Andor Furst , Ludwig Labler , Werner Meier , John William Scott
发明人： Paul Buchschacher , Andor Furst , Ludwig Labler , Werner Meier , John William Scott
IPC分类号： C07C49/417 , C07D261/08 , C07J1/00 , C07J7/00 , C07J17/00 , C07J43/00 , C07D261/06 , C07C49/54 , C07C49/60 , C07D317/08
CPC分类号： C07D261/08 , C07C49/417 , C07J1/00 , C07J17/00 , C07J43/00 , C07J7/00 , C07C2103/16 , C07C2103/26
摘要： Treatment of de-A steroids with a methylation agent at extremely low temperatures, i.e., below -50.degree. C. produces corresponding 10.beta.-methyl-.DELTA..sup.9(11) -deA steroids with a high 10.beta. to 10.alpha. isomer ratio. A number of the product 10.beta.-methyl-.DELTA..sup.9(11) -deA steroids are novel compounds. They are useful as intermediates in the synthesis of known medicinally valuable steroids.
摘要翻译：用非常低的温度（即低于-50℃）用甲基化剂处理de-A类固醇，产生相应的具有高10β-10α异构体比例的10个β-甲基-DETTA 9（11）-deA类固醇。一些产品10β-甲基-DTATA 9（11）-deA类固醇是新化合物。它们可用作合成已知药用有价值类固醇的中间体。

12. 发明授权

US5850825A Bowstring release device 失效
标题翻译：弓弦释放装置
公开(公告)号：US5850825A
公开(公告)日：1998-12-22
申请号：US781297
申请日：1997-01-13
申请人： John William Scott
发明人： John William Scott
IPC分类号： F41B5/18
CPC分类号： F41B5/1469
摘要： A bowstring release with a fixed jaw and a single movable jaw is controlled by a trigger mechanism to provide enhanced accuracy. The bowstring release mechanism is adapted to rotate about its longitudinal axis to readily align the jaws with a bowstring, and the bowstring release is further attached to a wrist strap by means of a ring or attachment plate having two relatively straight sides engaged by leather tabs on the wrist strap. The straight sides and the leather tabs control and define the location of the ring thereby removing positional variances of the point of force transmission between the wrist strap and the bowstring release device and eliminate at least some variations which will affect consistent bowstring draw and release. The use of both a single fixed jaw and a movable jaw improves the accuracy and the smoothness with which the bowstring is released by stabilizing the bowstring during the initial portions of its flight after release. An interconnection between the release and the wrist strap is comprised of two members that nest with each other and have aligned holes therein which accept a pin or bolt member to retain the members in the nested relation under bowstring pull loading. The pin or bolt extends transverse to the longitudinal axes of the members. A plurality of holes may be provided in one or both of the members for adjustability.
摘要翻译：具有固定钳口和单个活动钳口的弓弦释放装置由触发机构控制以提供更高的精度。弓弦释放机构适于围绕其纵向轴线旋转以容易地将颚板与弓弦对准，并且弓弦释放装置通过环或附接板进一步附接到腕带，所述环或附接板具有由皮革翼片接合的两个相对直的侧面腕带。直边和皮革翼片控制和限定环的位置，从而消除腕带和弓弦释放装置之间的力传递点的位置变化，并消除至少一些影响一致弓弦牵引和释放的变化。使用单个固定夹爪和可动夹钳可以在释放后在其飞行的最初部分稳定弓弦，提高了弓弦释放的准确性和平滑度。释放和腕带之间的互连由彼此嵌套并且具有对准的孔中的两个构件组成，其中接纳销或螺栓构件以在弓弦牵引负载下将构件保持在嵌套关系中。销或螺栓横向于构件的纵向轴线延伸。可以在一个或两个构件中设置多个孔，用于可调节性。

13. 发明授权

US4080334A Intermediates in the total synthesis employing substituted isoxazole derivatives 失效
标题翻译：使用取代的异恶唑衍生物的全合成中的中间体
公开(公告)号：US4080334A
公开(公告)日：1978-03-21
申请号：US696100
申请日：1976-06-14
申请人： Gabriel Saucy , John William Scott
发明人： Gabriel Saucy , John William Scott
IPC分类号： A61K31/5685 , C07D261/08 , C07D261/18 , C07D295/145 , C07D317/72 , C07F9/653 , C07J1/00 , C07J15/00 , C07D493/10
CPC分类号： C07D317/72 , A61K31/5685 , C07D261/08 , C07D261/18 , C07D295/145 , C07F9/653 , C07J1/00 , C07J1/0059 , C07J15/00 , C07J15/005 , C07C2103/16
摘要： The intermediates and processes of this invention provide a new synthetic route for the preparation of pharmaceutically valuable 19-norsteroids. Further, the intermediates and processes of the invention provide a route for the preparation of pharmaceutically valuable estrones. The present invention provides a facile total synthesis of 19.beta.-alkyl-C/D-trans-steroidal materials. This desirable result is obtained via a unique asymmetric induction followed by subsequent stereo-specific reaction steps. As a precursor to the steroidal Ring A, a 3,5-disubstituted-4-isoxazolylmethylene group is employed in this synthesis.
摘要翻译：本发明的中间体和方法提供了用于制备药学上有价值的19-降胆甾类的新的合成途径。此外，本发明的中间体和方法提供了用于制备药学上有价值的爱因子的途径。本发明提供了19个β-烷基-C / D-反式甾体材料的简便总合成。通过独特的不对称诱导，然后是随后的立体特异性反应步骤获得该期望的结果。作为甾体环A的前体，在该合成中使用3,5-二取代-4-异恶唑基亚甲基。

14. 发明授权

US4018799A Antioxidant chroman compounds 失效
标题翻译：抗氧化色满化合物
公开(公告)号：US4018799A
公开(公告)日：1977-04-19
申请号：US637611
申请日：1975-12-04
申请人： John William Scott , David Richard Parrish , Gabriel Saucy
发明人： John William Scott , David Richard Parrish , Gabriel Saucy
IPC分类号： C07D311/58 , C11B5/00 , C07D311/20
CPC分类号： C07C255/00 , C11B5/0035
摘要： The (6-hydroxy-chroman-2-yl) acetic or carboxylic acid derivatives useful as antioxidants and a method for preparing these derivatives from hydroquinones and intermediates in this synthesis as well as the use of these derivatives as intermediates in the preparation of optically active alpha-tocopherol.
摘要翻译：用作抗氧化剂的（6-羟基 - 苯并二氢吡喃-2-基）乙酸或羧酸衍生物以及在该合成中由氢醌和中间体制备这些衍生物的方法以及这些衍生物作为制备光学活性剂的中间体的用途 α-生育酚。

15. 发明授权

US5765536A Bowstring release device 失效
标题翻译：弓弦释放装置
公开(公告)号：US5765536A
公开(公告)日：1998-06-16
申请号：US657334
申请日：1996-06-03
申请人： John William Scott
发明人： John William Scott
IPC分类号： F41B5/18
CPC分类号： F41B5/1469
摘要： A bowstring release with a fixed jaw and a single movable jaw is controlled by a trigger mechanism to provide enhanced accuracy. The bowstring release mechanism is adapted to rotate about its longitudinal axis to readily align the jaws with a bowstring, and the bowstring release is further attached to a wrist strap by means of a ring or attachment plate having two relatively straight sides engaged by leather tabs on the wrist strap. The straight sides and the leather tabs control and define the location of the ring thereby removing positional variances of the point of force transmission between the wrist strap and the bowstring release device and eliminate at least some variations which will affect consistent bowstring draw and release. The use of both a single fixed jaw and a movable jaw improves the accuracy and the smoothness with which the bowstring is released by stabilizing the bowstring during the initial portions of its flight after release.
摘要翻译：具有固定钳口和单个活动钳口的弓弦释放装置由触发机构控制以提供更高的精度。弓弦释放机构适于围绕其纵向轴线旋转以容易地将颚板与弓弦对准，并且弓弦释放装置通过环或附接板进一步附接到腕带，所述环或附接板具有两个相对直的侧面，腕带。直边和皮革翼片控制和限定环的位置，从而消除腕带和弓弦释放装置之间的力传递点的位置变化，并消除至少一些将影响一致的弓弦牵引和释放的变化。使用单个固定夹爪和可动夹钳可以在释放后在其飞行的最初部分稳定弓弦，提高了弓弦释放的准确性和平滑度。

16. 发明授权

US4044004A Total steroid synthesis employing substituted isoxazole derivatives 失效
标题翻译：使用取代的异恶唑衍生物的总类固醇合成
公开(公告)号：US4044004A
公开(公告)日：1977-08-23
申请号：US695610
申请日：1976-06-14
申请人： Gabriel Saucy , John William Scott
发明人： Gabriel Saucy , John William Scott
IPC分类号： A61K31/5685 , C07D261/08 , C07D261/18 , C07D295/145 , C07D317/72 , C07F9/653 , C07J1/00 , C07J15/00 , C07J43/00
CPC分类号： C07D317/72 , A61K31/5685 , C07D261/08 , C07D261/18 , C07D295/145 , C07F9/653 , C07J1/00 , C07J1/0059 , C07J15/00 , C07J15/005 , C07C2103/16
摘要： The novel intermediates and processes of this invention provide a new synthetic route for the preparation of pharmaceutically valuable 19-norsteroids. Further, the intermediates and processes of the invention provide a novel route for the preparation of pharmaceutically valuable estrones. The present invention provides a facile total synthesis of 19.beta.-alkyl-C/D-trans-steroidal materials. This desirable result is obtained via a unique asymmetric induction followed by subsequent stereospecific reaction steps. As a precursor to the steroidal Ring A, a 3,5-disubstituted-4-isoxazolylmethylene group is employed in this synthesis.
摘要翻译：本发明的新颖中间体和方法为制备药学上有价值的19-降胆甾醇提供了新的合成途径。此外，本发明的中间体和方法提供了用于制备药学上有价值的酮的新途径。本发明提供了19个β-烷基-C / D-反式甾体材料的简便总合成。通过独特的不对称诱导，然后随后的立体特异性反应步骤获得该期望的结果。作为甾体环A的前体，在该合成中使用3,5-二取代-4-异恶唑基亚甲基。

17. 发明授权

US4003919A Antioxidant chroman compounds 失效
公开(公告)号：US4003919A
公开(公告)日：1977-01-18
申请号：US637547
申请日：1975-12-04
申请人： John William Scott , David Richard Parrish , Gabriel Saucy
发明人： John William Scott , David Richard Parrish , Gabriel Saucy
IPC分类号： C11B5/00 , C07D311/72
CPC分类号： C07C255/00 , C11B5/0035
摘要： The (6-hydroxy-chroman-2-yl) acetic or carboxylic acid derivatives useful as antioxidants and a method for preparing these derivatives from hydroquinones and intermediates in this synthesis as well as the use of these derivatives as intermediates in the preparation of optically active alpha-tocopherol.

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